Nanometer platinum polymer, and preparation method and application thereof

A nano-platinum and polymer technology, applied in the medical field, achieves the effects of high degradability, simple preparation method and good swelling performance

Active Publication Date: 2017-09-26
广州博士派生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using nano-platinum as an antibacterial substance and applying it to hydrogel pharmaceutical products has not yet been researched and applied in this regard.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] A preparation method of nano-platinum polymer, the steps are:

[0032] 1) Take each raw material according to the ratio, add nano-platinum into deionized water, sonicate for 10 minutes, mix evenly, and prepare a 0.1g / mL nano-platinum solution;

[0033] 2) Put 0.1g of poly-γ-glutamic acid powder in a 50mL beaker, dissolve it in 45mL of deionized water to prepare a transparent solution, then add 200μL of EDC / NHS cross-linking agent (the molar ratio of EDC to NHS is 1:1 ) and 0.02g nano-platinum solution (nano-platinum particle size is 20-30nm), and stir evenly to obtain poly-γ-glutamic acid solution;

[0034] 3) Slowly add 2.5g of chitosan powder into the poly-γ-glutamic acid solution in step 2), stir gently, then add 1mL of propylene glycol, and stir to form a uniform mixed solution;

[0035] 4) Slowly add 0.75 times the volume of deionized water to the mixture in step 3), mix well, and react at 2-8°C for 15 hours to form a uniform hydrogel polymer;

[0036] 5) The pol...

Embodiment 1

[0037] The nano-platinum polymer obtained in Example 1 has a dense three-dimensional network structure, and the encapsulation efficiency of nano-platinum is 99.89%, and the load rate is 97.5%. Escherichia coli, Bacillus, Staphylococcus aureus have an antibacterial efficiency All are very good, among them, the bacteriostatic efficiency of Escherichia coli reached 89.3%, the bacteriostatic efficiency of Bacillus reached 88.9%, and the bacteriostatic efficiency of Staphylococcus aureus reached 94.6%. It was proved by MTT cytotoxicity experiment that it was consistent with negative The ratio of the control material is close to 1, indicating that the cytotoxicity is low, and the biocompatibility is good, which meets the relevant regulations of medical products.

[0038] Example 2 (method 1)

[0039] A preparation method of nano-platinum polymer, the steps are:

[0040] 1) Take each raw material according to the ratio, add nano-platinum into deionized water, sonicate for 10 minutes...

Embodiment 2

[0045]The nano-platinum polymer obtained in embodiment 2 has a dense three-dimensional network structure, and the encapsulation efficiency of nano-platinum is 96.3%, and the load rate is 95.7%. Escherichia coli, Bacillus, Staphylococcus aureus have an antibacterial efficiency All are very good, among them, the bacteriostatic efficiency to Escherichia coli reaches 93.7%, the bacteriostatic efficiency to Bacillus reaches 90.5%, the bacteriostatic efficiency to Bacillus reaches 96%, proves by MTT cytotoxicity experiment, and negative The ratio of the control material is close to 1, indicating that the cytotoxicity is low, the biocompatibility is good, and it meets the relevant regulations of medical products.

[0046] Embodiment 3 (method 1)

[0047] A preparation method of nano-platinum polymer, the steps are:

[0048] 1) Take each raw material according to the ratio, add nano-platinum into deionized water, sonicate for 10 minutes, mix evenly, and prepare a 0.1g / mL nano-platinu...

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Abstract

The invention discloses a nanometer platinum polymer, and a preparation method and application thereof. The nanometer platinum polymer is prepared from the following raw materials of nanometer platinum, chitosan oligosaccharide, poly gamma-glutamic acid, propanediol and cross linking agents EDC/NHS. The nanometer platinum polymer obtained through preparation can be applied to medical products, in particular to the wound dressing aspect. Compared with the prior art, the obtained nanometer platinum polymer medicine has good biocompatibility and antibacterial activity; the nanometer platinum is preferably selected to be used as the medicine; propanediol is used as a lubricating agent; the medicine coating rate is higher; high degradability is realized; the swelling behavior performance is good; the raw materials are cheap and can be easily obtained; the production process is simple.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to a nano-platinum polymer and its preparation method and application. Background technique [0002] Poly-γ-glutamic acid (γ-PGA) is a high molecular polymer polymerized by D-glutamic acid or L-glutamic acid through the acylation reaction of α-amino group and γ-carboxyl group to form an amide bond. Containing a large number of free carboxyl groups, it is an anionic polymer that can undergo reactions such as crosslinking, chelation, and derivatization. The molecular weight ranges from 10KD to 10000KD. Through certain degradation conditions, it can form small molecular weight γ-PGA. The γ-PGA extracted in the laboratory has a molecular weight of about 3000KD, and after acidic degradation conditions, it is degraded to a molecular weight of about 70KD. [0003] Because of its biodegradability, high water absorption and moisture retention, pH sensitivity, biocompatibility, and modifiabil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/18A61L15/44A61L15/46A61L15/62A61L15/42C08J3/075C08J3/24C08L77/04C08L5/08
CPCA61L15/18A61L15/26A61L15/28A61L15/42A61L15/44A61L15/46A61L15/62A61L2300/102A61L2300/404A61L2300/416C08J3/075C08J3/24C08J2305/08C08J2377/04C08J2477/04C08L5/08C08L77/04
Inventor 杨革梁鑫鑫孙阳刘金锋巩志金李媛
Owner 广州博士派生物科技有限公司
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