Medicine composite for preventing or treating diabetic nephropathy and application of medicine composite

Abstract

The invention discloses a medicine composite for preventing or treating a diabetic nephropathy and relates to the technical field of traditional Chinese medicine. The medicine composite is prepared by the following traditional Chinese medicinal raw materials in parts by weight: 15-23 parts of herba epimedii, 15-23 parts of morinda officinalis, 12-18 parts of fructus corni, 12-18 parts of selfheal and 12-18 parts of fructus polygoni orientalis. The medicine composite can reduce fasting blood glucose and excretion of urine protein, lower the serum creatinine level, increase the creatinine clearance rate, and prevent or treat the diabetic nephropathy, and is low in toxic and side effect.

Description

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for preventing or treating diabetic nephropathy. Background technique

[0002] Chronic complications of diabetes have gradually become the main disease that threatens the health of patients. Among them, diabetic nephropathy (DN) is one of the most serious chronic complications of diabetes and one of the leading causes of death in diabetic patients. According to reports, 50% of patients with type 1 diabetes died of chronic renal failure, while 5% to 10% of patients with type 2 diabetes died of renal failure.

[0003] With the increase of the incidence of diabetes, the number of DN patients is increasing day by day. Because of its hidden onset and slow progress, if it is allowed to develop, when persistent proteinuria appears clinically, the kidney disease is not in the early stage, and irreversible kidney disease has ap...

Examples

Embodiment 1

[0022] The preparation of embodiment 1 Chinese medicine capsule

[0023] Prescription: 200 grams of Epimedium, 200 grams of Morinda officinalis, 150 grams of Cornus officinalis, 150 grams of Prunella vulgaris, and 150 grams of Saffron.

[0024] Preparation process: Weigh the raw materials of the above-mentioned Chinese medicinal materials of the prescribed amount, add 12 times the amount of water, soak for 14 hours, and then decoct three times, the first time is 1.5 hours, and filter out the medicinal liquid for use; the second time add 9 times the amount of water, decoct for 1.2h, and filter out the medicinal solution for later use; add 8 times the amount of water for the third time, decoct for 0.8h, and filter out the medicinal solution for later use; combine the three decoctions, filter, and collect the filtrate; the filtrate is concentrated to relative Thick cream with a density of 1.3 is baked at low temperature for 7 hours to obtain dry cream powder: Add excipients accor...

Embodiment 2

[0025] The preparation of embodiment 2 Chinese medicine capsules

[0026] Prescription: 150 grams of Epimedium, 230 grams of Morinda officinalis, 180 grams of Cornus officinalis, 180 grams of Prunella vulgaris, and 120 grams of Saffron.

[0027] Preparation process: Weigh the above-mentioned raw materials of Chinese herbal medicines in the prescribed amount, add 11 times the amount of water, soak for 16 hours, then decoct three times, decoct for 2 hours for the first time, filter out the medicinal liquid for use; add 9 times the amount of water for the second time , decoct for 1.5h, filter out the medicinal liquid for use; add 8 times the amount of water for the third time, decoct for 1 hour, and filter out the medicinal liquid for use; combine three decoctions, filter, and collect the filtrate; the filtrate is concentrated to a relative density of The thick paste of 1.3 was baked at low temperature for 8 hours to obtain dry paste powder: according to the weight ratio of dry p...

Embodiment 3

[0028] The preparation of embodiment 3 Chinese medicine capsules

[0029] Prescription: 215 grams of Epimedium, 180 grams of Morinda officinalis, 180 grams of Cornus officinalis, 120 grams of Prunella vulgaris, and 180 grams of Saffron.

[0030] Preparation process: Weigh the raw materials of the above-mentioned Chinese medicinal materials of the prescribed amount, add 12 times the amount of water, soak for 15 hours, and then decoct three times, the first time is 1.5 hours, filter out the medicinal liquid for use; the second time add 8 times the amount of Water, decoct for 1 hour, filter out the medicinal liquid for use; add 8 times the amount of water for the third time, decoct for 0.8 hours, and filter out the medicinal liquid for use; combine the three decoctions, filter, and collect the filtrate; concentrate the filtrate to relative density It is a thick paste of 1.3, baked at low temperature for 7 hours to obtain dry paste powder: add auxiliary materials according to the ...

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for preventing or treating diabetic nephropathy. Background technique

[0002] Chronic complications of diabetes have gradually become the main disease that threatens the health of patients. Among them, diabetic nephropathy (DN) is one of the most serious chronic complications of diabetes and one of the leading causes of death in diabetic patients. According to reports, 50% of patients with type 1 diabetes died of chronic renal failure, while 5% to 10% of patients with type 2 diabetes died of renal failure.

[0003] With the increase of the incidence of diabetes, the number of DN patients is increasing day by day. Because of its hidden onset and slow progress, if it is allowed to develop, when persistent proteinuria appears clinically, the kidney disease is not in the early stage, and irreversible kidney disease has ap...

Examples

Embodiment 1

[0022] The preparation of embodiment 1 Chinese medicine capsule

[0023] Prescription: 200 grams of Epimedium, 200 grams of Morinda officinalis, 150 grams of Cornus officinalis, 150 grams of Prunella vulgaris, and 150 grams of Saffron.

[0024] Preparation process: Weigh the raw materials of the above-mentioned Chinese medicinal materials of the prescribed amount, add 12 times the amount of water, soak for 14 hours, and then decoct three times, the first time is 1.5 hours, and filter out the medicinal liquid for use; the second time add 9 times the amount of water, decoct for 1.2h, and filter out the medicinal solution for later use; add 8 times the amount of water for the third time, decoct for 0.8h, and filter out the medicinal solution for later use; combine the three decoctions, filter, and collect the filtrate; the filtrate is concentrated to relative Thick cream with a density of 1.3 is baked at low temperature for 7 hours to obtain dry cream powder: Add excipients accor...

Embodiment 2

[0025] The preparation of embodiment 2 Chinese medicine capsules

[0026] Prescription: 150 grams of Epimedium, 230 grams of Morinda officinalis, 180 grams of Cornus officinalis, 180 grams of Prunella vulgaris, and 120 grams of Saffron.

[0027] Preparation process: Weigh the above-mentioned raw materials of Chinese herbal medicines in the prescribed amount, add 11 times the amount of water, soak for 16 hours, then decoct three times, decoct for 2 hours for the first time, filter out the medicinal liquid for use; add 9 times the amount of water for the second time , decoct for 1.5h, filter out the medicinal liquid for use; add 8 times the amount of water for the third time, decoct for 1 hour, and filter out the medicinal liquid for use; combine three decoctions, filter, and collect the filtrate; the filtrate is concentrated to a relative density of The thick paste of 1.3 was baked at low temperature for 8 hours to obtain dry paste powder: according to the weight ratio of dry p...

Embodiment 3

[0028] The preparation of embodiment 3 Chinese medicine capsules

[0029] Prescription: 215 grams of Epimedium, 180 grams of Morinda officinalis, 180 grams of Cornus officinalis, 120 grams of Prunella vulgaris, and 180 grams of Saffron.

[0030] Preparation process: Weigh the raw materials of the above-mentioned Chinese medicinal materials of the prescribed amount, add 12 times the amount of water, soak for 15 hours, and then decoct three times, the first time is 1.5 hours, filter out the medicinal liquid for use; the second time add 8 times the amount of Water, decoct for 1 hour, filter out the medicinal liquid for use; add 8 times the amount of water for the third time, decoct for 0.8 hours, and filter out the medicinal liquid for use; combine the three decoctions, filter, and collect the filtrate; concentrate the filtrate to relative density It is a thick paste of 1.3, baked at low temperature for 7 hours to obtain dry paste powder: add auxiliary materials according to the ...