The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for preventing and treating
ulcerative colitis as well as a preparation method and application thereof. The pharmaceutical composition disclosed by the invention comprises
anhydroicaritin or a pharmaceutically acceptable salt of the
anhydroicaritin and N-(3-chlorphenyl)-1-(3-hydroxybenzoyl)
piperidine-4-
formamide or a pharmaceutically acceptable salt of the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl)
piperidine-4-
formamide, wherein the weight ratio of the
anhydroicaritin to the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl)
piperidine-4-
formamide is (0.1-3.0): 1. The anhydroicaritin or the pharmaceutically acceptable salt of the anhydroicaritin and the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide or the pharmaceutically acceptable salt of the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide in the pharmaceutical composition disclosed by the invention have a remarkable synergistic interaction effect in the aspect of preventing or treating
ulcerative colitis. The pharmaceutical composition disclosed by the invention has a remarkable
treatment effect on
ulcerative colitis and has important
social benefits and economic values.