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Traditional Chinese medicinal effective part for decreasing uric acid as well as preparation method and application thereof

An effective part and technology for lowering uric acid, which is applied to the effective part of traditional Chinese medicine for lowering uric acid and its preparation field

Inactive Publication Date: 2017-02-22
武汉药谷科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant literature report about the active part of galangal for reducing uric acid and its preparation method and application.

Method used

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  • Traditional Chinese medicinal effective part for decreasing uric acid as well as preparation method and application thereof
  • Traditional Chinese medicinal effective part for decreasing uric acid as well as preparation method and application thereof
  • Traditional Chinese medicinal effective part for decreasing uric acid as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Preparation of sample 1 of effective part of galangal

[0088] Take galanga 1KG, add 8 times the amount of 85% ethanol to extract 3 times, each time for 2 hours, filter, combine the filtrate, recover ethanol, add water to make the alcohol content 40%, let it stand for 12 hours, filter, add 50% ethanol to the solid After dissolving, filter, pass through D101 macroporous resin column, wash with water, elute with 50% ethanol, then elute with 85% ethanol, collect 85% ethanol eluate, recover ethanol, filter, and use 60% ethanol to weigh the filtrate Crystallized and dried to obtain 21 grams of galangal effective part sample 1, wherein the content of galangin was 53.6%, the content of kaempferol-4'-O-methyl ether was 4.69%, and the content of galangin-3-O-methyl ether was 9.4% , 1-phenyl-7-(3'-methoxy-4'-hydroxy)-5-ol-3-heptanone content 5.8%.

Embodiment 2

[0090] Preparation of Sample 2 of Effective Fraction of Galangal

[0091] Take galanga 1KG, add 8 times the amount of 95% ethanol to extract 3 times, each time for 2 hours, filter, combine the filtrate, recover ethanol, add water to make the alcohol content 30%, let it stand for 8 hours, filter, add 60% ethanol to the solid After dissolving, filter, pass through an AB-8 macroporous resin column, wash with water, elute with 50% ethanol, then elute with 95% ethanol, recover ethanol, filter, recrystallize with 50% ethanol to obtain 26g of dried effective parts of galanga , dried to obtain 21 grams of galangin effective part sample 2, wherein galangin content is 45.8%, kaempferol-4'-O-methyl ether content is 4.21%, galangin-3-O-methyl ether content is 8.29%, 1 -Phenyl-7-(3'-methoxy-4'-hydroxy)-5-ol-3-heptanone content 7.8%.

Embodiment 3

[0093] Preparation of Sample 3 of Effective Fraction of Galangal

[0094] Take galanga 1KG, add 8 times the amount of 75% ethanol to extract 3 times, each time for 2 hours, filter, combine the filtrate, recover ethanol, add water to make the alcohol content 30%, let it stand for 8 hours, filter, add 60% ethanol to the solid After dissolving, filter, pass through a HPD-600 macroporous resin column, wash with water, elute with 50% ethanol, then elute with 95% ethanol, recover ethanol, filter, recrystallize with 50% ethanol, and dry to obtain 24g of effective galanga Part sample 3, wherein the content of galangin is 42.5%, the content of kaempferol-4′-O-methyl ether is 3.56%, the content of galangin-3-O-methyl ether is 7.19%, and the content of 1-phenyl-7-(3 '-methoxy-4'-hydroxy)-5-ol-3-heptanone content 7.2%.

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Abstract

The invention provides a traditional Chinese medicinal effective part for decreasing uric acid as well as a preparation method and application thereof. The traditional Chinese medicinal effective part is total flavone and a diphenylheptane diarylheptanoid obtained by being extracted and separated from alpinia officinarum hance, and is prepared from the following components of 35wt% to 80 wt% of galangin, 5wt% to 14wt% of galangin-3-O-methyl ether, 1wt% to 7wt% of kaempferol-4'-O-methyl ether and 2wt% to 10wt% of 1-phenyl-7-(3'-methoxyl-4'-hydroxyl)-5-ol-3-heptanone; the sum of the components does not exceed 100 percent. The effective part prepared and obtained by the preparation method provided by the invention is definite and is high in purity. According to the whole preparation method, except for ethanol, other organic solvents are not used; the preparation method is environment-friendly and pollution-free. The industrialized mass production is easily realized in the whole production process. In-vitro and in-vivo pharmacodynamic experiments and preliminary clinical experiments all show that an alpinia-officinarum-hance effective part prepared and obtained by the preparation method provided by the invention has an obvious uric acid decreasing effect. The traditional Chinese medicinal effective part has a quite good effect on a patient suffering from hyperuricemia or gout.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to an effective part of a traditional Chinese medicine for lowering uric acid, a preparation method and application thereof. Background technique [0002] Hyperuricemia refers to the level of blood uric acid on an empty stomach twice on different days under a normal purine diet: men > 420 μmol / L, women > 360 μmol / L. With socioeconomic development and changes in lifestyle, the prevalence of hyperuricemia is on the rise worldwide. In the 1980s, the prevalence of hyperuricemia in European and American countries was 2% to 18%. In 2006, a survey in the Beijing area showed that the prevalence rate was 13.8% for men and 6.00% for women, and in some areas the prevalence rate even reached 22.6% for adult men. According to reports on the prevalence of hyperuricemia in various places in recent years, it is conservatively estimated that there are about 120 million patients in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P19/06A61K125/00
CPCA61K36/9062A61K2236/333A61K2236/39A61K2236/53A61K2236/55
Inventor 杨博吴宁陈少军
Owner 武汉药谷科技开发有限公司
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