Cordyceps militaris extract and preparation method thereof

A technology of extracting Cordyceps militaris, which is applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of single extraction process, reduce extraction efficiency, and prolong extraction time, so as to reduce the concentration of uric acid, Reduce damage and improve the effect of gout symptoms

Pending Publication Date: 2018-12-04
江苏国桢生物科技有限公司
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  • Abstract
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Problems solved by technology

[0003] At present, the methods for directly extracting active substances from Cordyceps militaris include water extraction, water extraction and alcohol precipitation, and alcohol extraction, etc., but the above-mentioned extraction process is single, and there are problems of low extraction efficiency and serious damage to the active substances during the extraction process.
Therefore, most of the development and utilization of Cordyceps militaris is to extract active substances by fermentation or on the basis of fermentation. However, the fermentation process prolongs the extraction time and reduces the extraction efficiency.

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  • Cordyceps militaris extract and preparation method thereof

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preparation example Construction

[0024] In one embodiment of the present invention, the preparation method of the provided Cordyceps militaris extract, its specific steps are as follows:

[0025] (1) Drying the Cordyceps militaris raw material to a water content of 15-25%, and then performing vacuum low-temperature puffing treatment, the conditions of the vacuum low-temperature puffing treatment are: puffing temperature 50-60°C; vacuum pumping times 3-5 times , The puffing time is 1-2 hours.

[0026] (2) Mix the raw materials after vacuum low-temperature puffing treatment with water at a mass ratio of 1:15-20, adjust the pH to 4-6, and then perform ultra-high pressure treatment and ultrasonic extraction in sequence. The conditions for ultra-high pressure treatment are: ultra-high pressure treatment The pressure is 400-600Mpa, the processing time is 100-200s; the conditions of ultrasonic extraction are: temperature 40-60°C, time 10-20min, power 80-120W; after centrifugation, precipitate and liquid are obtained...

Embodiment 1

[0038] (1) Using the fruit body of Cordyceps militaris as raw material, dry 1kg of Cordyceps militaris raw material to a water content of 20%, and then carry out vacuum low-temperature puffing treatment, the conditions of the vacuum low-temperature puffing treatment are: puffing temperature 55°C; 4 times, and the puffing time is 1.5 hours.

[0039] (2) Mix the raw material after vacuum low-temperature puffing treatment with water at a mass ratio of 1:18, adjust the pH to 5, and then perform ultra-high pressure treatment and ultrasonic extraction in sequence. The conditions for ultra-high pressure treatment are: ultra-high pressure treatment pressure 500Mpa, treatment The time is 150s; the conditions of ultrasonic extraction are: temperature 50°C, time 15min, power 100W; after centrifugation, precipitate and liquid are obtained, and the liquid is collected as the first intermediate product.

[0040] (3) Carry out supercritical extraction to precipitate, supercritical extraction...

Embodiment 2

[0043] (1) Using Cordyceps militaris sporocarp as raw material, dry 1kg of Cordyceps militaris raw material to a water content of 15%, and then carry out vacuum low-temperature puffing treatment, the conditions of said vacuum low-temperature puffing treatment are: puffing temperature 50°C; vacuum pumping times 5 times, and the puffing time is 2 hours.

[0044] (2) Mix the raw materials after vacuum low-temperature puffing treatment with water at a mass ratio of 1:15, adjust the pH to 4, and then perform ultra-high pressure treatment and ultrasonic extraction in sequence. The conditions for ultra-high pressure treatment are: ultra-high pressure treatment pressure 400Mpa, treatment The time is 200s; the conditions of ultrasonic extraction are: temperature 40°C, time 20min, power 80W; after centrifugation, precipitate and liquid are obtained, and the liquid is collected as the first intermediate product.

[0045] (3) carry out supercritical extraction to precipitation, supercriti...

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Abstract

The invention discloses a Cordyceps militaris extract and a preparation method thereof. The method comprises the following steps: drying a Cordyceps militaris raw material until the water content is 15-25%, and performing vacuum low-temperature puffing treatment; mixing the vacuum low-temperature puffed raw material with water according to a mass ratio of 1:(15-20), adjusting the pH value to 4-6,and sequentially performing ultrahigh-pressure treatment and ultrasonic extraction; performing centrifuging to obtain a precipitate and a liquid, and collecting the liquid to obtain a first intermediate; performing supercritical extraction on the precipitate, and collecting the obtained extract to obtain a second intermediate; and mixing the first intermediate with the second intermediate, and concentrating the obtained mixture to obtain the Cordyceps militaris extract. The preparation method can quickly and effectively improve active components in the extracted Cordyceps militaris and reducethe damages to the active components in the extraction process. The Cordyceps militaris extract prepared by the preparation method has high content of cordycepin, cordyceps polysaccharides and adenosine, and has remarkable antitumor activity and uric acid lowering effect.

Description

technical field [0001] The invention relates to the technical field of active ingredient extraction, in particular to an extract of Cordyceps militaris and a preparation method thereof. Background technique [0002] Cordyceps militaris, also known as Cordyceps militaris, Cordyceps militaris, etc., belongs to Ergotaceae and Cordyceps in taxonomy. It is a traditional Chinese medicine with great medicinal value. Cordyceps militaris contains a variety of chemical components and has a variety of medicinal effects. It is similar to the pharmacological function and clinical effect of Cordyceps sinensis, but the price is lower than that of Cordyceps sinensis. Therefore, Cordyceps militaris is gradually becoming a substitute for Cordyceps sinensis and has a great potential market. [0003] At present, methods for directly extracting active substances from Cordyceps militaris include water extraction, water extraction and alcohol precipitation, and alcohol extraction, etc., but the ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61P35/00A61P19/06
CPCA61K36/068A61K2236/17A61K2236/331A61K2236/37A61P19/06A61P35/00
Inventor 唐进顾凯丁立鹏屈园园马伟
Owner 江苏国桢生物科技有限公司
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