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253results about How to "Stable baseline" patented technology

Method for formation configuration of distributed satellites with synthetic aperture radars

The invention relates to a design method for the formation configuration of distributed satellites with synthetic aperture radars (SAR). The method comprises the following five operation steps: step 1: designing the formation configuration of the distributed satellites and conforming fly-by path equations; step 2: confirming an optimal base line length range of the distributed satellites in start time; step 3: confirming an optimal base line sequence of the distributed satellites in start time; step 4: confirming track parameters of the formed satellites forming a concentric circle configuration; and step 5: calculating effective base lines and vertical path base lines in a track period. The invention provides the concentric circle formation configuration, uses the optimal base line combined constraint conditions of multi-base line interference SARs as design input parameters and designs a control law of radar antenna visual angles to realize that a distributed satellite SAR system can satisfy the design requirements of the optimal base line combined constraint conditions in any time in a track operation period and a basis is provided for the distributed satellite SAR system to obtain high-precision DEM products by a multi-base line interference SAR treatment method.
Owner:BEIHANG UNIV

Di-substituted amides for enhancing glutamatergic synaptic responses

This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
Owner:CORTEX PHARMA INC

Full-differential same-phase parallel amplifying device for acquiring bioelectric signal

The invention discloses a full-differential same-phase parallel amplifying device for acquiring a bioelectric signal. The amplifying device comprises an input buffer circuit, a differential filtering circuit, a data selector, a same-phase parallel amplifying circuit and an analog-digital conversion circuit which are connected sequentially. The input buffer circuit performs impedance conversion on the bioelectric signal first; the bioelectric signal subjected to low-pass filtering by the differential filtering circuit passes through the data selector and the same-phase parallel amplifying circuit; the bioelectric signal is amplified and a common-mode signal is suppressed; the noise of the bioelectric signal outside a signal high-frequency band is filtered through an anti-aliasing filtering network; and the amplified signal is subjected to analog-digital conversion by the analog-digital conversion circuit and then is output. The noise and common-mode suppression ratio can reach a high index, a base line is stable, a dynamic signal input range is wide, signals are difficult to saturate, and the device has high in reliability and can support perfect PACE detection. Meanwhile, the circuits are simple and are low in cost, and the device can be used for various bioelectric detection instruments and systems and has obvious economic benefit.
Owner:EDAN INSTR

Di-substituted amides for enhancing glutamatergic synaptic responses

This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
Owner:CORTEX PHARMA

Detection method for atractylodes macrocephala koidz medicinal materials

InactiveCN102680631ATrue reflection of qualityEnsure medication safetyComponent separationHplc fingerprintMedicine
The invention discloses a detection method for atractylodes macrocephala koidz medicinal materials. The method adopts HPLC (high performance liquid chromatography) fingerprint spectrum for detection and includes the operation steps of: (1) preparing sample solution; (2) preparing reference solution; and (3) respectively and precisely absorbing the sample solution and the reference solution to inject into a liquid chromatograph so as to elute by taking an acetonitrile-water system as a flowing phase and detect at wavelengths of 248+ / -5nm. After the atractylodes macrocephala koidz medicinal materials are decocted with water, and then the HPLC fingerprint spectrum is applied for detection, so that quality of the atractylodes macrocephala koidz medicinal materials can be reflected more truly. Moreover, chromatographic conditions such as the flowing phase are selected specifically, so that chromatogram baselines are stable and convenient to integrate, resolution of characteristic peaks is good, and similarity among different medicinal materials is high. The detection method for the atractylodes macrocephala koidz medicinal materials can be effectively used for quality control of atractylodes macrocephala koidz and provides a guarantee of medication security of the atractylodes macrocephala koidz medicinal materials.
Owner:CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE

Methods for the treatment of respiratory depression

This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stoke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning, hi a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
Owner:CORTEX PHARMA

Fingerprint spectrum detection method for meridian warming decoction

The invention relates to a fingerprint spectrum detection method for meridian warming decoction. The method comprises the following steps: 1) preparing a test solution; weighing 1-2g of angelica sinensis, 1-2g of ligusticum wallichii, 1-2g of radix paeoniae alba, 1-2g of cinnamon, 1-2g of moutan bark, 1-2g of curcuma zedoary powder, weighing 3-4g of ginseng powder, 3-4g of liquorice powder and 3-4g of radix achyranthis bidentatae powder; adding 250-350mL of water, uniformly mixing, heating to boil with strong fire, slowly decocting with slow fire, filtering while the decoction is about 150-170mL, and adding water into the filtrate to dilute to 240-260mL; precisely sucking 8-12mL of the standard decoction of the meridian warming decoction, adding methanol to dilute to 40-60mL, sealing, weighing the mass, carrying out ultrasonic (the power is 180-220W and the frequency is 40-60kHz) treatment for 8-12min, standing overnight, weighing the mass again, supplementing the lost mass with methanol, uniformly shaking, filtering, and taking the subsequent filtrate, thereby obtaining the test solution; 2) detecting: taking and injecting 5-15 [mu]L of the test solution obtained in the previous step into a high performance liquid chromatograph, and obtaining a chromatogram; and 3) performing result judgment: comparing the chromatogram obtained in the previous step with a standard control fingerprint, and if the similarity is greater than 90%, the sample being qualified.
Owner:SHANDONG WOHUA PHARMACEUTICALS CO LTD

Method for formation configuration of distributed satellites with synthetic aperture radars

InactiveCN101520511BApplicable interference processingStable baselineRadio wave reradiation/reflectionOrbital periodStart time
The invention relates to a design method for the formation configuration of distributed satellites with synthetic aperture radars (SAR). The method comprises the following five operation steps: step 1The invention relates to a design method for the formation configuration of distributed satellites with synthetic aperture radars (SAR). The method comprises the following five operation steps: step 1: designing the formation configuration of the distributed satellites and conforming fly-by path equations; step 2: confirming an optimal base line length range of the distributed satellites in start: designing the formation configuration of the distributed satellites and conforming fly-by path equations; step 2: confirming an optimal base line length range of the distributed satellites in starttime; step 3: confirming an optimal base line sequence of the distributed satellites in start time; step 4: confirming track parameters of the formed satellites forming a concentric circle configuratitime; step 3: confirming an optimal base line sequence of the distributed satellites in start time; step 4: confirming track parameters of the formed satellites forming a concentric circle configuration; and step 5: calculating effective base lines and vertical path base lines in a track period. The invention provides the concentric circle formation configuration, uses the optimal base line combinon; and step 5: calculating effective base lines and vertical path base lines in a track period. The invention provides the concentric circle formation configuration, uses the optimal base line combined constraint conditions of multi-base line interference SARs as design input parameters and designs a control law of radar antenna visual angles to realize that a distributed satellite SAR system caned constraint conditions of multi-base line interference SARs as design input parameters and designs a control law of radar antenna visual angles to realize that a distributed satellite SAR system cansatisfy the design requirements of the optimal base line combined constraint conditions in any time in a track operation period and a basis is provided for the distributed satellite SAR system to obt satisfy the design requirements of the optimal base line combined constraint conditions in any time in a track operation period and a basis is provided for the distributed satellite SAR system to obtain high-precision DEM products by a multi-base line interference SAR treatment method.ain high-precision DEM products by a multi-base line interference SAR treatment method.
Owner:BEIHANG UNIV

Fmoc-protected amino acid purity and related substance analysis method

The invention discloses an Fmoc-protected amino acid purity and related substance analysis method. The method comprises the following steps of S1, preparing an Fmoc-Osu impurity control solution, andenabling the ratio of Fmoc-Osu to Fmoc-protected amino acid to be (0.1-1.0): 100 to obtain an Fmoc-Osu impurity control solution; S2, preparing a related impurity control solution, enabling the ratioof single related impurity to Fmoc-protected amino acids to be 0.1-1.0: 1 100, obtaining a plurality of reference substance solutions, etc. According to the invention, a mobile phase, an impurity control solution and the gradient elution conditions are comprehensively designed and optimized, the analysis method is applied to the operation process of the system, the baseline is smooth, no interference peak basically exists in a blank test, the impurity separation effect is prominent, and the specificity is good. The test data shows that the detection limit can achieve 0.002%, the sensitivity isextremely high, the detection result can provide the reliable and effective information for the research, the production and the purification of the product, the solid foundation is established for the protected amino acid quality control standard, and the positive effect is provided for the quality control of the final product.
Owner:成都市科隆化学品有限公司

Anti-inflammatory tablet HPLC fingerprint construction method

An anti-inflammatory tablet HPLC fingerprint construction method comprises the following steps: 1, preparing a test solution: grinding an anti-inflammatory tablet, weighing the ground tablet, placing the ground tablet in an extractor, adding petroleum ether, carrying out hot reflux extraction, removing the petroleum ether, adding methanol, carrying out ultrasonic treatment, supplementing methanol, and filtering the obtained solution; 2, preparing a reference solution: taking a chlorogenic acid reference substance, an aesculetin reference substance, a scutelloside reference substance, a linarin reference substance, a baicalein reference substance and a wogonin reference substance; and 3, determining: respectively taking the reference solution and the test solution, respectively injecting the reference solution and the test solution to a liquid chromatograph, recording the chromatogram in 120min, and processing the chromatogram through using fingerprint software to obtain the fingerprint of the anti-inflammatory tablet. The method has the advantages of establishing the common mode of the HPLC characteristic fingerprint of the anti-inflammatory tablet, calibration of 27 common peaks, effective characterization of the quality of the anti-inflammatory tablet, overcoming of unicity and one-sidedness of original quality control methods, and high application values.
Owner:吉林修正药业新药开发有限公司 +1

Method for detecting ingredients of Mailuoning oral liquid for clearing heat, nourishing yin, activating blood circulation and removing blood stasis

The invention discloses a method for detecting ingredients of Mailuoning oral liquid for clearing heat, nourishing yin, activating blood circulation and removing blood stasis. The method comprises thefollowing steps: performing HPLC detection on a Mailuoning oral liquid test solution and a standard solution, wherein the chromatographic conditions are as follows: a C18 chromatographic column, anda column temperature of 25-40 DEG C; using methanol as a mobile phase A, using an aqueous acid solution as a mobile phase B, performing gradient elution, recording a chromatogram, calculating the similarity of a test sample by using similarity software with a fingerprint of the Mailuoning oral liquid as the reference, wherein the fingerprint of the test sample should be similar with a standard fingerprint; and calculating the contents of the ingredients in the Mailuoning oral liquid by using an external standard one point method. The method disclosed by the invention has good precision, linearrelationship, stability, repeatability, high recovery rate and good durability; the method disclosed by the invention has the advantages of good degree of separation and reproducibility of the fingerprint of the Mailuoning oral liquid, and comprehensive information, 21 common peaks are marked in total, the similarity of each batch of samples is above 0.95, and the quality of the Mailuoning oral liquid can be evaluated comprehensively, objectively and scientifically.
Owner:JINLING PHARMA
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