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A kind of pharmaceutical composition for treating diabetic nephropathy and its preparation method and application

A technology for diabetic nephropathy and a composition is applied in the field of pharmaceutical compositions for the treatment of diabetic nephropathy and its preparation, and achieves the effects of stable curative effect and no toxic and side effects

Active Publication Date: 2018-06-22
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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Problems solved by technology

There is no specific treatment for diabetic nephropathy

Method used

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  • A kind of pharmaceutical composition for treating diabetic nephropathy and its preparation method and application

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Embodiment Construction

[0029] The following describes but does not limit the present invention through the description of specific embodiments of the present invention.

[0030] The pharmaceutical composition used for the treatment of diabetic nephropathy of the present invention is made up of the raw material medicine of following weight ratio:

[0031] 1) When the pharmaceutical composition of the present invention is made of Caulis chinensis, Fructus Shayuan, Radix Astragali, Coptidis Rhizoma, and Safflower as raw materials:

[0032] The weight ratio of raw materials is as follows: 10-120 parts of Qingfengteng, 10-120 parts of Shayuanzi, 10-120 parts of Astragalus, 5-60 parts of Coptidis Rhizoma, and 5-50 parts of Safflower.

[0033] The preferred weight proportion of raw materials is as follows: 10-50 parts of Qingfengteng, 10-50 parts of Shayuanzi, 10-50 parts of Astragalus, 5-30 parts of Coptidis Rhizoma, and 10-50 parts of Safflower.

[0034] The further preferred weight proportion of the ra...

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Abstract

The invention belongs to the field of medicine, and particularly relates to a drug composition for treating diabetic nephropathy, a preparation method and uses thereof. The technical problem solved by the present invention is to provide a completely-new drug composition for treating diabetic nephropathy. According to the drug composition of the present invention, caulis sinomenii, astragalus complanatus, milkvetch root, coptis chinensis and safflower are adopted as main bulk drugs to achieve the diabetic nephropathy treating purpose; and rosa laevigata michx and euryale ferox can further be added so as to further improve the treatment effect of the drug composition. According to the present invention, the most typical symptom of the diabetic nephropathy is nodular glomerulosclerosis and mainly the excretion amount of the urinary albumin is adopted as the diagnostic indicator, and after patients take the drug composition, the proteinuria excretion is significantly reduced, the 24 h urine total protein level and the urinary albumin excretion rate are reduced, the urinary albumin / creatinine ratio is reduced, the serum creatinine level is lowered, the life quality of patients is significantly improved, and the progress of the diabetic nephropathy disease is delayed.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating diabetic nephropathy, a preparation method and application thereof. Background technique [0002] Diabetic nephropathy is one of the microvascular complications of diabetes and an important cause of death in diabetic patients. Diabetic nephropathy in a broad sense includes infectious lesions and vascular lesions. Infectious lesions include pyelonephritis and renal papillary necrosis. Vascular lesions are divided into microvascular and macrovascular lesions, and macrovascular lesions include renal arteriosclerosis (involving the main trunk and branches) and renal arteriosclerosis (involving the glomerular and efferent arterioles). Microangiopathies refer to glomerulosclerosis, which can be divided into three types: nodular, exudative, and diffuse. The three can exist alone or in combination. Among the above changes, nodular glomerulos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P3/10A61P13/12
Inventor 钟森涂翔
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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