22results about How to "Stable baseline" patented technology

The invention provides a construction method and application of an angelica sinensis potion fingerprint spectrum, and belongs to the technical field of drug detection.The construction method includes the steps that firstly, an angelica sinensis potion is used for preparing a test solution, then 0.08-0.12 wt% phosphoric acid aqueous solution (A)-acetonitrile (B) serves as a mobile phase, and the angelica sinensis potion fingerprint spectrum is obtained through high performance liquid chromatography detection, a standard fingerprint spectrum is established and is used for quality evaluation or control in the whole process of research / development / production / clinical application of the angelica sinensis potion. According to the construction method of the fingerprint spectrum of the angelica sinensis potion, main medicinal material components in the angelica sinensis potion can be detected only through high performance liquid chromatography, so that the quality condition of the angelica sinensis potion is reflected more comprehensively.

The invention discloses a construction method of a characteristic chromatogram of a rhizoma dryopteris crassirhizomae medicinal material, formula granules, decoction pieces or standard decoction, and the construction method comprises the following steps: preparing a reference substance solution which comprises a reference substance solution of a reference medicinal material and a reference substance solution of a reference substance, the reference substance solution comprises a protocatechuic acid reference substance, a protocatechuic aldehyde reference substance, a neochlorogenic acid reference substance and a chlorogenic acid reference substance; taking a rhizoma dryopteris crassirhizomae medicinal material, formula granules, decoction pieces or a standard decoction to prepare a test solution; a preset amount of the reference substance solution and the test solution are taken and injected into a liquid chromatograph, the liquid chromatograph takes octadecylsilane chemically bonded silica as a filler, methanol as a mobile phase A and a phosphoric acid solution as a mobile phase B for gradient elution, and the characteristic chromatogram is established. The method can provide a data basis for quality control of rhizoma dryopteris crassirhizomae medicinal materials, formula granules, decoction pieces or standard decoction, and ensures the stability and controllability of product quality.

The invention belongs to the field of substance content detection, and discloses a method for determining the content of soybean phosphatidylcholine or phosphatidylethanolamine in a soft capsule, which comprises the following steps: (1) preparing a soybean phosphatidylcholine or phosphatidylethanolamine standard solution; (2) preparing a to-be-detected sample solution; (3) performing high performance liquid chromatography analysis; (4) drawing a standard curve; and (5) calculating the content of soybean phosphatidylcholine or phosphatidyl ethanolamine. The method has the advantages of high response value, short retention time and stable base line, and is not interfered by other components in the soft capsule; the method has the advantages of simple operation, high precision and good repeatability, the recovery rate meets the analysis requirement, and the method can efficiently, quickly and accurately detect the content of two components, namely soybean phosphatidylcholine and phosphatidyl ethanolamine, of soybean phospholipid in the soft capsule content.

The present invention relates to the technical field of detection of Chinese medicine formula granules, and discloses a detection method for orange and citrus aurantium formula granules. The method comprises first comparing the correspondence of characteristic peaks in the chromatograms of the test solution and the control medicinal material solution, and then further detecting the citrus aurantium formula granules according to the peak area ratio α1 of rutin naringin to naringin and the peak area ratio α2 of neohesperidin to hesperidin. The UPLC detection method has good accuracy, repeatability and separation, shortens the detection time, and is easy to operate. The present invention uses the simulated formula granule extraction solution as the evaluation benchmark, can accurately detect whether the formula granules are orange and citrus aurantium formula granules, makes up for the vacancy in the technical field of its origin identification, and the method can be used as an exclusive identification method for orange and citrus aurantium formula granules.

The invention discloses an image restoration method and system based on dynamic re-parameterization, and the method comprises the following steps: obtaining a training image and a control parameter k, selecting a pre-trained denoising network on a natural image restoration task as a basic model, and constructing a dynamic controllable re-parameterization network based on the basic model; inputting the training image and the control parameter k into the dynamic controllable re-parameterization network for forward propagation, then constructing a loss function for back propagation, and updating parameters in the dynamic controllable re-parameterization network to obtain a dynamic controllable re-parameterization mother model; setting a target scene for image restoration, calibrating the optimal processing intensity of the target scene, determining a corresponding krep value, and processing the re-parameterized mother model based on the krep value to obtain an image restoration model; and performing image restoration by using the image restoration model.

This invention provides a fingerprint spectrum of Yishen Wufa Oral Liquid, its construction method, and its application, as well as a multi-index component detection method for Yishen Wufa Oral Liquid, relating to the field of pharmaceutical analysis and structural technology. The fingerprint spectrum of Yishen Wufa Oral Liquid constructed by this invention includes 20 characteristic peaks, including ferulic acid, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, astragaloside A, psoralen, isopsoralen, and emodin. The chromatographic peaks are abundant and attributed to the effective components of psoralen (roasted with black sesame seeds), angelica, poria cocos, wolfberry, fleeceflower root (processed with black bean wine), achyranthes bidentata, and astragalus complanatus. This provides a more comprehensive reflection of the overall chemical composition and quality of Yishen Wufa Oral Liquid, facilitating more effective guidance for feed addition and strict standardization of production operations. It also helps improve the safety and efficacy of Yishen Wufa Oral Liquid in clinical use, possessing high application value.

The invention belongs to the technical field of quality detection of traditional Chinese medicine preparations, and particularly provides a fingerprint spectrum construction method and a quality detection method of a liver regulating decoction compound preparation. According to the fingerprint spectrum construction method of the liver regulating decoction compound preparation, octadecylsilane chemically bonded silica is used as a filling agent; an acetonitrile-phosphoric acid-containing aqueous solution is used as a mobile phase for gradient elution, an elution procedure is obtained through repeated tests, under the elution condition of the method, the number of common peaks (up to 22) is remarkably increased, the common peaks are good in peak shape and separation effect, a base line is stable, and the method is suitable for large-scale industrial production. Therefore, the quality of the liver regulating decoction compound preparation can be detected more comprehensively, clearly and effectively.

The present invention relates to the technical field of traditional Chinese medicine detection, and in particular to a detection method and quality control method for a Tangut rhubarb product. The detection method for the Tangut rhubarb product provided by the present invention uses octadecylsilane bonded silica gel as a filler, uses methanol-phosphoric acid aqueous solution as a mobile phase for gradient elution, selects a specific elution program, and obtains 18 common characteristic peaks, which not only significantly improves the number of characteristic peaks, but also achieves good separation of these common characteristic peaks, the elution program is simple, the obtained characteristic spectrum baseline is stable, each characteristic peak has a good peak shape, and the separation between each characteristic peak is high, so the detection method can effectively improve the accuracy of the characteristic spectrum of the Tangut rhubarb product, and can fully reflect the integrity and characteristic of the Tangut rhubarb product, which is conducive to more comprehensive monitoring of the quality of the Tangut rhubarb product.

The application provides a kind of Fuling drink piece, fried Fuling drink piece and the construction method and application of its preparation characteristic map, the construction method of fried Fuling and its preparation characteristic map, comprising: preparing test sample solution;Using high performance liquid chromatography to detect test sample solution, chromatographic conditions include with octadecylsilane bonded silica as filler, with methanol as mobile phase A, with 0.08%-0.4% formic acid as mobile phase B, and using specific elution procedure, while shortening the detection time also significantly improves the separation effect of multiple effective components, so that the characteristic map contains more characteristic peaks, greatly enriches the atlas information, realizes the effective separation of characteristic peaks such as uridine, thymine, gallic acid and guanosine, the characteristic of the obtained characteristic map is obvious, fully reflects the integrity and characteristic of the drug preparation of fried Fuling, and the baseline is stable, the peak shape is good, which provides basis for comprehensively detecting the quality of Fuling drink piece, fried Fuling and its pharmaceutical preparations.

The application belongs to the technical field of food detection, and provides a detection method of soluble dietary fiber in resistant dextrin. The method adopts amylodextrinase to perform enzymatic digestion on the resistant dextrin, adds water to prepare a test solution; glucose is used as a standard, high performance liquid chromatography is used for detection, and the content of the soluble dietary fiber in the resistant dextrin is obtained by an external standard method. The detection method is simpler than the existing standard method, greatly reduces the error sources, can guarantee the accuracy and precision of the detection results, shortens the detection time, saves manpower and economic cost, and can meet the detection needs of inspection supervision departments and enterprises.

The invention provides a method for simultaneously measuring fluorine ions, chloride ions, sulfate ions and main contents in bis (fluorosulfonyl) imide acid, which is characterized by comprising the following steps: (1) preparing standard solutions of fluorine ions, chloride ions and sulfate ions, and establishing a standard curve according to the peak area and corresponding concentration of each anion; (2) adding a pH regulator into the bis (fluorosulfonyl) imide acid sample, and regulating the pH to a certain range; (3) feeding the treated sample to an ion chromatograph for testing; and (4) calculating the concentration of each anion in the sample to be detected according to the standard curve and a sample test result, and calculating the content of the bis (fluorosulfonyl) imide acid by adopting an area normalization method.

The invention provides a construction method and a quality detection method of a characteristic spectrum of a traditional Chinese medicine composition, and the construction method of the characteristic spectrum comprises the following steps: taking a solution of a traditional Chinese medicine composition test sample and a solution of a reference substance, and carrying out high performance liquid chromatography detection to obtain the characteristic spectrum of the traditional Chinese medicine composition; wherein the traditional Chinese medicine composition comprises radix scutellariae, cortex mori radicis, fructus trichosanthis, semen armeniacae amarae, radix adenophorae, radix ophiopogonis, semen coicis, semen benincasae, fructus aurantii, radix curcumae, rhizoma imperatae, radix salviae miltiorrhizae, indigo naturalis and clam shells; the liquid chromatographic analysis conditions of the detection are as follows: octadecylsilane chemically bonded silica is used as a filler, acetonitrile is used as a mobile phase A, a phosphoric acid solution with the volume percentage of 0.09-0.11% is used as a mobile phase B, gradient elution is performed, the detection wavelength is 207-286nm, the column temperature is 25-35 DEG C, and the flow velocity is 0.9-1.1 mL / min. The specific chromatogram constructed by the invention can objectively evaluate the quality of a traditional Chinese medicine composition sample and improve the quality of the traditional Chinese medicine composition, so that the curative effect is ensured.

This invention belongs to the field of pharmaceutical analysis technology, specifically relating to a method for constructing characteristic chromatograms of Dajianzhong Decoction and a method for determining the content of its effective components. The construction method includes the preparation of a test solution, and under specific conditions, characteristic chromatograms 1 and 2 are obtained using UPLC-UV-ELSD chromatography. Characteristic chromatogram 1, obtained under ultra-high performance liquid chromatography and a UV detector, is specific to dried ginger and roasted Sichuan pepper, with characteristic peaks mainly consisting of gingerol components in dried ginger and amide alkaloids in roasted Sichuan pepper. Characteristic chromatogram 2, obtained under ultra-high performance liquid chromatography and an evaporative light scattering detector, is specific to ginseng, consisting entirely of ginsenosides, thus solving the problem of large differences in detection wavelengths and mutual interference between the two major categories of components.

The invention belongs to the technical field of traditional Chinese medicine detection, and particularly relates to a specific chromatogram construction method and application of a Xiangbai powder compound preparation, and the specific chromatogram construction method comprises the following steps: (1) preparing a test solution; (2) the test solution is taken and detected by adopting a high performance liquid chromatography, octadecylsilane chemically bonded silica is taken as a filler, a mobile phase comprises acetonitrile and an aqueous solution containing phosphoric acid, a gradient elution procedure comprises 0-10 min, 12 min, 32 min, 60 min, 70 min, 90 min, 93 min, 98 min, 99 min and 105 min, and the volume percentage of acetonitrile in the mobile phase is 5%-5%-7%-25%-50%-60%-80%-5%-5%. According to the method, effective separation of 12 common characteristic peaks including the boxthorn A peak can be realized, and the obtained characteristic spectrum is stable in baseline, good in peak shape of the characteristic peaks and high in separation degree.

The invention provides a construction method and application of a chelidonium album sample specific chromatogram, the method adopts ultrahigh performance liquid chromatography to establish the specific chromatogram of chelidonium album formula granules or upstream raw materials thereof, and the method comprises the following specific steps: preparation of a test solution, preparation of a reference medicinal material solution, preparation of a reference substance solution and acquisition of the specific chromatogram. The specific chromatogram construction method provided by the invention makes up the vacancy of research on water-soluble components of the chelidonium majus, and the method is simple and convenient to operate, short in analysis period, good in common peak separation degree and stable in baseline, and provides a new analysis means for quality control of the chelidonium majus formula granules.

The present application relates to the technical field of traditional Chinese medicine detection, and specifically provides a characteristic spectrum construction method of Herba Centipedae and its preparation. A specific elution procedure is obtained through a large number of experiments by using octadecylsilane bonded silica gel as a filler and a mobile phase including methanol and an acid-containing aqueous solution for gradient elution, 13 or more common characteristic peaks are obtained, and effective separation of characteristic peaks including neochlorogenic acid, caffeic acid, chlorogenic acid, cryptochlorogenic acid, 1,4-dicaffeoylquinic acid, 1,5-dicaffeoylquinic acid, big pothos glycoside and thymotin lactone ketone is achieved, the peak shape is good, the baseline is smooth, the determined components can be completely separated, the detection time is short, and the method provides a basis for quality detection and control of Herba Centipedae and its preparation, can fully reflect the integrity and characteristics of Herba Centipedae and its preparation, and is simple to operate and applicable to quality control of different preparation types of Herba Centipedae.

The invention discloses a method for constructing a characteristic spectrum and a control spectrum of fructus broussonetiae and a method for distinguishing true and fake fructus broussonetiae. The method comprises the following steps: respectively injecting a fructus broussonetiae test solution and a reference substance solution into ultra-high performance liquid chromatography to obtain a characteristic chromatogram; and importing the characteristic chromatogram into a traditional Chinese medicine chromatographic fingerprint similarity evaluation system to establish a control chromatogram. And comparing the characteristic peak with the peak of the reference substance solution spectrum, and distinguishing the test sample as the fructus broussonetiae or the counterfeit product. The characteristic chromatogram is rich in chromatographic information, high in specificity, short in time, good in chromatographic peak separation degree and stable in base line, and the technology is good in reproducibility and high in stability; technical guarantee is provided for true and false identification of fructus broussonetiae raw materials and preparations; the method is simple, accurate, reliable and convenient to operate, and compared with a traditional biological identification method, the required sample amount is small, the detection time is saved, and the efficiency is high; and the solvent consumption is low, the toxicity of the used solvent is low, and the environmental pollution is small.

The invention relates to the field of quality analysis and evaluation of Chinese patent medicines, and particularly provides a toad skin extract and a separation method of chemical components of a preparation of the toad skin extract or a construction method of a fingerprint spectrum and a quality control method. Octadecylsilane chemically bonded silica is used as a filler, a mobile phase comprises acetonitrile and water, gradient elution is carried out, a specific elution procedure is obtained through a large number of experiment screening, and the fingerprint spectrum is obtained. The method realizes effective separation of seven characteristic peaks of bufotalin, arenobufogenin, bufagin, deacetylcinobufotalin, telocinin, bufotalin and cinobufotalin, has the advantages of good peak shape, stable base line, complete separation of the measured components, short detection time, rapidness and high efficiency, provides a basis for quality detection and control of cinobufotalin tablets, and has a wide application prospect. The integrity and characteristics of cinobufagin tablets can be fully reflected, the operation is simple, and the specificity is strong.

This utility model discloses a coaxiality laser testing device for bearings, belonging to the technical field of coaxiality laser testing devices. It includes a worktable, a laser emitting fixture, and a photosensitive position sensor. Support legs are fixed at each of the four corners of the worktable's bottom, and mounting bases are installed at the bottom of each support leg. A centering and positioning mechanism is installed at the bottom of the worktable. This device features a centering and positioning mechanism that allows two clamping pads to clamp the bearing synchronously, ensuring precise alignment between the centerline of the two clamping pads and the bearing's axis. This avoids errors caused by insecure or misaligned fixture installation, providing a stable benchmark for laser measurement and making the test results more reliable. A lifting and adjusting mechanism allows for convenient adjustment of the vertical height of the mounting pads and the laser emitting fixture, and locking the height after adjustment is simple, adapting to the height adjustment requirements of coaxiality laser testing for bearings.

The application discloses a kind of HPLC detection method and application for simultaneously identifying Dajiujun and Ziyuanhua simultaneously, belong to the technical field of quality detection of traditional Chinese medicine.Using unified chromatographic conditions, two kinds of medicinal materials fingerprint are established simultaneously, combined with common peak identification, multi-component content determination and PCA, HCA, OPLS-DA chemometrics analysis, realize fast, accurate identification and quality evaluation.15 batches of Ziyuanhua samples similarity is 0.997~1.000, 15 batches of Dajiujun samples similarity range is 0.813~0.990. The similarity between two kinds of medicinal materials is 0.888~0.995 by similarity analysis. The method has high precision and good repeatability, can simultaneously complete qualitative identification, quantitative determination and difference marker screening, suitable for quality control of traditional Chinese medicine, market supervision and medicinal material standardized production, has higher practical value and application prospect.

The application relates to a characteristic chromatogram of Qinshi Jiedu granules and a construction method and application thereof, and belongs to the technical field of quality detection of traditional Chinese medicine preparations. High performance liquid chromatography is adopted; test product solution, control product solution and each single medicine control solution are respectively injected into a high performance liquid chromatograph for determination; a chromatogram is recorded; a characteristic chromatogram of the Qinshi Jiedu granules is established under the same chromatographic condition; 14 characteristic peaks are calibrated; and quality detection is carried out on the Qinshi Jiedu granules. The characteristic chromatogram of the Qinshi Jiedu granules established based on the high performance liquid chromatography technology can comprehensively, systematically and objectively evaluate the quality of the Qinshi Jiedu granules.

The invention relates to a construction method and application of an HPLC (High Performance Liquid Chromatography) fingerprint spectrum of a clear paste extracted from an anti-inflammatory and cough-relieving tablet. The invention establishes a high performance liquid chromatography analysis method, the method is used for detecting the extract clear paste of the anti-inflammatory and cough-relieving tablet, the separation degree between peaks is good, the peak distribution is uniform, and the baseline is stable; a methodological investigation result shows that the method disclosed by the invention is good in specificity and also has good repeatability, stability and durability. The HPLC fingerprint spectrum of the extracted clear paste of the anti-inflammatory and cough-relieving tablets is constructed by using the method, can be used for quality evaluation of the extracted clear paste of the anti-inflammatory and cough-relieving tablets, and lays a foundation for quality control of the extracted clear paste of the anti-inflammatory and cough-relieving tablets.