114results about How to "The dose-effect relationship is obvious" patented technology

A health-care eucommia leaf beverage for relieving fatigue is prepared from the eucommia leaves through extracting in non-ionic water, and adding sweetening agent and sour agent.

The invention belongs to the medical technical field and discloses the application of high-purity in the preparation of antibacterial medicine, antiviral medicine and other medicines. The invention proves the antipyretic, anti-inflammation, immunity enhancement, antibacterial and anti-virus effects of high-purity forsythiaside through the following experiments: (1) the experiment that high-purity forsythiaside has antipyretic effect on fever rats; (2) the experiment that high-purity forsythiaside inhibits xylene-induced mice ear edema, xylene-reduced capillary permeability of mice; (3) the experiment that high-purity forsythiaside increases carbon clearance ability of mice and increases the lymphocyte transformation rate; (4) the experiment that high-purity forsythiaside has vitro anti-influenza A type virus effect and in-vivo anti-respiratory syncytial virus effect; (5) the experiment that high-purity forsythiaside has vitro inhibition effects on beta-hemolytic streptococcus, staphylococcus aureus, streptococcus viridans and staphylococcus epidermidis.

The invention discloses maca leaf black tea and a preparation method thereof. The maca leaf black tea is prepared by the following steps: removing stalks of selected maca leaves; loosening the cut maca leaves to prevent the maca leaves from sticking together; putting the maca leaves in a steamer paved with clean gauze in advance, wherein the stacking thickness of the maca leaves is 5-7cm and is proper for the uniform steaming of the maca leaves, wherein through the steaming process, the maca leaves are soft but bright green; immediately pouring the maca leaves into a clean container after taking the maca leaves out from the steamer, spreading and cooling, rolling and fermenting, wherein air temperature in a fermentation chamber is 24-25 DEG C, relative humidity is 95% and a leaf spreading thickness is 8-12cm; immediately drying the fermented maca leaves to prevent the tea leaves from being fermented continuously; spreading, sieving and packaging the tea leaves to obtain the maca leaf tea rich in total flavonoids. The tea disclosed by the invention can effectively eliminate a DPPH free radical,.OH and O2<->.; and the black team is obvious in dose-effect relationship and wide in application value.

The invention provides a pyrimidine compound, and the structure of the pyrimidine compound is shown in the following formulas (I) and (II), wherein R is substituted phenyl or substituted pyridyl; R1 is -NO2, -Br, -COOH or -OCH3; n is an integer of 1-3; X is -Br or CI; and R8, R9 and R10 are identical or different -H, -OCH3, -COOMe, -Br, -COOEt, -CH2COOMe, -NO2 or (CH2)1-4OH. The pyrimidine compound provided by the invention has an effect of FAK inhibition, can effectively enter tumor cells, has a good effect of inhibiting the tumor cells and can be better detained. The invention also provides a preparation method of the compound and the application of the compound to the preparation of preparing a tumor inhibitor.

The invention relates to a new compound separated from Mythic Fungus, a preparation method thereof and a medicinal purpose thereof. The invention discloses a compound with the chemical structural formula shown in the specification. The preparation method of the compound comprises the following steps: 1, extracting Mythic Fungus with alcohol or an alcoholic solution once or more than twice, filtering, collecting a filtrate, carrying out reduced pressure concentration, and drying to obtain an alcohol extract; 2, adding water to the alcohol extract, extracting with petroleum ether for degreasing, extracting with ethyl acetate, extracting an obtained ethyl acetate extract with an aqueous solution of NaHCO3, taking an ethyl acetate phase, and evaporating to dryness to obtain a crude product; and 3, carrying out chromatogram separating separation and purification on the obtained crude product to obtain the compound. The compound of the present invention can be treated as a medicine for treating tumors.

The invention discloses a method for testing vascular endothelial inhibitor biological activity, the method utilizes vascular endothelial inhibitor standard and sample with the same concentration gradient after dilution in multiple proportions to inhibit HUVEC cell proliferation, and detects the proliferate inhibition activity of vascular endothelial inhibitor to HUVEC cells with trace enzyme reaction colorimetry, and then analyzes biological activity of angiogenesis inhibition of vascular endothelial inhibitor. The method uses the vascular endothelial inhibitor standard to correct testing errors of vascular endothelial inhibitor samples in different batches, which causes the cell proliferation inhibition activity testing results of vascular endothelial inhibitor have specificity and repeatability, and overcomes the defects that existed in prior vascular endothelial inhibitor activity testing method that the repeatability is bad, the method can not be unified, and the method can not meet the needs of large scale production and multiple-batch quality control.

The invention provides a pharmaceutical composition for treating thrombocytopenia, which comprises gen-seng, epimeddium, radix astragali, angelica sinensis, radix rehmanniae preparata, spatholobus stems, hairyvein agrimony, and tangerine peel. The pharmaceutical composition of the invention can be prepared into clinically-acceptable dosage forms by adding routine auxiliary materials according to routine technology. The pharmaceutical composition of the invention has significant effect on treating thrombocytopenia and leucopenia, promoting proliferation of bone marrow hematopoietic stem cells, repairing damage and injury of bone marrow hematopoietic tissue caused by radiation, preventing marrow inhibition caused by radiotherapy and chemotherapy, or improving symptoms and increasing life quality of tumor patients, and has no side effect.

The invention discloses application of 2-methoxy-6-acetyl-7-methyljuglone (MAM) for preparing a medicine for treating neoplastic diseases. According to the invention, found from research on the anti-neoplastic activity of MAM, MAM has obvious inhibitory activity on proliferation of a plurality of measured neoplastic cells in vitro; the better cytotoxic effect is shown; the IC50 (50% inhibiting concentration) of MAM is less than or equal to 10 mu M; furthermore, MAM has good dose-effect relationship; simultaneously, when MAM is acted on a normal hepatic cell strain LO2, the cytotoxicity of MAM is lower than the toxic reaction of MAM on a hepatic neoplastic cell HepG2; and furthermore, the research also finds that MAM is capable of obviously reducing mitochondrial membrane potential of neoplastic cells and inducing apoptosis.

The invention relates to an extracting and purifying method for prunella vulgaris total flavonoids. The method comprises the steps: (1) fetching and crushing a prunella vulgaris medicinal material, sieving the crushed prunella vulgaris medicinal material, adding 5-95% ethanol, of which the weight is 1-30 times that of the crushed prunella vulgaris medicinal material, into the crushed prunella vulgaris medicinal material, carrying out refluxing extraction for 1-3 times, carrying out refluxing extraction for 1-5 hours at a time, filtrating extractions, and combining filtrates, so as to obtain an extract; (2) heating to concentrate the extract until the concentration of the extract is 0.05-0.5g / mL, and then, adjusting the pH value to 1-7, so as to obtain a liquid sample; (3) loading the liquid sample to macroporous adsorption resin NKA-9, carrying out impurity removal with 1-10BV water, and then, eluting with 1-10BV 10-95% ethanol; (4) continuously carrying out a purifying process in the step (3) repeatedly so as to obtain enrichment, drying the enrichment at reduced pressure until the enrichment becomes powder or extractum, thereby obtaining the prunella vulgaris total flavonoids. The invention also provides application of the prunella vulgaris total flavonoids in preparation of drugs for treating liver cancer. Proven by pharmacological drug effect researches, the prunella vulgaris total flavonoids have obvious liver tumor resisting activity and are of an obvious dose-effect relationship, so that a theoretical and experimental basis is provided for the development of new liver tumor resisting drugs, which are prepared from enrichment of the prunella vulgaris total flavonoids and have extensive clinical use value and commercial development value, and industrial production.

The invention discloses a novel flurbiprofen chalcone compound (I), pharmaceutically acceptable salt thereof, a preparation method thereof, a pharmaceutical composition and application to preparationof drugs for treating and / or preventing diseases related to neurodegeneration, including but not limited to neurodegeneration diseases of vascular dementia, an Alzheimer's disease, a Parkinson's disease, a Huntington's disease, HIV-related dementia, MS (multiple sclerosis), progressive lateral sclerosis spinal cord, neuropathic pain, glaucoma and the like.

The invention discloses a novel 2,5-dyhydroxy-p-phthalamide compound (I) and pharmaceutically acceptable salts thereof, a preparation method of the compound and application in preparing medicine treating and / or preventing nervous system related diseases. The diseases include but not limited to the vascular dementia, presenile dementia, Parkinson's disease, Huntington's disease, HIV related Alzheimer disease, nerve injuries caused by the traumatic brain injury and other diseases. The formula is defined in the description.

The invention relates to the technical field of medicine preparation, and in particular relates to application of 3,5,3',4'-trihydroxy-stilbene-3'-b-D-glucoside in preparation of medicines for treating cancers. The cytotoxic effect of the 3,5,3',4'-trihydroxy-stilbene-3'-b-D-glucoside on 12 human tumor cells cultured in vitro and a human normal cell is tested through an MTT method; and the 3,5,3',4'-trihydroxy-stilbene-3'-b-D-glucoside has a relatively good inhibiting effect on proliferation of a human lung cancer cell line, a human colon cancer cell line, a human erythroleukemia cell line, a human gastric cancer cell line and a human breast cancer cell line, and has no inhibiting action on proliferation of human normal cells. The curative effect of the 3,5,3',4'-trihydroxy-stilbene-3'-b-D-glucoside on a nude mouse transplantation tumor of a human lung cancer cell line A549 is also tested. The result shows that the 3,5,3',4'-trihydroxy-stilbene-3'-b-D-glucoside has obvious inhibiting action on proliferation of the nude mouse transplantation tumor of the human lung cancer cell line A549 after continuous intravenous injection for 14 days; and the dose-effect relationship is obvious.

The invention discloses a depolymerized holothurian glycosaminoglycan composition, as well as a preparation method and application of the depolymerized holothurian glycosaminoglycan composition. The depolymerized holothurian glycosaminoglycan composition is one or more of depolymerized holothurian glycosaminoglycan with the weight-average molecular weight between 2000Da and 12000Da, and the preparation method of the depolymerized holothurian glycosaminoglycan composition comprises extracting and purifying holothurian glycosaminoglycan, degrading the holothurian glycosaminoglycan and the like. Screened through a plurality of experiments, echinodermata holothurian is chosen as an object of study, and an extracting and purifying process of the holothurian glycosaminoglycan and a degrading process of the depolymerized holothurian glycosaminoglycan are chosen from a large quantity of experiments. The whole process is reasonable in design and strong in operability, and the industrial production is implemented. The anti-tumor study shows that the depolymerized holothurian glycosaminoglycan composition remarkably inhibits the generation of a lumen of a human umbilical vein endothelial cell in vitro, inhibits the transfer of melanin and a breast cancer in vivo, has an excellent anti-tumor effect, is expected to be developed into an efficient antitumor drug or healthcare product with low toxic or side effects, and has an important application prospect.

The invention belongs to the technical field of food production, and in particular relates to functional food for preventing and treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The functional food for preventing and treating cardiovascular and cerebrovascular diseases comprises the following components by weight: 10%-20% of nattokinase, 10%-20% of nitric oxide, 5%-10% of coenzyme Q10, 30%-50% of a red yeast rice extractive and 20%-25% of a ginkgo biloba extractive. Functional components with good effects in resisting cardiovascular and cerebrovascular diseases are combined scientifically and rationally; the functional food on the basis of dissolving thrombus, garbage and toxins deposited in blood vessel can enhance the elasticity and permeability of blood vessels, so as to reach the goals of clearing blood lipids and reducing blood pressure; and the coenzyme Q10 added in the functional food can protect the heart function, and enhance the body's own ability to reduce cholesterol and blood lipid. Through LD50 acute toxicity test, 30 days feeding test, and crowd efficacy observation experiments, the functional food provided by the present invention is proved to be safe, nontoxic and effective.

The invention relates to a method for preparing a bee pollen cookie. The bee pollen cookie comprises the following main ingredients: bee pollen and plain flour. The bee pollen cookie is faint yellow and has the fresh scent of pollen. The bee pollen cookie contains much bee pollen, is comprehensive in nutritional ingredients and particularly high in content of flavonoid substances, has a certain effect of cancer prevention and cancer resistance, can improve the immunity of bodies and is suitable to be eaten by all kinds of people.

The invention relates to an application of levetiracetam injection in preparation of nootropic drugs. At present, levetiracetam is an antiepileptic drug with a very good curative effect, and researches find that the drug has a better curative effect in the nootropic aspect. The invention aims to further explore the application of the levetiracetam injection in the nootropic aspect, which has the advantages of quick drug effect, strong practicability and storability, compared with oral preparations.

The invention discloses an enzyme process extracted Radix angelicae anomalae polysaccharide, and a preparation method and an application thereof. The Radix angelicae anomalae polysaccharide has alpha-configuration and beta-configuration polysaccharide linking modes, the apparent molecular weight of the Radix angelicae anomalae polysaccharide is 3.93 kDa. The Radix angelicae anomalae polysaccharide is obtained through enzyme process extraction of a Radix angelicae anomalae medicinal material, alcohol precipitation and impurity removal, protein and salt removal, and DEAE-agarose gel FF column and agarose gel 6FF gel column chromatography separation. The Radix angelicae anomalae polysaccharide obtained in the invention has good whitening activity and has an inhibitory effect on the tyrosinase activity, and the tyrosinase inhibition rate gradually increases with the increase of concentration, and the dose-effect relationship is obvious. The method for extracting the Radix angelicae anomalae polysaccharide has the advantages of small dosage of an enzyme preparation, simple process and low production cost.

The invention discloses a yin-nourishing dryness-moisturizing milk-fragrance chicken steak. The yin-nourishing dryness-moisturizing milk-fragrance chicken steak is prepared from the following raw materials by weight: 50 to 55 parts of small chicken breast, 8 to 13 parts of a rapeseed cake, 6 to 7 parts of dried green plum, 4 to 6 parts of milk powder, 5 to 7 parts of aloe peel, 1 to 2 parts of Reinwardtia indica Dum., 0.5 to 1 part of donkey-hide gelatin, 0.4 to 1 part of evening primrose, 20 to 25 parts of egg liquid, 6 to 7 parts of onion juice and a proper amount of glycerin, cross-linked hydroxypropyl starch and water-soluble chitosan. A cross-linked hydroxypropyl starch-chitosan edible film coating the chicken steak has better tensile strength, elongation at break, resistance to oxidation and oxygen-permeation and moisture-permeation coefficients compared with an edible film prepared from a single raw material. The chicken steak prepared in the invention has savoury, mellow and delicious taste, lingering aftertaste and good tasting quality, maximally maintains nutritional components of the chicken steak and is endowed with blood-enriching, yin-nourishing, dryness-moisturizing and tendon-strengthening health care functions through addition of food materials like Reinwardtia indica Dum., donkey-hide gelatin and evening primrose.

The invention discloses a novel triterpenoid compound, a preparation method and a medical application thereof. The novel triterpenoid compound is represented as the formula (I) as follows. The preparation method includes the following steps: extracting ganoderma lucidum in alcohol or an alcohol solution for one or more than two times, filtering the extracts and collecting filtrates, performing pressure-reducing concentration and drying to obtain an alcohol extract; adding water to the alcohol extract, extracting and defatting the alcohol extract with petroleum ether, and extracting the extract with ethyl acetate to obtain an ethyl acetate extract liquid; extracting the ethyl acetate extract liquid in an alkaline water solution being 8-12 in pH; evaporate-drying an ethyl acetate phase to obtain a crude product, and performing chromatograph separation and purification to the crude product to obtain the pure compound (I). The compound can be used for treating tumor.

The present invention discloses a dendranthema indicum chicken fried steak helpful for tonifying spleen and benefiting intelligence and a preparation method thereof. The chicken fried steak is made from the following raw materials in parts by weight: chicken breast meat (inside chicken breast) 50-55, lemon juice 4-5, sunflower seed kernel powder 9-13, soy sauce 6-8, polygala roots 1-1.2, radix codonopsis 1-2, dendranthema indicum 1-1.3, egg liquid 20-25, onion juice 6-7, and a proper amount of glycerin, cross-linking hydroxypropyl starch and water soluble chitosan. Cross-linking hydroxypropyl starch-chitosan co-mixed edible coatings used to coat the chicken fried steak are better in tensile strength, breaking elongation rate, oxidation resistance, oxygen permeability coefficient and moisture permeability coefficient than single raw material edible coatings; the prepared chicken fried steak is savoury and mellow and delicious in taste, long in aftertaste and good in mouthfeel and quality, and maximally maintains nutritional values of the chicken fried steak; and the addition of polygala roots, radix codonopsis and dendranthema indicum gives the chicken fried steak health-care effects in relieving uneasiness of mind and benefiting intelligence, strengthening middle-Jiao and tonifying Qi, and tonifying spleen and benefiting lung.

The present invention relates to a preparation method of anticancer cancer-preventing marine active medicine using 2,3-indol quinone as main component. Said preparation method includes the following steps: purifying artificial synthetic 2,3-indol quinone; weighing (by mass%) 10-20% of 2,3-indol quinone, 30-40% of lactose, 25-35% of microcrystal cellulose, 1-5% of calcium carboxymethyl cellulose, 1-5% of anhydrous silicic acid, 3-8% of carboxypropionyl cellulose and 1-3% of magnesium stearate; uniformly mixing 2,3-indol quinone, lactose, microcrystal cellulose, calcium carboxymethyl cellulose and anhydrous silicic acid, adding them into carboxypropionyl cellulose dissolved by isopanol, mixing the obtained granules with magnesium stearate, using wet granule method and tabletting to obtain tablet preparation. Besides, it can use medicinal starch and 2,3-indel quinone according to mass ratio of 1:1-10 and proper quantity of magnesium stearate, uniformly mix them and make them into capsule.

This invention concerns the method of extracting salvianolic acid A from Chinese crude drug: danshen root, and the quality control methods and drug combinations, and the application of this drug. It can be used in the preparation of the prevention drugs for cardiovascular disease, liver damage, liver fibrosis, pulmonary fibrosis and other.

The invention discloses a class of novel salicylamide compounds (I) and a pharmaceutically acceptable salt thereof, a preparation method and a pharmaceutical composition thereof, and applications of the novel salicylamide compounds (I) and the pharmaceutically acceptable salt thereof in preparation of drugs for treating and / or preventing nervous system related diseases, wherein the diseases include but are not limited to vascular dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, glaucoma, cerebral arterial thrombosis, cerebral hemorrhagic stroke, nerve injury caused by cerebral trauma and the like.

The invention relates to the technical field of medicinal chemistry, in particular to a compound, an extraction method of the compound, application of the compound to the preparation of antitumor drugs, and the antitumor drugs prepared by using the compound. The compound is extracted from a camellia oleifera abel root; structure identification results show that the compound is a novel compound, and the structural formula is shown in the formula I; an in vitro cell test shows that after the compound shown in the formula I acts for 24 h, the compound has a remarkable inhibiting effect (P is less than 0.05) on the growth of human lung cancer A549 cells, B16 murine melanoma cells, human liver cancer BEL-7402 cells and human breast cancer MCF-7 cells; a murine transplantation tumor model test shows that the compound has a remarkable inhibiting effect (P is less than 0.05) on the growth of murine liver cancer H22 transplantation tumors and murine S180 sarcomas, and the dose-effect relationship is remarkable.

The invention relates to application of a polyphenol compound to preparation of a pharmaceutical for treating senile dementia, and relates to polyphenol compounds. The polyphenol compound is derived from a compound of miyabenol C of vitis thunbergii with nerve protection effects. The polyphenol compound can be used for preparing the pharmaceutical for treating senile dementia and can be obtained from Chinese traditional medicine or natural medicine through many separation and purification methods. The protein expression quantity of beta-CTFs and sAPPbeta (Sodium Acid Pyrophosphate) generated by beta-secretase (BACE-1) (Beta Amyloid Cleaving Enzyme) cutting APP can be reduced, and has obvious dose-effect relationship; and the cutting on APP can be reduced by inhibiting the activity of beta-secretase (BACE-1), the generation of Abeta 1-40 and Abeta 1-42 closely related to senile dementia is remarkably decreased.

The invention discloses an application of a bamboo fungus spore composition in cosmetics. The composition mainly comprises 1-50 wt% of bamboo fungus spore powder and 0.1-20 wt% of bamboo fungus powder extract as main components. The bamboo fungus spore powder is obtained after elution, drying and ultrafine crushing; and the bamboo fungus spore extract is obtained through extracting wall-broken bamboo fungus spores with a solvent, filtering or centrifuging the obtained solution to obtain an extract liquid, and concentrating the extract liquid into an extract. The bamboo fungus spore powder and the bamboo fungus powder extract are mixed according to a certain ratio, and cosmetically acceptable auxiliary materials are added to produce the cosmetics. The cosmetics have a substantial skin whitening effect, and the composition effectively inhibits in vivo tyrosinase activity, inhibits self oxidation and deepening of dopa, prevents infringement of free radicals to skin cells and effectively inhibits hyaluronidase activity in order to realize inflammation prevention and cooperative moisture retention dual effects.

The invention discloses a pharmaceutical composition, in particular to a pharmaceutical composition for treatment of qi-blood deficiency, irregular menstruation, metrorrhagia and leukorrheal diseases and a preparation method thereof. The pharmaceutical composition contains 20 crude drugs: unhaired, declawed and intestine removed silky fowl, Salvia Miltiorrhiza, calcined oyster, cornu cervi degelatinatum, astragalus and the like. The preparation method includes: (1) conducting enzymolysis extraction on silky fowl to obtain an extracted liquid; (2) extracting volatile oil from cyperus rotundus, Chinese angelica and Ligusticum wallichii for standby use, and concentrating the water extracted liquid obtained in the volatile oil extraction process into an extract; (3) subjecting Salvia Miltiorrhiza and ginseng to alcohol extraction and water precipitation to obtain an alcohol extract, and performing concentration to obtain an extract; (4) subjecting the extracted herb residue in step (3) and radix paeoniae alba, radix asparagi, astragalus, Radix Stellariae, rehmannia root, prepared rehmannia root, Euryale ferox, Chinese yam, licorice, turtle shell and Mantis Egg-case together to water extraction and alcohol precipitation, concentrating the obtained extracted liquid and the silky fowl extracted liquid obtained in step (1) together into an extract; (5) carrying out superfine pulverization on deer-horn glue, cornu cervi degelatinatum and oyster; and (6) mixing and pulverizing the extracts obtained in step (2), (3) and (4) with the superfine pulverized powder, and spraying the volatile oil in step (2) so as to obtain the pharmaceutical composition.

The invention discloses a salicylic acid berberine type alkaloid quaternary ammonium salt compound represented by a general formula I, a preparation method, a solubility characteristic and a pharmaceutical composition thereof, and application of the salicylic acid berberine type alkaloid quaternary ammonium salt compound in preparation of medicinal products. According to the invention, the salicylic acid berberine type alkaloid quaternary ammonium salt compound represented by the general formula I can be prepared by an organic synthesis method, shows obvious alcohol-water mixed solvent solubility, can be conveniently prepared on a large scale, has remarkable ulcerative colitis resisting activity, has the characteristics of no toxicity or low toxicity, and can be used for preventing, relieving and / or treating ulcerative colitis.

The invention discloses a compound medicine composite with a breast cancer resistance function, application of the composite and medicine based on the composite. The active content of the compound medicine composite is composed of doxorubicin and piperlongumine with the mole ratio of 1:5-1:15. According to an experiment, an MDA-MB-231 human breast cancer cell is used as a model, and through an MTTexperiment, by applying CompuSyn software analysis, it is discovered that a good synergistic effect is achieved during compatibility of doxorubicin and piperlongumine with the mole ratio of 1:10; through a cell apoptosis experiment, it is discovered that the apoptosis-promoting effect is obviously superior that that of a single medicine group when the two kinds of medicines cooperate for use; through a naked mouse cancer-bearing medicine application experiment, it is discovered that growth of heterograft tumors of MDA-MB-231 cells in the naked mouse can be effectively inhibited through a medicine cooperation application group, and the effect of the medicine cooperation application group is obviously superior that that of the single medicine group. In this way, medicine cooperation application of doxorubicin and piperlongumine has the high function of inhibiting the breast cancer through cooperation, and accordingly the composite has good clinical medicine application development prospects.

The invention discloses four astraisoflavan-7-O-beta-D-glucoside compounds with nerve cell protection activity and a preparation method thereof, and relates to a pharmaceutical compound and a preparation method thereof. Four novel astraisoflavan-7-O-beta-D-glucoside compounds are separated from alfalfa roots. Four novel astraisoflavan-7-O-beta-D-glucoside compounds are separated from alfalfa rootsby an activity tracking technology and then purified. Four novel compounds can prevent the H2O2 induced SH-SY5Y nerve cell damage and well protects the nerve cells. An H2O2 induced SH-SY5Y nerve celldamage model is used to evaluate the nerve cell protection performance of the compounds; a prominent dose-effect relationship is represented, and thus the compounds have a good application prospect in the preparation of drugs for treating neurodegenerative diseases.