121results about How to "Improve pathological changes" patented technology

An application of the Chinese medicine 'Superfine Tongxinluo' in relaxing the vascular endothelial injury caused by atherosclerosis, decreasing the cardiac infarction range after AMI reperfusion, preventing hyperlipemia and atherosclerosis, and treating arteria coronaria spasm, pile, thromboangiitis obliterans, platelet coagulation, etc is disclosed.

The invention discloses a use of butenolide I for preparing drugs for controlling immunological liver injury. With the present invention, the butenolide I can reduce levels of TNF-alpha and NO, wherein the TNF-alpha and the NO play important roles in a pathogenic process of the immunological liver injury; the butenolide I can reduce elevated levels of the NO and the iNOS in liver homogenates of immunological liver injury mice so as to decrease the liver injury induced by the NO; the butenolide I can inhibit a overexpression of the TNF-alpha so as to decrease the direct liver injury or the indirect liver injury induced by the TNF-alpha. In addition, the use of the butenolide I as the drug for controlling the immunological liver injury has advantages of convenient preparation, extensive sources, low price and high safety, and has good development and application prospect.

This invention relates to a pharmaceutical composition used for treating cardiovascular diseases and a method for preparing it. The pharmaceutical composition mainly contains polysacchrides, saponins and amino acids extracted from Radix ginseng, Radix ophiopogonis and Fructus schisandrae chinensis. The method of preparing it includes the following steps: Radix ginseng, Radix ophiopogonis and Fructus schisandrae chinensis are decocted together in water; water extract or eluate is precipitated with alcohol or acetone, treated with macroporous adsorption resin and with ion exchange resin, and then separated to obtain pharmaceutical composition containing effective fractions of polysacchrides, saponins and amino acids. The above mentioned pharmaceutical composition can be formed into various preparations by mixing with any pharmaceutically acceptable auxiliary materials.

The invention discloses pulse ultrasound treatment equipment for male erectile dysfunction.The pulse ultrasound treatment equipment comprises a master control device, a micro-control system and a treatment probe.The treatment probe comprises an ultrasound generator.The master control device sends control signals to the micro-control system, the micro-control system converts the control signals into control instructions and sends the control instructions to the ultrasound generator, and the ultrasound generator generates corresponding ultrasound according to the control instructions.The pulse ultrasound treatment equipment can generate the ultrasound for therapeutic use, treatment is conducted in vitro in a non-intrusive mode, pain brought to a patient by an operation is avoided, and harm of medicine to the human body of dependence of the human body on the medicine are avoided.The low-intensity pulse ultrasound can promote neovascularization, proliferation of cavernous body smooth muscle cells and eNOS and nNOS expression, improve blood flow of the penis, lower a TGF-beta1/Smad/CTGF signal channel and relieve fibrosis of the penis, the pathological change of the erection organ is improved accordingly, and finally the erection function of the penis is improved.

The invention discloses lucid ganoderma-corydalis saxicola compound chewable tablets. The formula of the lucid ganoderma-corydalis saxicola compound chewable tablets comprises 10-25 parts of lucid ganoderma, 10-15 parts of fructus lycii, 2-6 parts of corydalis saxicola, 5-10 parts of fructus momordicae, 20-30 parts of hydroxypropyl methyl cellulose, 5-15 parts of maltodextrin and 1-3 parts of lubricant. A production method of the lucid ganoderma-corydalis saxicola compound chewable tablets comprises the following steps: grinding the raw materials separately and sieving with a 500-mesh sieve to obtain ultrafine powder; combining according to the formula and stirring uniformly; granulating with alcohol by a wet process; drying at 60-80 DEG C until the water content reaches 4-6% by weight; cooling to room temperature, and sieving with a 60-mesh sieve; adding the lubricant and tabletting to obtain the lucid ganoderma-corydalis saxicola compound chewable tablets. The chewable tablets disclosed by the invention have the healthcare effects of clearing heat and removing toxin, protecting and nourishing liver, adjusting immunity, reducing blood sugar and blood fat, resisting oxidation and aging, replenishing vital essence to improve eyesight, promoting longevity and the like.

The invention discloses an oral medicament for treating hyperplasia of mammary glands. The medicament is prepared from the following traditional Chinese medicine materials in parts by weight: 40 to 70 parts of raw oysters, 25 to 50 parts of seaweed, 25 to 50 parts of radices paeoniae alba, 25 to 50 parts of radices zedoariae, 20 to 40 parts of radix bupleuri, 20 to 40 parts of pericarpium citri reticulatae viride, 20 to 40 parts of citri reticulatae, 20 to 40 parts of radix angelicae sinensis, 20 to 40 parts of cowherb seed, 5 to 20 parts of rhizoma corydalis and 5 to 20 parts of thunberg fritillary bulb; and the medicament is prepared in a conventional preparation method. Efficacy tests indicate that the medicament disclosed by the invention has obvious treatment effects on the hyperplasia of mammary glands of rats and mice, can be used for obviously reducing the nipple height of the rats and mice serving as models of the hyperplasia of mammary glands and remarkably reducing the increased uterine ovarian indexes of the rats and mice serving as the models of the hyperplasia of mammary glands, and has improving effects of different degrees on the pathological changes of mammary glands of the rats and mice serving as the models of the hyperplasia of mammary glands; and the medicament disclosed by the invention has remarkable effects of promoting blood circulation and removing blood stasis on the rats serving as the models of the hyperplasia of mammary glands and has remarkable pain-relieving and anti-inflammation effects.

The invention discloses an external traditional Chinese medicine bag prescription, a medicine bag and a using method thereof, and belongs to the field of traditional Chinese medicines. The medicine bag prescription consists of the following components in parts by weight: 10-30 parts of dried ginger, 5-15 parts of herba menthae, 10-20 parts of rhizoma curcumae longae, 10-20 parts of radix angelicae, 5-15 parts of cassia twig, 2-10 parts of radix angelicae sinensis, 2-10 parts of rhizoma ligustici wallichii, 2-10 parts of herba asari cum radice and 50-90 parts of folium artemisiae argyi. The traditional Chinese medicine bag, which is manufactured on the basis of the prescription, is relatively strong in effects of promoting blood circulation and removing stasis, diminishing inflammation and alleviating pain, warming and activating meridians, dispelling cold and the like through a synergistic effect among the various components, and the traditional Chinese medicine bag, in combination with a massaging effect, is capable of promoting blood circulation and promoting metabolism through hot compress; the traditional Chinese medicine bag is relatively high in comfort degree and can be widely applied to health care industry as well as to the treatment of osteoarthropathy such as cervical spondylosis, lumbar spondylosis and the like and diseases of deficiency-cold; meanwhile, the traditional Chinese medicine bag has the advantages of being low in cost, convenient to use, high in safety, free from side effects, large in operating area, rapid to take effects, significant in curative effect and the like; and the using method provided by the invention is simple to operate, easily available in raw materials and low in cost, and conforms to the market demands of traditional Chinese medicine and the health care industry.

The invention discloses application of human amniotic mesenchymal stem cells in preparation of a preparation for treating a myocardial ischemia reperfusion injury generated after cardiopulmonary bypass.In the myocardial ischemia reperfusion process after the cardiopulmonary bypass, the human amniotic mesenchymal stem cells can effectively prevent myocardial cells from being injured in myocardial ischemia reperfusion, obviously improve the cardiac functions, lower the levels of myocardial injury specific marker protein lactic dehydrogenase, creatine kinase isoenzyme and troponin I, lower the levels of a plasma inflammatory factor interleukin-8 and a tumor mecrosis factor-alpha, increase the content of the plasma inflammatory factor interleukin-10, obviously improve pathological changes of the myocardial tissue, reduce myocardial cell apoptosis, lower the expression level of cell apoptosis promoting protein, increase the expression quantity of anti-apoptoasis protein and can protect the functions of myocardial cell mitochondria.By preparing the human amniotic mesenchymal stem cells into an injection for treatment on the myocardial ischemia reperfusion injury generated after the cardiopulmonary bypass, the cardiac functions can be effectively protected, and postoperative complications of the cardiopulmonary bypass are relieved.

The invention discloses a method for establishing an animal model with opportunistic infections and chronic wasting diseases, and a traditional Chinese medicinal preparation for treating opportunistic infections and chronic wasting diseases. The traditional Chinese medicinal preparation is prepared by the following components in parts by weight: 100-180 parts of monkhood, 100-180 parts of dry ginger, and 100-160 parts of liquorice. The method has the positive effects that the method for establishing the animal model with opportunistic infections and chronic wasting diseases is found, and the model has high controllability, reliability and repeatability, and is convenient and economical to use; the model syndrome accords with the attack process of opportunistic infections and chronic wasting diseases; the model establishing factor accords with the theory of the Internal Canon of Medicine, and does not relates to causal organisms, so that the testing risks can be reduced, and the organism safety can be guaranteed; the traditional Chinese medicinal preparation obtained by screening has the characteristics of high efficiency, no toxicity, wide medicine sources and the like, is convenient to use and economical, can be used for prolonging the life of patients with opportunistic infections and chronic wasting diseases, improving the living quality of the patients and improving lesion of each tissue, and does not have toxic or side effect when a large dosage is used.

The invention relates to a method for preparing efflorescence tang grass extractive, wherein, the content of E-6-O-P-coumaric spatholobus stem is 7-40%. The invention also provides relative preparation and the application in cholecystitis treatment. The invention has stable quality and simple production.

The invention discloses a rhodiola extract and a pharmaceutical composition thereof and application of the rhodiola extract in treatment of a fatty liver disease. A preparation method for an effective part of rhodiola is characterized by comprising the following steps of: (A) crushing dry rhizomes of a rhodiola plant, performing extraction by using an organic solvent, and recovering the solvent from the extraction liquid under reduced pressure to obtain an extract; adjusting the extract to a proper density, performing water deposition in pure water, filtering the sediment, and concentrating the filtrate under reduced pressure to obtain a total rhodiola extract; and (B) separating the total rhodiola extract by using macromolecular adsorption resin, performing gradient elution by using a water or ethanol system, concentrating the eluent under reduced pressure, performing freeze drying, thus obtaining the effective part of the rhodiola.

The invention discloses health-care tea capable of reducing blood sugar. The health-care tea is prepared from the following components in parts by weight: 40-60 parts of screwtree wild sesame seeds, 10-30 parts of mulberry leaves, 5-15 parts of corn stigma, 5-15 parts of divaricate velvetplant roots and rhizomes, 3-8 parts of pomelo peel, and 3-8 parts of bitter gourds. The preparation method of the health-care tea comprises the following steps of weighing the components of the screwtree wild sesame seeds, the mulberry leaves, the corn stigma, the divaricate velvetplant roots and rhizomes, the pomelo peel and the bitter gourds in a compounding ratio, and then cleaning the weighed components with water; drying the cleaned components, sterilizing the dried components, crushing the sterilized components to obtain screwtree wild sesame seed powder, mulberry leaf powder, corn stigma powder, divaricate velvetplant root and rhizome powder, pomelo peel powder and bitter gourd powder, then performing uniform mixing so as to obtain a mixture, and subpackaging the mixture in a measurement manner to obtain tea bags. The health-care tea disclosed by the invention is purely traditional Chinese medicine products, is scientific in formula, is mainly used for reducing blood sugar, reducing blood lipid, and nourishing the kidney and the liver, and the formula enables the characteristics of traditional Chinese medicine materials to be exerted. The health-care tea is free from any toxic and side effects and convenient to take, can reduce the blood sugar under the condition of protecting the liver and the kidney, and is suitable for patients suffering from high blood sugar to drink.

The invention belongs to the field of drug or health care product, and more specifically relates to a gynura formosana Kitam. total flavonoids extract, a preparation method thereof, and applications of the gynura formosana Kitam. total flavonoids extract in treating acute pharyngitis. The gynura formosana Kitam. total flavonoids extract comprises, by weight, 80 to 85% of rutin. It is shown by drugeffect experiment results that the gynura formosana Kitam. total flavonoids extract possesses certain curative effect on mice acute pharyngitis models, is capable of relieving symptoms of mouse acutepharyngitis, and improving pathological changes of mouse pharyngeal mucosa, and can be taken as a potential drug used for treating acute pharyngitis. According to the preparation method, after extraction, a composite enzyme is composed of enzymes of specific composition and specific ratio, and is used for enzymatic hydrolysis; and in addition, macroporous resin extraction condensation and macroporous resin separation purifying are adopted. The HPLC purity of rutin in the gynura formosana Kitam. total flavonoids extract is capable of reaching 80 to 85%.

The invention relates to the field of traditional Chinese medicines and in particular relates to a traditional Chinese medicine composition for preventing and treating hyperplasia of mammary glands. The traditional Chinese medicine composition is composed of lychee seed, tangerine seed, mulberry twig, pangolin scales, common selfheal fruit-spike, zedoray rhizome, nutgrass galingale rhizome, green tangerine peel, bulb of thunberg fritillary, Indian buead, radix bupleuri, cowherb seed, Chinese angelica, dragon's blood, frankincense, white paeony root, pinellia tuber, radix codonopsis, suberect spatholobus stem, glossy privet fruit, barbary wolfberry fruit, motherwort herb, oriental waterplantain rhizome, and the like. Compared with the prior art, the traditional Chinese medicine composition has the advantages of good curative effects, low cost, small limitation, no adverse reactions, and the like. The traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition has the functions of relieving the depressed liver, reducing phlegm and resolving masses and promoting blood circulation to dispel blood stasis; through mutual compatibility, all the ingredients act on various pathological levels of hyperplasia of mammary glands; and the traditional Chinese medicine composition has the functions of removing toxicity, resolving masses and eliminating diseases and inducing diuresis for treating stranguria and can achieve the effect of improving various pathological changes of hyperplasia of mammary glands as a whole to achieve the aim of treating hyperplasia of mammary glands.

The invention discloses an application of baicalein in preparation of drugs for preventing and/or treating diseases caused by novel coronavirus infection. Specifically, the invention relates to the application of the baicalein and a pharmaceutical composition containing baicalein in preparation of drugs for preventing and/or treating diseases caused by the novel coronavirus (SARS-CoV-2) infection, and the infectious diseases comprise mild, medium and severe infections caused by novel coronavirus, especially novel coronavirus pneumonia.

The multifunctional cervical spondylopathy and lumbar vertebrae disease therapeutic equipment is a comprehensive therapeutic equipment integrating neodymium-iron-boron magnetic device, far infrared radiator, vibration massage device, pulse and electronic acupuncture and moxibustion device, nano bio-active multifunctional fibre and natural static traction therapeutic function into one body in which the above-mentioned all the therapeutic device are driven by a small motor with an eccentric hammer. It is safe and reliable in therapeutic effect.

The invention discloses an application of gallocatechin in the preparation of drugs for resisting benign prostatic hyperplasia. According to the invention, through a prostatic hyperplasia model in ovariectomized rats induced by testosterone propionate, gallocatechin is selected as a therapeutic drug so as to observe the influence on rat prostate weight and index and pathological changes of prostate tissues. Research results show that gallocatechin can significantly reduce the prostate weight and prostate index of the animal model and improve pathological symptoms of prostate tissues.

The invention relates to a method for treating and/or improving male erectile dysfunction by using low-intensity pulsed ultrasound. According to the method of the invention, as proved by experiments, low-intensity pulsed ultrasound therapy can repair corpus cavernosum vascular endothelial cell functions so as to promote corpus cavernosum smooth muscle cell proliferation, promote eNOS and nNOS expression, improve penile blood flow, lower a TGF-beta 1/Smad/CTGF signal pathway and reduce penile fibrosis, and thereby, improving penile pathological change and ultimately achieving erectile dysfunction treatment effects.

The invention relates to the technical field of traditional Chinese medicine, and discloses a radix stephaniae tetrandrae and radix astragali decoction and application of components thereof in preparation of myocardial hypertrophy resisting medicine. The radix stephaniae tetrandrae and radix astragali decoction is prepared from 50-70 g of radix stephaniae tetrandrae, 60-90 g of radix astragali, 35-55 g of rhizoma atractylodis macrocephalae, 20-40 g of radix glycyrrhizae, 35-55 g of fresh ginger and 25-45 g of fructus ziziphi jujubae, and the radix stephaniae tetrandrae and radix astragali decoction is obtained after the raw materials are decocted with water, filtered and concentrated under reduced pressure. The radix stephaniae tetrandrae and radix astragali decoction is dispersed with water and then eluted with water, 15-22% ethyl alcohol, 35-45% ethyl alcohol and 90-100% ethyl alcohol in sequence, and 35-45% ethyl alcohol eluent and 90-100% ethyl alcohol eluent are a component A and a component B of the radix stephaniae tetrandrae and radix astragali decoction; animal pharmacodynamic study confirms that the radix stephaniae tetrandrae and radix astragali decoction, the component A and the component B can obviously improve the heart function level of a heart failure model mouse, reduce serum heart failure markers, relieve inflammatory response, improve pathological changes of heart tissues and play an obvious role in resisting the heart failure of the mouse; certain development potential is realized in the aspect of preparing medicines for treating myocardial hypertrophy.

The invention discloses a Chinese medicinal plaster, in particular an externally applied medicament for a pediatric umbilical part and a preparation method thereof. The externally applied medicament for the pediatric umbilical part is characterized by being prepared from the following components: common burreed rhizome, curcuma zedoary, pangolin scales, medicine terminalia fruit, pepper, hawthorn, pharbitis seed, clove, Indian buead, medicinal evodia fruit, cinnamon, atractylodes rhizome, areca seed, oriental waterplantain rhizome, plantain seed, dried ginger, cuttlebone, radish seed, malt, amomum fruit, borneolum, musk and honey. The Chinese medicinal plaster is specially used for treating pediatric indigestion, diarrhea, anorexia, dyspepsia and malnutrition; the various medicaments are combined to activate qi, blood circulation and coronary circulation so as to fulfill the aim of tonification and purgation in combination; the plaster is safe in clinic application; medicament concentration in tissues of the umbilical part is obviously higher than blood concentration in the tissues of the umbilical part; therefore, the plaster is brought into full effect, the local curative effect is obviously superior to that of internal treatment, and the plaster has quick response, broad indication, is safe in use and has less toxic or side effect. 150 cases are treated in all, and the total effective rate reaches 96 percent.

The invention discloses a traditional Chinese drug plaster, in particular to an umbilically applied drug for treating gynaopathy and a preparation method thereof. The drug is characterized by comprising the following components: frankincense, myrrh, dragon's blood, fructus cnidii, pale catechu, radix angelicae, realgar, borax, stalactite, musk, pepper, fennel, cassia twig, crocus sativus, rhizoma sparganii, curcuma zedoary, clove, asarum, pangolin, cinnamon, plum blossom borneol, semen brassicae and honey. The traditional Chinese drug plaster provided by the invention is specially used for treating the gynaopathy; the synergy of different medicines smoothes qi, dredges the artery and circulates the blood, thus achieving the purpos of tonification and purgation in combination and ensuring safe clinical application; the concentration of the drug applied in the local tissue of the umbilical region is obviously higher than the concentration of blood, thus giving full play to the functions; the local curative effect is obviously superior to the internal treatment; the drug takes effects rapidly, is suitable for wide diseases, and is safe in use and less in non-toxic side effect; and 162 patients has been treated, and the total efficiency reaches 96%.

The invention discloses a traditional Chinese medicine composition for treating chronic ulcerative colitis and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-22 parts of semen cuscutae, 10-14 parts of morinda officinalis, 5-9 parts of radix cyathulae, 6-12 parts of radix dipsaci, 16-22 parts liquorice, 9-14 parts of alpinia oxyphylla, 4-9 parts of peach seed, 12-18 parts of fructus mume, 6-11 parts of herba rabdosiae, 3-6 parts of platycodon grandiflorum, 14-19 parts of fructus kochiae and 4-8 parts of swamp mahogany leaf. The preparation method comprises the following steps: washing and cutting the various raw materials, drying, adding water into semen cuscutae and morinda officinalis for decocting for three times, concentrating, performing alcohol precipitation, and drying, thereby obtaining the extract A; adding ethanol into herba rabdosiae and platycodon grandiflorum for refluxing, and drying, thereby obtaining the extract B; merging the extract A and extract B, grinding, and mixing, thereby obtaining the material. The traditional Chinese medicine composition can achieve the effects of eliminating clinical symptoms, such as diarrhea, bloody purulent stool and abdominal pain, of patients suffering from chronic ulcerative colitis, obviously improving the intestinal mucose pathological change, eliminating inflammatory mediators and promoting ulcer healing, so that a good treatment effect is achieved. Moreover, the total effective rate is 96 percent, and adverse effects and toxic or side effects are not discovered.

The invention relates to an application of Bacillus licheniformis live bacteria which is applied in the field of biotechnology in preparation of medicine for preventing acute and chronic intestinal endotoxemia and medicine for treating chronic intestinal endotoxemia; an application of the Bacillus licheniformis live bacteria in preparation of medicine for preventing acute and chronic intestinal endoxemia; and an application of the Bacillus licheniformis live bacteria in preparation of medicine for treating chronic intestinal endotoxemia. The intestinal endotoxemia is caused by factor causing damage to liver; a dosage of the Bacillus licheniformis live bacteria is 0.45-1.35 billion live bacteria per kilogram every day. The Bacillus licheniformis live bacteria provided by the invention ameliorates the intestinal endotoxemia caused by acute and chronic liver injury in rat induced by thioacetamide, improves histopathology change of the liver injury of rat, relieves lipid peroxidatic injury of hepatic tissue when chronic liver injury occurs, and partially decreases levels of serum glutamic pyruvic transaminase, glutamic-oxalacetic transaminease and lactic dehydrogenase.

The invention discloses blood glucose-lowering oral liquid and a preparation method thereof. The blood glucose-lowering oral liquid is prepared from the following raw materials in proportions by weight: 35%-45% of tartarian buckwheat water extract, 35%-45% of seabuckthorn fruit water extract, 8%-12% of bitter gourd water extract, 0.5%-1.5% of kudzuvine root water extract, 1%-4% of gynura divaricata water extract, 0.5%-1.5% of mulberry leaf water extract and 1%-6% of Neotame solution, with the balance being deionized water. The blood glucose-lowering oral liquid belongs to pure traditional Chinese medicine products, and is reasonable in proportion, suitable in mouthfeel, ready to drink by warm water brewing, convenient for drinking, capable of lowering blood glucose on the basis of not harming liver and kidney organs of diabetic patients and suitable for people with high blood glucose and diabetic patients to drink.

The invention relates to blood sugar reducing healthy tea. The blood sugar reducing healthy tea is prepared from the following raw materials in parts by weight: 30 to 50 parts of cortex cinnamomi, 20to 30 parts of tartary buckwheat, 10 to 20 parts of radix puerariae, 10 to 20 parts of folium mori, 2 to 7 parts of gynura divaricata, 2 to 7 parts of radix ginseng and 2 to 7 parts of liquorice root.The blood sugar reducing healthy tea disclosed by the invention belongs to pure traditional Chinese medicine products, and has the advantages that reasonable proportioning and proper taste are achieved, and the tea can be drunk just by being brewed by boiled water, is convenient to drink, is capable of reducing blood sugar on the basis that organs of liver and kidney of patients suffering from diabetes are not injured, and is suitable for populations suffering from hyperglycemia and the patients suffering from diabetes to drink.