Traditional Chinese medicine composition for preventing and treating vascular dementia

A technology of vascular dementia and composition, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve the effect of convenient operation

Active Publication Date: 2016-10-12
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] With the increase of the elderly population, the prevention and treatment of vascular dementia has bec

Method used

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  • Traditional Chinese medicine composition for preventing and treating vascular dementia
  • Traditional Chinese medicine composition for preventing and treating vascular dementia
  • Traditional Chinese medicine composition for preventing and treating vascular dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 Shenma Yizhi prescription

[0028] Weigh 9 parts of ginseng, 9 parts of Gastrodia elata, 9 parts of ghost arrow feather, and 6 parts of Chuanxiong.

[0029] The process preparation of medicine adopts the combination of traditional method and modern method, and the specific treatment is as follows:

[0030] Ginseng and Rhizoma Chuanxiong were prepared and mixed in proportion, and 8 times the weight of 70% (v / v) ethanol aqueous solution was used for reflux extraction for 2 hours. v) Reflux extraction with ethanol aqueous solution for 1.5 hours, collect the leachate, combine the two leachates, concentrate under reduced pressure to a thick paste, and obtain a thick paste for alcohol extraction.

[0031] Gastrodia elata and ghost arrow feather are prepared and mixed according to the proportion, and extracted by adding water to the tank, first add 10 times the weight of water to decoct for 2.0 hours, filter, add 8 times the weight of water to ...

Embodiment 2

[0034] Toxicological Research of Example 2 Shenma Yizhi Prescription

[0035] Acute Toxicity Test of Shenma Yizhi Prescription (Maximum Dosage Test)

[0036] 1. As experimental animals, 40 4-week-old clean-grade ICR mice, half male and half male, weighing 20 g to 28 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number: SCXK (Beijing) 2011-0004. Experiments were performed after one week of feeding and acclimatization in a clean-grade experimental animal room.

[0037] 2. The liquid extract of Shenma Yizhi Fang, with a crude drug content of 4.00 g / g, was prepared by the Chinese Medicine Preparation Room of Xiyuan Hospital, China Academy of Chinese Medical Sciences (see Example 1 for the preparation method). Before the test, distilled water was used to prepare a medicinal solution containing a crude drug concentration of 2.00 g / ml.

[0038] 3. Grouping and administration, 40 mice were randomly divided into 2 groups (using SPS...

Embodiment 3

[0041] Example 3. Drug efficacy research of Shenma Yizhi Prescription

[0042] 1 The influence of VD caused by the blood vessel blocking method of Shenma Yizhi Prescription

[0043] The pharmacodynamic study adopts the 4-vascular blocking method (4-VO method) VD model, from multiple links: behavior (water maze test), cell apoptosis and regulation of gene expression, inflammatory factor levels, oxidative stress and other factors To study the characteristics and relationship of primary and secondary targets of this drug, and to clarify the curative effect and mechanism of its multi-channel, multi-target integrated effect on VD intervention.

[0044] Grouping of animals: blank group, given an equal volume of normal saline;

[0045] The sham operation group was given an equal volume of normal saline;

[0046] The model group was given an equal volume of normal saline;

[0047] Donepezil group, by intragastric administration of 0.51g / d (gastric administration of Western medicine...

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating vascular dementia. The traditional Chinese medicine composition for preventing and treating vascular dementia comprises ginseng, gastrodia elata, Euonymus alatus and Ligusticum wallichii. The composition can be prepared into Chinese herbal preparation crude drug for preventing and treating vascular dementia. The ginseng and the Ligusticum wallichii are extracted with alcohol, the gastrodia elata and the Euonymus alatus are extracted with water, the obtained alcohol extract and the obtained water extract are mixed, the mixture is dried under vacuum and then is pulverized to obtain the final product, and the composition can be directly taken orally or is prepared into other dosage forms such as granules, capsules, soft capsules, electuaries, pills and decocted extracts. The composition is completely prepared from natural medicinal plants, does not contain hormones, and does not contain other chemical synthetic products such as pigment, and even if a patient orally takes the composition continuously, no toxic and side effect is performed on the human body. The traditional Chinese medicine composition contains various easily absorbable ingredients such as ginsenoside, chuanxiongol, chuanxiongzine, gastrodin and quercetin, can be effectively used for treating the vascular dementia, increases cerebral blood flow, reduces cerebral vascular resistance, improves body immunocompetence, and has effects of tonifying deficiency, promoting intelligence, suppressing the hyperactive liver, subsiding Yang, dispelling blood stasis and dredging collaterals.

Description

technical field [0001] The invention relates, in particular, to a traditional Chinese medicine composition for preventing and treating vascular dementia. Background technique [0002] Vascular dementia (VD) is a group of intelligence and cognitive dysfunction syndromes caused by cerebrovascular diseases, and it is one of the common diseases of senile dementia. The onset of VD is relatively clear and potentially preventable. It is also called "reversible dementia". Early diagnosis and early treatment are particularly significant for the improvement or reversal of intelligence. With the aging of the population, the incidence of VD is on the rise, which seriously threatens the health and quality of life of middle-aged and elderly people, and brings long-term pain and burden to patients, families and society. widespread attention. As of 2010, the prevalence of dementia in people over 65 years old worldwide was 15%, of which 9% were AD and 4% were VD. The annual incidence of V...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61P25/28A61K36/37A61K36/236A61K36/258
CPCA61K36/236A61K36/258A61K36/37A61K36/8988A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 李浩刘剑刚韦云刘美霞裴卉刘龙涛郭明冬
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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