37 results about "Berberine Chloride" patented technology

The invention discloses a composition for treating diarrhea and a preparation thereof, relating to a medicinal composition for stopping the diarrhea. The invention also relates to a preparation of the medicinal composition for stopping the diarrhea. The medicinal composition is mainly prepared from the main raw materials of 1 part of Racecadotril and 0.25-25 parts of berberine hydrochloride as well as 0.01-250 parts of auxiliary materials in proportion. The medicinal composition has scientific and reasonable prescription, and can be used for inhibiting the rise of calcium ion concentration in colon smooth muscle cells and improving the motion functional coordination of the intestinal tract to realize the effect on stopping the diarrhea mainly by inhibiting the activity of enkephalinase and further inhibiting the excessive secretion of water and electrolyte via the Racecadotril, and simultaneously by the stronger bactericidal effect of the berberine hydrochloride on escherichia coli, Streptococcus hemolyticus, Diplococcus pneumoniae and the like.

The present invention provides a kind of Chinese medicine composition for clearing away heat and toxic matter, drying damp and treating dysentery and its preparation process and application. The Chinese medicine composition has effective components prepared with berberine hydrochloride, celandine, Chinese pulsatilla and ash bark in certain weight proportion. It is prepared into oral liquid, tablet, capsule or granule. The present invention also provides the application of the Chinese medicine composition in preparing medicine for treating diarrhea and dysentery caused by dampness and heat in the large intestine.

The invention provides a weight-loss and lipid-lowering composition and an application thereof, and relates to the technical field of biochemistry. The weight-loss and lipid-lowering composition of the invention comprises, in parts by weight, 6-15 parts of berberine hydrochloride and 1-5 parts by weight of berberine hydrochloride. A lipid-soluble extract of Ascidian constellation is obtained; the lipid-soluble extract of Ascidian constellation is obtained by homogenizing the Ascidian constellation, filtering to obtain a filtrate, extracting the filtrate with n-butanol and concentrating. The composition provided by the invention has the functions of significantly reducing body weight and regulating blood lipids, and can obviously prevent and treat hyperlipidemia, prevent obesity, reduce body weight, regulate abnormal lipoproteins, regulate lipid metabolism and reduce the incidence of coronary heart disease.

The invention provides a traditional Chinese medicine composition for controlling enteritis, bacillary dysentery, dysentery and intractable diarrhea. The traditional Chinese medicine composition is mainly prepared from rhizoma acori graminei, scutellaria baicalensis and white atractylodes rhizomes in cooperation with berberis poiretii schneid or berberine sulfate or cortex phellodendri or coptidisrhizome or berberine hydrochloride, and pills or capsules or tablets or powder or granules or oral liquid or injection preparations are prepared according to the requirements of preparations of all dosage forms in the formula; the traditional Chinese medicine composition can be effectively used for controlling enteritis, bacillary dysentery, dysentery and intractable diarrhea.

The invention provides a new high B-ring berberine and palmatine derivative. The structural formula is shown in the description. The invention also provides a preparation technology and application ofthe high B-ring berberine and palmatine derivative. Pharmacodynamic tests prove that the compound provided by the invention has a relatively good effect of reducing blood glucose in vitro and is partially superior to a positive control of berberine hydrochloride. The high B-ring berberine and palmatine derivative provided by the invention has a remarkable drug effect and possibly provides a new clinical medication option.

The invention relates to a method for using alcaine 13-hexyl berberine to prepare the drug that treats gastritis enteritis caused by pylorus bacillus (Hp), etc. Wherein, alcaine 13-hexyl berberine is the derivate replaced by replacing the thirteenth -H with hexyl -C6H13 in parent compound alcaine berberine, its MIC resistant to pylorus bacillus is 2 mug / ml, and anti-inflammatory cell factor is IC505-10 mug / ml. It has stronger activity then alcaine berberine. And it can be made into oral tablet and capsule.

The invention discloses berberine derivatives, their synthesis method and their application in the preparation of products for preventing, alleviating and / or treating tumors. Described berberine derivatives are 12-aminotetrahydroberberine derivatives shown in general formula I or their physiologically acceptable salts and 12-N, N-disubstituted amino tetrahydro berberine derivatives Berberine derivatives or their physiologically acceptable salts and 12-aminoberberine quaternary ammonium salt derivatives or their physiologically acceptable salts and 12-N, N-disubstituted Amino berberine quaternary ammonium derivatives or physiologically acceptable salts thereof. Compared with the raw material berberine chloride quaternary ammonium compounds, the solubility of these berberine derivatives in organic solvents has been significantly improved. The berberine derivatives have inhibitory activity on the growth of tumor cell lines, and the intensity of action may be significantly higher than that of the raw material of berberine quaternary ammonium salt, or equivalent to or higher than that of the positive control drug, and can be used to prepare Products for the prevention, mitigation and / or treatment of tumors.

The invention relates to a preparation for improving the menstrual cycle of patients with polycystic ovary syndrome. The invention uses isubuthrenone and berberine hydrochloride as therapeutic active ingredients in a specific ratio to make an oral preparation. It is proved by experiments that the combination of the two has Synergistically improve the menstrual cycle of polycystic ovary syndrome patients, and the results of clinical experiments further confirm that the pharmaceutical preparation of the present invention can significantly improve the menstrual cycle of polycystic ovary syndrome patients with oligomenorrhea or amenorrhea, and increase their pregnancy rate.

The invention discloses a preparation method and an oral application method of a microcapsule nanoparticle chimeric preparation of oral berberine intestinal targeted delivery release and long-short double-effect differential integration and its oral application method. The three components of degradable sustained-release material and enteric coating material are prepared according to a specific ratio to form microcapsules, and the chimeric dosage form of berberine and biodegradable sustained-release material loaded with berberine hydrochloride nanoparticles is simultaneously encapsulated, which not only effectively protects the content, and target specific intestinal segments to play a differential integration of the first-dose effect provided by the microcapsules and the sustained-release and long-acting effect provided by the nanoparticles, while improving the bioavailability and efficacy of the drug, reducing the number of medications , improve medication compliance.

The invention relates to the field of pharmacy, in particular to a pharmaceutical composition for treating diabetes. The pharmaceutical composition of the invention is composed of paulownia fruit extract, chromium nicotinate, turmeric root extract, berberine hydrochloride and green coffee bean extract. It is confirmed by pharmacological and toxicological experiments that the pharmaceutical composition of the present invention has a very ideal hypoglycemic effect in a mouse model of diabetes, and has good safety in administration. In addition, the pharmaceutical composition of the present invention can be made into various oral dosage forms, which are convenient to carry and take.

The invention provides a medicine composition for preventing and / or treating alcoholic stomach injury. The medicine composition comprises berberine hydrochloride, palmatine hydrochloride, evodiamine and rutaecarpin. The invention provides an application of a drug combination of berberine hydrochloride, palmatine hydrochloride, evodiamine and rutaecarpin in a drug for preventing and / or treating alcoholic stomach injury. Research finds that the pharmaceutical composition can significantly improve pathological changes of stomach tissues in an acute alcohol stomach injury rat model, can significantly improve functional indexes (improving superoxide dismutase (SOD) activity and reducing malondialdehyde (MDA) and gastrin (GAS) content) in serum of acute alcohol injury modeling rats, can reduce indexes of inflammatory factors (IL-1, iNOS and TNF-alpha), and can significantly reduce inflammatory factors (IL-1, iNOS and TNF-alpha) in serum of the acute alcohol injury modeling rats. The gene expression and the protein expression of inflammatory factors (IL-1, IL-6 and TNF-alpha) in stomach tissues are reduced, and a good effect of relieving the alcoholic stomach injury is achieved.

The invention discloses a cocrystal of berberine hydrochloride and fumaric acid, a preparation method, a composition and an application thereof. Specifically, the invention discloses a new co-crystal of berberine hydrochloride and fumaric acid, which uses berberine hydrochloride as the active ingredient and fumaric acid as the co-crystal precursor; berberine hydrochloride Preparation method of fumaric acid co-crystal; berberine hydrochloride and fumaric acid co-crystal are used as pharmaceutical active ingredients in the preparation and prevention of cardiovascular disease, anti-virus, anti-cancer, lowering blood fat, lowering blood sugar, anti-aging Inflammation, antibacterial and anti-infective drugs.

The invention relates to the technical field of cortex phellodendri chinensis extraction, and provides an extraction process for optimizing berberine hydrochloride in cortex phellodendri chinensis decoction pieces, the extraction process for optimizing berberine hydrochloride in the cortex phellodendri chinensis decoction pieces comprises the following steps: taking the cortex phellodendri chinensis decoction pieces, naturally air-drying, and sieving the crushed powder to obtain berberine hydrochloride powder; adding water into dilute sulphuric acid, beta-glucanase and cellulase, and mixing for later use; respectively loading the cortex phellodendri chinense powder in the step 1 and sulfuric acid into a feeding device, adding into different extraction tanks, and carrying out reflux extraction; combining all filtrates, concentrating, and adjusting the pH with diluted hydrochloric acid; and cooling, adding a saturated NaCl solution, preserving overnight at 4 DEG C, carrying out suction filtration, and drying. According to the optimized extraction process for berberine hydrochloride in cortex phellodendri chinensis decoction pieces, the enzyme activity is improved through dilute sulphuric acid, plant cell walls are thoroughly damaged by beta-glucanase and cellulase, effective components are extracted more sufficiently, and therefore the effects of being capable of accelerating extraction, sufficient in extraction and high in extraction rate are achieved.