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Medical application of anhydroicaritin

A technology of icariin and its application is applied in the field of medicine to achieve the effects of reducing complications, lowering toxic and side effects of human body, and improving medication compliance.

Inactive Publication Date: 2014-03-12
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are many deficiencies in the existing oral anti-diabetic drugs. Combining the pathophysiological characteristics of diabetes and its complications, it is a research hotspot in the treatment of diabetes to expand the thinking and find new types of drugs.

Method used

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  • Medical application of anhydroicaritin
  • Medical application of anhydroicaritin
  • Medical application of anhydroicaritin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 icarigenin tablet

[0018]

[0019] Preparation process: icariin is passed through a 100-mesh sieve, microcrystalline cellulose and low-substituted hydroxypropyl cellulose are passed through a 80-mesh sieve, and the prescribed amount of icariin and low-substituted hydroxypropyl cellulose, microcrystalline cellulose, and microcrystalline cellulose are weighed. Mix crystal cellulose evenly, add appropriate amount of 8% hydroxypropyl methylcellulose solution to granulate, dry at 60°C, sieve through a 16-mesh sieve, add prescription amount of magnesium stearate to the dry granules, mix evenly, and compress into tablets.

Embodiment 2

[0020] Embodiment 2 icarigenin tablet

[0021]

[0022] Preparation process: with embodiment 1.

Embodiment 3

[0023] Example 3 Icarigenin enteric-coated tablet

[0024]

[0025]

[0026] Preparation process: According to the conventional tablet process, it is made into tablets (ball cores) of required specifications, and then coated with enteric coating powder.

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PUM

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Abstract

The invention provides application of anhydroicaritin in preparation of drugs used for treatment or prevention of diabetes, which belongs to the field of medicine. Anhydroicaritin is a Chinese herbal monomer extracted from the traditional Chinese medicine epimedium; when used for treating a patient with diabetes, anhydroicaritin can substantially reduce the contents of fasting blood-glucose and 2-h postprandial blood sugar and substantially lower down the rate of glycosylated hemoglobin and the content of microalbuminuria, and anhydroicaritin has a better treatment effect compared with those of an epimedium extract treatment group and an icariin treatment group. Anhydroicaritin has the advantages of definite therapeutic effects, small side effects, capacity of alleviating occurrence of diabetic complications and wide medical application prospects when used for treatment of diabetes.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a medical use of icariin, in particular to the medical use of icariin in preparing medicines for treating or preventing diabetes. Background technique [0002] Diabetes is an endocrine and metabolic disease, which is a disorder of carbohydrate metabolism caused by relative or absolute insufficiency of insulin in the body, causing sugar, protein, fat and secondary water and electrolyte metabolism disorders. Diabetes is clinically divided into two types: insulin-dependent diabetes (ie, type I diabetes), and non-insulin-dependent diabetes (ie, type II diabetes). Among them, the incidence rate of type II diabetes is very high, accounting for about 90% of the number of diabetic patients. The harm of diabetes mainly comes from complications, and its incidence rate is very high, resulting in high mortality rate and high disability rate. Studies have shown that 30% to 40% of patients will develop...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P3/10
Inventor 赵志全关永霞赵云张伟
Owner LUNAN PHARMA GROUP CORPORATION
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