13 results about "Memory retention disorder" patented technology

The invention provides an electroencephalogram signal-based dysmnesia assessment system, which comprises a signal acquisition module for acquiring an electroencephalogram signal of a target object; the preprocessing module is used for performing 0.5-40Hz band-pass filtering on the electroencephalogram signal of the target object; the signal segmentation module is used for segmenting each channel and determining a plurality of non-overlapping Epoches corresponding to each channel; the feature extraction module is used for performing linear feature extraction and nonlinear feature extraction on each Epoch in each channel, and determining electroencephalogram signal fusion features of the target object based on the linear feature and the nonlinear feature of each Epoch; and the dysmnesia assessment module is used for inputting the electroencephalogram signal fusion features into a trained dysmnesia assessment model, and performing dysmnesia assessment on the target object by using the dysmnesia assessment model to obtain a dysmnesia assessment result of the target object. According to the scheme, dysmnesia evaluation of the target object can be efficiently realized.

Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for memory dysfunction, Alzheimer's disease, and cognitive decline. Also disclosed are new methods of use for drugs and natural compounds repurposed for use in improving memory, as well as for preventing and treating memory disorders, Alzheimer's disease and cognitive decline. All the above-mentioned methods are computer assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. A universal approach in everybody, as well as a personalized approaches by gender, and by diagnosis, are disclosed.

The present invention provides a Chinese medicine composition for treating or preventing Alzheimer's disease, and its preparation method and application, wherein the Chinese medicine composition comprises the following raw materials in parts by mass: 10-20 parts of ginseng, 10-20 parts of polygala, 10-20 parts of calamus, 10-20 parts of tuckahoe, 10-20 parts of yam, 10-20 parts of polygonatum, 10-20 parts of green tea pigments and 10-20 parts of quercetin, and optionally comprises 0.1-0.5 parts of black pepper. The Chinese medicine composition of the present invention has a significant therapeutic effect on 5XFAD transgenic AD mice, which is specifically manifested in that daily oral administration of the Chinese medicine composition of the present invention improves the spatial learning and memory disorders of dementia mice, reduces the deposition of amyloid plaques in the dentate gyrus of the hippocampus of mice, and significantly inhibits the generation of Aβ without causing liver and kidney toxicity and weight loss. Therefore, the Chinese medicine composition of the present invention is a safe and effective method for treating AD.

1. Name of the Design Product: Dynamic Graphical User Interface for Neurorehabilitation Training of Display Screen Panel. 2. Use of the Design Product: Used for displaying graphical user interface and interaction. 3. Design Key Points of the Design Product: Lie in the interface content of the graphical user interface on the screen. 4. Picture or Photo that Best Illustrates the Design Key Points: Front View. 5. The display screen panel is of conventional design, so the left view, right view, top view, bottom view are omitted; the rear view is omitted. 6. Use of the Graphical User Interface: Used for the rehabilitation training of patients with memory disorders. 7. Human-Machine Interaction Method of the Graphical User Interface: Clicking, voice prompts, and blood oxygen data of the trainee. 8. Explanation of the Changing States of the Graphical User Interface: The front view is the welcome interface for neurorehabilitation training, with a voice prompt "Training items are being loaded, please wait a moment" and enters the interface changing state diagram 1, which is the training item loading interface; the interface changing state diagram 2 is the interface when the item loading is about to be completed; the interface changing state diagram 3 is the resting state interface during the training process of the trainee after the loading of the item is completed; the interface changing state diagram 4 is the interface ending the resting state stage, and a voice prompt: "Please try to remember the colored graphics that appear on the carriage" is given, and at the same time as the voice prompt, it enters the interface changing state diagram 5; the interface changing state diagram 5 is the teaching training stage interface during the training process of the trainee, the interface changing state diagram 6 is the animation interface at the end of the teaching training stage of the trainee; the interface changing state diagram 7 is the animation interface at the end of the teaching training stage of the trainee; from the interface changing state diagram 3 to the interface changing state diagram 4 is the resting state stage during the training process; from the interface changing state diagram 5 to the interface changing state diagram 7 is the teaching training stage during the training process, and while testing from the interface changing state diagram 3 to the interface changing state diagram 7, the blood oxygen concentration of the trainee is determined and then enters the interface changing state diagram 8, which is the interface showing the start screen of the training; the interface changing state diagrams 9-13 are the interfaces of the training questions; in the interface changing state diagrams 9 to 13, the vines on the roof of the carriage become longer or shorter according to the blood oxygen concentration of the trainee; the interface changing state diagram 13 is the last question, and after the end, it enters the interface changing state diagram 14, and at the same time a voice prompt: "Training ended". 9. Other Situations Requiring Explanation: Other Explanation: The display screen panel and the displayed graphical user interface are applied to computers, laptops, tablets, and mobile phones. The blood oxygen concentration data is received through a communication connection in the near-infrared data acquisition module.

The invention discloses application of TRPM8 in preparation of a medicine for preventing and / or treating learning and memory disorder related diseases. The application provides a new treatment target or strategy for learning and memory disorder related diseases.

The present invention aims to provide a method for evaluating dementia and a composition for preventing or treating deterioration in brain function, or for maintaining or improving brain function, and compared the gut microbiota of healthy individuals, individuals with mild cognitive impairment, and individuals with Alzheimer's disease. As a result, gut microorganisms were selected, such as microorganisms belonging to the genus Faecalibacterium, that are associated with cognitive function. Furthermore it was revealed that Faecalibacterium prausnitzii, possessing specific DNA, exhibited an improvement effect against brain function deterioration, such as learning and memory disorders.

To deal with dementia of elderly people or difficulties of communications due to memory disorder.SOLUTION: A communication assist system includes: means for a family and an elderly person to wear a virtual reality goggle and regenerate images in the past; means for the family and the elderly person to have a conversation through an artificial intelligence chat bot; and means for digitizing the conversation and experiencing the conversation in combination with pictures of the elderly person.SELECTED DRAWING: Figure 1

The present invention provides a novel memory disorder ameliorating agent. A PKC [gamma] activity inhibitor is useful as an active ingredient of a dysmnesia ameliorating agent.

The invention discloses a pharmaceutical composition for preventing and treating AD (Alzheimer's disease). The pharmaceutical composition is prepared from the following components in parts by weight: 50 to 100 parts of salidroside, 60 to 80 parts of protocatechuic acid, 70 to 80 parts of wedelolactone, 50 to 80 parts of apigenin, 30 to 60 parts of luteolin and 10 to 30 parts of oleanolic acid. The invention further discloses application of the pharmaceutical composition for preventing and treating AD as a central nervous protective agent. The behavioral, morphological and immunological experiments show that a mouse learning and memory disorder model can be successfully copied by intraperitoneal injection of D-gal, and the pharmaceutical composition and the positive drug can improve the structural morphology of neurons in a hippocampus region by improving the exploration ability, the working memory ability and the space exploration ability of a mouse on new things, so that the learning and memory disorder of the mouse can be successfully copied. The number of neurons in the hippocampus and the number of nissl's somes are increased, so that the neuroprotective effect on D-gal model mice is achieved, and experimental and theoretical basis is provided for clinical application of the pharmaceutical composition for preventing and treating AD and research and development of new anti-AD traditional Chinese medicines.

The application provides a memory disorder evaluation system based on an electroencephalogram, comprising: a signal acquisition module configured to acquire an electroencephalogram of a target object; a preprocessing module configured to perform a band-pass filtering of 0.5Hz-40Hz on the electroencephalogram of the target object; a signal segmentation module configured to segment each channel and determine a plurality of non-overlapping Epochs corresponding to each channel; a feature extraction module configured to perform linear feature extraction and nonlinear feature extraction on each Epoch in each channel, and determine an electroencephalogram fusion feature of the target object based on the linear feature and the nonlinear feature of each Epoch; and a memory disorder evaluation module configured to input the electroencephalogram fusion feature into a trained memory disorder evaluation model, use the memory disorder evaluation model to evaluate the memory disorder of the target object, and obtain a memory disorder evaluation result of the target object. The scheme can efficiently evaluate the memory disorder of the target object.

To resolve the hindrance in daily life due to dementia and memory disorder of the elderly, and to support their life through reminders of schedules and important information.SOLUTION: A system includes a memory auxiliary device, and the memory auxiliary device includes means for reminding a person about schedules and important information with audio and visuals.SELECTED DRAWING: Figure 1

The application belongs to an animal model, and aims to solve the technical problems that the evaluation method of the current Skinner box experimental data lacks a systematic experimental paradigm and evaluation means, and lacks related parameters, and provides an experimental animal learning and memory disorder model, a construction method and application. The traditional chronic social frustration model experiment process is optimized, the learning and memory disorder model of the mouse is stably induced, and the obtained experimental animal learning and memory disorder phenotype is obvious, and the diversity of stress-related disorder animal models is enriched. The learning and memory ability of the animal is evaluated by the Skinner box, the learning and memory related evaluation means is expanded, and new data support is provided for the construction and evaluation of the acute violent stress induced learning and memory disorder animal model.

The invention belongs to the technical field of essential oil, and particularly provides compound essential oil for improving learning and memory disorders as well as a preparation method and application of the compound essential oil. The liquid compound essential oil comprises the following raw materials in parts by weight: 30-40 parts of ginseng essential oil, 10-15 parts of rhizoma acori graminei essential oil, 1-5 parts of frankincense essential oil, 30-40 parts of perilla essential oil, 1-5 parts of borneol and 1-5 parts of ginkgo leaf essential oil. The compound essential oil for improving learning and memory disorders provided by the invention takes multiple traditional Chinese medicine extracts as raw materials, so that the compound essential oil has the effects of tonifying qi and inducing resuscitation, refreshing mind and restoring consciousness, soothing nerves and stabilizing mind and enhancing memory.