Long-acting compound ceftiofur suspension injection and its preparation method

A technology of ceftiofur and ceftiofur hydrochloride, which is applied in the field of veterinary drug preparations, can solve problems such as frequent drug use, high irritation at the injection site, and failure to achieve clinical effects, and achieve easy scale-up production, low tissue irritation, and The effect of increasing release amount and release speed

Inactive Publication Date: 2012-04-04
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it cannot solve the problem of frequent medication in clinical practice, and the injection made by this method has the disadvantage of high irritation at the injection site
In veterinary clinics, diseases caused by multiple i

Method used

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  • Long-acting compound ceftiofur suspension injection and its preparation method
  • Long-acting compound ceftiofur suspension injection and its preparation method
  • Long-acting compound ceftiofur suspension injection and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Party:

[0026] Component Dosage

[0027] Ceftiofur Hydrochloride 1000g±5%

[0028] Tylosin Tartrate 1000g±5%

[0029] Aluminum stearate 200g±5%

[0030] Span-80 50g±5%

[0031] Propyl gallate 5g±5%

[0032] Add soybean oil for injection to 10L

[0033] Preparation:

[0034] A. Measure each component according to the prescription and set aside.

[0035] B. Mix soybean oil for injection, aluminum stearate and propyl gallate, add to a pressure cooker or an autoclave cabinet and heat to 120-125°C for 2 hours to form a gel.

[0036] C. Under stirring, cool the gel to below 40°C, prepare oil gel, and set aside.

[0037] D. Take the prescribed amount of ceftiofur hydrochloride and tylosin tartrate, add an appropriate amount of oil gel, and stir in a high-speed mixer.

[0038] F. Transfer the above-mentioned stirred liquid to a quantitative container, add the prescribed amount of Span-80 into the container, add the remaining oil glue to 10L, and stir while adding.

...

Embodiment 2

[0041] Party:

[0042] Component Dosage

[0043] Ceftiofur Hydrochloride 500g±5%

[0044] Tylosin Tartrate 500g±5%

[0045] Polyvinylpyrrolidone 100g±5%

[0046] Tween-80 100g±5%

[0047] Vitamin C Palmitate 2g±5%

[0048] Add tea oil for injection to 10L

[0049] Preparation:

[0050] A. Measure each component according to the prescription and set aside.

[0051] B. Mix camellia oil for injection, polyvinylpyrrolidone and vitamin C palmitate, add to a pressure cooker or an autoclave cabinet and heat to 120-125°C for 2 hours to make a gel.

[0052] C. Under stirring, cool the gel to below 40°C, prepare oil gel, and set aside.

[0053] D. Take the prescribed amount of ceftiofur hydrochloride and tylosin tartrate, add an appropriate amount of oil gel, and stir in a high-speed mixer.

[0054] F. Transfer the above-mentioned stirred liquid to a quantitative container, add the prescribed amount of Tween-80 into the container, add the remaining oil gel to 10L, and stir whil...

Embodiment 3

[0057] Party:

[0058] Component Dosage

[0059] Ceftiofur Hydrochloride 2000g±5%

[0060] Tylosin Tartrate 2000g±5%

[0061] Aluminum stearate 200g±5%

[0062] Soy lecithin 10g±5%

[0063] Span-80 200g±5%

[0064] tert-butyl p-hydroxyanisole 20g±5%

[0065] Dibutyl hydroxytoluene 20g±5%

[0066] Refined corn oil to 10L

[0067] Preparation:

[0068] A. Measure each component according to the prescription and set aside.

[0069] B. Mix refined corn oil, aluminum stearate, tert-butyl p-hydroxyanisole and dibutyl hydroxytoluene, add to a pressure cooker or autoclave cabinet and heat to 120-125°C for 2 hours to form a gel .

[0070] C. Under stirring, cool the gel to below 40°C, prepare oil gel, and set aside.

[0071] D. Take the prescribed amount of ceftiofur hydrochloride and tylosin tartrate, add an appropriate amount of oil gel, and stir in a high-speed mixer.

[0072] F. Transfer the above-mentioned stirred liquid to a quantitative container, add the prescribed am...

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Abstract

The invention discloses a long-acting compound ceftiofur suspension injection and its preparation technology. According to the invention, the compound ceftiofur suspension injection is prepared by using ceftiofur hydrochloride and tylosin tartrate as main drugs with assistance of appropriate auxiliary drugs. The suspension contains 5-20% (W/V) of ceftiofur hydrochloride, 5-20% (W/V) of tylosin tartrate, 0.5-2% (W/V) of a suspending agent, 0.01-0.5% (W/V) of an anti-oxidant, 0.1-3% (W/V) of a dispersant, and injection oil which is added to 100%. In comparison with a ceftiofur single preparation, the long-acting compound ceftiofur suspension injection has a strong antibacterial activity for Gram-negative bacteria and simultaneously has a strong effect of inhibiting Gram positive bacteria and mycoplasma. In addition, the preparation method provided by the invention provides a feasible approach for extended reproduction, and can be used to minimize times of drug administration and save manpower and material resources.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a long-acting compound ceftiofur suspension injection and a preparation method thereof. Background technique [0002] Ceftiofur is a third-generation cephalosporin antibiotic for animals. It is insoluble in water, slightly soluble in acetone, and almost insoluble in ethanol. It is often made into sodium salt or hydrochloride for injection. It is mainly used for digestive tract and respiratory tract infections caused by drug-resistant Staphylococcus aureus and certain Gram-negative bacilli such as Escherichia coli, Salmonella, Salmonella typhi, Shigella, and Pasteurella. However, the antibacterial activity of this product against Gram-negative bacteria is better than that against Gram-positive bacteria, and Tylosin tartrate has inhibitory effects on Gram-positive bacteria, mycoplasma, and spirochetes, especially mycoplasma. Strong inhibitory effect. [0003] Patent (C...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/546A61K9/10A61P31/04
Inventor 魏德宝夏雪林王小武刘桂兰刘爱玲
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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