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Effective fraction of plantain seeds as well as preparation method and application thereof

An effective part, the technology of psyllium, applied in the preparation of diabetes and hypertension drugs, the effective part of psyllium and its preparation field, can solve problems such as cough and asthma, adverse reactions, organ toxicity, etc., and achieve lowering of fasting blood sugar , lowering animal blood pressure and promoting insulin secretion

Active Publication Date: 2011-10-26
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drugs currently used to treat diabetes and hypertension are mainly chemical synthetic drugs. These drugs have a certain therapeutic effect on diabetes and hypertension, but they are also accompanied by many side effects, such as adverse reactions in the digestive tract, abnormal blood lipids and blood sugar levels , bradycardia, cough and asthma, certain organ toxicity, etc.
However, there is no relevant report about the effective parts and preparation methods of the psyllium extract for the treatment of diabetes and hypertension.

Method used

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  • Effective fraction of plantain seeds as well as preparation method and application thereof
  • Effective fraction of plantain seeds as well as preparation method and application thereof
  • Effective fraction of plantain seeds as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Pulverize the psyllium seeds into particles with an average diameter of 4 mm, sieve, reflux extract with 4 times the volume of 75% ethanol aqueous solution for 4 times, collect the extract, filter, and concentrate the dry solvent;

[0026] Dilute the concentrated extract with water at a weight / volume ratio of 1:1 to obtain a suspension solution;

[0027] Add the obtained suspension solution into HPD-100 macroporous resin column, elute with 40% ethanol aqueous solution, collect the eluate, concentrate and dry the solvent, and obtain the effective part of Plantaginaceae.

[0028] Take by weighing an appropriate amount of the obtained effective part of Plantaginaceae, dissolve it in a volumetric flask with a solution of 0.1% (V:V) formic acid aqueous solution and methanol in a volume ratio of 90:10, dilute to the scale, shake well, and prepare Make every 1mL solution contain 1g sample, and utilize ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS) to ...

Embodiment 2

[0035] Pulverize the psyllium seeds into particles with an average diameter of 1 mm, sieve, reflux extract with 3 times the volume of 60% ethanol aqueous solution for 5 times, collect the extract, filter, and concentrate the dry solvent;

[0036] Dilute the concentrated extract with water at a weight / volume ratio of 1:3 to obtain a suspension solution;

[0037] Add the obtained suspension solution into HPD-100 macroporous resin column, elute with ethanol water solution with a volume fraction of 50%, collect the eluate, concentrate and dry the solvent, and obtain the effective part of Plantaginaceae.

[0038] After analysis, it is known that the weight ratio of psyllium A and ergosteroside contained in the effective part of psyllium prepared in this embodiment is 1:2, and the sum of the weights of the two accounts for 50% of the total weight of the effective part.

Embodiment 3

[0040] Grinding Semen Plantaginis into particles with an average diameter of 6mm, sieving, refluxing and extracting with 5 times the volume of an 80% ethanol aqueous solution for 3 times, collecting the extract, filtering, and concentrating the dry solvent;

[0041] Dilute the concentrated extract with water at a weight / volume ratio of 1:2 to obtain an aqueous suspension;

[0042]Add the obtained suspension solution into HPD-100 macroporous resin column, elute with ethanol water solution with a volume fraction of 30%, collect the eluate, concentrate and dry the solvent, and obtain the effective part of Plantaginaceae.

[0043] After analysis, it is found that the weight ratio of psyllium A and ergosteroside contained in the effective part of psyllium prepared in this embodiment is 1:4, and the sum of the weights of the two accounts for 70% of the total weight of the effective part.

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Abstract

The invention discloses an effective fraction of plantain seeds, as well as a preparation method and an application thereof. The effective fraction of plantain seeds is obtained by separating and purifying a plantain seed ethanol extract with a macroporous resin and contains hispidulin A and acteoside; and the weight ratio of hispidulin A to acteoside ranges from 1:1 to 1:5 and the sum weight of hispidulin A and acteoside accounts for 40% to 80% of the total weight of the effective fraction. The effective fraction of plantain seeds, disclosed by the invention, can promote the secretion of insulin and reduce fasting blood-glucose levels and can also effectively reduce blood pressure in animals and reduce blood plasma angiotensin II level, shows good medicinal values in treatment of diabetes and hypertension, and can be used alone or in combination with pharmaceutically-acceptable carriers to prepare pharmaceutical formulations for treating diabetes and / or hypertension.

Description

technical field [0001] The present invention relates to an effective part of psyllium seed and its preparation method and application, in particular, it relates to an effective part of plantago seed for treating diabetes and hypertension, its preparation method and its use in preparing medicines for diabetes and hypertension The application belongs to the technical field of traditional Chinese medicine. Background technique [0002] At present, diabetes and hypertension have become chronic diseases that seriously endanger the health of modern human beings. The causes and mechanisms of their pathogenesis are not very clear, but one thing is generally recognized, that is, both hypertension and diabetes are chronic lifelong diseases with multiple causes. , is the result of metabolic disturbances in several systems in the body. The drugs currently used to treat diabetes and hypertension are mainly chemically synthesized drugs. These drugs have a certain therapeutic effect on di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/68A61P3/10A61P9/12
Inventor 王峥涛杨莉祁萌季光
Owner SHANGHAI UNIV OF T C M
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