17 results about "Anti ulcerogenic" patented technology

The invention discloses a preparation method and application of ulcerative colitis resisting kelp fucoidin, and belongs to the technical field of polysaccharide preparation and application, the preparation method is used for preparing the kelp fucoidin, and the preparation method comprises the following steps: taking kelp as a raw material, cleaning, drying, crushing and sieving, and then performing reflux degreasing to obtain kelp powder; carrying out hot water-ultrasonic synergistic extraction on the algae powder, and carrying out centrifugation and rotary evaporation concentration to obtain a supernatant; performing graded alcoholization and deproteinization treatment on the supernate to obtain a deproteinized polysaccharide solution; and dialyzing the deproteinized polysaccharide solution to remove impurities, freeze-drying to obtain the kelp fucoidin, and applying the obtained kelp fucoidin to treatment of ulcerative colitis. The preparation process is simple, efficient and high in repeatability, compared with an artificially synthesized ulcerative colitis resisting medicine mesalazine, the obtained natural fucoidin has the same level of ulcerative colitis resisting activity, a new natural active raw material is provided for ulcerative colitis treatment, and the natural fucoidin has a good application prospect.

The invention belongs to the technical field of organic compound preparation, and discloses a tryptanthrin compound as well as a preparation method and application thereof. The preparation method of the tryptanthrin compound disclosed by the invention comprises the step of enabling an indole-2, 3-diketone derivative, 2H-thieno [3, 2-D] [1, 3] oxazine-2, 4 (1H)-diketone, triethylamine and methylbenzene to react, so as to obtain the tryptanthrin compound. The obtained tryptanthrin compound is novel in structure, shows ulcerative colitis resisting activity and has the potential of being developed into ulcerative colitis resisting drugs.

The invention discloses application of phenylpyruvic acid in prevention and control of citrus canker, and belongs to the field of treatment of agricultural canker. The invention discloses a new application of phenylpyruvic acid in treating and / or preventing citrus canker, and the effective dosage of phenylpyruvic acid is 0.01-1.5 M. The phenylpyruvic acid is externally applied, so that the scab area of the citrus canker can be reduced to a great extent, and the attack degree of the canker is reduced. In addition, the content of phenylpyruvic acid in citrus can be increased through multiple technologies, and the phenylpyruvic acid can be used for canker-resistant molecular breeding.

Disclosed are a pharmaceutical composition for preventing and treating ulcerative colitis, a preparation method therefor, and use thereof. The pharmaceutical composition comprises icaritin or a pharmaceutically acceptable salt thereof and N-(3-chlorophenyl)-1-(3-hydroxybenzoyl)piperidine-4-carboxamide or a pharmaceutically acceptable salt thereof, and the weight ratio of icaritin to N-(3-chlorophenyl)-1-(3-hydroxybenzoyl)piperidine-4-carboxamide is 0.1-3.0:1. Icaritin or the pharmaceutically acceptable salt thereof and N-(3-chlorophenyl)-1-(3-hydroxybenzoyl)piperidine-4-carboxamide or the pharmaceutically acceptable salt thereof in the pharmaceutical composition exhibit a significant synergistic effect in preventing or treating ulcerative colitis, resulting in a notable therapeutic effect on ulcerative colitis.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for preventing and treating ulcerative colitis as well as a preparation method and application thereof. The pharmaceutical composition disclosed by the invention comprises anhydroicaritin or a pharmaceutically acceptable salt of the anhydroicaritin and N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide or a pharmaceutically acceptable salt of the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide, wherein the weight ratio of the anhydroicaritin to the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide is (0.1-3.0): 1. The anhydroicaritin or the pharmaceutically acceptable salt of the anhydroicaritin and the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide or the pharmaceutically acceptable salt of the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide in the pharmaceutical composition disclosed by the invention have a remarkable synergistic interaction effect in the aspect of preventing or treating ulcerative colitis. The pharmaceutical composition disclosed by the invention has a remarkable treatment effect on ulcerative colitis and has important social benefits and economic values.

The invention discloses an asiatic acid saponin compound and medical application thereof. The asiatic acid saponin compound comprises a compound with a structural formula as shown in a formula (I), and pharmaceutically acceptable salt or ester or solvate of the compound. The compound shown in the formula (I) has anti-inflammatory and anti-ulcer activity, so that the compound can be used for preparing medicines for preventing or treating inflammatory diseases or ulcerative diseases.

The invention discloses a preparation method of portulaca oleracea polysaccharide. The preparation method comprises the steps of degreasing, water extraction, deproteinization, alcohol precipitation, drying, crushing and the like. The preparation method of the portulaca oleracea polysaccharide has the remarkable advantages of simple and convenient process, low cost, safety, high efficiency and the like. Pharmacological experiments prove that the portulaca oleracea polysaccharide prepared by the preparation method disclosed by the invention has obvious effects of resisting ulcerative colitis and secondary osteoporosis, and can be used for preparing healthy products, including medicines, health foods and foods, for resisting ulcerative colitis and secondary osteoporosis.

The invention discloses an asiatic acid saponin compound and medical application thereof. The asiatic acid saponin compound comprises a compound with a structural formula as shown in a formula (I), and pharmaceutically acceptable salt or ester or solvate of the compound. The compound shown in the formula (I) has anti-inflammatory and anti-ulcer activity, so that the compound can be used for preparing medicines for preventing or treating inflammatory diseases or ulcerative diseases.

The invention relates to the technical field of biological medicines, in particular to distillers' grain polysaccharide VPS-30 for resisting ulcerative colitis as well as a preparation method and application of the distillers' grain polysaccharide VPS-30. The specific preparation method comprises the following steps: (1) treating a vinasse raw material by adopting a water extraction and alcohol precipitation method and a Sevage method in sequence to obtain crude vinasse polysaccharide VPS; and (2) separating and purifying the VPS by adopting an ethanol fractional alcohol precipitation method to obtain the vinasse polysaccharide VPS-30. The preparation method is simple, high in yield and suitable for large-scale production, the obtained vinasse polysaccharide VPS-30 can be used as a functional food and a medicine raw material, the weight loss induced by ulcerative colitis is remarkably relieved, the disease activity (DAI) index is effectively reduced, the colon shortening and pathological injury degree of a mouse with ulcerative colitis is relieved, and the ulcerative colitis can be effectively treated. And a new solution is provided for the treatment of ulcerative colitis.

The invention belongs to the technical field of biology, and particularly relates to an anti-ulcer product based on wood frog fertilized eggs and a preparation method and application of the anti-ulcer product based on the wood frog fertilized eggs. The active ingredient of the anti-ulcer product is one or more of wood frog fertilized egg active peptide, wood frog fertilized egg freeze-dried powder and wood frog fertilized egg protein; the amino acid sequence of the wood frog fertilized egg active peptide is as shown in SEQ ID NO: 1. The anti-gastric ulcer product is based on jelly colloidal wood frog fertilized eggs with good water absorption and elasticity, and can effectively realize covering film protection on damaged gastric mucosa, repair ulcer surfaces and quickly recover gastric motility.

The present invention belongs to the field of medicine and discloses the use of a trifluoromethyl vinyl ester compound in the preparation of a drug for treating ulcerative colitis. The compound has the chemical structure shown in Formula 1: The present invention reveals that the compound has the effect of treating ulcerative colitis. The present invention uses a mouse ulcerative colitis model and an LPS-induced macrophage RAW264.7 inflammation model to observe a series of tests such as the therapeutic effect of the novel trifluoromethyl vinyl ester compound BLF-16 on ulcerative colitis, and explores the therapeutic effect of compound BLF-16 on dextran sulfate sodium-induced ulcerative colitis in mice. It is first revealed that compound BLF-16 can treat ulcerative colitis and has good medicinal prospects.

The invention provides a preparation method and application of resveratrol / piperine composite nanoparticles for improving ulcerative colitis, and belongs to the technical fields of biological medicines, nano delivery systems and natural product utilization. Resveratrol-zein nanoparticles constructed by an anti-solvent precipitation method are used as a core, propylene glycol alginate is used as an intermediate layer and wraps piperine, and finally carboxymethyl chitosan is used as an outer layer coating material, so that synergistic encapsulation and slow release of difunctional components are realized. The composite nano-particles constructed by the invention have relatively high encapsulation efficiency and excellent stability and biocompatibility, the bioavailability of resveratrol and piperine is remarkably improved, and the composite nano-particles have a good ulcerative colitis resisting effect; the method has a great application prospect in the fields of medicines for adjuvant therapy of ulcerative colitis, prevention and health care products, functional foods and the like.

The invention relates to the technical field of plant disease control, in particular to an immunomodulator for improving poplar canker resistance and a preparation method and application thereof. The invention provides application of salicylic acid in preparation of a preparation for preventing and treating poplar canker. Salicylic acid, absolute ethyl alcohol and Tween 80 cooperate to prepare the immunomodulator, so that a plant ethylene signal channel is activated, and scab expansion caused by botryosphaeria dothidea is remarkably inhibited. Transcriptome analysis proves that the disease resistance is improved by enhancing the gene expression quantity of an ethylene signal channel, and the gene has the advantages of high efficiency, environmental protection, broad spectrum and the like, and is suitable for green prevention and control of poplar canker.

The application belongs to the technical field of organic compound preparation, and discloses a tryptanthrin compound and a preparation method and application thereof. The preparation method of the tryptanthrin compound is that an indole-2,3-dione derivative, 2H-thieno[3,2-D][1,3]oxazin-2,4(1H)-dione, triethylamine and toluene are reacted to obtain the tryptanthrin compound. The tryptanthrin compound obtained by the method has a novel structure, shows an anti-ulcerative colitis activity, and has a potential to be developed into an anti-ulcerative colitis drug.

The invention discloses oridonin sulfonate as well as a preparation method and application thereof, and the oridonin sulfonate has a structure as shown in a formula (I), the oridonin sulfonate disclosed by the invention is relatively high in exposure in an animal body. The method disclosed by the invention is simple, green and efficient, an ulcerative colitis experiment is established by taking mice freely drinking 2% dextran sodium sulfate (DSS) as a research model to evaluate the drug effect of the oridonin sulfonate disclosed by the invention, and the oridonin sulfonate is found to have a remarkable ulcerative colitis resisting drug effect; the compound can be applied to medicines for treating and / or preventing human and animal ulcerative colitis.

The invention provides application of cistanche deserticola polysaccharide in preparation of an anti-ulcerative colitis product, and belongs to the technical field of biological medicine. The cistanche deserticola polysaccharide is uniform glucomannan which is prepared from cistanche deserticola as a raw material through water extraction, alcohol precipitation, deproteinization, ion exchange chromatography and molecular sieve chromatography, consists of mannose and glucose in a ratio of 1: (20-80) and has the molecular weight of 5000-15000 Da; the homogeneous polysaccharide can relieve colonic shortening of zebra fish with colitis, plays a remarkable role in resisting ulcerative colitis by regulating inflammatory cells, inhibiting NO generation, regulating ROS level and other expressions, and has a remarkable intestinal tract protection function; in addition, the homogeneous polysaccharide can effectively scavenge free radicals, has good oxidation resistance, and has wide application prospects in preparation of anti-UC products, anti-oxidation products and the like.

The application discloses application of Jatrophulang fruit or stem extract in preparation of a medicine for treating ulcerative colitis. The Jatrophulang fruit or stem extract is an ethanol extract of Jatrophulang fruit or stem. The Jatrophulang fruit or stem extract provided by the application can significantly improve colitis inflammation of a mouse induced by dextran sulfate sodium, reduce a disease activity index of the mouse, obviously improve a shortened colon length of the mouse caused by modeling, significantly improve a survival rate of the mouse with ulcerative colitis, and significantly reduce inflammatory cell infiltration of colon tissue, and has a significant anti-ulcerative colitis activity, and the effect is equivalent to that of a positive medicine, i.e., sulfasalazine, and has a good application prospect in preparation of a medicine for treating inflammatory bowel disease.