37 results about "Anti ulcerogenic" patented technology

The invention belongs to the scientific and technical field of oral medicine and oral health, and particularly relates to an oral health-care agent capable of clearing away heat and toxic materials, and a preparation method thereof. The oral health-care agent contains a food-grade heat-clearing and detoxicating prescription, an anti-ulcer agent, a caries-prevention agent, a cell adhesion moisturizer, a natural antibacterial and anti-inflammatory agent and an oral health-care agent, preferably, the preparation further contains a preservative, more preferably, the preparation further contains apreparation-acceptable safety carrier or excipients; and all the ingredients are scientifically prepared and optimized to obtain a group of safety and multi-effect compositions which not only can clear away heat and toxic materials and is antibacterial and anti-inflammatory, but also can prevent tooth and periodontium and other oral diseases, and then a convenient and practical oral health-care agent is prepared by adopting a mild technological method. The oral health-care agent capable of clearing away heat and toxic materials not only has medicine efficacy, but also has the safety of health-care food, and is convenient to use, good in efficacy and fast in effect.

This invention provides a solid preparation without enteric coating which contains an acid labile active ingredient, particularly, a benzimidazole compound having an antiulcer action, and can neutralize the acid in stomach quickly, and exerts quickly the pharmacological effect of the active ingredient and suppresses the generation of a carbon dioxide gas as much as possible. A gastric disintegrable solid preparation contains an acid labile active ingredient, particularly, a benzimidazole compound, and at least one component selected from metal oxides and metal hydroxides. The preparation does not enteric-coated, but has a disintegration time of 7 minutes or less.

The invention provides a preparation method for a degreased periplaneta americana linnaeus extract. The preparation method comprises the following steps: (1) killing and grinding; (2) degreasing; (3)extracting; (4) concentration under reduce pressure; (5) degreasing and filtering; (6) macroporous adsorption resin column chromatography; (7) concentration under reduce pressure. According to the degreased periplaneta americana linnaeus extract prepared by the preparation method, ineffective components such as grease, polysaccharide and macromolecular protein are effectively removed, polypeptidecomponents with good anti-ulcer activity in periplaneta americana Linnaeus are enriched, the content of the polypeptide component reaches 85% or more; and the obtained degreased periplaneta americanalinnaeus extract has light color and is odor-free.

The present invention provides a method for creating rat acetic acid gastric ulcer recurrence model. Said method includes the following steps: creating rat acetic acid gastric ulcer and ulcer natural healing model, and using aspirin to induce the naturally-heated ulcer to be recurred, measuring the change of physiological and biochemical indexes in the process of rat ulcer recurrence so as to confirm that the recurrence model of gastric ulcer is created. Said model not only can be used in the research of clinical peptic ulcer recurrence mechanism, but also can be used for screening the medicines for clinically curing peptic ulcer and medicines for resisting ulcer recurrence.

The invention discloses a salicylic acid berberine type alkaloid quaternary ammonium salt compound represented by a general formula I, a preparation method, a solubility characteristic and a pharmaceutical composition thereof, and application of the salicylic acid berberine type alkaloid quaternary ammonium salt compound in preparation of medicinal products. According to the invention, the salicylic acid berberine type alkaloid quaternary ammonium salt compound represented by the general formula I can be prepared by an organic synthesis method, shows obvious alcohol-water mixed solvent solubility, can be conveniently prepared on a large scale, has remarkable ulcerative colitis resisting activity, has the characteristics of no toxicity or low toxicity, and can be used for preventing, relieving and/or treating ulcerative colitis.

The Convolvulus extract for treating peptic ulcer and Helicobacter pylori infection is an ethanolic extract from C. pilosellifolius. The extract is prepared by homogenizing Convolvulus pilosellifolius aerial plant parts to prepare a powder, percolating the powder with an organic solvent to prepare a suspension, filtering the suspension to obtain a filtrate, and obtaining the extract as a dry powder by drying the solvent under reduced pressure from the filtrate. The active ingredient in the extract is a compound that was isolated from the extract of C. pilosellifolius as a purified triterpene using silica gel column chromatography, the compound being named: 2-propoxyethyl 13-(4-ethoxy-4-oxobutyl)-6b,8a12b,14a-tetramethyl-5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,14a-tetradecahydropicene-2-carboxylate. Both the extract and the isolated active ingredient exhibit anti-ulcerogenic activity, and disk diffusion tests show that various strains of H. pylori are susceptible to both the extract and the active ingredient.

A compound, carboxymethylchitasan bismuth zink potassium [(C12H16O8N2R2Zn)m(C12H20O8N2R2)n], for treating digestive ulcer, protecting mucosa of stomach and sobering-up is prepared through reaction between chitosan and Zn, carboxymethylation reaction, reacting on potassium hydroxide and bismuth salt, depositing, washing, filtering, baking and pulverizing.

The invention provides a traditional Chinese patent medicine for treating peptic ulcer disease. The medicine is prepared from the following traditional Chinese herbal raw materials in parts by weight: 90-150 parts of cinnamon, 80-150 parts of galangal, 50-100 parts of cuttlebone, 80-150 parts of malt, 50-100 parts of bletilla striata, 40-80 parts of golden thread, 30-70 parts of pseudo-ginseng, 40-80 parts of rhizoma atractylodis, 40-80 parts of costusroot, 50-100 parts of radix ophiopogonis, 50-100 parts of sculellaria barbata and 50-100 parts of liquidambar formosana hance. Clinical pharmacodynamic tests prove that the traditional Chinese content medicine has the remarkable effects of resisting ulcer, inhibiting gastric acid, protecting gastric mucosa, stopping bleeding and relieving pain, toxicological test results indicate that the traditional Chinese patent medicine is low in toxicity, is safe for long-time application in a clinically specified dosage range, and is a safe and effective drug for treating peptic ulcer disease. The traditional Chinese patent medicine for treating epigastralgia cold-heat jumbled peptic ulcer disease has the effects of warming spleen and kidneys, dispelling cold, regulating middle warmer, inhibiting acid, relieving pain, and removing stasis to stop bleeding.

Disclosed is the use of compounds obtained from roots, stem, bark and leaves extracts from plant species of genus Arrabidaea, in particular Arrabidaea brachypoda, also known in Brazil under the names “cipó-una” or “cervejinha do campo”, to treat ulcerogenic diseases.

The invention discloses schisandra chinensis powder capsulate and a preparation method thereof. The capsulate consists of the schisandra chinensis powder and the auxiliary material. The weight percentages of the components are: 40 percent to 77 percent of the schisandra chinensis powder and 60 percent to 23 percent of the auxiliary material. The auxiliary material consists of calcium phosphate dibasic and micro-silica gel, the weight ratio of which is 1.5 to 4: 0.5 to 2. The product of the invention is brown, contains the natural component in the raw material and improves the schisandra chinensis lignanoid content. Taking the products can reach the goals of antitussive and expectorant effects, decreasing transaminase, expanding blood vessel, regulating the energy metabolism of myocardial cell, regulating immunity, sedation effect, anti-ulcer and anti-aging. The schisandra chinensis powder capsulate can be conserved for a long time without deterioration, the preparation method of which is simple, thereby can be easy to applied to the large scale industry production.

Orally administrable acid stable anti-ulcer benzimidazole derivatives which are polymer based. The process of preparation comprises condensing a benzimidazole with a biocompatible partially orally biodegradable synthetic cross linked polymer in aqueous medium at 5°-80° C. and pH 4-11 under inert atmosphere. The weight percentage of benzimidazole with respect to the polymeric benzimidazole is 1-50. The reaction mixture is cooled and the product is isolated and dried at 25°-45° C. There is also provided a formulation of the polymeric benzimidazoles in combination with pharmaceutically acceptable excipients.

The invention provides toothpaste with anti-halitosis and anti-ulcer effects, and relates to the technical field of toothpaste. The invention discloses the toothpaste with the anti-halitosis and anti-ulcer effects includes the following materials in parts by weight: Aluminum hydroxide 43-47 parts; calcium pyrophosphate 16 to 18 parts; sorbierite, 8 to 10 parts; 10 to 12 parts of spice; 0.2 to 0.4part of sweetening agent; 9 to 11 parts of red pyroxene powder; 18 to 22 parts of tea polyphenol; 8.5 to 9.5 parts of clove extract; 6 to 9 parts of zinc citrate; 0.3 to 0.5 part of triclosan; 8 to 12parts of vitamin C; 0.1 to 0.3 part of frankincense and 5 to 7 parts of xylitol. The invention discloses toothpaste with the anti-halitosis and anti-ulcer effects. The tea polyphenol has antibacterial and anti-inflammatory effects and has the effects of deodorizing and detoxifying; vitamin C is used for promoting combination and synergy of ossein and tea polyphenol; the triclosan can reduce bacterial plaque, relieve periodontitis, reduce dental calculus and prevent gingivitis and decayed teeth, the problems can be solved from the roots; by using the toothpaste, after teeth are brushed, halitosis is slowly generated and even cannot be generated, the red pyroxene powder has an adsorption function, and the sweetening agent and the clove extract are adsorbed on the teeth.

The invention provides a solid dispersion for treating peptic ulcer, which is prepared from raw material medicine powder: polyethylene glycol-6000=(1 to 2):(3 to 5)w/w, wherein the raw material medicine powder is prepared by grinding the following raw material medicines into 200 to 500 meshes according to a weight proportion: 0.2 to 0.4 part of bismuth potassium citrate, 1 to 3 parts of cortex daphnes, 7 to 13 parts of bighead atractylodes rhizome, 2 to 3 parts of fruiting body of ganoderma, 5 to 10 parts of radix codonopsis, 5 to 10 parts of radix pseudostellariae, 5 to 10 parts of herba artemisiae capillariae, 5 to 10 parts of herba taraxaci, 3 to 7 parts of radix platycodonis, 3 to 7 parts of herba pogostemonis and 2 to 4 parts of kernel of netmeg. According to the solid dispersion, the raw material medicine powder is prepared into the solid dispersion, so that bioavailability of a medicament is improved, and the anti-ulcerogenic activity is obviously improved.

The invention discloses a natural moisturizing lotion, which is mainly prepared from the following components: 1 to 5 parts of irisin, 0.1 to 2 parts of dipotassium glycyrrhizinate, 0.1 to 3 parts of liquiritigenin, 5 to 10 parts of glycerol, 0.1 to 0.5 part of sodium cocoyl isethionate, 0.1 to 1 part of composite sodium hyaluronate, 20 to 40 parts of polyglycerol ether and 40 to 70 parts of deionized water. The invention also discloses a preparation method thereof. According to the natural moisturizing lotion, natural plant extracts serve as main active ingredients, irisin has the effects of diminishing inflammation, resisting bacteria, whitening, moisturizing and the like, dipotassium glycyrrhizinate has the effects of resisting allergy and irritation and is good in transdermal absorption effect, and liquiritigenin has the effects of resisting ulcer, resisting inflammation and the like.