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Application of curcumin in preparing medicine for treating IIIV-1 relevant cognitive disorder

A technology for cognitive impairment and HIV-1, which can be used in drug combinations, antiviral agents, pharmaceutical formulations, etc., and can solve problems that have not been seen in research and development.

Inactive Publication Date: 2007-08-22
JINAN UNIVERSITY
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0005] Curcumin is a phenolic pigment extracted from the rhizome of turmeric (curcuma longa), a plant of the genus Zingiberaceae. The research and development of curcumin in HIV-1gp120-induced cognitive impairment has not been seen.

Method used

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  • Application of curcumin in preparing medicine for treating IIIV-1 relevant cognitive disorder
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  • Application of curcumin in preparing medicine for treating IIIV-1 relevant cognitive disorder

Examples

Experimental program
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Embodiment 1

[0020] Experimental animals: 90 healthy and clean SD rats, half male and half male, weighing 150-200 grams, divided into 6 groups, namely blank control group, sham operation group, gp120 model group, gp120+curcumin low, medium and high 3 dose groups, 15 rats in each group. Inject gp120 into the lateral ventricle of rats for 3 consecutive days, 50ng / d, to prepare a model of pseudo-HAD learning and memory impairment. The blank control group, the sham operation group and the gp120 model group were gavaged with double distilled water for 2 weeks, and the treatment group was given turmeric Three doses of low (50mg / kg), medium (100mg / kg), and high (200mg / kg) were given orally, once a day, for 2 consecutive weeks. Then:

[0021] 1. The spatial learning ability of rats in each group was detected by Morris water maze.

[0022] 2. Through the brain slice patch clamp technique, the extracellular field potential was recorded, and then the long-term potentiation (LTP) of rats in each gro...

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Abstract

The present invention provides the application of curcumin in preparing medicine for treating HIV-1 relevant cognitive disorder. Curcumin may be used in preparing medicine for treating HIV-1 relevant cognitive disorder alone or through combination with other memory improving medicine. Experiment shows that curcumin can improve the memory capacity of rat with memory disorder caused by HIV-1gp120, with curcumin in low dosage (50 mg / kg) possessing higher effect.

Description

technical field [0001] The raw materials involved in the present invention are traditional Chinese medicines, specifically the use in the preparation of anti-HIV-1 related cognitive impairment Chinese medicine preparations. Background technique [0002] Public health organizations believe that HIV (human immunodeficiency virus) disease is currently the greatest threat to public health. At present, there are about 40 million HIV-infected people in the world, and the number of HIV-infected people in China has reached 1 million, and the number of infected people is increasing by 16,000 every day. In the global AIDS caused by HIV-1, about 30% of adults and 50% of children develop AIDS-associated dementia (HIV-1 associated dementia, HAD) due to the presence of progressive viral infection, that is, cognitive, motor or behavioral impairment. But because some antiretroviral drugs cannot effectively cross the blood-brain barrier and enter the brain parenchyma, although patients can...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K36/258A61K36/69A61K36/39A61P31/18A61P25/00
Inventor 董军陆大祥潘锐唐红梅
Owner JINAN UNIVERSITY
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