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Pharmaceutical composition for treating thrombocytopenia and preparation method thereof

A technology of thrombocytopenia and composition, which is applied in the field of medicine, can solve the problems that need further research, the occurrence of blood-borne infection, and the production of platelet antibodies, so as to promote the production of bone marrow megakaryocytes and platelets, and increase the level of thrombopoietin , no toxic side effects

Inactive Publication Date: 2013-04-03
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the wide application of granulocyte colony-stimulating factor, neutropenia has been effectively controlled; for the treatment of thrombocytopenia caused by radiotherapy and chemotherapy, western medicine mainly transfuses platelets, but there are short storage time and lack of blood supply sources. , high cost, and possible blood-borne infection, blood transfusion reaction, and platelet antibody production. Although recombinant interleukin-11 and thrombopoietin that have been marketed in recent years have good curative effects, they are expensive and their safety needs to be further improved. Research, for example, two studies in 2012 reported that increased levels of thrombopoietin, interleukin-11, and interleukin-6 may be associated with tumor proliferation, which has attracted widespread attention

Method used

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  • Pharmaceutical composition for treating thrombocytopenia and preparation method thereof
  • Pharmaceutical composition for treating thrombocytopenia and preparation method thereof
  • Pharmaceutical composition for treating thrombocytopenia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0148] Weigh raw Chinese herbal medicines: 1.5kg of ginseng, 6kg of epimedium, 15kg of astragalus, 3kg of angelica, 3kg of Rehmannia glutinosa, 10kg of Caulis Spatholobus, 10kg of Agrimony, and 1.5kg of tangerine peel.

[0149] Add 15 times the quality of the above medicinal materials to decoct for 3 hours, filter, add water to the filter residue and decoct once, filter, combine the filtrate twice, centrifuge to remove solid matter, take the supernatant and concentrate to obtain a clear paste, The relative density is 0.8.

[0150] Add 1.6kg of sweetener and 3.2kg of potassium sorbate, stir and add 48L of water, adjust the pH value to 6-7 with 10wt% NaOH aqueous solution, filter, fill and sterilize to prepare an oral liquid preparation.

Embodiment 2

[0152] Weigh raw Chinese medicinal materials: 5kg ginseng, 20kg epimedium, 50kg astragalus, 10kg angelica, 10kg Rehmannia glutinosa, 30kg Caulis Spatholobus, 30kg agrimony, 5kg tangerine peel.

[0153] Add astragalus, epimedium, angelica, Rehmannia glutinosa, Caulis Spatholobus, and Agrimony with 15 times the mass of water to decoct for 3 hours, filter, add water to the filter residue and decoct again, filter, combine the filtrates twice, and centrifuge to remove For solid matter, take the supernatant and concentrate to obtain a clear paste with a relative density of 1.0.

[0154] Ginseng is dried and pulverized into fine powder, mixed evenly with the above-mentioned clear paste, dextrin equal to the quality of the above-mentioned drug and 5% sweetener are added, and then dried, granulated, and granulated to prepare granules.

Embodiment 3

[0156] Weigh raw Chinese medicinal materials: 10kg ginseng, 40kg epimedium, 100kg astragalus, 20kg angelica, 20kg Rehmannia glutinosa, 60kg Caulis Spatholobus, 60kg agrimony, 10kg tangerine peel.

[0157] Add 15 times the quality of the above medicinal materials to decoct for 3 hours, filter, add water to the filter residue and decoct once, filter, combine the filtrate twice, centrifuge to remove solid matter, take the supernatant and concentrate to obtain a clear paste, The relative density is 1.5.

[0158] 8.5kg of starch was added, mixed evenly, granulated, sieved, dried, granulated, filled, and prepared into capsules.

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Abstract

The invention provides a pharmaceutical composition for treating thrombocytopenia, which comprises gen-seng, epimeddium, radix astragali, angelica sinensis, radix rehmanniae preparata, spatholobus stems, hairyvein agrimony, and tangerine peel. The pharmaceutical composition of the invention can be prepared into clinically-acceptable dosage forms by adding routine auxiliary materials according to routine technology. The pharmaceutical composition of the invention has significant effect on treating thrombocytopenia and leucopenia, promoting proliferation of bone marrow hematopoietic stem cells, repairing damage and injury of bone marrow hematopoietic tissue caused by radiation, preventing marrow inhibition caused by radiotherapy and chemotherapy, or improving symptoms and increasing life quality of tumor patients, and has no side effect.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating thrombocytopenia. Background technique [0002] Malignant tumors are a serious threat to human life, and their morbidity and mortality are increasing year by year. Chemoradiotherapy is still an important means of comprehensive treatment of malignant tumors. The non-selective killing effect of chemotherapy and radiotherapy damages the normal bone marrow hematopoietic stem cells and the microenvironment of bone marrow hematopoiesis, resulting in bone marrow suppression and peripheral blood picture reduction, especially neutropenia and thrombocytopenia, which can lead to infection or bleeding in severe cases. Often therefore forced to reduce the dose or shorten the course of treatment, or even terminate treatment. In recent years, with the wide application of granulocyte colony-stimulating factor, neutrop...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P7/00A61P35/00
Inventor 张苗海史凤磊张英羽胡小燕
Owner QINGDAO MUNICIPAL HOSPITAL
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