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Cordyceps militaris water extract as well as preparation method and application thereof

A technology for water extract and Cordyceps militaris, which is applied in directions such as pharmaceutical formulations, pharmaceutical combinations, plant raw materials, etc., can solve the problems of complex preparation methods, large organic solvent pollution and high cost, and achieves simple preparation process, low cost, and uric acid-lowering effect. Effect

Active Publication Date: 2015-04-01
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its preparation method is complicated, the cost is high, and all of them are extracted with organic solvents, so there is a problem of large organic solvent pollution.

Method used

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  • Cordyceps militaris water extract as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] One, the preparation of Cordyceps militaris aqueous extract (ETCM)

[0024] Take 100 g of Cordyceps militaris fruiting body, pulverize it with a pulverizer, put it into an Erlenmeyer flask, and add 2 L of distilled water, extract the mixture in a water bath at 80° C. for 2 hours, and then filter it with a 400-mesh filter. The extraction experiment was repeated once, and the resulting filtrates were combined and concentrated to 300 mL by vacuum distillation, and freeze-dried to obtain 53 g of Cordyceps militaris water extract, with a yield of 53%.

[0025] 2. Determination of the content of each component in the Cordyceps militaris water extract

[0026] Determination of mannitol: use the color reaction of mannitol with sodium periodate and Nash reagent to determine the content of mannitol. The preparation of the reagents used is as follows: Nash reagent: take 150g of ammonium acetate, dissolve it with an appropriate amount of distilled water, add 2mL of glacial acetic ...

Embodiment 2

[0034] Take 100 g of Cordyceps militaris fruiting bodies, pulverize them with a pulverizer, put them into an Erlenmeyer flask, and add 500 mL of distilled water, extract the mixture ultrasonically at 60°C for 2 hours, and then filter with a 400-mesh filter. The extraction experiment was repeated once, and the resulting filtrates were combined and concentrated to 250 mL by vacuum distillation, and freeze-dried to obtain 39 g of Cordyceps militaris water extract with a yield of 39%.

[0035] According to the detection method described in Example 1, the mannitol content in the Cordyceps militaris aqueous extract is 7%, the polysaccharide content is 20%, and the nucleoside content is 0.35%.

Embodiment 3

[0037] Take 100 g of Cordyceps militaris fruiting bodies, pulverize them with a pulverizer, put them into an Erlenmeyer flask, add 2.5 L of distilled water, decoct and extract the mixture at 100° C. for 2 hours, and then filter with a 400-mesh filter. The extraction experiment was repeated once, and the resulting filtrates were combined and concentrated to 350 mL by vacuum distillation, and freeze-dried to obtain 45 g of Cordyceps militaris water extract with a yield of 45%.

[0038] According to the detection method described in Example 1, the mannitol content in the Cordyceps militaris aqueous extract was measured to be 5.4%, the polysaccharide content was 25%, and the nucleoside content was 0.25%.

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Abstract

The invention provides a method for preparing a cordyceps militaris water extract. Water which is rich in resources and low in price serves as a solvent, and the aims of reducing the production cost and avoiding pollution of organic solvents are achieved. The cordyceps militaris water extract prepared by the method can be used for preparing medicines, health care products or auxiliary agents for reducing the uric acid level and improving the gout diseases.

Description

【Technical field】 [0001] The invention relates to an aqueous extract of Cordyceps militaris, a preparation method and an application thereof, belonging to the fields of health care products and traditional Chinese medicines. 【Background technique】 [0002] Gout seriously plagues human life. Epidemiological studies in New Zealand, the United States and China have shown that gout is becoming more and more common, with an incidence rate of about 2% and increasing. Among them, the incidence rate is highest in people aged 65 and over, and the incidence rate of men is twice as high as that of women. Gout is the result of the development of hyperuricemia. It is because the concentration of uric acid in the body is higher than the dissolving capacity of the blood (>360μmol / L), resulting in the deposition of sodium urate crystals in soft tissues and joints. These deposited crystals cause repeated inflammation of soft tissues, joints and bone tissues severe pain, seriously reducin...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61P19/06
CPCA61K36/068A61K2236/15A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 雍天乔张命龙谢意珍焦春伟
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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