24results about How to "Improve pathological changes" patented technology

The invention discloses an application of pinoresin-4-O-glucoside in preparation of a medicine for treating allergic asthma diseases, and according to the application provided by the invention, the pinoresin-4-O-glucoside can inhibit expression and activity of induced nitric oxide synthase, remarkably improve airway hyperresponsiveness, relieve lung inflammation and relieve expression of asthma related indexes, and can be used for treating allergic asthma diseases. The application has a prospect of developing a novel anti-asthma medicine.

The present invention relates to the application of glycyrrhizin drug-loaded nanoparticles for preparing drugs for treating psoriasis, and belongs to the technical field of nano traditional Chinese medicine. The multi-component drug includes baicalin, paeoniflorin, and liquiritin. Baicalin can regulate NF-κB and JAK / STAT signaling pathways, inhibit skin inflammatory reactions, and improve atopic dermatitis lesions; it can also relieve skin inflammation in psoriasis mice by inhibiting the IL-17 / IL-23 axis. Peony glycosides can regulate a variety of signaling pathways, including the GPCR pathway and the JAK2 / STAT3 pathway, etc., can significantly reduce the transcription level of STAT3, inhibit the secretion of cytokines by Th17 cells, and thus alleviate the symptoms of psoriasis. As one of the main active ingredients of licorice, liquiritin has a good therapeutic effect on acute lung injury, cancer, and cell damage caused by inflammation. The present invention utilizes glycyrrhizin nanoparticles to load the above-mentioned drugs, and the corresponding drug-loaded nanoparticles can be better absorbed by intestinal cells and inflammatory cells, and exert a good therapeutic effect on psoriasis.

The invention relates to the technical field of medicines, in particular to application of L-pyroglutamic acid and related products. It is found for the first time that L-pyroglutamic acid can be applied to preparation of the medicine for preventing or treating hypertension or heart and vasculopathy caused by hypertension, the treatment effect is good, safety is achieved, and a new treatment approach is provided for treating hypertension or hypertension-related diseases.

The invention discloses a traditional Chinese medicine composition for treating diabetic kidney diseases, relates to the field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating diabetic kidney diseases, which is prepared from 15 to 30 parts of radix astragali seu hedysari, 10 to 30 parts of radix salviae miltiorrhizae, 3 to 6 parts of leech powder, 3 to 6 parts of raw radix et rhizoma rhei, 15 to 45 parts of rhizoma coptidis and 10 to 30 parts of rhizoma zingiberis recens. The traditional Chinese medicine composition disclosed by the invention can reduce fasting blood-glucose, regulate blood fat, reduce triglyceride and total cholesterol levels, reduce the ratio of urinary albumin to creatinine, inhibit ferroptosis and improve the pathology of the diabetic kidney disease.

The invention relates to the field of genetic engineering and life science, in particular to application of taxus chinensis extracellular vesicles in preparation of drugs for preventing and / or treating inflammation, a method and a pharmaceutical composition. It is found for the first time that the taxus chinensis extracellular vesicles protect cells from being damaged by lipopolysaccharide by inhibiting expression of pro-inflammatory cytokines, so that the effect of resisting cell inflammation is achieved, and the taxus chinensis extracellular vesicles can be used as a medicine for preventing and / or treating colitis.

The invention discloses a traditional Chinese medicine composition for treating chronic viral hepatitis B. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 16-20 parts of herba artemisiae scopariae, 10-15 parts of fructus gardeniae, 4-8 parts of radix et rhizoma rhei, 13-17 parts of rhizoma atractylodis macrocephalae and 8-12 parts of pericarpium citri reticulatae. On the basis of the artemisia capillaris decoction, the atractylodes macrocephala koidz and the pericarpium citri reticulatae are combined, and the dosage proportion of all the medicines is precisely matched, so that the syndrome performance, liver function and liver pathological change of the CHB liver and gallbladder damp-heat syndrome are remarkably improved, FBG and TG are reduced, and the Lep and EPI levels are improved; the traditional Chinese medicine composition disclosed by the invention has incomparable advantages in the aspects of improving the typical clinical manifestation fatigue and weakness of the CHB liver and gallbladder damp-heat syndrome and highly active HBV replication.

The invention discloses a supraspinatus tendinopathy treatment medicine and a preparation method thereof, and relates to the technical field of tendinopathy medicine preparation. The preparation raw materials comprise 500 g of radix astragali medicinal material and 5 g of cellulase. The specific preparation method comprises the following steps: S1: pretreatment and enzymolysis: S11: selecting and cleaning a radix astragali medicinal material; s12, performing crushing treatment; s13, cellulase treatment: 5 g of cellulase is weighed and pre-activated with warm water for 10 min, and the enzyme activity is increased; and S14, carrying out an enzymatic hydrolysis reaction, namely uniformly spraying the pre-activated cellulase onto the astragalus membranaceus powder. The traditional Chinese medicinal material astragalus membranaceus is adopted, so that the treatment effect of the medicine can be remarkably improved; a method of combining cellulase pretreatment and ethanol reflux extraction is adopted, so that the extraction rate of effective components in the medicinal materials is increased; by optimizing enzymolysis and extraction conditions, such as temperature, pH value, solvent proportion and the like, high purity and high activity of effective components in the extract are ensured.

The invention relates to a pharmaceutical composition for treating chronic atrophic gastritis and precancerous lesions and application thereof, the pharmaceutical composition is a Xiansheng stomach tonifying formula and comprises herba epimedii, codonopsis pilosula, fructus alpiniae oxyphyllae, poria cocos, roasted rhizoma atractylodis macrocephalae, caulis perllae, vinegar-processed rhizoma cyperi, galangal, rhizoma nardostachyos, vinegar-processed rhizoma sparganii, vinegar-processed curcuma zedoary, dark plum and honey-fried licorice root. The formula is scientific and reasonable, clinical research proves that the Xiansheng stomach tonifying formula has a good curative effect on clinical symptoms of patients suffering from chronic atrophic gastritis and precancerous lesions, has the effect of preventing the precancerous lesions of gastric cancer from being converted into gastric cancer, and has the effects of recovering and improving the gastric mucosa state under a gastroscope, improving the gastric mucosa quality and improving the gastric mucosa quality. The curative effect of reversing pathological changes such as atrophy, intestinal metaplasia and atypical hyperplasia and precancerous lesions is achieved; animal experiments prove that the traditional Chinese medicine composition can improve the pathological state of glandular gastric mucosa of a CAG mouse model, delay glandular gastric mucosa tissue cell senescence of the CAG mouse model and prevent gastric precancerous lesions from being converted into gastric cancer, and also has the effect of resisting gastric senescence.

This invention relates to the application of mitochondrial formulations in the preparation of drugs for treating chronic obstructive pulmonary disease (COPD). The mitochondrial formulations contain active mitochondria isolated from healthy donor cells, with a particle size of 400–1000 nm, possessing normal mitochondrial membrane potential and ATP generation function, and capable of being internalized by mammalian COPD lung epithelial cells. In vitro cell experiments have confirmed that this mitochondrial formulation can repair CSE-induced mitochondrial dysfunction in lung epithelial cells, inhibit mPTP opening, reduce mtDNA leakage into the cytoplasm, thereby blocking the activation of the cGAS-STING signaling pathway and reducing the release of inflammatory factors such as IL-1β and TNF-α. In vivo experiments in COPD mouse models show that tail vein injection of the mitochondrial formulation can effectively accumulate in lung tissue, significantly improving lung pathological changes such as emphysema and collagen fiber deposition in model mice. This invention provides a novel strategy for COPD treatment based on repairing mitochondrial function and intervening in inflammatory signaling pathways.

This invention belongs to the field of traditional Chinese medicine preparations, and relates to the preparation method and application of a compound preparation of Yao Yu effervescent tablets with anti-rheumatoid arthritis effect. The compound preparation comprises the following traditional Chinese medicine components: 4 parts by weight of Dioscorea cirrhosa, 3 parts by weight of Tinleaf Vine, 2 parts by weight of Camphor Tree, 2 parts by weight of Rhus chinensis, 3 parts by weight of Rhododendron molle, 1 part by weight of Ephedra sinica, 2 parts by weight of Semi-Acer palmatum, 2 parts by weight of Gynostemma pentaphyllum, and 1 part by weight of Cinnamomum cassia. The preparation steps include: placing Dioscorea cirrhosa, Tinleaf Vine, Camphor Tree, Rhus chinensis, Rhododendron molle, Gynostemma pentaphyllum, Semi-Acer palmatum, Gynostemma pentaphyllum, and Cinnamomum cassia in 6000 parts by weight of 70% ethanol. Extract for 2 hours, repeat three times, filter, and combine the filtrates; concentrate, freeze-dry, pulverize, and pass through an 80-mesh sieve for later use; mix 27.5% freeze-dried powder with 26.45% citric acid, 34.11% sodium bicarbonate, 5.61% PEG6000, and 6.33% lactose evenly, pass through an 80-mesh sieve, and prepare a soft mass using anhydrous ethanol as a wetting agent; pass the soft mass through a 20-mesh sieve and dry at 37℃ for 30 minutes to obtain compound preparation granules; granulate through a 20-mesh sieve for granulation, add lubricant PEG6000 and mix evenly; compress into tablets to obtain compound preparation effervescent tablets. This invention, through pharmacological experiments, confirms that the Yaoyu effervescent tablet compound preparation has a good anti-rheumatoid arthritis effect: it can reduce local inflammatory mediators and serum IL-1β, IL-6, TNF-α, and PEG2 levels, downregulate MDA and increase SOD to improve oxidative stress, inhibit the expression of MMP3, COX-2, and P38 proteins in the synovial membrane, and reduce pathological tissue damage. The medium and high dose groups showed the best effect, and it has a good therapeutic and protective effect on the ankle joint of AA rats, with good clinical application value.

The invention provides application of phloretin in preparation of a medicine for preventing or treating renal ischemia-reperfusion injury, and belongs to the technical field of medical application. According to the application, research finds that the phloretin can up-regulate the protein expression level of PAK3 and reduce the apoptosis level under the conditions of renal ischemia reperfusion or hypoxia reoxygenation. On the basis, the phloretin or the pharmaceutically acceptable salt, ester or solvate thereof not only can be used as an activator of PAK3, but also can effectively inhibit cell apoptosis induced by renal ischemia reperfusion or hypoxia reoxygenation, so that a relatively good prevention and treatment effect on renal ischemia reperfusion injury caused by cell apoptosis is achieved. The application not only provides a new application for phloretin, but also provides a new drug choice for activation of PAK3, inhibition of apoptosis and renal ischemia-reperfusion injury, and has important guiding significance for prevention and treatment of renal ischemia-reperfusion injury.

The present invention discloses the application of protease-related active preparations in treating inflammatory diseases with hyperactive immune responses, and belongs to the field of biomedical technology. In order to provide a method for effectively improving allergic intestinal inflammation, the present invention provides the application of cysteine ​​protease inhibitors in the preparation of drugs for treating allergic intestinal inflammation, and provides new ideas for treating and preventing allergic enteritis.

The invention belongs to the technical field of traditional Chinese medicine, and relates to application of a yin-nourishing and lung-clearing composition in preparation of medicine for preventing and / or treating pulmonary fibrosis, and the yin-nourishing and lung-clearing composition is prepared from the following raw materials: rehmannia, radix scrophulariae, radix ophiopogonis, moutan bark, bulbus fritillariae cirrhosae, radix paeoniae alba, mint and liquorice. The invention provides the application of the yin-nourishing and lung-clearing composition in preparing the medicine for preventing and / or treating the pulmonary fibrosis, bleomycin is injected into the trachea to construct a pulmonary fibrosis mouse model, and the effect of the yin-nourishing and lung-clearing composition on treating the pulmonary fibrosis is determined from the three aspects of the lung coefficient, the pathological change and the hydroxyproline content of a model animal. Basic data support is provided for increasing clinical application of the composition for nourishing yin and clearing away lung-heat.

The invention discloses a screening method of a traditional Chinese medicine monomer composition for resisting heart failure. The method comprises the following steps: 1, carrying out water extraction and enrichment on astragalus membranaceus and monkshood to obtain astragalus membranaceus and monkshood soup enriched components; 2, synthesizing myocardial mitochondrial membrane coated magnetic beads and myocardial lysosome membrane coated magnetic beads; 3, gathering enriched components of the astragalus mongholicus-monkshood decoction, and carrying out ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry to obtain components of songorine, neoline, calycosin and formononetin as traditional Chinese medicine monomer composition; the traditional Chinese medicine monomer composition is prepared by dissolving songlin, neoline, calycosin and formononetin in a sodium carboxymethyl cellulose solution. The synthesized myocardial mitochondrial membrane coated magnetic beads and the myocardial lysosome membrane coated magnetic beads are used for adsorbing and identifying active ingredients in the astragalus mongholicus-monkshood decoction, the effective ingredient composition for resisting heart failure is successfully screened, and the preparation method is simple and easy to implement; the traditional Chinese medicine monomer composition plays a role in preparing anti-heart-failure medicines by improving heart functions and the like.

The invention discloses a human mesenchymal stem cell exosome preparation loaded with astaxanthin and application of the human mesenchymal stem cell exosome preparation, and relates to the technical field of biological preparations. The preparation is prepared by performing in-vitro amplification on human mesenchymal stem cells, extracting secreted exosomes, then mixing the exosomes with an RVG modification enhancing preparation and loading an astaxanthin medicine. The human mesenchymal stem cell exosome preparation loaded with astaxanthin is obtained, and the therapeutic effect and safety of the human mesenchymal stem cell exosome preparation in cell models and animal experiments are studied. The invention provides a new thought and method for clinical treatment of Parkinson's disease, and has certain innovativeness and application value.

The application relates to an application of a traditional Chinese medicine composition in a drug for chronic obstructive pulmonary disease, characterized in that the traditional Chinese medicine composition comprises the following components in parts: Magnolia officinalis 1-100 parts, Strychnos ignatii 1-100 parts, Toddalia asiatica 1-100 parts, Ephedra 1-100 parts, Amygdalus 1-100 parts, Notopterygium 1-100 parts, Zingiber officinale 1-100 parts, Pogostemonis 1-100 parts, Perilla 1-100 parts, Atractylodes 1-100 parts, Poria cocos 1-160 parts, Atractylodes macrocephala 1-120 parts, Gypsum fibrosum 1-100 parts, Fructus Crataegi 1-100 parts, Fructus Junci 1-100 parts, Fructus Hordei 1-100 parts, Lumbricus 1-100 parts, Radix et Rhizoma Veratri 1-100 parts, Herba Eupatorii Fortunei 1-100 parts, Semen Lepidii 1-100 parts and Semen Platycladi 1-100 parts.

The invention belongs to the technical field of new application of medicines, and particularly relates to application of a Chinese rhubarb # imgabs0 # insect composition in preparation of medicines for treating, relieving or preventing non-alcoholic steatohepatitis hepatic fibrosis. According to the application of the Chinese rhubarb # imgabs1 # composition in preparing the medicine for treating, relieving or preventing the non-alcoholic steatohepatitis hepatic fibrosis, the Chinese rhubarb # imgabs2 # composition has the effects of removing blood stasis and promoting tissue regeneration and is mainly used for treating the symptoms of deficiency of five consumptions and internal stagnation of dry blood; the traditional Chinese medicine composition has the effects of slimming body, hypogalactia and spasm, abdominal pain and refusal to press, or non-reduction in press, abdominal fullness and less food intake, skin onychomycosis, dull eyes, dark orbits, ecchymosis on tongues, and astringent or slender pulse. The pharmacodynamic study of the Chinese rhubarb # imgabs3 # worm pill for treating the non-alcoholic steatohepatitis hepatic fibrosis is carried out, and the result shows that the Chinese rhubarb # imgabs4 # worm pill can reduce the liver visceral organ coefficient, the serum biochemical index and the hepatic fibrosis index of a non-alcoholic steatohepatitis hepatic fibrosis model mouse and improve the pathological change of the liver tissue, so that the Chinese rhubarb # imgabs3 # worm pill can be used for treating the non-alcoholic steatohepatitis hepatic fibrosis. The traditional Chinese medicine composition has an obvious treatment effect on non-alcoholic steatohepatitis hepatic fibrosis.

The invention relates to application of 5-methyltetrahydrofolic acid in preparation of a medicine for preventing or treating renal fibrosis. It is found that 5-methyltetrahydrofolic acid can inhibit expression of HK2 cells and animal kidney fibrosis injury markers COL-1, alpha-SMA and FN, reduce the cell fibrosis level, relieve mouse kidney fibrosis and improve histopathological changes in the kidney fibrosis process, and has remarkable prevention and treatment effects on chronic kidney injury.

The invention provides a topical Chinese medicinal compound essential oil for scleroderma, and relates to the technical field of topical Chinese medicinal essential oil pharmaceuticals. The invention follows the principle of TCM syndrome differentiation and treatment, and rationally combines the ingredients to form the Chinese medicinal compound essential oil with wormwood essential oil, peony bark essential oil, salvia miltiorrhiza essential oil, prickly ash essential oil, cnidium monnieri essential oil, clove essential oil, angelica essential oil, and borneol essential oil. The Chinese medicinal compound essential oil has good therapeutic effects of promoting blood circulation and removing blood stasis, warming the meridians and dispelling cold, reducing swelling and relieving pain, and clearing away heat and detoxifying.

The invention relates to application of a small-molecule diterpene compound in preparation of a medicine for preventing and treating acute pancreatitis. The small-molecule diterpene compound is selected from a compound with a structure as shown in a formula (I) or pharmaceutically acceptable salt, ester and solvate of the compound. The research finds that the traditional Chinese medicine composition has an excellent effect of preventing and treating acute pancreatitis, can inhibit expression of inflammatory factors of human peripheral blood mononuclear cells induced by lipopolysaccharide, and has a good anti-inflammatory effect; meanwhile, the composition can improve pancreatic tissue pathological changes of mice with acute pancreatitis, alleviate edema injury, alleviate inflammation reaction and inhibit expression of lipase in serum of the mice. The invention provides a theoretical basis for researching a treatment strategy of acute pancreatitis, and provides an embedding point for preparing a new medicine for preventing or treating acute pancreatitis.

The application discloses a Mongolian medicine characteristic enema for treating ulcerative colitis and relates to the technical field of biological medicine. The enema is prepared from a Mongolian medicine composition. The Mongolian medicine composition comprises the following components in parts by weight: Punica granatum 25-35 parts, Cinnamomum cassia 15-25 parts, cold water stone 15-25 parts, Amomum villosum 15-25 parts, Forsythia suspense 15-25 parts, Curcuma longa 15-25 parts, Terminalia chebula 15-25 parts, dried ginger 15-25 parts, Calvatia 15-25 parts, Caulis Sargentodoxae 15-25 parts, Radix Glycyrrhizae 5-15 parts, Platycladus orientalis 5-15 parts, Amomum kravanh 5-15 parts, alkali 5-15 parts and Polygonatum 5-15 parts. The Mongolian medicine characteristic enema has the advantages of improving the local effect of the medicine, reducing adverse reactions, having clear clinical curative effect and being innovative in the Mongolian medicine characteristics, and can provide a safe, effective and economical treatment scheme for UC patients.

The invention discloses an application of spermidine and pharmaceutically acceptable salts thereof in preparation of drugs for treating DKD, which can significantly reduce UACR, present a dose-dependent trend, improve renal function indexes, reduce blood sugar level and improve renal histopathologic change, thereby alleviating diabetic nephropathy related kidney injury and delaying disease progression.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to application of Panaxydol in preparation of a medicine for preventing and treating heart failure, Panaxydol (Panaxydol) has a down-regulation effect on lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), aspartate aminotransferase (AST) and alpha-hydroxybutyrate dehydrogenase (HBDH) rise caused by heart failure, and the Panaxydol (Panaxydol) can be used for preventing and treating heart failure. A cardiac echocardiography result shows that the ginseng epoxy alkynol has a protection effect on functional damage caused by heart failure and can improve the heart function of a heart failure rat to a certain extent, and an HE staining result shows that the ginseng epoxy alkynol can also protect the heart tissue structure and improve the pathological change of the heart tissue caused by the heart failure. The result shows that the medicine has a good application prospect in the aspect of treating heart failure.

The application discloses a genus cryptoporus polysaccharide and application thereof, the genus cryptoporus polysaccharide is the glucan of different configuration glucose composition, and the chemical structure includes 1,4,6-connected glucose residue, 1-connected glucose residue 1,4-connected glucose residue and 1,6-connected glucose residue.The genus cryptoporus polysaccharide is used for lipopolysaccharide-induced liver injury model mice, can improve liver tissue pathological change, reduce inflammatory cell infiltration, up-regulate the expression of FoxO3, Pten, Ces1f gene, inhibit the synthesis of fat, avoid lipid accumulation to cause hepatitis, and remove active oxygen.The application provides a solid technical foundation for the research and development of the genus cryptoporus polysaccharide in the prevention and treatment of liver injury or hepatitis, and has important significance for the treatment of liver diseases such as liver injury and hepatitis.