720 results about "Cordyceps sp." patented technology

The invention relates to a saccharomyces cerevisiae strain for efficiently synthesizing cordycepin as well as a construction method and application of the saccharomyces cerevisiae strain, and belongs to the technical field of microbial genetic engineering. The construction method provided by the invention comprises the following steps: carrying out multi-copy genome integrated expression on heterologous codon optimized 2 '-carbonyl-3'-deoxyadenosine reductase genes and 3 '-adenosine monophosphate phosphohydrolase genes, so as to increase the dosage of key enzymes; and supplementing the defective gene of the engineering strain to obtain the saccharomyces cerevisiae strain B5U3 with high yield of cordycepin. According to the obtained saccharomyces cerevisiae strain for efficiently synthesizing the cordycepin, the cordycepin yield reaches 2.92 g / L after shake flask fermentation, the cordycepin yield reaches 7.5 g / L after fermentation in a fermentation tank, and a foundation is laid for safer and more reliable industrial production of the cordycepin.

The invention discloses a cordyceps militaris mycelium fermentation product as well as a preparation method and application thereof, and belongs to the technical field of daily cosmetics. A preparation method of a cordyceps militaris mycelium fermentation product comprises the following steps: taking cordyceps militaris mycelium as a strain, inoculating the strain into a liquid culture medium, and carrying out enlarged culture to obtain a seed solution; transferring the seed solution into a fermentation tank containing a liquid culture medium, introducing oxygen, stirring, and fermenting for a certain time to obtain a fermentation solution; adding an industrial compound enzyme into the fermentation liquid, and heating and stirring to obtain an enzymolysis treatment liquid; adding a certain amount of alcoholic solution into the enzymolysis treatment liquid, and fully and uniformly mixing to obtain alcohol precipitation liquid; and separating the alcohol precipitation liquid, filtering the supernatant, and collecting the clarified filtrate to obtain the cordyceps militaris mycelium fermentation product. The specific compound enzyme which is low in price and suitable for industrialization is adopted, active substances of cordyceps militaris are fully released, and the effect of the product in cosmetics is improved.

The invention relates to the technical field of microbial genetic engineering, in particular to a method for improving cordycepin synthesized by saccharomyces cerevisiae and saccharomyces cerevisiae engineering bacteria. According to the invention, codon-optimized 2 '-carbonyl-3'-deoxyadenosine reductase gene and 3 '-adenosine monophosphate phosphohydrolase gene from cordyceps militaris are expressed by using plasmids, and then the plasmids are transformed into host cells to obtain the saccharomyces cerevisiae engineering bacteria. And inoculating a seed solution obtained by seed culture of the activated saccharomyces cerevisiae engineering bacteria into a fermentation culture medium containing a metabolic effector, and carrying out fermentation culture to synthesize cordycepin. Metabolic effectors (Cu < 2 + >, Fe < 2 + >, Mg < 2 + >, Zn < 2 + >, citric acid, cysteine, aspartic acid, glycine, VB1 and tea polyphenol) are added into a fermentation culture medium strain, and the variety and concentration of the metabolic effectors are optimized, so that the yield and synthesis efficiency of cordycepin are remarkably improved. By using the combination of the strain obtained by the invention and the optimal effector, the yield of cordycepin in a fermentation tank reaches 2.9 g / L.

The invention provides a cordyceps militaris strain with high yield of cordycepin as well as a sporocarp cultivation method and application of the cordyceps militaris strain, and relates to the technical field of microorganisms. The cordyceps militaris strain KN1.6. 778 provided by the invention is a mutant strain obtained in a conventional breeding process, and the preservation number is CGMCC No.40465. The cordyceps militaris strain is cultured and cultivated under proper conditions, and after harvesting, the content of cordycepin in a cordyceps militaris sporocarp reaches 35000mg / Kg or above, the highest content can reach 148000mg / Kg and is far beyond the level of the prior art, and an unexpected technical effect is generated.

The invention relates to the technical field of functional health care products, and discloses a cordyceps militaris probiotic beverage for regulating intestinal flora balance, the probiotic beverage is composed of the following materials by weight: cordyceps militaris extract; a probiotic strain; inulin; fructo-oligosaccharide; a stevia rebaudiana extract; honey; vitamin and mineral supplements; and the balance of distilled water. Studies prove that bifidobacterium, lactic acid bacteria and lactobacillus acidophilus have positive benefits in the aspect of regulating intestinal flora, growth of beneficial bacteria can be promoted, harmful bacteria can be inhibited, and honey, vitamins and mineral supplements are beneficial to improving the overall taste and improving the immunity of the human body. More nutrition support can be provided for intestinal microflora, the balance of the intestinal flora can be maintained and repaired, and the beneficial effect of screening strains aiming at specific health benefits and specially adjusting the balance of the intestinal flora is achieved.

The invention provides an anti-hair loss and anti-dandruff composition and a preparation method thereof, and belongs to the technical field of wash supplies. The anti-hair loss and anti-dandruff composition is prepared from the following raw materials: a plant raw material, a plant extract, a caffeine composition and an oil control composition, wherein the plant raw materials comprise the following raw materials in parts by mass: 5-20 parts of ginger root, 5-20 parts of black ginger root, 5-20 parts of alpinia japonica root, 1-3 parts of ligusticum wallichii, 5-10 parts of radix sophorae flavescentis, 2-4 parts of fructus cnidii, 1-5 parts of fructus viticis, 3-5 parts of saponin, 5-8 parts of soapberry peel, 1-5 parts of dandelion, 5-8 parts of polygonum multiflorum, 1-3 parts of mulberry, 3-6 parts of cacumen biotae, 3-6 parts of mulberry leaf, 7-10 parts of purslane and 1-4 parts of mangnolia officinalis; the plant extract is prepared from the following raw materials in parts by mass: 5 to 20 parts of aloe extract, 1 to 10 parts of herba menthae extract, 5 to 20 parts of fructus forsythiae fruit extract, 5 to 20 parts of tea leaf extract, 5 to 20 parts of herba centellae extract and 1 to 10 parts of cordyceps militaris extract. The composition prepared by the invention not only has good anti-dropping and anti-dandruff effects, but also has good stability.

The invention provides a preparation method of a cordyceps militaris fermentation product with anti-aging, mitochondrial function enhancing, anti-oxidation and autophagy promoting effects, and the preparation method comprises the following steps: inoculating cordyceps militaris into a fermentation substrate for liquid fermentation culture to obtain a fermentation mycelium; the fermented mycelium is subjected to wall breaking or centrifugal separation, concentration and freeze-drying, and the cordyceps militaris fermented product is prepared; wherein the fermentation substrate comprises oat bran and / or lily. The cordyceps militaris fermentation product prepared by the method shows remarkable anti-aging, anti-oxidation, mitochondrial function enhancing and autophagy promoting effects in in-vitro cell experiments and in-vivo animal models, the process period is short, the preparation process is simple and easy, liquid fermentation in the whole process is suitable for large-scale production, and the preparation cost is low.

The invention relates to the technical field of data processing, in particular to a data processing method for component content detection.The method comprises the steps that a chromatogram of a cordyceps militaris extract is obtained through high performance liquid chromatography, the abscissa of the chromatogram is retention time, and the ordinate of the chromatogram is an absorbance value; and performing baseline correction on the chromatogram by using an ALS algorithm, in the correction process, adjusting the peak sensitivity of the ALS algorithm based on the adaptive weight of each data point in the chromatogram, and performing baseline correction so as to detect the cordycepin concentration in the cordyceps militaris extract based on the chromatogram after baseline correction. According to the method, the baseline correction accuracy of the chromatographic data of the cordyceps militaris extract can be improved, so that accurate detection of the concentration of cordycepin in cordyceps militaris is realized.

The invention provides cytokine hydrogel as well as a preparation method and application thereof in skin injury repair, and belongs to the technical field of biological medicines. Comprising the following steps: (1) adding beta-GP into a chitosan solution to obtain a CS-beta-GP pregel solution; (2) dissolving Pluronic F127 and hyaluronic acid in a PBS (Phosphate Buffer Solution) until the Pluronic F127 and the hyaluronic acid are completely transparent to obtain an F127-HA solution; and (3) sequentially dissolving trehalose, cordycepin, a cell factor composition and collagen peptide in a PBS solution, incubating to obtain a cell factor mixed solution, and mixing the cell factor mixed solution with the CS-beta-GP pregel solution and the F127-HA solution. According to the invention, a dual temperature-sensitive system is established, the gel can be quickly formed under the conditions of injection at low temperature and body temperature, the effective period of active ingredients is prolonged by utilizing a trehalose stabilization technology, and meanwhile, the anti-inflammatory effect of cordycepin and the cell repair effect of collagen peptide are combined, so that the efficient repair of skin injury can be realized.

The invention discloses a cordycepin derivative as well as a preparation method and application thereof. The structural general formula of the cordycepin derivative is # imgabs0. The cordycepin derivative provided by the invention is structurally modified by adopting a special group, so that not only is the stability of the cordycepin derivative improved, but also the biological activities of bacteriostasis, inflammation resistance, oxidation resistance, tumor resistance and the like are remarkably improved. Besides, the cordycepin derivative provided by the invention has certain selectivity on strains, especially on certain beneficial bacteria, in the aspect of bacteriostasis, and the application range of the cordycepin derivative is expanded.

The invention provides a skin-care and immunity-enhancing traditional Chinese medicine extract, milk powder and a preparation method, and relates to the technical field of food. The traditional Chinese medicine extract comprises the following components: red ginseng powder, cordyceps militaris powder, astragalus membranaceus powder, angelica sinensis powder, rehmannia powder, eucommia ulmoides leaf powder, fingered citron powder, rhizoma polygonati powder, sea-buckthorn powder, spina date seed powder, coix seed powder, donkey-hide gelatin powder, poria cocos powder, liquorice powder, longan aril powder, Chinese date powder, wolfberry fruit powder, longan powder and Chinese yam powder. By optimizing the components and combining the specific traditional Chinese medicine extract, ergothioneine and nervonic acid, it is found that the three components have the functions of synergistically promoting immunity and protecting skin, and under the specific proportion, the prepared milk powder for women has the better functions of promoting immunity and protecting skin.

The invention discloses a cordyceps militaris polysaccharide fluorescent carbon dot capable of being used for detecting and degrading tetracycline antibiotics as well as a preparation method and application thereof, and belongs to the technical field of nano materials and environmental monitoring. The cordyceps militaris polysaccharide fluorescent carbon dots are prepared by the following steps: dissolving cordyceps militaris polysaccharide and zinc chloride in water, and then carrying out high-temperature reaction; and after the reaction is finished, filtering, dialyzing and drying to obtain the cordyceps militaris polysaccharide fluorescent carbon dots. The carbon quantum dot prepared by the invention realizes the integration of detection and degradation of tetracycline antibiotics, and has a series of advantages of simplicity in operation, high selectivity, low detection limit, environmental friendliness and the like, thereby having important value in the technical fields of nano materials and environmental monitoring.

The invention relates to the field of functional food processing, and discloses a qi-tonifying and blood-activating dietary therapy formula based on the theory of qi and blood in traditional Chinese medicine, which comprises astragalus membranaceus, angelica sinensis, red dates, lycium barbarum, lycium ruthenicum, ginseng, salvia miltiorrhiza, mulberry, lucid ganoderma, cordyceps mycelium, rhodiola rosea, American ginseng, acanthopanax, grape seed extract and chrysanthemum. Through a compound formula based on the theory of qi and blood in traditional Chinese medicine, and by combining various core medicinal materials and functional plants such as the astragalus membranaceus, the angelica sinensis, the ginseng, the lucid ganoderma, the rhodiola rosea and the fructus lycii, the multi-level effects of tonifying qi, enriching blood, activating blood, resisting oxidation and regulating immunity are achieved. The technical effects of comprehensively regulating qi and blood and improving body immunity and resistance are achieved through the synergistic effect of the compound components, compared with a scheme of regulating qi and blood by depending on a single component in the prior art, the compound formula remarkably improves the overall drug effect, solves the problems that a single component is limited in regulating function and insufficient in curative effect, and is suitable for popularization and application. Therefore, the requirements of modern people on comprehensive conditioning and immunity enhancement are met.

The invention provides a cordyceps militaris fermentation extract and application thereof in preservation of agaricus bisporus, and belongs to the technical field of deep processing of edible mushrooms and preservation of agricultural products. The preparation method of the cordyceps militaris fermentation extract comprises the following steps: (1) taking cordyceps militaris sporocarp, adding water, grinding, and performing enzymolysis by using cellulase and papain in sequence to obtain cordyceps militaris pulp; (2) adding glucose and waste beer yeast powder into the cordyceps militaris pulp, then inoculating lactobacillus paracasei and bifidobacterium bifidum, and fermenting; and (3) after fermentation is completed, carrying out ultrasonic crushing, centrifuging to remove thalli, and carrying out spray drying to obtain the cordyceps militaris fermentation extract. The method can effectively reduce the browning index and weight loss ratio of agaricus bisporus, can slow down the increase of malonaldehyde, reduces the activity of PPO enzyme, and prevents enzymatic browning caused by the synergistic effect of the PPO enzyme and peroxidase. The SOD enzyme activity in the agaricus bisporus can be kept, active oxygen in tissues can be removed, and the metabolic balance of the active oxygen can be maintained.

The invention relates to a cordyceps militaris cultivation device which comprises a cultivation frame and a cultivation box, the cultivation frame comprises a plurality of sets of independent cultivation chambers, and each set of cultivation chambers are divided into cultivation cavities of a plurality of levels according to cultivation stages; an inoculated culture medium is contained in the culture box; each group of cultivation chambers is internally provided with an independent transfer mechanism, the transfer mechanisms control the cultivation boxes to gradually transfer from low-grade cultivation cavities to high-grade cultivation cavities according to needs, each cultivation cavity is internally provided with an independent illumination system, and the cultivation cavities of the same grade are internally provided with the same ventilation system; the cultivation boxes in the static state and the corresponding cultivation cavities form closed or sealed spaces; efficient partitioned independent cultivation management is achieved, environment parameters such as illumination, temperature and humidity can be better controlled on the basis of the growth stage of mycelia, high-yield and high-quality cordyceps militaris can be obtained, and the growth processes of the mycelia in different cultivation boxes can be compared and observed more visually.

The invention discloses a preparation method of cordyceps sobolifera polysaccharide and application of the cordyceps sobolifera polysaccharide in relieving acute chemical liver injury. Monosaccharide of the cordyceps sobolifera polysaccharide (abbreviated as CCPW) is composed of glucose, mannose and galactose according to the molar ratio of 8.918: 1: 0.356, and the relative molecular mass is 2.62 * 10 < 4 > Da. Efficacy experiments show that the cordyceps sobolifera homogeneous polysaccharide CCPW can significantly inhibit increase of ALT and AST in a CCl4-induced acute chemical liver injury model mouse, effectively improve the degree of liver cell disruption and swelling, relieve liver inflammatory response, relieve CCl4-induced mouse liver tissue injury, protect mouse intestinal barriers, recover intestinal microbial balance and have obvious liver protection activity. The cordyceps sobolifera polysaccharide CCPW is clear in composition and remarkable in effect, and has wide development and application prospects in the aspect of relieving acute chemical liver injury.

The utility model discloses a unitized tussah cordyceps militaris liquid strain inoculator, which relates to the technical field of cordyceps militaris cultivation and comprises a strain storage barrel, and an inoculation component is fixedly mounted on the upper surface of the strain storage barrel. According to the unitized tussah cordyceps militaris liquid strain inoculator, tussah is close to an injection needle, so that the injection needle is inserted into the body of the tussah, a rotating handle is rotated to drive a rocker to rotate, a push rod is driven by the rocker to pull a sliding rod and a piston to move, and liquid bacteria in a bacteria storage barrel are extracted through a one-way valve and a liquid extraction pipe; the rotating handle and the rocker rotate for half a circle to complete liquid extraction, the rotating handle and the rocker continue to rotate to drive the protective shell to push the sliding rod and the piston, liquid bacteria extracted into the injection cylinder are injected into the body of tussah through the one-way valve and the injection needle, and liquid extraction and injection can be completed by rotating the rotating handle and the rocker for one circle. The injection amount of the liquid bacteria temporarily stored in the injection cylinder is just equal to the injection amount required by one tussah, so that workers can easily master the injection amount, and the working efficiency is improved.

The invention discloses a method for preparing a cordyceps culture medium by taking polygonatum kingianum as a culture medium, and relates to the technical field of culture medium preparation. The method comprises the following steps: performing enzymolysis treatment on a polygonatum kingianum raw material to obtain enzymatic hydrolysate rich in micromolecular nutrition; active components of polygonatum kingianum are extracted to prepare microcapsules with response release characteristics; preparing at least two kinds of 3D biological printing ink by utilizing the enzymatic hydrolysate and a component containing the microcapsule and a polygonatum kingianum material which is not subjected to enzymolysis; the ink is constructed into a three-dimensional culture medium with a layered or gradient structure layer by layer through a 3D printing technology and is solidified, the culture medium prepared by the method can realize gradient distribution of nutrients and programmed release of active ingredients, and an optimized microenvironment is provided for growth of cordyceps sinensis, so that the culture efficiency, yield and quality of cordyceps sinensis are effectively improved.

The invention discloses an application of cordyceps sobolifera polysaccharide in preparation of a medicine for intervening in male dyszoospermia and reproductive injury, the molecular weight of the cordyceps sobolifera polysaccharide is 2.92 * 10 < 4 > Da, the cordyceps sobolifera polysaccharide is composed of galactose, mannose and glucose according to the molar ratio of 68.125: 43.875: 12, a novel cordyceps sobolifera homogeneous polysaccharide component CCP-1 is separated and purified, and the cordyceps sobolifera polysaccharide can be used for preparing a medicine for intervening in male dyszoospermia and reproductive injury. The influence on reproductive injury of a cyclophosphamide-induced immunocompromised male mouse and a potential mechanism thereof are discussed through an HPT axis; an apoptosis inducer is used for inducing mouse spermatogont-GC-1spg cells to construct an apoptosis model to discuss the influence on cell apoptosis; the understanding of the cordyceps sobolifera polysaccharide CCP-1 as a potential health supplement for intervening male dyszoospermia and reproductive injury is improved.

The invention provides a cordyceps militaris mycelium and a preparation method and application thereof, and relates to the technical field of biological materials. According to the invention, chitinase is added into the cordyceps militaris mycelium material to carry out enzymolysis on chitin to obtain chitooligosaccharide and N-acetylglucosamine, so that beta-glucan in a mycelium framework is dissolved out, and the grafting efficiency of the cordyceps militaris mycelium material is improved; furthermore, the antibacterial effect of the antibacterial material is improved by carrying out grafting reaction on the cordyceps militaris mycelium material and an exogenous monomer antibacterial peptide which has antibacterial performance and contains carboxyl groups.

The invention belongs to the technical field of medicine crystals, and relates to cordycepin-oxalate as well as a preparation method and application thereof. The invention relates to a preparation method of cordycepin-oxalate. The preparation method comprises the following steps: (1) physical mixing: sufficiently and uniformly mixing oxalic acid and cordycepin-crystal form II crystals; (2) liquid auxiliary grinding: adding an auxiliary agent, and continuously grinding to obtain a solid mixture; and (3) drying the solid mixture to obtain the cordycepin-oxalate. According to the method, the cordycepin-oxalic acid eutectic salt is prepared for the first time, the dissolution rate of the cordycepin-oxalic acid eutectic salt is obviously lower than the dissolution rate of cordycepin reported in the prior art, and the cordycepin-oxalic acid eutectic salt has extremely high potential medicinal application value. The cordycepin-oxalic acid eutectic salt has important technical innovation and market application potential due to the slow release effect.

The invention belongs to the field of genetic engineering and metabolic engineering, and discloses a method for rapidly iteratively acquiring a saccharomyces cerevisiae recombinant with high copy integration of long-fragment DNA (Deoxyribose Nucleic Acid). By means of a CRISPR-Cas9 gene editing technology, an auxotrophic gene weakening and back-supplementing screening strategy and a delta sequence / rDNA sequence multi-copy integration strategy are combined to construct a method for rapidly iteratively acquiring a long-fragment DNA high-copy integrated saccharomyces cerevisiae recombinant, and the method is applied to construction of saccharomyces cerevisiae engineering bacteria for producing natural products. By applying the method, the yield of two natural products of ergothioneine and cordycepin is greatly improved. The method for obtaining the saccharomyces cerevisiae recombinant with high copy integration of the long fragment DNA through rapid iteration is beneficial for developing saccharomyces cerevisiae engineering bacteria and applying the saccharomyces cerevisiae engineering bacteria to efficient production of natural products.

The invention relates to the field of health supplements, and discloses a preparation method of cordyceps sinensis hypha powder rich in cubilose peptide and elastin peptide, which comprises the following steps: carrying out superfine grinding on the cordyceps sinensis hypha powder to obtain powder with the particle size of 10-50 microns; mixing the obtained cordyceps sinensis mycelium powder with cubilose peptide powder, elastin peptide, small molecule peptide of gadus and the like and cubilose acid to form mixed powder; carrying out wet granulation on the mixed powder, and adding 1%-3% of a binding agent to form the mixed powder; and carrying out fluidized bed drying on the granulated particles at the temperature of 60-80 DEG C to obtain dry particles with the water content of less than or equal to 7.0%. The stability of the nutrition powder is remarkably enhanced by adopting vacuum packaging and the aluminum foil composite bag, and external oxygen and moisture are effectively isolated. The packaging protects active ingredients such as cordycepin, protein peptide and the like in the nutrition powder, and prevents oxidation or wet decomposition, so that the shelf life is prolonged, and the efficacy of the product is maintained.

The invention discloses application of a traditional Chinese medicine composition in preparation of a product for resisting colon cancer and tumor hemagglutinin, and relates to the technical field of biology. The traditional Chinese medicine composition is prepared from the following components: 5-150 parts of American ginseng, 5-160 parts of lucid ganoderma, 1-90 parts of fermented cordyceps sinensis powder and 5-90 parts of roses. Or 5-150 parts of American ginseng, 5-160 parts of lucid ganoderma, 1-60 parts of cordyceps sinensis and 5-90 parts of rose. The traditional Chinese medicine composition provided by the invention can improve weight loss related to tumors, inhibit tumor growth, recover food intake, improve the athletic ability of a patient, relieve muscle and fat atrophy, inhibit spleen swelling, improve anemia and peripheral inflammation, and effectively relieve cancer-related fatigue caused by colon cancer, so that the traditional Chinese medicine composition provided by the invention has the advantages that the effect is obvious; the traditional Chinese medicine composition can be used for effectively treating colon cancer and malignant fluid, and has a wide application prospect in preparation of products for treating colon cancer and malignant fluid.

The invention provides a composition for improving a barrier function and application thereof, and relates to the technical field of cell injury nursing. Gamma-aminobutyric acid (GABA) and cordyceps militaris fermentation filtrate (FCM) are used for treating barrier damage for the first time. Specifically, the combination of the gamma-aminobutyric acid and the cordyceps militaris fermentation filtrate can significantly improve damage of an epithelial mechanical barrier and an immune barrier caused by external stimulation, so that the epithelial barrier function can be prevented and improved from multiple dimensions.

The invention relates to the technical field of mycelium culture, and provides a culture method and application of cordyceps militaris mycelium with high selenium content and high cordycepin content. The culture method comprises the following steps: inoculating cordyceps militaris mycelia into a liquid culture medium, and carrying out shake culture for 4-7 days to obtain cordyceps militaris liquid seeds; adding a plant selenium source into the solid culture medium, sterilizing to obtain a cordyceps militaris selenium-rich solid culture medium, adding the cordyceps militaris liquid seeds into the cordyceps militaris selenium-rich solid culture medium, and continuously culturing for 30-40 days to obtain the high-selenium and high-cordycepin cordyceps militaris mycelium. According to the culture method, the steps are simple and convenient, the raw materials are cheap and safe, the total selenium content of the produced mycelium is 0.76-191.45 mg / kg, the organic selenium content is more than 99%, the cordycepin content is 17707.3-24769 mg / kg, the content of various effective components such as the total selenium, the organic selenium and the cordycepin is outstanding, the yield is high, standardized popularization and application of the selenium industry in multiple fields are facilitated, and the wide market prospect is achieved.

The utility model provides a cordyceps sinensis piece storage device, and relates to the technical field of storage devices. The cordyceps sinensis piece storage device comprises a box body used for storing cordyceps sinensis pieces, the box body is hollow, the two ends of the box body are open, a frame-shaped cavity is formed in the bottom of the box body, the frame-shaped cavity communicates with the inner wall of the box body, a frame-shaped dehumidification plate is placed in the frame-shaped cavity, a sealing base is connected to the bottom of the box body in an inserted mode, and a sealing cover is connected to the top of the box body. The box body with the two ends open is arranged, the frame cavity is formed in the bottom of the box body, the frame type dehumidification plate is placed in the frame cavity, and meanwhile the inner walls of the four faces of the frame cavity communicate with the hollow interior of the box body, so that the frame type dehumidification plate can dehumidify the interior of the box body; and the sealing cover is connected with the top of the box body, so that the purpose of sealing the box body is achieved, and the box body is convenient to carry.

The invention relates to the field of health care products, and particularly discloses a composition containing active peptides and application of the composition in improving male functions. The composition is prepared from 0.5 to 1.0 part of oyster peptide, 1.8 to 2.8 parts of ginseng peptide, 0.5 to 1.0 part of fructus perillae peptide, 1 to 3 parts of cordyceps militaris peptide, 2 to 4 parts of penis et testis cervi peptide, 0.5 to 1.5 parts of cordyceps sinensis extract, 3 to 7 parts of total flavonoids of herba epimedii, 1 to 3 parts of cycloastragenol, 1 to 3 parts of fructus lycii extract, 2 to 6 parts of herba dendrobii extract, 1.5 to 2.5 parts of herba cynomorii extract and 0.05 to 0.15 part of glycine. The composition disclosed by the invention has the effects of tonifying kidney qi, nourishing essence and blood, tonifying Yang, tonifying spleen and replenishing qi, strengthening and consolidating body resistance, resisting fatigue and the like, can also improve the sperm motility and improve the reproductive injury condition of an organism, and has positive influence on the fertility and sexual function of males.

This invention discloses a protein-polysaccharide ternary nanoparticle loaded with cordycepin, its preparation method, and its applications. The invention employs a layer-by-layer self-assembly method to modify the surface of zein nanoparticles. Since zein has a positive surface charge, the first layer modification uses the anionic polysaccharide sodium alginate for electrostatic bonding, and the second layer modification uses the cationic polysaccharide chitosan, constructing positively charged ternary composite nanoparticles. These nanoparticles have small particle size, high encapsulation efficiency, high drug loading capacity, and a sustained-release effect, significantly reducing cytotoxicity and significantly improving the therapeutic effect on osteoarthritis. This invention develops a novel cordycepin formulation, overcoming the limitations of cordycepin's clinical use.

The invention provides a peptide beverage capable of dispelling effects of alcohol, protecting liver and relieving fatigue and a preparation method and application thereof.The peptide beverage comprises hovenia dulcis thunb oligopeptide, walnut peptide, antioxidant peptide, energy release auxiliary peptide and the like, and the antioxidant peptide is prepared by mixing cordyceps militaris, sea-buckthorn and sunflower heads. The energy release auxiliary peptide is prepared from carnosine and arginine succinic acid peptide through microbial fermentation. The preparation method comprises the following steps: mixing the components according to a certain ratio, stirring, homogenizing, sterilizing and the like. The peptide beverage has the effects of dispelling the effects of alcohol, protecting the liver and relieving fatigue, and is suitable for preparing drugs or health-care products for dispelling the effects of alcohol and protecting the liver. The preparation method has the characteristics of strict raw material selection and fine preparation process, and ensures the quality and efficacy of the product. Through a scientific ratio and an advanced preparation technology, the peptide beverage provides a new choice for dispelling the effects of alcohol, protecting the liver and relieving fatigue, and has a wide market application prospect.