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Aivlosin injection for swine and preparation method thereof

A technology of tivalamectin and injection, which is applied in the field of animal medicine, can solve the problems of short biological half-life and inconvenience, and achieve the effect of prolonging the half-life of elimination

Inactive Publication Date: 2011-07-13
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the short biological half-life of oral tivalamectin in animals, it brings inconvenience to the clinic

Method used

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  • Aivlosin injection for swine and preparation method thereof
  • Aivlosin injection for swine and preparation method thereof
  • Aivlosin injection for swine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Measure 40 mL of triacetin in a 250 mL beaker, then measure 30 mL of propylene glycol, 2 mL of benzyl alcohol, and 11 mL of N,N-diformylacetamide on a magnetic stirrer and mix well;

[0021] (2) Add 0.3 g of 2,6-di-tert-butyl-p-cresol and let it fully dissolve;

[0022] (3) Weigh 20 g of tivalamectin into a beaker, and stir at 600 r / min for 40 min.

[0023] (4) Dilute the volume to 100 mL with glycerol triacetate, and filter with suction to obtain Tivanmectin Injection.

[0024] The physical and chemical properties of the injection are stable, and the potency of the injection is 96.35%. Oily solvents and other excipients are well miscible with tivalamectin without delamination (see figure 2 ). The samples obtained in this example were divided into three batches, and stored in 4°C refrigerator, normal temperature and 40°C oven respectively, and the investigation found that the clarity and color of the injection were relatively stable. The drug is easy to separate...

Embodiment 2

[0028] (1) Measure 50 mL of triacetin in a 250 mL beaker, then measure 20 mL of propylene glycol, 2 mL of benzyl alcohol, and 11 mL of N,N-diformylacetamide on a magnetic stirrer and mix well;

[0029] (2) Add 0.5 g of 2,6-di-tert-butyl-p-cresol and let it fully dissolve;

[0030] (3) Weigh 20 g of tivalamectin into a beaker, and stir at 600 r / min for 30 min.

[0031] (4) Dilute the volume to 100 mL with glycerol triacetate, and filter with suction to obtain Tivanmectin Injection.

[0032] The physical and chemical properties of the injection are stable, and the potency of the injection is 98.68%. Oily solvents and other excipients are well miscible with tivalamectin without delamination (see image 3 ).

[0033] The tyvanectin injection prepared in this test passed the normal temperature test and the accelerated test, and its content was 90% to 110%, which met the quality standard requirements of the injection. During the investigation process, there was no precipitation,...

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Abstract

The invention relates to an aivlosin injection for swine. Each 100ml of tylosin injection contains 20g of acetylisovaleryl tylosin tartrate, 20-35g of propylene glycol, 10-15g of N,N-dimethyl acetamide, 2-4g of benzyl alcohol, 0.1-1.0g of di-tert-butyl-4-methylphenol and balance of glyceryl triacetate. The preparation method comprises the following steps of: mixing the glyceryl triacetate, the propylene glycol, the benzyl alcohol and the N,N-dimethyl acetamide evenly to obtain an oil phase; adding an antioxidant to the oil phase and stirring until the added particles are dissolved; and adding the aivlosin and stirring to dissolve. The aivlosin injection for swine adopts the oily solvent as a solvent, the medicament is dissolved in the oily solvent, and the elimination half life of the medicament in an animal body is prolonged by the characteristic of slow elimination of the oily solvent after intramuscular injection.

Description

technical field [0001] The invention belongs to the field of animal medicines, and in particular relates to an injection of macrolide antibacterial drug tyvanectin specially used for animals and a preparation method thereof. Background technique [0002] Tylvalerin (the trade name of its tartrate salt is AIVLOSIN) is a new macrolide antibiotic commercialized by Echo Animal Health Co., Ltd., UK. Its chemical name is acetylisovaleryl tylosin tartrate (Acetylisovaleryl Tylosin Tartrate). It is a derivative produced by chemical modification of Tylosin A. It is mainly used for the treatment of proliferative enteritis (PPE), dysentery, mycoplasma pneumonia (swine panting disease) of pigs, mycoplasma disease of chickens, bacillus perfringens, and rhinotracheal ornithosis. [0003] Currently, only premixes and drinking water preparations are available in the market for tivalamectin preparations. However, due to the short biological half-life of oral tivalamectin in animals, it br...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7048A61K47/16A61P31/04
Inventor 张卫元操继跃肖飞陈翠兰
Owner 武汉回盛生物科技股份有限公司
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