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Method for controlling quality of corydalis tuber and preparation thereof and drug effect thereof by using finger print

A technology of fingerprint and Corydalis, applied in the field of raw material quality control of Corydalis, can solve the problems of no quality control of the production of traditional Chinese medicine, no quality control method, etc.

Inactive Publication Date: 2008-10-22
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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Problems solved by technology

[0007] From the above, it can be seen that the different chemical components of Corydalis Corydalis have different pharmacological effects. At present, the quality of Corydalis Corydalis and its preparations has not been truly controllable, and it has not been applied to the quality control of the production of Chinese medicinal materials, especially not specific to it. Efficacy-linked quality control methods

Method used

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  • Method for controlling quality of corydalis tuber and preparation thereof and drug effect thereof by using finger print
  • Method for controlling quality of corydalis tuber and preparation thereof and drug effect thereof by using finger print
  • Method for controlling quality of corydalis tuber and preparation thereof and drug effect thereof by using finger print

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Effect test

experiment example 1

[0055] Corydalis Corydalis: Zhejiang, China

[0056] Instrument: Waters 2690 high performance liquid chromatography (515 pump, 996 PAD detector, Millennium 32 Workstation); Agilent 1100 high performance liquid chromatograph and API 3000 mass spectrometer detector (Analyst 1.1 data processing system); Chinese medicine chromatographic fingerprint similarity evaluation software (National Pharmacopoeia Commission, 2004A edition).

[0057] Preparation of active site test solution:

[0058]Corydalis Corydalis is moderately crushed, refluxed with 80% ethanol for 3 times, 4 hours each time, the extract is passed through X-5 macroporous adsorption resin, first washed with 5% ammonia water to remove impurities, then eluted with 50% ethanol, collected and eluted solution, and the eluate was concentrated under reduced pressure and dried to obtain the active fraction of Corydalis Corydalis. Take 20 mg of the active part, dissolve it with 80% methanol and dilute it to a 10 mL volumetric f...

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Abstract

The invention relates to a fingerprint map for controlling the quality and efficacy of rhizoma corydalis and preparation of the rhizoma corydalis and a preparation method of the fingerprint map. The invention discloses that the fingerprint map is one of anti-myocardial ischemic active site in the rhizoma corydalis, and the active site mainly comprises quaternary ammonium base components, wherein, columbamine, 13-methyldehydrocorydalmine, dehydrocorybulbine, palmatine, dehydrocorydaline are the main five components of quaternary ammonium base. The fingerprint map can identify the authenticity of samples and evaluate the quality and efficacy of the rhizoma corydalis or the preparation thereof, so that the quality of the rhizoma corydalis and the preparation thereof have real controllable standards, so as to ensure the product quality to be stable. The method has the advantages of being simple to operate and being accurate and reliable, which is applicable to controlling the quality and efficacy of the rhizoma corydalis and the preparation thereof.

Description

technical field [0001] The invention belongs to the field of quality control methods for raw materials of Corydalis Corydalis, in particular to a method for controlling the quality and efficacy of Corydalis Corydalis and its preparations by utilizing the fingerprints of active parts of Corydalis Corydalis for anti-myocardial ischemia. Background technique [0002] Most of the traditional Chinese medicines and their preparations in my country lack strict quality control standards and scientific testing methods, and it is difficult to effectively control their internal quality, especially the quality control methods for active ingredients (groups) associated with their efficacy, which cannot guarantee the safety of medication , effective, and does not meet the requirements of the international pharmaceutical market, which seriously restricts the development of my country's traditional Chinese medicine industry. Strengthening the research on the quality control of traditional Chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66G01N30/02A61P9/10A61K125/00
Inventor 石钺程星烨孙虹金文郑顺亮
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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