66results about How to "Improve memory impairment" patented technology

The present invention relates to a kind of Chinese medicine preparation for treating senile dementia, and the Chinese medicine preparation is prepared with astragalus root, gastrodia tuber, tuckahoe, grass-leavedsweetflag, ginseng and other ten kinds of Chinese medicinal materials. The Chinese medicine preparation is used mainly for treating and preventing senile dementia, and has the advantages of fast acting, high curative effect and no toxic side effect.

The present invention provides compositions and methods for ameliorating neurological, attention, or memory disorders and improving learning and cognition through the delivery of insulin A-chain and analogs thereof to a subject. Insulin A-chain, peptides comprising the 21 amino acid sequence GIVEQ CCASV CSLYQ LENYC N (SEQ ID NO:1), and functional analogs thereof are disclosed to modulate neurological activity when administered to a subject. The methods of the invention can be used to prevent or treat neurological disorders as well as improve memory retention and acquisition. The invention includes pharmaceutical compositions comprising a therapeutically or prophylactically effective amount of insulin A-chain peptide or a functional analogs thereof.

The invention relates to applications of a cysteinyl leukotriene receptor antagonist (CysLT1R) on preparation of a medicament for treating the Alzheimer disease. Research finds that intracerebral CysLT1R mediates A beta aggregation and dysmnesia; and by oral medication, CysLT1R antagonists such as pranlukast, zafirlukast and montelukast can improve mice memory impairment caused by A beta. The CysLT1R antagonists such as pranlukast, zafirlukast and montelukast, and analogs thereof such as iralukast, ablukast, imitrodast, pobilukast, cinalukast, verlukast, pemirolast and ibudilast, have significant protection effect on primarily-cultured mice neuron damage caused by A beta. The CysLT1R antagonists such as pranlukast, zafirlukast and montelukast, and the analogs thereof such as iralukast, ablukast, imitrodast, pobilukast, cinalukast, verlukast, pemirolast and ibudilast, can be used for preparing anti-AD medicaments.

The present invention relates to kind one ginsenoside Rg2 preparing process suitable for industrial production, and gradient salt separation process with simple operation is used in substituting traditional silicon gel chromatography process. The present invention also relates to medicine composition with ginsenoside Rg2 as active component and its application in medicine for preventing and treating dementia, depression, peripheral circulation disturbance and related diseases.

The invention discloses a small molecular polypeptide TAT-siP-PTPN1-HA and application thereof in preparation of a medicament for treating or preventing senile dementia. An artificially synthesized TAT protein transduction structural domain and an siP-PTPN1-HA fusion protein polypeptide TAT-siP-PTPN1-HA are used, TAT can carry the siP-PTPN1-HA protein polypeptide to pass through a blood-brain carrier via blood to be absorbed by neurons, and by applying the small molecular polypeptide TAT-siP-PTPN1-HA to an in-vivo senile dementia model, the biological action of blocking the binding of miR-124 and protein tyrosine phosphatase, non-receptor type 1, PTPN1 3'-non-coding sequence (3'-untranslated region, 3'-UTR) can be effectively realized, the expression of PTPN1 is further effectively reversed, excessive phosphorylation of microtube-associated protein tau and amyloid protein deposition, as well as animal learning and memory disorders represented by an senile dementia model animal are improved, and a new direction is provided for further development of the medicaments for clinical treatment of senile dementia.

The invention relates to a traditional Chinese medicine for treating schizophrenia and treating the side effect caused by antipsychotics and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicines according to the proportion by weight: 10-17 ophiopogon roots, 7-14 medlar, 3-10 earthworms, 10-18 kudzu roots, 3-10 arillus longan, 7-14 lycopodium calvatum, 4-11 lotus leaf, 7-14 flos albiziae, 3-10 chrysoidine, 4-11 dates, 4-14 grass-leaved sweetflag, 4-11 radix curcumae and 7-14 liquorice. The dosage form comprises granules, sirup, tablets, capsules and oral liquid. The preparation method is as follows: adding water to boil to obtain liquid medicine, concentrating, filtering, adding antiseptic, subpackaging and sterilizing to obtain the oral liquid. The traditional Chinese medicine has the functions of nourishing Yin and clearing away the heart fire, tonifying the kidney and the brain as well as promoting blood circulation and removing obstruction in channels and the advantages of low cost, remarkable curative effect and no side effect, thereby achieving the aims of mainly treating muffing, fremitus, lags in response, witless expression, retardation of thinking, achexia, fidgety and confusion, talk nonsense, uncommunication, hygrostomia and indifference of patients suffering from schizophrenia, improving the memory impairment, promoting the recovery of psychopathy and preventing or reducing the recrudescency of psychopathy.

The invention relates to an application of levetiracetam injection in preparation of nootropic drugs. At present, levetiracetam is an antiepileptic drug with a very good curative effect, and researches find that the drug has a better curative effect in the nootropic aspect. The invention aims to further explore the application of the levetiracetam injection in the nootropic aspect, which has the advantages of quick drug effect, strong practicability and storability, compared with oral preparations.

The invention relates to a medicinal composition, in particular to a composition comprising 4-hydroxyl-2-oxo-1-pyrrolidine acetamine and 2-borneol, and application of the composition in medicines for preventing and / or treating cognition impairment. The composition provided by the invention can remarkably improve a cerebral trauma neural function of a rat and can remarkably prolong the time of passive activities. The composition provided by the invention plays a role in improving dysmnesia of the rat, caused by scopolamine, and can remarkably improve cognitive disorder of the rat, caused by cerebral ischemia. The composition has a remarkable effect in preventing and / or treating cognition impairment.

The invention relates to the field of biochemical engineering, in particular to a traditional Chinese medicine composition with a blood sugar reduction effect, and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 2-6 parts of ginseng, 2-6 parts of astragalus mongholicus, 1-5 parts of Chinese wolfberries, 2-6 parts of mulberry leaves, 2-8 parts of guava leaves and 1-5 parts of Chinese yam. The traditional Chinese medicine composition with the bloodsugar reduction effect adopts various kinds of medicinal and edible food, can be eaten for a long term and prevent and assist in treatment of hyperglycemia, has a small side effect and a better treatment effect, takes effect quickly and has a very good prevention or treatment effect on diabetes mellitus and complications of the diabetes mellitus.

The invention discloses a huperzine-a lipid micro-sphere preparation. The huperzine-a lipid micro-sphere preparation is mainly made of huperzine-a, oil for injection, emulsifiers and isotonic agents. The huperzine-a lipid micro-sphere preparation has the advantages that perfect treatment effects can be realized, problems of insolubilization of huperzine-a in water and adverse reaction under high-dosage conditions can be solved, the stability of medicine can be improved, irritation and toxic reaction can be reduced, the quality of preparation products can be improved, and the huperzine-a lipid micro-sphere preparation is applicable to industrial large-scale production.

A medicine which comprises a combination of an acetylcholine esterase inhibitor and a 5-substituted 3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivative represented by the following general formula (I). It is useful for the treatment of memory disorders accompanying neuropsychiatric diseases and other cognition disorders. Also provided are: a method of treatment of any of these diseases which comprises using a combination of these drugs; and a use of the medicine. (In the formula (I), Het is oxadiazolyl; R<1> is hydrogen, lower alkyl, cyclo(lower alkyl), lower alkenyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, etc.; and R<2> is hydrogen, lower alkyl, cyclo(lower alkyl), (un)substituted aryl, etc.).

The invention discloses bifidobacterium breve capable of relieving Alzheimer's disease and increasing fecal acetic acid content and application thereof, and belongs to the field of microorganisms. The bifidobacterium breve CCFM1179 can significantly improve cognitive and memory disorders of mice with Alzheimer's disease, reduce the content of A beta 1-42 in the brains of the mice with Alzheimer's disease, increase the level of brain-derived neurotrophic factors and postsynaptic density protein in the brains of the mice with Alzheimer's disease, increase the content of 5-hydroxytryptamine in the serum of the mice with Alzheimer's disease, and regulate intestinal flora and metabolites thereof. The bifidobacterium breve CCFM1179 can be used for preparing pharmaceutical compositions for relieving dementia and Alzheimer's disease and improving cognitive disorders, can also be used as a microecological preparation to be applied to drugs, fermented food or health care products, and has a very wide application prospect.

The invention discloses a Chinese patent medicine for treating dysphagia after stroke. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: astragalus membranaceus, safflower carthamus, morinda officinalis, ligusticum wallichii, leech, semen pharbitidis, rhizoma acori graminei, borneol, platycodon grandiflorum, mint, fructus gleditsiae, geckos, semen strychni, American ginseng, trichosanthes kirilowii maxim, parasitic loranthus, oroxylum indicum, fructus broussonetiae, Chinese Starjasmine stem, fructus xanthii, rhizoma dioscoreae nipponicae, flose caryophylli, fructus chebulae, dalbergia odorifera, pearls and cornu bubali. The total clinical effective rate of the Chinese patent medicine is 88.67%, the total clinical effective rate of a control group is 57.58%, and the curative effect is better than that of the control group, specifically P is smaller than 0.05.

The present invention relates to beverage technology, and is especially one kind of kudzu vine and leaf tea. The kudzu vine and leaf tea is made with kudzu vine and leaf, and has good color and taste. The present invention makes best use of kudzu vine and leaf.

The invention discloses a frog oil magnetic wine and making method, which is characterized by the following: adopting frog oil, ganoderam lucidum karst, Dioscorea japonica, Siberian solomonseal rhizome, boxthorn fruit and wine; using lodestone magnetizing wine to soak frog oil; leaching completely with rapid leaching speed; allocating with ganoderam lucidum karst, Dioscorea japonica, Siberian solomonseal rhizome, boxthorn fruit and honey. The invention has more obvious effect with good taste, which improves the immunity of human body and modifies the nervous prostration to delay senescence.

The invention provides a lactobacillus paracasei Jlus66 microbial inoculum with a function of improving memory disorder and application, and belongs to the technical field of functional microorganisms. Experiments show that the dietary supplement lactobacillus paracasei strain Jlus66 can improve brain hippocampal neuron injury caused by long-term high-fat diet, increase neurotrophic factor BDNF expression and inhibit learning and memory ability weakening, and has the function of improving memory disorder. Therefore, the lactobacillus paracasei strain Jlus66 has the potential of developing the product for improving the memory disorder function, can be used as an auxiliary product of the existing treatment medicine and treatment method, and has great application value.

The invention discloses a synthesis method for preparing a huperzine A intermediate, which comprises the following steps: carrying out substitution at the alpha site of the carbonylic group by using 1,4-cyclohexyl diketone ethylene glycol and N,N-dimethylformamide dimethyl acetal as raw materials to obtain a substitution product, cyclizing the substitution product under the action of methyl cyanoacetate to obtain a cyclization product, and decarboxylating the cyclization product under the action of a strong base to obtain 2-carbonyl-6-ethylene ketal-5,7,8-dihydro-quinoline. The method has the advantages of fewer synthesis reaction steps, mild reaction conditions, low requirements for operating personnel and low environmental pollution, greatly lowers the raw material cost, and is simple to operate and convenient for refinement; and the obtained 2-carbonyl-6-ethylene ketal-5,7,8-dihydro-quinoline has high quality and high yield.

The invention provides an acylated derivative for an ornithine and aspartate dipeptide compound or an officinal salt thereof, a preparation method thereof, a medicine composition containing the derivative or the officinal salt thereof, and the application of the derivative or the officinal salt thereof for preparing medicines for preventing or curing hyperammonemia or liver diseases, particularlyhepatic encephalopathy. Experimental results definitely indicate that the concentration of blood ammonia can be obviously reduced after administration for the acylated derivative for the ornithine andaspartate dipeptide compound, the acylated derivative takes effect quickly by preferably compared with LOLA, subsequent dysmnesia after TAA-induced rat liver injury can be obviously improved, and theacylated derivative for the dipeptide has a certain treatment effect on hyperammonemia or liver diseases, particularly hepatic encephalopathy.

The embodiment of the invention discloses a traditional Chinese medicine composition for treating vascular dementia. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 30 parts of fructus alpiniae oxyphyllae, 10 o 15 parts of semen cuscutae, 10 to 15 parts of rhizoma chuanxiong, 15 to 20 parts of rhizoma acori tatarinowii, 5 to 10 parts of stiff silkworm, 10 to 15 parts of radix rehmanniae praeparata, 10 to 15 parts of cortex eucommiae, 5 to 10 parts of pheretima, 10 to 15 parts of radix curcumae, 10 to 15 parts of rhizoma gastrodiae and 10 to 15 parts of ramulus et uncus uncariae. The traditional Chinese medicine composition is prepared by screeing natural medicines with the effects of tonifying kidney, activating blood andreducing phlegm are screened based on a disease differentiation and syndrome differentiation principle of traditional Chinese medicine and mixing according to a certain weight ratio, and has the advantages of remarkable curative effect, low cost and small toxic side effect. The embodiment of the invention also discloses a preparation method and application of the traditional Chinese medicine composition. The preparation method is simple and easy for production and preparation, and effective components of each medicinal component can be extracted to the greatest extent.

The invention relates to agaricus blazei murill polypeptide as well as a preparation method and an application thereof, and belongs to the technical field of natural active products. The preparation method comprises the following steps: extraction: taking an agaricus blazei murill fruiting body, adding water for homogenization, performing ultrasound extraction and centrifugation, and obtaining supernate, salting out: adding ammonium sulfate into the supernate for salting out and sediment, and taking a sediment for dialysis to form a dialysate, and purification: separating the dialysate throughan ion-exchange column to form a crude extract, and purifying the crude extract through a sephadex column to form the agaricus blazei murill polypeptide. The agaricus blazei murill polypeptide prepared according to the method has obvious bioactivity and can improve animal dysmnesia and learning capacity.

The invention discloses lactobacillus BB1 capable of enhancing memory ability as well as a fermented food and application of the lactobacillus BB1, and belongs to the technical field of microorganisms. According to the present invention, the lactobacillus BB1 can be used for preparing functional food, health care products and medicines that improve memory ability of healthy individuals and improve memory impairment, the invention further provides fermented food, the fermented food is prepared by fermenting the lactobacillus BB1, the fermented food comprises solid food, liquid food and semi-solid food, and the lactobacillus BB1 has a very wide application prospect.

The invention provides a pharmaceutical composition for treating dementia and a preparation method thereof. The pharmaceutical composition comprises a combination of bilobalide and any one or both of ginkgolides A and C. The pharmaceutical composition containing bilobalide provided by the present invention has multiple neuroprotective effects, including promoting nerve growth, improving old memory function, preventing the occurrence of senile dementia, and the like. Experiments have shown that in the treatment of dementia, this product has a certain effect on improving memory impairment in mice.

The invention relates to a composition for treating a degenerative disease. For solving the technical problems that an existing medicament can not reverse pathological changes of the degenerative disease and the treatment effect is not ideal, the adopted technical scheme is that the composition comprises royal jelly acid or a royal jelly acid derivative and ginkgo leaves in the ratio according to parts by weight of (0.1-10): (1-100). The composition has the technical effects that the royal jelly acid or the royal jelly acid derivative, gamma-aminobutyric acid or a gamma-aminobutyric acid derivative and the ginkgo leaves can play respective roles and simultaneously realize synergy, thereby significantly increasing the overall functions, effectively improving lipid metabolism caused by organism deterioration of old people, making up for defects of insufficient secretion of in-vivo synthesis, increasing brain blood supply, achieving the effects of effectively treating and delaying the progress of the degenerative disease, improving memory and cognitive dysfunction of a patient and greatly improving the quality of life of the patient with the degenerative disease (P<0.01).

The invention discloses an application of an anchovy peptide-catechin conjugate in memory improvement. The preparation method of the anchovy peptide-catechin conjugate comprises the following steps: mixing an anchovy polypeptide solution and a catechin solution according to the mass ratio of anchovy polypeptide to catechin of 5: 1, reacting for more than 24 hours in the presence of oxygen, and continuously stirring in the reaction process; and performing low-temperature dialysis on the reacted sample, and performing vacuum freeze drying to obtain the anchovy peptide-catechin conjugate. According to the coilia tail peptide-catechin conjugate, the variety of polyphenol and the dosage ratio of coilia tail peptide to polyphenol are optimized, and the prepared coilia tail peptide-catechin conjugate can improve the memory impairment improvement effect of model mice.

The invention relates to an Agaricus blazei murill small peptide, and a preparation method and an application thereof, and belongs to the technical field of natural active products. The Agaricus blazei murill small peptide comprises a peptide fragment with the amino acid sequence reprensted by SEQ ID No. 1. The Agaricus blazei murill small peptide is obtained through enzymolysis and chromatographic column purification, and the main peptide fragment sequence of the Agaricus blazei murill small peptide is RQR (arginine-glutamine-arginine); and animal experiments prove that the Agaricus blazei murill small peptide can improve the learning and memory ability of mice in a Morris water maze, detection of biochemical indexes in serum of mice shows that the Agaricus blazei murill small peptide cansignificantly improve the oxidative stress level in the mice, the CAT and T-AOC values are significantly increased, and the ROS and MDA contents are reduced, that is, the Agaricus blazei murill smallpeptide can improve animal dysmnesia and improve learning ability, and has an obvious anti-aging effect. Experiments show that the Agaricus blazei murill small peptide has good effects of improving dysmnesia, improving learning ability and resisting aging, has the advantages of short peptide fragment, good solubility and good absorption, and has a wide application prospect.

The invention provides a pharmaceutical composition for the treatment of dementia and a preparation method thereof. The pharmaceutical composition comprises bilobalide and one or two or a combination of ginkgolide A and ginkgolide C. The pharmaceutical composition containing bilobalide provided by the invention has a neuroprotective effect in many aspects, including promoting nerve growth, improving the memory function of the elderly and preventing the occurrence of dementia, etc. Experiments show that the product has certain role to improve memory impairment in mice in the treatment of Alzheimer's disease.

The present invention relates to one kind of medicine for treating amnesia and dementia, and aims at solving the technological problem of providing one medicine capable of improving memory function comprehensively and thus curing amnesia and dementia. The medicine has the effects of strengthening body resistance, eliminating evil, invigorating kidney, tranquilizing, strengthening memory and benefiting intelligence. The medicine is prepared with sea snake, sea cucumber, polygala root and grassleved sweetflag.

The present invention provides active salts of ornithine and aspartate dipeptide compounds, preparation methods thereof, pharmaceutical compositions comprising the active salts, and preparation of the dipeptide compounds or their active salts for preventing or treating hyperemia Use in the medicament of ammonia disease or liver disease, especially hepatic encephalopathy. The test results clearly show that the ornithine and aspartate dipeptide compounds and their active salts of the present invention can significantly reduce blood ammonia concentration after administration, and can significantly improve the memory secondary to TAA-induced liver injury in rats. It means that the dipeptide compound and its active salt have a certain therapeutic effect on hyperammonemia or liver disease, especially hepatic encephalopathy.

The invention relates to a traditional Chinese medicine for treating schizophrenia and treating the side effect caused by antipsychotics and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicines according to the proportion by weight: 10-17 ophiopogon roots, 7-14 medlar, 3-10 earthworms, 10-18 kudzu roots, 3-10 arillus longan, 7-14 lycopodium calvatum,4-11 lotus leaf, 7-14 flos albiziae, 3-10 chrysoidine, 4-11 dates, 4-14 grass-leaved sweetflag, 4-11 radix curcumae and 7-14 liquorice. The dosage form comprises granules, sirup, tablets, capsules and oral liquid. The preparation method is as follows: adding water to boil to obtain liquid medicine, concentrating, filtering, adding antiseptic, subpackaging and sterilizing to obtain the oral liquid. The traditional Chinese medicine has the functions of nourishing Yin and clearing away the heart fire, tonifying the kidney and the brain as well as promoting blood circulation and removing obstruction in channels and the advantages of low cost, remarkable curative effect and no side effect, thereby achieving the aims of mainly treating muffing, fremitus, lags in response, witless expression, retardation of thinking, achexia, fidgety and confusion, talk nonsense, uncommunication, hygrostomia and indifference of patients suffering from schizophrenia, improving the memory impairment, promotingthe recovery of psychopathy and preventing or reducing the recrudescency of psychopathy.

The invention provides active salt of a dipeptide compound of ornithine and an aspartic acid, a preparation method of the active salt, a pharmaceutical composition including the active salt, and application of the dipeptide compound or the active salt thereof in preparation of medicine for preventing or treating hyperammonemia or liver diseases, in particular to hepatic encephalopathy. A test result clearly indicates that after the dipeptide compound of the ornithine and the aspartic acid and the active salt of the dipeptide compound are administered, the concentration of blood ammonia can beobviously reduced, and secondary memory disorder after TAA(tumor-associated antigen)-induced liver injury in rats can be obviously improved, indicating that the dipeptide compound and the active saltof the dipeptide compound have a certain treatment effect on hyperammonemia or liver diseases, in particular to the hepatic encephalopathy.