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37 results about "Berberine Chloride" patented technology

The orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the expression of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1), hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription 3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism.

Berberine cyclodextrin inclusion compound, preparation thereof and preparation method

The invention relates to a hydrochloric acid berberine / hydroxide propyl-beta-cyclodextrin clathrate, a preparation thereof and a method for preparing the same. By a gradient temperature reduction sealing method, the hydrochloric acid berberine and the hydroxide propyl-beta-cyclodextrin between which the mol ratio is 1:0.2-10 are sealed so as to improve the water solubility and biological availability of the hydrochloric acid berberine; the clathrate has the advantages of high sealing rate, large medicine loading capability and high purity; and the clathrate can be prepared into a clinically acceptable formulation with quick curative effect. The invention also clarifies the pharmacological functions of the clathrate.
Owner:TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE

Medicinal composition for treating diarrhea and preparation thereof

The invention discloses a composition for treating diarrhea and a preparation thereof, relating to a medicinal composition for stopping the diarrhea. The invention also relates to a preparation of the medicinal composition for stopping the diarrhea. The medicinal composition is mainly prepared from the main raw materials of 1 part of Racecadotril and 0.25-25 parts of berberine hydrochloride as well as 0.01-250 parts of auxiliary materials in proportion. The medicinal composition has scientific and reasonable prescription, and can be used for inhibiting the rise of calcium ion concentration in colon smooth muscle cells and improving the motion functional coordination of the intestinal tract to realize the effect on stopping the diarrhea mainly by inhibiting the activity of enkephalinase and further inhibiting the excessive secretion of water and electrolyte via the Racecadotril, and simultaneously by the stronger bactericidal effect of the berberine hydrochloride on escherichia coli, Streptococcus hemolyticus, Diplococcus pneumoniae and the like.
Owner:KUNMING BANGYU PHARMA

Berberine hydrochloride and fumaric acid eutectic substance as well as preparation method, composition and application thereof

ActiveCN110041326AAdvantages of good safety medicineNo crystallizationAntibacterial agentsOrganic active ingredientsDrugChemistry
The invention discloses a berberine hydrochloride and fumaric acid eutectic substance as well as a preparation method, composition and an application thereof, specifically discloses a novel berberinehydrochloride and fumaric acid eutectic substance with berberine hydrochloride as an active pharmaceutical ingredient and fumaric acid as a eutectic precursor, a preparation method of the berberine hydrochloride and fumaric acid eutectic substance as well as an application of the berberine hydrochloride and fumaric acid eutectic substance as the active pharmaceutical ingredient in preparation of drugs for preventing and treating cardiovascular diseases, resisting viruses and cancer, reducing blood fat and blood sugar and resisting inflammation, bacteria and infection.
Owner:INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI

Berberine hydrochloride and malic acid eutectic substance and preparation method, composition and application thereof

ActiveCN109988164AAdvantages of good safety medicineIncrease biological activityAntibacterial agentsOrganic active ingredientsActive componentBerberine hydrochloride
The invention discloses a berberine hydrochloride and malic acid eutectic compound as well as a preparation method, a composition and application thereof. Specifically, the invention discloses a novelberberine hydrochloride and malic acid eutectic substance which takes berberine hydrochloride as a medicinal active component and malic acid as a eutectic precursor, a preparation method of the berberine hydrochloride and malic acid eutectic substance, and application of the berberine hydrochloride and malic acid eutectic substance as a medicinal active ingredient in preparation of medicines forpreventing and treating cardiovascular diseases, resisting viruses and cancers, reducing blood fat, reducing blood sugar, resisting inflammation, resisting bacteria and resisting infection.
Owner:INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI

Chinese medicine composition for clearing away and toxic material, drying damp and treating dysentery and its preparing method and application

The present invention provides a kind of Chinese medicine composition for clearing away heat and toxic matter, drying damp and treating dysentery and its preparation process and application. The Chinese medicine composition has effective components prepared with berberine hydrochloride, celandine, Chinese pulsatilla and ash bark in certain weight proportion. It is prepared into oral liquid, tablet, capsule or granule. The present invention also provides the application of the Chinese medicine composition in preparing medicine for treating diarrhea and dysentery caused by dampness and heat in the large intestine.
Owner:HEILONGJIANG ZBD PHARMA

Extract for treating enteritis and dysentery, preparation comprising same, and preparation method and applications of preparation

The invention relates to an extract for treating enteritis and dysentery, a preparation comprising the same, and a preparation method and applications of the preparation. The extract comprises the following traditional Chinese medicines in parts by weight: 620-1680 parts of pericarpium granati, 178-267 parts of radix pulsatillae, 8-13 parts of radix aucklandiae, and 8-13 parts of berberine hydrochloride. The preparation comprises active ingredients: an alcohol extract of pericarpium granati, a mixture of alcohol and water extracts of radix pulsatillae, an alcohol extract of radix aucklandiae and berberine hydrochloride. The extract is high in active ingredient content, the preparation method is simple, and the preparation has unexpected curative effect on the aspect of treating enteritis and dysentery.
Owner:ANHUI JINGFANG PHARMA

Technique for preparing berberine hydrochloride by microwave-enzyme method

The invention relates to a technique for preparing berberine hydrochloride by a microwave-enzyme method, which comprises the following steps: a. pulverization and screening of berberis root; b. acidic cellulase enzymolysis; c. microwave-assisted extraction; d. high-temperature and adjusted pH inactivation; and e. near-saturation precipitation of berberine hydrochloride with diluted acid and sodium chloride. The berberis root is used as the raw material, thereby fully utilizing the cellulase to destroy the cell walls of the plant; and the cavitation of ultrasonic is utilized to increase the molecular motion frequency and speed of the substance and enhance the penetrating power of the solvent, thereby enhancing the leaching speed and leaching frequency of the effective component, and further enhancing the leaching rate of berberine. The invention has the advantages of simple technique, mild reaction conditions, high selectivity, short extraction time and the like, and maximizes the extraction yield.
Owner:NANJING TONGZE AGRI SCI & TECH

Application of berberine-oryzanol tablet in treatment of diabetes

The invention provides a berberine-oryzanol tablet and application thereof in treatment of diabetes. The berberine-oryzanol tablet is obtained through mixing of modified berberine-oryzanol granules and other adjuvants at a certain ratio and tabletting of the mixture, wherein the modified granules comprise drugs, surfactants and dispersants. Through the modified granules, the solubility of berberine and oryzanol can be improved well, and the dissolution and bioavailability of the drugs can be improved. According to the tablet, a good treatment effect on diabetes can be achieved through compatibility of the drugs, a reasonable prescription and preparation process.
Owner:YICHUN WANSHEN PHARMA MACHINERY

Berberine hydrochloride-matrine-carboxymethyl chitosan composite hydrogel and preparation method and application thereof

The invention discloses berberine hydrochloride-matrine-carboxymethyl chitosan composite hydrogel and a preparation method and application thereof. According to the berberine hydrochloride-matrine-carboxymethyl chitosan composite hydrogel disclosed by the invention, berberine hydrochloride and matrine are used as model medicines, carboxymethyl chitosan and poloxamer are used as substrate materials, and temperature sensitive type composite hydrogel having a slow release function and a phase change characteristic is prepared. According to the in vitro bacteriostasis effect research result, the inventor finds that the berberine hydrochloride-matrine-carboxymethyl chitosan composite hydrogel provided by the invention has favorable bacterium restraining properties on staphylococcus aureus, andhas potential to become a medicine for preventing or treating staphylococcus aureus infection, and a new prevention and treatment method is provided for mastitis of cows.
Owner:BEIJING UNIV OF AGRI

Traditional Chinese medicine composition for controlling enteritis, bacillary dysentery, dysentery and intractable diarrhea

The invention provides a traditional Chinese medicine composition for controlling enteritis, bacillary dysentery, dysentery and intractable diarrhea. The traditional Chinese medicine composition is mainly prepared from rhizoma acori graminei, scutellaria baicalensis and white atractylodes rhizomes in cooperation with berberis poiretii schneid or berberine sulfate or cortex phellodendri or coptidisrhizome or berberine hydrochloride, and pills or capsules or tablets or powder or granules or oral liquid or injection preparations are prepared according to the requirements of preparations of all dosage forms in the formula; the traditional Chinese medicine composition can be effectively used for controlling enteritis, bacillary dysentery, dysentery and intractable diarrhea.
Owner:湖南慧谷农业生态研究院有限公司

Pharmaceutical composition and application thereof in preparing medicine for improving insulin resistance and reducing blood sugar

The invention discloses a pharmaceutical composition and application of the pharmaceutical composition in preparing a medicine for improving insulin resistance and reducing blood sugar. It is found that berberine hydrochloride and isoliquiritigenin with the mass ratio of 3: 1 have the activity of synergistically reducing blood sugar and synergistically improving insulin resistance, the effect that1 + 1 is larger than 2 is achieved, and the composition formed by berine hydrochloride and isoliquiritigenin can be used for preparing medicine for reducing blood sugar and improving insulin resistance.
Owner:CHINA PHARM UNIV

Biocompatible aggregation-induced luminogen and application thereof

The present subject material relates to the discovery of Berberine Chloride as aggregation induced emission (AIE) luminogen and use of this material in staining lipid droplets both in mammalian cellsand in living tissue slices. In particular, the present innovation is associated with proposing a new source to acquire more natural AIEgens with obvious advantages over artificial luminogens.
Owner:THE HONG KONG UNIV OF SCI & TECH

Pharmaceutical composition and application thereof

The invention discloses a pharmaceutical composition and application thereof. The invention provides an application of a medicine composition in preparation of a medicine for treating and / or preventing diabetic nephropathy. The medicine composition comprises berberine hydrochloride and stachyose. The invention also discloses a pharmaceutical composition for treating and / or preventing diabetic nephropathy. The pharmaceutical composition disclosed by the invention can be used for improving the renal function of a diabetic model mouse induced by high fat diet and STZ, specifically, the content of blood sugar, creatinine and urea nitrogen in blood and urine ACR are remarkably reduced, inflammation outcome in the kidney of the diabetic mouse is promoted, and abnormal reconstruction and fibrosis of kidney tissues are relieved. The invention provides a scientific basis for reasonable use of the combination of berberine hydrochloride and stachyose in the field of prevention and treatment of diabetic nephropathy.
Owner:BEIJING WEIFENG YIMIN TECH

Berberine derivatives, their preparation method, pharmaceutical composition and anti-tumor application

The invention discloses berberine derivatives, their synthesis method and their application in the preparation of products for preventing, alleviating and / or treating tumors. Described berberine derivatives are 12-aminotetrahydroberberine derivatives shown in general formula I or their physiologically acceptable salts and 12-N, N-disubstituted amino tetrahydro berberine derivatives Berberine derivatives or their physiologically acceptable salts and 12-aminoberberine quaternary ammonium salt derivatives or their physiologically acceptable salts and 12-N, N-disubstituted Amino berberine quaternary ammonium derivatives or physiologically acceptable salts thereof. Compared with the raw material berberine chloride quaternary ammonium compounds, the solubility of these berberine derivatives in organic solvents has been significantly improved. The berberine derivatives have inhibitory activity on the growth of tumor cell lines, and the intensity of action may be significantly higher than that of the raw material of berberine quaternary ammonium salt, or equivalent to or higher than that of the positive control drug, and can be used to prepare Products for the prevention, mitigation and / or treatment of tumors.
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI

Combined application of ginsenoside and berberine or berberine salt to preparation of drugs for treating atherosclerosis or hyperlipidemia

InactiveCN107158013AJoint securityCombined non-toxicOrganic active ingredientsMetabolism disorderBerberineSide effect
The invention relates to the technical field of pharmacy and particularly discloses combined application of ginsenoside and berberine or a berberine salt to preparation of drugs for treating atherosclerosis or hyperlipidemia. The ginsenoside is selected from ginsenoside Rb1, and the berberine salt is selected from berberine hydrochloride. The invention further provides a pharmaceutical composition. The pharmaceutical composition comprises the ginsenoside and the berberine or the berberine salt, and a mass ratio of the ginsenoside to the berberine or the berberine salt is 1-10:1-10. The pharmaceutical composition is remarkably effective in prevention and treatment of the atherosclerosis and hyperlipidemia and is exact in efficacy, safe and free of obvious toxic and side effects, thereby being promising in application prospect.
Owner:GUANGDONG PHARMA UNIV

Use of chloride 13-hexyl berberine in preparation of medicine for treating peptic ulcer and bacteriological gastroenteritis

The invention relates to a method for using alcaine 13-hexyl berberine to prepare the drug that treats gastritis enteritis caused by pylorus bacillus (Hp), etc. Wherein, alcaine 13-hexyl berberine is the derivate replaced by replacing the thirteenth -H with hexyl -C6H13 in parent compound alcaine berberine, its MIC resistant to pylorus bacillus is 2 mug / ml, and anti-inflammatory cell factor is IC505-10 mug / ml. It has stronger activity then alcaine berberine. And it can be made into oral tablet and capsule.
Owner:CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO

Application of traditional Chinese medicine monomer composition in prevention and/or treatment of alcoholic stomach injury

The invention provides a medicine composition for preventing and / or treating alcoholic stomach injury. The medicine composition comprises berberine hydrochloride, palmatine hydrochloride, evodiamine and rutaecarpin. The invention provides an application of a drug combination of berberine hydrochloride, palmatine hydrochloride, evodiamine and rutaecarpin in a drug for preventing and / or treating alcoholic stomach injury. Research finds that the pharmaceutical composition can significantly improve pathological changes of stomach tissues in an acute alcohol stomach injury rat model, can significantly improve functional indexes (improving superoxide dismutase (SOD) activity and reducing malondialdehyde (MDA) and gastrin (GAS) content) in serum of acute alcohol injury modeling rats, can reduce indexes of inflammatory factors (IL-1, iNOS and TNF-alpha), and can significantly reduce inflammatory factors (IL-1, iNOS and TNF-alpha) in serum of the acute alcohol injury modeling rats. The gene expression and the protein expression of inflammatory factors (IL-1, IL-6 and TNF-alpha) in stomach tissues are reduced, and a good effect of relieving the alcoholic stomach injury is achieved.
Owner:PEKING UNIV

Application of berberine ion pair compound to preparation of anti-breast-cancer drug

The invention discloses the application of a berberine ion-pair compound in the preparation of anti-breast cancer drugs. The compound has dual mother nuclear pharmacological effects and lipophilicity. The present invention shows that triple-negative breast cancer cells are highly sensitive through in vitro tumor cell tests and in-vivo animal tests, and the compound has obvious inhibitory effects on breast cancer cells, especially triple-negative breast cancer cells. Proliferation, inducing apoptosis, and inhibiting the growth of nude mouse transplanted tumors in vivo, the potency in vitro is significantly higher than that of its lead berberine hydrochloride. It is a safe, effective, abundant drug source, low price, convenient to take, and excellent Potential drugs with promising clinical applications.
Owner:FUJIAN MEDICAL UNIV

Substituted calix carbazole derivative as well as synthesis method and application thereof

The invention belongs to the technical field of medicines, and relates to a substituted calix carbazole derivative as well as a synthesis method and application thereof, in particular to substituted calix [n] carbazole containing thiophene and the like as well as a synthesis method and application thereof in a drug delivery system, and in particular to application of substituted calix carbazole containing thiophene and the like in improving the drug loading function of berberine hydrochloride and reducing the cytotoxicity of drugs and application in depolymerizing protein and preparing senile dementia drugs. The chemical structural general formula of the substituted calix [n] carbazole derivative salt is shown in the specification. The substituted calix [n] carbazole derivative salt can effectively improve the cavity depth and rigid strength of calix [n] carbazole and improve the matching degree of combination of novel calix [n] carbazole and berberine hydrochloride, so as to reduce the cytotoxicity of drugs under the condition of high dosage. The calix [n] carbazole derivative can also be used for depolymerizing protein and preparing senile dementia drugs.
Owner:SHENYANG PHARMA UNIVERSITY

Extraction process for optimizing berberine hydrochloride in cortex phellodendri chinensis decoction pieces

The invention relates to the technical field of cortex phellodendri chinensis extraction, and provides an extraction process for optimizing berberine hydrochloride in cortex phellodendri chinensis decoction pieces, the extraction process for optimizing berberine hydrochloride in the cortex phellodendri chinensis decoction pieces comprises the following steps: taking the cortex phellodendri chinensis decoction pieces, naturally air-drying, and sieving the crushed powder to obtain berberine hydrochloride powder; adding water into dilute sulphuric acid, beta-glucanase and cellulase, and mixing for later use; respectively loading the cortex phellodendri chinense powder in the step 1 and sulfuric acid into a feeding device, adding into different extraction tanks, and carrying out reflux extraction; combining all filtrates, concentrating, and adjusting the pH with diluted hydrochloric acid; and cooling, adding a saturated NaCl solution, preserving overnight at 4 DEG C, carrying out suction filtration, and drying. According to the optimized extraction process for berberine hydrochloride in cortex phellodendri chinensis decoction pieces, the enzyme activity is improved through dilute sulphuric acid, plant cell walls are thoroughly damaged by beta-glucanase and cellulase, effective components are extracted more sufficiently, and therefore the effects of being capable of accelerating extraction, sufficient in extraction and high in extraction rate are achieved.
Owner:SICHUAN ACAD OF FORESTRY +1

Pharmaceutical composition of transdermal plaster for treating diarrhea and transdermal plaster

The invention discloses a pharmaceutical composition of a transdermal plaster for treating diarrhea and the transdermal plaster. The pharmaceutical composition comprises the following components in parts by mass: 5-20mg of 654-2, 480-900mg of qi-regulating pill of aucklandia and 240-480mg of berberine hydrochloride; or 10-40mg of 654-2, 600-1200mg of qi-regulating pill of aucklandia and 4-12mg of diphenoxylate; or 10-40mg of 654-2, 600-1200mg of qi-regulating pill of aucklandia and 4-8mg of loperamide hydrochloride. The pharmaceutical composition disclosed by the invention can be used for treating bacterial diarrhea, virus diarrhea, fungal diarrhea, indigestion diarrhea and other multiple diarrhea diseases, is applicable to a patient who is sick for more than 1 month, is safe to take and convenient to use, achieves an obvious effect after 24 hours, and realizes healing after 3-5 days.
Owner:邓蜀俐

Anti-streptococcus agalactiae traditional Chinese medicine extract effective part formula and production process thereof

The invention discloses an anti-streptococcus agalactiae traditional Chinese medicine extract effective part formula. The formula is composed of the following raw materials in parts by weight: 100-120parts of a rhubarb root and rhizome extract, 15-25 parts of berberine hydrochloride, 70-90 parts of a baical skullcap root extract, and 75-95 parts of a weeping forsythia capsule extract. Because theberberine hydrochloride content in the prescription is low and the baical skullcap root extract has poor fluidity, on the basis of previous experiments, a production process adopts a manner of performing pre-mixing of a small amount of a filling agent with berberine hydrochloride and the baical skullcap root extract, and then performing total mixing to increase the uniformity and ensure stable drug effects. The test shows that the minimum bacteriostatic concentration of the formula against streptococcus agalactiae is 5.625 [mu]g / mL; and the minimum bactericidal concentration is 31.25 [mu]g / mL, so that the formula shows good antibacterial effects. Therefore, the anti-streptococcus agalactiae traditional Chinese medicine extract with antibacterial effects, non-toxicity and no residue, and being capable of replace antibiotics, and a powder thereof have great significance and broad prospects.
Owner:GUANGXI UNIV

Berberine hydrochloride dimer as well as preparation method and application thereof

The invention provides a berberine hydrochloride dimer which has a chemical structure shown in the specification. The anti-tumor effect of the berberine hydrochloride dimer is remarkably superior to that of positive control berberine hydrochloride, and the berberine hydrochloride dimer has good anti-tumor activity and strong druggability; and as a novel anti-tumor compound, the compound has great development value. The invention also provides a preparation method of the berberine hydrochloride dimer.
Owner:PEKING UNIV SHENZHEN HOSPITAL
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