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Preparation method and application of nano-porous gold/carbon fiber paper composite sensing electrode allowing uric acid and dopamine to be detected simultaneously

A nanoporous gold and carbon fiber paper technology, applied in the field of electrochemical detection, can solve the problems of high material and process cost, inability to realize industrialized production, etc., achieve high sensitivity, excellent electrocatalytic performance and anti-interference performance, and increase electrode reaction. area effect

Inactive Publication Date: 2019-10-11
广州钰芯传感科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the cost of materials and processes used in this method is too high to realize industrial production.

Method used

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  • Preparation method and application of nano-porous gold/carbon fiber paper composite sensing electrode allowing uric acid and dopamine to be detected simultaneously
  • Preparation method and application of nano-porous gold/carbon fiber paper composite sensing electrode allowing uric acid and dopamine to be detected simultaneously
  • Preparation method and application of nano-porous gold/carbon fiber paper composite sensing electrode allowing uric acid and dopamine to be detected simultaneously

Examples

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Effect test

preparation example Construction

[0049] A method for preparing a nanoporous gold / carbon fiber paper composite sensing electrode that can be used for simultaneous detection of uric acid and dopamine, specifically comprising the following steps:

[0050] (1) Preparation of nickel / carbon fiber paper composite electrode (Ni / CFP): carbon fiber paper was placed in concentrated nitric acid solution, treated at 120°C for 80 min, then soaked in 1M sodium hydroxide solution for 1 h, and deionized After washing with water, dry in an oven at 60°C for later use; bind the dried carbon fiber paper on a nickel sheet and conduct electrodeposition treatment using a double-electrode constant current mode to obtain a nickel / carbon fiber paper composite electrode (Ni / CFP );

[0051] (2) Preparation of gold-tin alloy / nickel / carbon fiber paper composite electrode (AuSn / Ni / CFP): With nickel / carbon fiber paper composite electrode (Ni / CFP) as the substrate, gold-tin film was electrodeposited and washed to obtain gold Tin alloy / nickel...

Embodiment 1

[0061] Preparation of nanoporous gold / carbon fiber paper composite electrode (NPG / Ni / CFP):

[0062] Put the carbon fiber paper in concentrated nitric acid solution, treat it at 120°C for 80 minutes, then soak it in 1M sodium hydroxide solution for 1 hour, wash it with deionized water, and dry it in an oven at 60°C for later use; The dried carbon fiber paper was bound on a nickel sheet and subjected to electrodeposition treatment using a two-electrode constant current mode to obtain a Ni / CFP composite electrode. The composition of the electrodeposition solution is: nickel sulfate hexahydrate 250g / L, nickel chloride hexahydrate 40g / L, boric acid 35g / L, sodium dodecylsulfonate 0.1g / L, saccharin 0.8g / L, 1,4- Butynediol 0.1g / L; electrodeposition temperature is 50°C, current density is 0.80A / dm 2 , the time is 18min.

[0063] AuSn / Ni / CFP composite electrodes were obtained by electrodepositing AuSn thin films and cleaning them with Ni / CFP composite electrodes as substrates. The go...

Embodiment 2

[0069] NPG / Ni / CFP composite electrode simultaneously detects uric acid and dopamine:

[0070] According to the steps of Example 1, an electrochemical sensor was constructed for simultaneous detection of uric acid and dopamine. Add 1mA dopamine (DA) and 1mM uric acid (UA) solution to the 0.1MPBS solution, use the composite electrode to perform cyclic voltammetry detection on the mixed solution, and obtain the cyclic voltammetry curve as attached image 3 shown. From attached image 3 It can be seen that uric acid and dopamine show different oxidation peak potentials on the nanoporous gold / carbon fiber paper composite electrode (NPG / Ni / CFP), which can prove that the composite electrode of the present invention can be used for simultaneous detection of uric acid and dopamine.

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Abstract

The invention provides a preparation method of a nano-porous gold / carbon fiber paper composite sensing electrode (NPG / Ni / CFP) and application of the electrode to electrochemical detection of uric acidand dopamine under the condition that ascorbic acid exits. The preparation method comprises the steps that thin-layer metallic nickel is pre-deposited on carbon fiber paper (CFP) to obtain an Ni / CFPcomposite electrode, then a gold-tin alloy thin film is electro-deposited to obtain an AuSn / Ni / CFP composite electrode, then the AuSn / Ni / CFP composite electrode is placed in an alkaline corrosive liquid to be subjected to dealloying completely, and the composite electrode NPG / Ni / CFP is obtained. The preparation method has the advantages of being simple in preparation technology, low in cost, easyand convenient to use, good in stability and the like; and the composite electrode has high selectivity, high stability and anti-interference capability, can be used for determining the uric acid andthe dopamine separately or simultaneously and has a low detection limit and high sensitivity.

Description

technical field [0001] The invention belongs to the field of electrochemical detection, in particular to a method for preparing a modified nanoporous gold (NPG) / carbon fiber paper composite sensing electrode (NPG / Ni / CFP), and its application in uric acid (UA) and dopamine (DA) electrodes. Application in chemical rapid detection. Background technique [0002] Uric acid (UA) is the final product of purine nucleotide metabolism. Uric acid in the human body is further oxidized to allantoin by urate oxidase and excreted through urine. In human serum, the content of uric acid is stable at a certain value. When the uric acid content in the human body is lower or higher than this value, it indicates that the human body has diseases such as gout, high blood pressure, and hyperuricemia; As an important neurotransmitter, it participates in the transmission of nerve signals in the brain, and several neurological diseases are related to the dysfunction of the dopamine system. Therefore...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/327G01N27/48
CPCG01N27/308G01N27/3278G01N27/48
Inventor 奚亚男胡淑锦
Owner 广州钰芯传感科技有限公司
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