A kind of icariin tablet

A technology of astrogenin tablets and icariin, which is applied in the field of medicine, can solve the problems of poor fat solubility, low bioavailability, toxic and side effects, etc., and achieve the effect of fast dissolution rate and simple process

Active Publication Date: 2019-05-31
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] CN101485630B discloses a liposome of icariin, which improves the poor in vitro dissolution rate and low bioavailability of icariin
However, a large amount of surfactants bring a large number of toxic and side effects to the human body
[0008] CN101637467A discloses a icariinin phospholipid complex or a cycloicariin phospholipid complex, which greatly improves their solubility and solves the problem of It has the disadvantages of poor water solubility and fat solubility and low bioavailability

Method used

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  • A kind of icariin tablet
  • A kind of icariin tablet
  • A kind of icariin tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]

[0023]

[0024] Preparation Process:

[0025] Dissolve icariin in diethylene glycol monoethyl ether, add hydroxypropyl cellulose, stir to dissolve, then add the prescribed amount of fumed silica for adsorption, and then mix with microcrystalline cellulose and croscarmellose Sodium cellulose and magnesium stearate are uniformly mixed, and compressed by direct compression technology.

Embodiment 2

[0027]

[0028] Preparation Process:

[0029] Dissolve icariin in diethylene glycol monoethyl ether, add hydroxypropyl cellulose, stir to dissolve, then add the prescribed amount of fumed silica for adsorption, and then mix with lactose, crospovidone, hard Magnesium fatty acid is mixed evenly and compressed by direct compression technology.

Embodiment 3

[0031]

[0032] Preparation Process:

[0033] Dissolve icariin in diethylene glycol monoethyl ether, add hydroxypropyl cellulose, stir to dissolve, then add the prescribed amount of fumed silica for adsorption, and then mix with microcrystalline cellulose and carboxymethyl starch Sodium and magnesium stearate are uniformly mixed and compressed by direct compression technology.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to an anhydroicaritin tablet. The anhydroicaritin tablet contains anhydroicaritin, hydroxy propyl cellulose, fumed silica, diethylene glycol monoethyl ether and other pharmaceutically acceptable auxiliary materials. A preparation method comprises the following steps: dissolving anhydroicaritin and hydroxy propyl cellulose in diethylene glycol monoethyl ether, adding with fumed silica for adsorption, then uniformly mixing with the pharmaceutically acceptable auxiliary materials, and carrying out pressing by adopting a direct tableting technology. The medicine dissolution speed is high, the process is simple, a surfactant does not need to be added, and the micronization treatment is not needed. The acceleration test result shows that the prepared anhydroicaritin tablet is good in stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an icarigenin tablet. Background technique [0002] Icaritin (IT) is a polyhydroxy flavonoid monomer component in Epimedium genus Epimedium of Berberidaceae, and its structural formula is as follows: [0003] [0004] Pharmacological studies have shown that the anti-osteoporosis activity of IT is stronger than that of other flavonoid glycosides in Epimedium, and it can promote the activity of osteoblasts and inhibit the activity of osteoclasts in vitro. Icariin, as one of its main active ingredients, has attracted the attention of many scholars at home and abroad in recent years, and has conducted in-depth and extensive research on its pharmacological effects. The results so far have found that the main physiological activity of icariin lies in improving Cardiovascular and cerebrovascular system functions, enhance the body's immunity and regulate endocrine, and a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/352A61P19/10A61K47/38
Inventor 张贵民赵星星沈艳丽
Owner SHANDONG NEWTIME PHARMA
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