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A kind of slow-release pellet preparation method of tylosin tartrate premix composition

A technology of tylosin tartrate and sustained-release pellets, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, antibacterial drugs, etc., and can solve the problem of not being able to effectively control the release of tylosin tartrate Efficiency, light protection, poor palatability, and difficulty in industrial production, etc., to achieve the effect of small fluctuations in blood drug concentration levels, small differences between products, and good palatability

Inactive Publication Date: 2019-05-24
乐山市佰尔特生物工程合伙企业(有限合伙)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides a method for preparing slow-release pellets of a tylosin tartrate premix composition, which solves the problem of low encapsulation rate of tylosin tartrate, poor palatability, and inability to effectively control tylosin tartrate in the prior art Bacterin release efficiency, and not easy to industrial production and other issues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Weigh each component of the tylosin tartrate premix composition by weight percentage, pulverize the solid components in each component, and sieve the powder through a sieve of 60 mesh to 100 mesh, each The components are stored separately, then take tylosin tartrate and microcrystalline cellulose and add them to the wet granulator, the stirring speed is 500r / min~1000r / min, and the stirring time is 1min~3min, so that tylosin tartrate and filling The agent is mixed evenly to obtain the tylosin tartrate filler mixture;

[0045] (2) Add hydroxypropyl cellulose aqueous solution with a mass concentration of 2% to 10% to the tylosin tartrate filler mixture obtained in step (1), and mix evenly in a wet granulator at a stirring speed of 800r / min ~1800r /

[0046] min, the shearing speed is 1200r / min~2500r / min, the stirring time is 2min~3min, and the soft material of tylosin tartrate is obtained;

[0047] (3) The tylosin tartrate soft material produced in step (2) is extrude...

Embodiment 2

[0052] (1) Weigh each component of the tylosin tartrate premix composition by weight percentage, pulverize the solid components in each component, and sieve the powder through a sieve of 60 mesh to 100 mesh, each The components are stored separately, and then take tylosin tartrate and croscarmellose sodium into the wet granulator, the stirring speed is 500r / min~1000r / min, and the stirring time is 1min~3min, so that tylosin tartrate The tylosin tartrate filler mixture is obtained by uniformly mixing the tylosin with the filler;

[0053] (2) Add polyvinylpyrrolidone aqueous solution with a mass concentration of 2% to 10% to the tylosin tartrate filler mixture obtained in step (1), and mix evenly in a wet granulator at a stirring speed of 800r / min~ 1800r /

[0054] min, the shearing speed is 1200r / min~2500r / min, the stirring time is 2min~3min, and the soft material of tylosin tartrate is obtained;

[0055] (3) The tylosin tartrate soft material produced in step (2) is extruded t...

Embodiment 3

[0060] (1) Weigh each component of the tylosin tartrate premix composition by weight percentage, pulverize the solid components in each component, and sieve the powder through a sieve of 60 mesh to 100 mesh, each The components are stored separately, then take tylosin tartrate and lactose and add them to the wet granulator, the stirring speed is 500r / min~1000r / min, the stirring time is 1min~3min, so that the tylosin tartrate and the filler are evenly mixed , to obtain the filler mixture of tylosin tartrate;

[0061] (2) Add hydroxypropyl cellulose with a mass concentration of 2% to 10% to the tylosin tartrate filler mixture obtained in step (1), and mix evenly in a wet granulator at a stirring speed of 800r / min~1800r / min, the shearing speed is 1200r / min~2500r / min, the stirring time is 2min~3min, and the soft material of tylosin tartrate is obtained;

[0062] (3) The tylosin tartrate soft material produced in step (2) is extruded to obtain a strip-shaped material with a sieve...

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Abstract

The invention relates to a tylosin tartrate premix composition and a preparation method of tylosin tartrate sustained-released pellets, aiming at solving the problems in the prior art that the encapsulation efficiency of tylosin tartrate is low, the light-shielding property and the palatability are poor, the releasing efficiency of the tylosin tartrate cannot be effectively controlled and industrial production is not easy to realize and the like. The preparation method comprises: firstly crushing a solid component and sieving; mixing the tylosin tartrate and a filling agent; adding an adhesive and covering an enteric coating layer and a sustained-released layer on the tylosin tartrate through a granulator. According to the tylosin tartrate premix composition and the preparation method of the tylosin tartrate sustained-released pellets, provided by the invention, whole encapsulation is realized and the palatability is good; the releasing efficiency of the tylosin tartrate can be effectively controlled and the industrial production can be realized.

Description

technical field [0001] The invention relates to a method for preparing sustained-release pellets of a tylosin tartrate premix composition, and belongs to the technical field of veterinary drug preparation. Background technique [0002] Tylosin tartrate belongs to the class of macrolide antibiotics, which is specially used for poultry and is an ideal drug for the treatment of mycoplasma in animals. Tylosin tartrate is usually used by mixing it into the feed for administration or putting it into the drinking water of animals. However, the raw material of tylosin tartrate has a strong smell, bitter taste, and is easy to scatter, making it poor in palatability and affecting animals. Feed intake requires an increase in the number of administrations, which is not conducive to achieving a high-efficiency therapeutic effect. The prior art CN103301144B discloses a preparation method for veterinary acetylisovaleryl tylosin tartrate premix, using acetylisovaleryl tartrate tylosin Mix ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K47/32A61K47/14A61K31/7048A61P31/04
CPCA61K9/0002A61K9/5015A61K9/5026A61K9/5089A61K31/7048
Inventor 李竹王莉田刚曹程明谌京梅
Owner 乐山市佰尔特生物工程合伙企业(有限合伙)
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