Permeability nose absorption type medicine for treating and preventing senile dementia, improving learning memory faculty and regulating blood brain barrier

A learning and memory, blood-brain barrier technology, applied in the field of medicine, can solve problems such as irritation of the nasal mucosa, long residence time, and unsatisfactory treatment rate of patients, so as to achieve good recovery, good treatment effect, and shorten hospitalization and treatment time. Effect

Inactive Publication Date: 2006-11-15
李光武
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The spray preparation method is simple, easy to use, less irritating to the nasal mucosa, and patients are more willing to use it; the dry powder inhaler has a long residence time, good absorption, high drug content, and small administration volume, which is conducive to drug stability. The medicine is sent into the nasal cavity by a special device. The medicine is not as convenient as taking it orally or spraying it, and it will irritate the nasal mucosa. The treatment rate of the patient is not ideal.

Method used

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  • Permeability nose absorption type medicine for treating and preventing senile dementia, improving learning memory faculty and regulating blood brain barrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Neurobehavioral Research on Learning and Memory

[0079] Program-controlled autonomous activity box

[0080] The program-controlled autonomous activity box consists of four black cylindrical darkrooms (diameter 25cm, height 10cm). There are three pairs of photoelectric tubes around the darkroom. The measurement of spontaneous activity is based on the change of the horizontal light beam by the animal's activity, which is converted into an electrical signal, connected to the computer through a data transmission line, and the response is a digital change. Keep quiet during the experiment. The spontaneous activities of the mice were recorded within 180s, and the experimental recording unit (number of times, n). The voluntary activity of the animal marks the excited state of the central nervous system of the animal. Observing the animal's autonomous activity is a main index to evaluate the state of central nervous excitement.

[0081] LashleyIII water maze

[0082] Lash...

Embodiment 2

[0084] The method of making the model of olfactory bulb removal

[0085] Chloral hydrate 0.38g / kg intraperitoneal injection of anesthetized mice, the head is fixed on the brain stereotaxic instrument (SN-2,8208, NARISHIGE, Japan), exposes the skull, with reference to The Mouse Brain mouse atlas (George Paxinos) The electric drill opened a window 3.2 mm in front of the anterior bregma to expose the bilateral olfactory bulbs. A blade with a thickness of 0.5 mm was inserted vertically from the posterior border to remove the olfactory bulb tissue, and the residual tissue was sucked clean. The wound was sealed with gelatin sponge and hemostatic bone wax . Postoperative rest 1w.

[0086] 2. Results

[0087] 2.1. Water maze score analysis The 7d and 14d water maze latency of the eugenol administration group was significantly shorter than that of the blank group, indicating that olfactory inhalation of eugenol can enhance the spatial learning and memory ability of mice. (See Table ...

Embodiment 3

[0095] Nasal instillation

[0096] Each mouse was instilled with 50 μl of eugenol oil in nasal cavity, once a day for 2 weeks.

[0097] Program-controlled autonomous activity box

[0098] Ditto.

[0099] LashleyIII water maze

[0100] Ditto.

[0101] 1.6 Data processing

[0102] Use SPSS10.0 software. One-way analysis of variance was used to compare the means of multiple groups, and the t test was used to compare between groups. The experimental data were expressed as mean ± standard deviation (x ± s).

[0103] 2. Results

[0104] Autonomic activity experiment recording unit (number of times, n), water maze experiment recording unit (second, s).

[0105] group

1d

7d

14d

blank group

olfactory inhalation group

Nasal instillation group

Gavage group

75.62±26.42

74.38±16.64

84.17±21.61

85.50±28.69

71.00±18.72

71.00±18.72 □

92.58±27.22^

109.38±46.80*

63.55±22.51

63.55±22.10

6...

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Abstract

A snuff for preventing and treating senile dementia, improving memory and regulating the permeability of blood brain barrier is prepared from the active component(s) chosen from eugenol, its salt, its isomer and their mixture, and selective natural spice.

Description

Technical field: [0001] The invention belongs to the field of medicine, and specifically relates to the application of a new prescription formed by eugenol and its compatible traditional Chinese medicine active ingredients in the preparation of nasal absorption medicine for preventing and treating senile dementia and improving learning and memory and its new dosage form. technical background: [0002] my country is entering a country with an aging population, and a series of changes will follow, including a sharp increase in the incidence of neurodegenerative diseases. The incidence of Alzheimer's Disease (AD) is the first problem to bear the brunt. Senile dementia is a clinical syndrome mainly characterized by mental decline, behavior and personality changes, and mental decline should be the most prominent symptom. Pathologically, senile dementia is characterized by senile plaques and neurofibrillary tangles. Senile dementia not only seriously affects the quality of life ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/085A61K9/00A61K9/72A61K36/185A61K36/53A61K36/57A61K36/61A61K36/9064A61P25/28
Inventor 李光武曹金海任振华唐敏王海萍
Owner 李光武
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