The present invention discloses an indigo naturalis, acacia catechu, borneol and borax effervescent granule. The indigo naturalis, acacia catechu, borneol and borax effervescent granule comprises thefollowing raw materials in percentages by weight: 1-2% of indigo naturalis, 5-9% of acacia catechu, 5-9% of borax, 5-9% of dried alum, 2-5% of borneol, 1.5-3% of superfine silica powder, 1.6-3.2% of polyvinylpyrrolidone K30, 6-9% of sucrose, 10-17% of tartaric acid, 8-12% of citric acid, 20-28% of sodium bicarbonate, 2-4% of anhydrous sodium carbonate, 2.9-6.5% of low-substituted hydroxypropyl cellulose and 28-35% of absolute ethyl alcohol. Effervescent liquid of the indigo naturalis, acacia catechu, borneol and borax effervescent granule can be used for decomposing denatured proteins such aspus generated by fester as soon as possible, eliminating toxicity of the denatured proteins, removing wounds and accelerating healing of the wounds; The the indigo naturalis, acacia catechu, borneol and borax effervescent granule is mainly used for repairing viral trauma ulceration, specifically comprising oral ulceration, mouth corner ulceration and skin ulceration, ulceration after skin herpes,hoof decay and the like, and has a good effect of inhibiting replication of pathogenic microorganisms in the viral ulceration.