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Quality analysis method of compound Ganmaoling tablets

A technology for quality analysis of Ganmaoling tablets, applied in the field of quality analysis of compound Ganmaoling tablets, can solve the problems of high detection cost, heavy workload, long detection time, etc., and achieve the effects of high sensitivity, improved work efficiency, and stable baseline.

Active Publication Date: 2011-02-02
GUANGZHOU XIANGXUE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If these two content determinations are added, the variety has 4 content determination items of chlorogenic acid, acetaminophen, caffeine, and chlorpheniramine maleate, which are measured separately by different chromatographic conditions, and the detection time is long and the detection time is long. High cost and heavy workload
In the prior art, there is no bibliographic report about the simultaneous determination of the three components of acetaminophen, chlorogenic acid, and caffeine in Compound Ganmaoling, and the existing bibliographic reports only focus on the content determination of one or two of them ; It has been verified by experiments that the literature methods are not suitable for the simultaneous detection of the above three components

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0020] Embodiment 1 A kind of quality analysis method of Compound Ganmaoling Tablets

[0021] The content of chlorogenic acid, acetaminophen and caffeine in Compound Ganmaoling Tablets was determined by HLPC, including the following steps:

[0022] (1) Prepare the test solution

[0023] Take 10 tablets of Compound Ganmaoling Tablets, remove the coating, accurately weigh, grind into fine powder, accurately weigh about 0.67g of the fine powder, put it in a stoppered Erlenmeyer flask, add methanol-0.4% phosphoric acid with a volume ratio of 12:88 Solution 25ml, accurately weighed, after ultrasonic vibration for 20 minutes, take it out and let it cool, then accurately weigh the weight, make up the lost weight with methanol-0.4% phosphoric acid solution with a volume ratio of 12:88, shake well, filter, Precisely draw 2ml of the filtrate, put it in a 10ml brown measuring bottle, add methanol-0.4% phosphoric acid solution with a volume ratio of 12:88 to dilute to the mark, shake wel...

Embodiment 2

[0033] Example 2 Conditional screening and methodological verification of a quality analysis method for Compound Ganmaoling Tablets

[0034] 1. Preparation of test article

[0035] Refer to the relevant literature and use water ultrasonic extraction, and there are many impurities. Using methanol as solvent, the chromatographic peak shape is poor. After dissolving with an appropriate amount of methanol, and then diluting to volume with phosphate buffer, the resolution of paracetamol, chlorogenic acid and caffeine chromatographic peaks and adjacent peaks is greater than 1.5, the purity is better, and the content is the highest. Therefore, this preparation method was chosen.

[0036] 2. Measurement wavelength

[0037] Prepare acetaminophen, chlorogenic acid and caffeine reference substance solution of appropriate concentration, precisely draw 20 μl of the reference substance solution and inject it into the liquid chromatograph, check the peak spectrum of paracetamol, chlorogen...

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Abstract

The patent refers to the field of 'pharmaceutical preparations'. The invention discloses a quality analysis method of compound Ganmaoling tablets. In the method, high-performance liquid chromatography (HLPC) is used for measure the chlorogenic acid content, acetaminophen content and caffeine content of the compound Ganmaoling tablets, test product solution is prepared and reference product solution is prepared and measured. The quality analysis method of the invention can detect the acetaminophen, chlorogenic acid and caffeine components under the same color spectrum condition at the same time, so the test time and cost are saved and the working efficiency is improved; the test method has high sensitivity, high separating degree; the basic line is stable; a negative reference is not affected; and the accuracy, repeatability, linearity and stability of the test method meet scientific research and production requirements, and the detection method is suitable for promotion and application.

Description

technical field [0001] The invention belongs to the technical field of integrated Chinese and Western medicine pharmacy, and in particular relates to a quality analysis method for compound Ganmaoling tablets. Background technique [0002] Compound Ganmaoling Tablets are made of six traditional Chinese medicines including honeysuckle, five-finger mandarin orange, wild chrysanthemum, three-fork bitter, Nanbanlangen, and Gangmei, plus three chemical ingredients: acetaminophen, caffeine, and chlorpheniramine maleate. Chinese and Western medicine compound preparations. It has the effects of pungent and cool solution, heat-clearing and detoxification. Clinically, it is widely used for fever due to wind-heat and cold, slight aversion to wind-cold, head and body pain, dry mouth and thirst, turbid nasal congestion, sore throat, cough, yellow and sticky phlegm. The product standard is currently a trial standard, the standard number is WS-11191 (ZD-1191)-2002, and there are content d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/167A61K36/85A61K31/4402A61K36/754A61P11/00A61P31/00A61K9/20G01N30/02
Inventor 康志英李小妹连林生蔡春玲王德秀
Owner GUANGZHOU XIANGXUE PHARMA CO LTD
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