10results about How to "Stable baseline" patented technology

The invention discloses an image restoration method and system based on dynamic re-parameterization, and the method comprises the following steps: obtaining a training image and a control parameter k, selecting a pre-trained denoising network on a natural image restoration task as a basic model, and constructing a dynamic controllable re-parameterization network based on the basic model; inputting the training image and the control parameter k into the dynamic controllable re-parameterization network for forward propagation, then constructing a loss function for back propagation, and updating parameters in the dynamic controllable re-parameterization network to obtain a dynamic controllable re-parameterization mother model; setting a target scene for image restoration, calibrating the optimal processing intensity of the target scene, determining a corresponding krep value, and processing the re-parameterized mother model based on the krep value to obtain an image restoration model; and performing image restoration by using the image restoration model.

This invention provides a fingerprint spectrum of Yishen Wufa Oral Liquid, its construction method, and its application, as well as a multi-index component detection method for Yishen Wufa Oral Liquid, relating to the field of pharmaceutical analysis and structural technology. The fingerprint spectrum of Yishen Wufa Oral Liquid constructed by this invention includes 20 characteristic peaks, including ferulic acid, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, astragaloside A, psoralen, isopsoralen, and emodin. The chromatographic peaks are abundant and attributed to the effective components of psoralen (roasted with black sesame seeds), angelica, poria cocos, wolfberry, fleeceflower root (processed with black bean wine), achyranthes bidentata, and astragalus complanatus. This provides a more comprehensive reflection of the overall chemical composition and quality of Yishen Wufa Oral Liquid, facilitating more effective guidance for feed addition and strict standardization of production operations. It also helps improve the safety and efficacy of Yishen Wufa Oral Liquid in clinical use, possessing high application value.

The application provides a kind of Fuling drink piece, fried Fuling drink piece and the construction method and application of its preparation characteristic map, the construction method of fried Fuling and its preparation characteristic map, comprising: preparing test sample solution;Using high performance liquid chromatography to detect test sample solution, chromatographic conditions include with octadecylsilane bonded silica as filler, with methanol as mobile phase A, with 0.08%-0.4% formic acid as mobile phase B, and using specific elution procedure, while shortening the detection time also significantly improves the separation effect of multiple effective components, so that the characteristic map contains more characteristic peaks, greatly enriches the atlas information, realizes the effective separation of characteristic peaks such as uridine, thymine, gallic acid and guanosine, the characteristic of the obtained characteristic map is obvious, fully reflects the integrity and characteristic of the drug preparation of fried Fuling, and the baseline is stable, the peak shape is good, which provides basis for comprehensively detecting the quality of Fuling drink piece, fried Fuling and its pharmaceutical preparations.

The application belongs to the technical field of food detection, and provides a detection method of soluble dietary fiber in resistant dextrin. The method adopts amylodextrinase to perform enzymatic digestion on the resistant dextrin, adds water to prepare a test solution; glucose is used as a standard, high performance liquid chromatography is used for detection, and the content of the soluble dietary fiber in the resistant dextrin is obtained by an external standard method. The detection method is simpler than the existing standard method, greatly reduces the error sources, can guarantee the accuracy and precision of the detection results, shortens the detection time, saves manpower and economic cost, and can meet the detection needs of inspection supervision departments and enterprises.

The invention provides a construction method and a quality detection method of a characteristic spectrum of a traditional Chinese medicine composition, and the construction method of the characteristic spectrum comprises the following steps: taking a solution of a traditional Chinese medicine composition test sample and a solution of a reference substance, and carrying out high performance liquid chromatography detection to obtain the characteristic spectrum of the traditional Chinese medicine composition; wherein the traditional Chinese medicine composition comprises radix scutellariae, cortex mori radicis, fructus trichosanthis, semen armeniacae amarae, radix adenophorae, radix ophiopogonis, semen coicis, semen benincasae, fructus aurantii, radix curcumae, rhizoma imperatae, radix salviae miltiorrhizae, indigo naturalis and clam shells; the liquid chromatographic analysis conditions of the detection are as follows: octadecylsilane chemically bonded silica is used as a filler, acetonitrile is used as a mobile phase A, a phosphoric acid solution with the volume percentage of 0.09-0.11% is used as a mobile phase B, gradient elution is performed, the detection wavelength is 207-286nm, the column temperature is 25-35 DEG C, and the flow velocity is 0.9-1.1 mL / min. The specific chromatogram constructed by the invention can objectively evaluate the quality of a traditional Chinese medicine composition sample and improve the quality of the traditional Chinese medicine composition, so that the curative effect is ensured.

This invention belongs to the field of pharmaceutical analysis technology, specifically relating to a method for constructing characteristic chromatograms of Dajianzhong Decoction and a method for determining the content of its effective components. The construction method includes the preparation of a test solution, and under specific conditions, characteristic chromatograms 1 and 2 are obtained using UPLC-UV-ELSD chromatography. Characteristic chromatogram 1, obtained under ultra-high performance liquid chromatography and a UV detector, is specific to dried ginger and roasted Sichuan pepper, with characteristic peaks mainly consisting of gingerol components in dried ginger and amide alkaloids in roasted Sichuan pepper. Characteristic chromatogram 2, obtained under ultra-high performance liquid chromatography and an evaporative light scattering detector, is specific to ginseng, consisting entirely of ginsenosides, thus solving the problem of large differences in detection wavelengths and mutual interference between the two major categories of components.

The present application relates to the technical field of traditional Chinese medicine detection, and specifically provides a characteristic spectrum construction method of Herba Centipedae and its preparation. A specific elution procedure is obtained through a large number of experiments by using octadecylsilane bonded silica gel as a filler and a mobile phase including methanol and an acid-containing aqueous solution for gradient elution, 13 or more common characteristic peaks are obtained, and effective separation of characteristic peaks including neochlorogenic acid, caffeic acid, chlorogenic acid, cryptochlorogenic acid, 1,4-dicaffeoylquinic acid, 1,5-dicaffeoylquinic acid, big pothos glycoside and thymotin lactone ketone is achieved, the peak shape is good, the baseline is smooth, the determined components can be completely separated, the detection time is short, and the method provides a basis for quality detection and control of Herba Centipedae and its preparation, can fully reflect the integrity and characteristics of Herba Centipedae and its preparation, and is simple to operate and applicable to quality control of different preparation types of Herba Centipedae.

The application discloses a kind of HPLC detection method and application for simultaneously identifying Dajiujun and Ziyuanhua simultaneously, belong to the technical field of quality detection of traditional Chinese medicine.Using unified chromatographic conditions, two kinds of medicinal materials fingerprint are established simultaneously, combined with common peak identification, multi-component content determination and PCA, HCA, OPLS-DA chemometrics analysis, realize fast, accurate identification and quality evaluation.15 batches of Ziyuanhua samples similarity is 0.997~1.000, 15 batches of Dajiujun samples similarity range is 0.813~0.990. The similarity between two kinds of medicinal materials is 0.888~0.995 by similarity analysis. The method has high precision and good repeatability, can simultaneously complete qualitative identification, quantitative determination and difference marker screening, suitable for quality control of traditional Chinese medicine, market supervision and medicinal material standardized production, has higher practical value and application prospect.

The application relates to a characteristic chromatogram of Qinshi Jiedu granules and a construction method and application thereof, and belongs to the technical field of quality detection of traditional Chinese medicine preparations. High performance liquid chromatography is adopted; test product solution, control product solution and each single medicine control solution are respectively injected into a high performance liquid chromatograph for determination; a chromatogram is recorded; a characteristic chromatogram of the Qinshi Jiedu granules is established under the same chromatographic condition; 14 characteristic peaks are calibrated; and quality detection is carried out on the Qinshi Jiedu granules. The characteristic chromatogram of the Qinshi Jiedu granules established based on the high performance liquid chromatography technology can comprehensively, systematically and objectively evaluate the quality of the Qinshi Jiedu granules.

The invention relates to a construction method and application of an HPLC (High Performance Liquid Chromatography) fingerprint spectrum of a clear paste extracted from an anti-inflammatory and cough-relieving tablet. The invention establishes a high performance liquid chromatography analysis method, the method is used for detecting the extract clear paste of the anti-inflammatory and cough-relieving tablet, the separation degree between peaks is good, the peak distribution is uniform, and the baseline is stable; a methodological investigation result shows that the method disclosed by the invention is good in specificity and also has good repeatability, stability and durability. The HPLC fingerprint spectrum of the extracted clear paste of the anti-inflammatory and cough-relieving tablets is constructed by using the method, can be used for quality evaluation of the extracted clear paste of the anti-inflammatory and cough-relieving tablets, and lays a foundation for quality control of the extracted clear paste of the anti-inflammatory and cough-relieving tablets.