Method for preparing micro-spheres using modified ploylactic acid material as shell material

A polylactic acid material and modification technology, which are applied in the directions of botanical equipment and methods, medical preparations with inactive ingredients, microcapsules, etc. The effect of small particle size, simple process and controllable particle size is achieved

Inactive Publication Date: 2007-03-28
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first three methods all require the use of surfactants or dispersants, and the residues of these agents may affect the biocompatibility of the microspheres and the activity of the drug; the encapsulation efficiency of the drug and the yield of the microspheres in the spray-drying method are relatively low ; The high temperature of the melting method may affect the activity of the drug; the supercritical fluid method is affected by the properties of the supercritical fluid, which has certain selectivity for the drug and the preparation process, and has high requirements for the equipment.

Method used

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  • Method for preparing micro-spheres using modified ploylactic acid material as shell material

Examples

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Effect test

Embodiment 1

[0023] Embodiment 1: capsule heart thing is hydrophobic medicine

[0024]Take 100 grams of polyethylene glycol-modified polylactic acid material, dissolve it in 100 ml of tetrahydrofuran, and take another 30 grams of antiviral drug Aciclovir (Aciclovir), dissolve it in 1 liter of tetrahydrofuran, and dissolve the polyethylene glycol-modified polylactic acid material in 1 liter of tetrahydrofuran. The lactic acid material solution was added dropwise to the solution of acyclovir at a rate of 5 milliliters per minute, accompanied by mechanical stirring at a speed of 300 rpm for 10 hours, using a power of 200 watts and a frequency of 20 kHz for 2 hours, and filtering , to obtain microspheres coated with acyclovir, which were freeze-dried.

Embodiment 2

[0025] Embodiment 2: capsule heart thing is hydrophilic medicine

[0026] Take 10 grams of maltose-modified polylactic acid material, dissolve it in 1 liter of isopropanol, and take another 20 mg of anti-diabetic drug insulin, dissolve it in 100 ml of distilled water, and add the insulin solution to the maltose-modified polylactic acid dropwise at a rate of 2 ml per minute. In the solution of the lactic acid material, magnetic stirring at a speed of 1000 rpm for 2 hours, and ultrasonication with a power of 600 watts and a frequency of 40 kHz for 1 hour, filtering to obtain insulin-coated microspheres, and drying in a vacuum.

Embodiment 3

[0027] Embodiment 3: capsule heart thing is hydrophobic medicine

[0028] Take 10 grams of dextran-modified polylactic acid material and dissolve it in 500 milliliters of dimethyl sulfoxide, and take another 100 mg of antineoplastic drug hexamethylmelamine (Altretamine), and dissolve it in 500 milliliters of dimethyl sulfoxide. 10 ml was added dropwise into 25 liters of distilled water, accompanied by mechanical stirring at a speed of 500 rpm for 1 hour, and then centrifuged at a speed of 3000 rpm to obtain microspheres coated with hexamethylmelamine, which were spray-dried.

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Abstract

The present invention relates to a microphere preparation method using modified polylactic acid material as capsule material. Said preparation method includes the following steps: firstly, the capsule core material can be dissolved or dispersed in the water, the modified polylactic acid material is dissolved in the solvent which can be mixed with water-phase; then the aqueous solution of capsule core material is added into the solution of modified polylactic acid material or the solution of modified polylactic acid material is added into the aqueous solution of capsule core material or said two solutions are simultaneously added into the solvent capable of dissolving polylactic acid material or their mixed solution is added into the solvent capable of dissolving modified polylactic acid material, then they are stirred so as to obtain microsphere solution, filtered to obtain microspheres.

Description

technical field [0001] The present invention relates to a preparation method of microspheres, more precisely, the present invention relates to a modified polylactic acid material as a capsule material, especially the patent "a preparation method, product and application of bioactive polylactic acid" (patent No.: ZL200310121036.7) The modified polylactic acid material and the intermediate modified polylactic acid material obtained in the reaction, or these modified polylactic acid materials and polylactic acid materials, or these modified polylactic acid materials and other materials A method for preparing microspheres for combined application, the microspheres prepared by the method relate to applications in drug release and other fields. Background technique [0002] (1) Packaging requirements for drugs and other substances [0003] Traditional drug release generally does not have rate-controlling and targeted performance. In many cases, its r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K9/16A61K47/34A01N25/10A01N25/28
Inventor 潘君
Owner CHONGQING UNIV
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