The invention relates to a carbon dioxide acidification blocking remover and a process of not reversely discharging raffinate after acidification. The blocking remover comprises a reagent A which is prepared by directly mixing hydrochloric acid, hydrofluoric acid, glacial acetic acid, polyoxyethylene alkyl phenol ether, citric acid, a corrosion inhibitor, a mutual solvent and a clay stabilizer to form a homogeneous solution and a reagent B prepared by mutually mixing carbonate, a surfactant, an iron ion complexing agent, a demulsifier and clean water which are stirred for 1 hour at normal temperature. The process of not reversely discharging raffinate after acidification comprises the following steps: when an oil well is deblocked, first, injecting a medicament A into an oil layer; then, isolating the clean water by layers; then, injecting a medicament B into the oil layer; and finally, injecting clean water to extrude a mixture in a shaft to the stratum, then, injecting an acidizer into a loop space to a perforated interval, closing the well for 4-6 hours, opening the well, observing the pH value (control range from 6-7), periodically injecting the acidizer till raffinate is fully discharged out of the stratum, and finally, injecting clean water to extrude the mixture in the shaft into a dryline.