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Chlorophyll composition

A composition, chlorophyllin technology, applied in the direction of drug combination, medical preparation of non-active ingredients, medical science, etc., can solve the problem of decreased activity of cytochrome P450 enzymes

Pending Publication Date: 2017-12-01
C V 萨万基卡尔 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In vitro studies have shown that chlorophyllin can reduce the activity of cytochrome P450 enzymes

Method used

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  • Chlorophyll composition
  • Chlorophyll composition
  • Chlorophyll composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (A) Composition 1:

[0044] Chlorophyll composition without added water

[0045] The composition is prepared by the following steps:

[0046] To a mixture of 6.25 kg glycerin and 17.5 kg commercially available liquid sorbitol (which contains 30% water) was added 1.25 kg of a commercially available sodium copper chlorophyllin composition (containing 302 mg copper per kg); and mixed uniform.

[0047] (B) Case studies of patients with:

[0048] a A 13-year-old girl with only one kidney was diagnosed with chronic kidney disease. She was swollen all over and unable to carry out daily activities. Serum creatinine level has reached 4mg / dl. She took Composition 1 twice a day, one spoonful (12.5 g) each time in the first week, and one spoonful a day from the second week onwards. One month later, the serum creatinine level dropped to 1.4 mg / dl, the edema disappeared, and her quality of life returned to normal.

[0049]b. A 64-year-old diabetic patient who has undergo...

Embodiment 2

[0057] Composition 2:

[0058] The following are illustrative chlorophyllin compositions including other ingredients added to the composition to support renal function or form part of a kit containing the chlorophyllin composition.

[0059] To a mixture of 6.25 kg glycerin and 17.5 kg commercially available liquid sorbitol (which contains 30% water) was added 0.32 kg of a commercially available sodium copper chlorophyllin composition (containing 302 mg copper per kg), adding 30 g casein hydrolyzate (80%) and mix well.

[0060] Composition 2.1:

[0061] The compositions include a kit comprising a bottle of Composition 1 and a bottle of the composition comprising a "water insoluble high protein low fiber fraction" of fenugreek (Funugreek, Trigonella foenum graecum L.) and excipients. "Water insoluble high protein low fiber fraction", also known as leaf protein concentrate, is a high biological value protein concentrate which further includes natural beta-carotene, lutein, ce...

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Abstract

This invention comprises a chlorophyllin composition and method of administering the same for using the same for treatment of kidney disease patients to achieve decrease in serum creatinine level. The chlorophyllin composition and its method of administration is also for concurrent increase in blood hemoglobin level. The Chlorophyllin is selected from the group consisting of sodium copper chlorophyllin, Potassium copper chlorophyllin, Potassium Iron chlorophyllin and other metal containing chlorophyllin / s. To the chlorophyllin composition are added additives, optionally, (a) a diluent, excipient or a carrier, and optionally (b) the chlorophyllin composition is administered, either concurrently, sequentially or in any other order, with other ingredients / compositions supportive for kidney function. The dosage form of composition comprises a liquid, powder, tablet and a capsule. A kit is also provided comprising the chlorophyllin composition and the additional ingredients. The other ingredients comprise amino acids taken individually or as a mixture, protein hydrolysate, proteins or protein concentrates, vitamins and minerals.

Description

technical field [0001] The present invention discloses chlorophyll acid compositions for human consumption, commonly referred to as "chlorophyll compositions". The invention also discloses the chlorophyllin composition for treating nephropathy. Background technique [0002] Chlorophyllins comprise a class of closely related water-soluble salts which are semi-synthetic derivatives of chlorophyll differing in the cation associated with the anion. For the purposes of this specification, this type of chlorophyllin is designated "metal-containing chlorophyllin". The most commonly used forms are sodium copper derivatives, including sodium copper chlorophyllin (including sodium copper derivatives of chlorophyll extracted from green leaves / crops / plant materials). Potassium copper chlorophyllin and potassium iron chlorophyllin are also known and characterized / standardized. Chlorophyllin is usually available as a solid powder. Compositions of chlorophyllin, especially sodium coppe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/00A61Q11/00
CPCA61K31/555A61K9/0095A61K47/26A61P13/12A61K9/4866A61K47/10
Inventor C·V·萨万基卡尔V·A·萨万基卡尔
Owner C V 萨万基卡尔
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