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Application of levetiracetam injection in preparation of nootropic drugs

A technology for injections and uses, applied in the field of medicine, can solve problems such as inconvenience in use

Inactive Publication Date: 2012-07-18
SHIJAZHUANG ZHONGSHUO PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] As an oral dosage form, levetiracetam is inconvenient and restrictive for some patients with moderate and severe dementia

Method used

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  • Application of levetiracetam injection in preparation of nootropic drugs
  • Application of levetiracetam injection in preparation of nootropic drugs
  • Application of levetiracetam injection in preparation of nootropic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Weigh 100g of levetiracetam, 150g of glucose, and 500ml of water for injection to dissolve in the dilute tank, control at 40-50°C, and stir until completely dissolved in 500ml of water for injection, and cool the solution to 20°C. Add activated carbon to the prepared solution for decolorization, then remove the activated carbon by filtration, add the prepared citric acid and sodium citrate buffer solution to adjust the pH value of the solution to 4.0, and then add water for injection to 5000ml , filling and sealing the bag, and sterilizing the filled and sealed intermediate product at 105°C for 30 minutes to obtain levetiracetam injection, and the metal ion concentration of the levetiracetam injection was detected to be 0.5PPM.

Embodiment 2

[0068] Weigh 100g of levetiracetam, 250g of glucose, and 800ml of water for injection to dissolve in the dilute tank, control at 50-60°C, and stir until completely dissolved in 800ml of water for injection, and cool the solution to 20°C. Add activated carbon to the prepared solution for decolorization, then remove the activated carbon by filtration, add the prepared citric acid and sodium citrate buffer solution to adjust the pH value of the solution to 4.2, then add water for injection to 7000ml , and then use a 0.02μm ultrafiltration membrane to perform ultrafiltration, and then centrifuge in a centrifuge at 2500r / min for 3min to remove insoluble matter, add water for injection until the volume of the injection reaches 7000ml, and fill and seal the bag at 105°C The intermediate product was sterilized for 30min, filled and sealed into bags to obtain levetiracetam injection, and the metal ion concentration of the injection was detected to be 0.8PPM.

Embodiment 3

[0070] Weigh 100g of levetiracetam, 550g of glucose, and 1000ml of water for injection and dissolve it in a dilute tank, control it at 60-70°C, and stir until it is completely dissolved in 1000ml of water for injection, and cool the solution to 20°C. Add activated carbon to the prepared solution for decolorization, then remove the activated carbon by filtration, add the prepared citric acid and sodium citrate buffer solution to adjust the pH value of the solution to 4.5, and then add water for injection to 10000ml , and then use a 0.02μm ultrafiltration membrane to perform ultrafiltration, and then centrifuge in a centrifuge at 2500r / min for 3min to remove insoluble matter, add water for injection until the volume of the injection reaches 10000ml, and fill and seal the bag at 105°C The intermediate product was sterilized for 30min, filled and sealed into bags to obtain levetiracetam injection, and the metal ion concentration of the injection was detected to be 0.5PPM.

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Abstract

The invention relates to an application of levetiracetam injection in preparation of nootropic drugs. At present, levetiracetam is an antiepileptic drug with a very good curative effect, and researches find that the drug has a better curative effect in the nootropic aspect. The invention aims to further explore the application of the levetiracetam injection in the nootropic aspect, which has the advantages of quick drug effect, strong practicability and storability, compared with oral preparations.

Description

technical field [0001] The invention relates to the use of levetiracetam injection in the preparation of nootropic drugs, which belongs to the technical field of medicine. Background technique [0002] Dementia is a group of syndromes, and the diseases that cause dementia are common in the following categories. 1. Nervous system diseases with dementia as the main symptom, such as Alzheimer's disease, diffuse I-ewy body disease or Izwy body dementia, and lobar atrophy. 2. Other nervous system diseases with dementia as a component, common are: multiple cerebral infarction, subcortical arteriosclerotic encephalopathy, amyloid cerebrovascular disease, round cerebrovascular disease, subarachnoid hemorrhage, cerebral hemorrhage, etc. Cerebrovascular diseases; encephalitis and meningitis caused by various bacteria, viruses, fungi, etc., cerebral parasitic diseases, paralytic dementia, progressive multifocal leukoencephalopathy and other brain infectious diseases; Parkinson's disea...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/4015A61P9/10A61P25/00A61P25/28
Inventor 李佩服田建宣杨丽英刘福利韩亚南
Owner SHIJAZHUANG ZHONGSHUO PHARMA CO LTD
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