The invention discloses a
hippophae rhamnoides extract capable of preventing and treating
gout. The
hippophae rhamnoides extract is prepared by the following steps: taking a certain amount of
hippophae rhamnoides, crushing and sieving, adding a certain amount of
solvent for extraction, filtering, merging filtrate and concentrating to obtain the
hippophae rhamnoides extract. Animal experiment research shows that the
hippophae rhamnoides fruit extract with the
gout prevention and
treatment effect can remarkably reduce the
uric acid and
blood urea nitrogen level of an acute
hyperuricemia model mouse. In the experiment process, although the allopurine with a
large dose of a positive
drug has an obvious
uric acid reducing effect, the allopurine has an obvious
renal injury effect, and compared with a model group, the allopurine can obviously increase serum
creatinine and
blood uric acid nitrogen levels. And the sea-buckthorn extract, especially the water extract and
ethanol extract of sea-buckthorn, can reduce the
blood uric acid level and the
blood urea nitrogen level, has no obvious influence on the
serum creatinine level, has no obvious adverse reaction, and is
safer in clinical application.