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Medicament for preventing and treating senile dementia

A technology for senile dementia and drugs, which is applied in the field of research and development of drugs for the treatment of medical diseases, to achieve the effect of easy induction of expression purity and no toxic and side effects

Active Publication Date: 2015-04-01
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these drugs only slightly improve dementia symptoms or delay the progression of dementia in patients with advanced Alzheimer's disease

Method used

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  • Medicament for preventing and treating senile dementia
  • Medicament for preventing and treating senile dementia
  • Medicament for preventing and treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0071] Experimental Materials:

[0072] In the present invention, by injecting TAT-siP-PTPN1-HA polypeptide into 12-month-old Tg2576 mice, it is found that it can improve senile plaques, hyperphosphorylation of tau protein, and learning and memory impairment in senile dementia model animals.

[0073] The specific operation steps are as follows:

[0074] 1. Experimental subjects: 20 male Tg2576 mice (purchased from Jax Laboratory), SPF grade, weighing 25-32 grams, were raised in a conventional environment. Experimental groups: ① control group (wild-type control mice); ② model group (injected with TAT-scramble-HA); ③ treatment group (injected with TAT-siP-PTPN1-HA); 10 mice in each group.

[0075] 2. Experimental model preparation:

[0076] ①Normal group: 12-month-old wild-type control mice, no treatment

[0077] ②Model group: 12-month-old Tg2576 mice were given a single injection of TAT-scramble-HA polypeptide through the tail vein at a dose of 10 mg / kg.

[0078] ③Treatment...

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Abstract

The invention discloses a small molecular polypeptide TAT-siP-PTPN1-HA and application thereof in preparation of a medicament for treating or preventing senile dementia. An artificially synthesized TAT protein transduction structural domain and an siP-PTPN1-HA fusion protein polypeptide TAT-siP-PTPN1-HA are used, TAT can carry the siP-PTPN1-HA protein polypeptide to pass through a blood-brain carrier via blood to be absorbed by neurons, and by applying the small molecular polypeptide TAT-siP-PTPN1-HA to an in-vivo senile dementia model, the biological action of blocking the binding of miR-124 and protein tyrosine phosphatase, non-receptor type 1, PTPN1 3'-non-coding sequence (3'-untranslated region, 3'-UTR) can be effectively realized, the expression of PTPN1 is further effectively reversed, excessive phosphorylation of microtube-associated protein tau and amyloid protein deposition, as well as animal learning and memory disorders represented by an senile dementia model animal are improved, and a new direction is provided for further development of the medicaments for clinical treatment of senile dementia.

Description

technical field [0001] The invention relates to the field of research and development of drugs for treating medical diseases, in particular to a small molecular polypeptide TAT-siP-PTPN1-HA, and also relates to the application of the small molecular polypeptide TAT-siP-PTPN1-HA in the preparation of drugs for treating or preventing senile dementia. technical background [0002] Senile dementia (Alzheimer Disease, AD) is a common neurodegenerative disease, its main symptoms are memory loss, low cognitive ability and slow thinking, and progressive aggravation, finally unable to take care of itself and die, the course of the disease is generally 8 ~10 years. With the acceleration of the aging process of the society, the number of patients with AD has risen sharply, and it has become a serious disease that threatens the physical and mental health of the elderly, especially the elderly population, and has brought serious social, economic and family problems. [0003] The main pa...

Claims

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Application Information

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IPC IPC(8): C07K19/00C12N15/62A61K38/17A61K47/48A61P25/28
CPCA61K38/16C07K19/00C12N15/62
Inventor 朱铃强王雄王玉田刘丹黄和周
Owner HUAZHONG UNIV OF SCI & TECH
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