Rapamycin microemulsion injection for eyes and preparation method and application thereof

A technology of rapamycin and injection, applied in the field of rapamycin ophthalmic microemulsion injection and preparation thereof, can solve the problem of lack of theoretical knowledge of age-related macular degeneration and other types of retinal degeneration diseases, etc.
CN102008437BInactive Publication Date: 2012-11-14赵晨
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
赵晨
Publication Date
2012-11-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses rapamycin microemulsion injection for eyes and a preparation method and application thereof. In the injection, rapamycin is taken as an active ingredient and is added with a pharmaceutically acceptable carrier, and each 1,000ml of preparation contains 0.05 to 20g of rapamycin. The microemulsion injection for eyes has low cost and high stability, does not have obvious irritation and toxic or side effect on the eyes, can be used for treating retinal degenerative diseases, and particularly has obvious effect of treating age-related macular degeneration disease. The treatment effect of the injection is provided on the basis of breakthrough and discovery of a pathogenic mechanism, and the rapamycin microemulsion injection has profound significance for treating the diseases.
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Description

technical field

[0001] The invention belongs to the field of pharmacy, and in particular relates to a rapamycin ophthalmic microemulsion injection and a preparation method and application thereof. Background technique

[0002] Blinding eye disease is the third most affecting human disease assessed by WHO, and the most important one is retinal degenerative disease. Retinal degeneration is a large group of diseases characterized by progressive loss of photoreceptor cells, which can be divided into hereditary retinal degeneration caused by obvious genetic defects and complex retinal degeneration caused by multiple factors. Age-related macular degeneration (AMD) is the most common complex retinal degenerative disease, especially as the population ages, its incidence is increasing, and there are more than 10 million patients in the United States alone. AMD can be caused by age-related factors such as genetic factors, smoking, oxidative damage, and mitochondrial defects. Patients...

Claims

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