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NADH-containing (reduced nicotinamide adenine dinucleotide-containing) composition and preparation to improve climacteric symptoms and their preparation methods and applications

A composition and symptomatic technology, which is applied in the fields of medicine and health care, can solve the problems of large toxic and side effects, hyperplasia of endometrium, uterine bleeding, etc., achieve low production cost, easy large-scale production, and improve the effect of menopausal symptoms

Inactive Publication Date: 2019-02-19
HOBOOMLIFE BIO TECH SHENZHEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment method of Western medicine is to use artificially synthesized estrogens, such as diethylstilbestrol, nylestriol, ethinylestradiol, etc., but long-term use of these artificially synthesized estrogens can cause excessive hyperplasia of the endometrium, uterine bleeding, and even cause cervical cancer. , breast cancer, the above-mentioned treatment methods have relatively large toxic and side effects

Method used

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  • NADH-containing (reduced nicotinamide adenine dinucleotide-containing) composition and preparation to improve climacteric symptoms and their preparation methods and applications
  • NADH-containing (reduced nicotinamide adenine dinucleotide-containing) composition and preparation to improve climacteric symptoms and their preparation methods and applications

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preparation example Construction

[0028] Among them, NADH is nicotinamide adenine dinucleotide (reduced nicotinamide adenine dinucleotide), also known as reduced coenzyme I, with a chemical formula of C21H27N7O14P2 and a molecular weight of 663.43. Its oxidized form is nicotinamide adenine dinucleotide (oxidized nicotinamide adenine dinucleotide, abbreviated as NAD), which plays the role of transferring hydrogen and electrons in biological oxidation, and plays an important role in maintaining cell growth, differentiation and energy metabolism. It participates in the metabolism, rhythm, pathological changes, aging and apoptosis of body cells and other life processes. The current NADH preparation method includes the following steps: extracting the crude extract of nicotinamide riboside adenylyltransferase or its pure enzyme; immobilizing the crude extract of recombinant nicotinamide ribosyl adenylyltransferase or its pure enzyme; The recombinant nicotinamide riboside adenylyltransferase catalyzes the preparation...

Embodiment 1

[0043] (1) Raw materials: 5 parts by weight of NADH, 5 parts by weight of Epimedium secondary aglycone, 5 parts by weight of chondroitin sulfate, 5 parts by weight of ursodeoxycholic acid, 5 parts by weight of bird's nest acid, 5 parts by weight of parts of s-adenosylmethionine, 5 parts of Zhiyuan, 5 parts of DHA, and 5 parts of γ-aminobutyric acid.

[0044] (2) Accessories:

[0045] Including the following parts by weight: 15 parts of Shichangpu, 8 parts of Radix Paeoniae Rubra, 30 parts of Baiziren, 20 parts of theanine, 20 parts of Anemarrhena, 10 parts of Centella asiatica, 15 parts of ginseng leaves, 5 parts of Jiji, 10 parts of silver thread grass, 5 dragon boat flowers; accessories also include parkin complex ester, fumaric acid, fumed silica.

[0046] (3) Preparation method:

[0047] First, pass the dried raw and auxiliary materials through a 30-80 mesh sieve, so that the particle size distribution is uniform, the fluidity is better, and the raw and auxiliary materia...

Embodiment 2

[0050] (1) Raw materials: 10 parts by weight of NADH, 1 part by weight of Epimedium secondary aglycone, 10 parts by weight of chondroitin sulfate, 1 part by weight of ursodeoxycholic acid, 10 parts by weight of bird's nest acid, 1 part by weight of parts of s-adenosylmethionine, 10 parts by weight of Zhiyuan, 1 part by weight of DHA, and γ-aminobutyric acid of 10 parts by weight

[0051] (2) Accessories:

[0052] Including the following parts by weight: 4 parts of Shichangpu, 20 parts of Radix Paeoniae Rubra, 20 parts of Baiziren, 30 parts of theanine, 10 parts of Zhimu, 20 parts of Centella asiatica, 4 parts of ginseng leaves, 12 parts of Jiji, 5 parts Silver thread grass, 10 parts of dragon boat flower, 5 parts of lingxiaohua, 10 parts of wheat bottle grass, 4 parts of North China columbine, 8 parts of deergrass, 3 parts of Spatholobus yunnanensis, 20 parts of medlar, 7 parts of rehmannia, 15 parts Angelica, 4 parts of Cuscuta, 15 parts of Anemarrhena, 7 parts of Morinda of...

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Abstract

The invention discloses NADH-containing (reduced nicotinamide adenine dinucleotide-containing) composition and preparation to improve climacteric symptoms and their preparation methods and applications and relates to the field of medicine and health. The composition includes, by weight, 1-10 parts of NADH, 1-10 parts of secondary anhydroicaritin, 1-10 parts of chondroitin sulfate, 1-10 parts of ursodesoxycholic acid, 1-10 parts of sialic acid, 1-10 parts of S-adenosyl methionine, 1-10 parts of polygala root, 1-10 parts of DHA (docosahexaenoic acid), and 1-10 parts of gamma-aminobutyric acid. The components of the composition are in suitable ratio and can coact to all-directionally improve climacteric symptoms safely with no side effects. The preparation method of the preparation has a simple process flow, short process time and zero byproducts, is low in production cost and is easy to apply to large-scale production.

Description

technical field [0001] The invention relates to the fields of medicine and health care, in particular to a composition containing NADH for improving menopausal symptoms, a preparation, a preparation method and application thereof. Background technique [0002] Menopausal syndrome, also known as perimenopausal syndrome, is a series of syndromes characterized by autonomic nervous system dysfunction and neuropsychological symptoms caused by fluctuations or decreases in sex hormones before and after menopause. Menopause can be divided into natural menopause and artificial menopause. Natural menopause means that the follicles in the ovary are exhausted, or the remaining follicles lose their response to gonadotropins, and the follicles no longer develop and secrete estrogen, and cannot stimulate the growth of the endometrium, leading to menopause. Artificial menopause refers to the surgical removal of both ovaries or the use of other methods to stop ovarian function, such as radi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/69A61K9/20A61K9/48A61P15/12A23L33/175A23L33/10A61K31/7084A61K31/7048A61K31/737A61K31/575A61K31/7012A61K31/7076A61K31/202A61K31/197
CPCA23L33/10A23L33/175A61K9/20A61K9/48A61K31/197A61K31/202A61K31/575A61K31/7012A61K31/7048A61K31/7076A61K31/7084A61K31/737A61K36/69A61P15/12A61K2300/00
Inventor 刘喜元张慧梁倩
Owner HOBOOMLIFE BIO TECH SHENZHEN CO LTD
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