Salicylic acid berberine type alkaloid quaternary ammonium salt and application in preparation of medicines

A technology of quaternary ammonium salt compound and berberine, applied in the field of medicine, can solve problems such as limited clinical benefit, and achieve the effects of remarkable safety, remarkable practical value and excellent solubility

CN111662281AActive Publication Date: 2020-09-15INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI

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Patent Information

Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner: INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Publication Date: 2020-09-15

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Abstract

The invention discloses a salicylic acid berberine type alkaloid quaternary ammonium salt compound represented by a general formula I, a preparation method, a solubility characteristic and a pharmaceutical composition thereof, and application of the salicylic acid berberine type alkaloid quaternary ammonium salt compound in preparation of medicinal products. According to the invention, the salicylic acid berberine type alkaloid quaternary ammonium salt compound represented by the general formula I can be prepared by an organic synthesis method, shows obvious alcohol-water mixed solvent solubility, can be conveniently prepared on a large scale, has remarkable ulcerative colitis resisting activity, has the characteristics of no toxicity or low toxicity, and can be used for preventing, relieving and / or treating ulcerative colitis.

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Description

technical field

[0001] The invention relates to a salicylic acid berberine type alkaloid quaternary ammonium compound synthesized by taking salicylic acid aromatic organic acid and various acid radicals other than salicylic acid radicals as berberine type alkaloid quaternary ammonium compounds Salt compound, preparation method of the compound of the present invention, pharmaceutical composition containing the compound of the present invention and pharmaceutical use of the compound of the present invention against ulcerative colitis. The compound of the present invention shows remarkable effectiveness in the drug effect experiment of treating ulcerative colitis disease; The compound of the present invention shows remarkable safety in the toxicology experiment; The compound of the present invention has excellent performance in 60% ethanol water mixed solvent solubility. The above-mentioned properties of the compound of the present invention are obviously outstanding. Therefore,...

Claims

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