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Quality evaluation method of five-ingredient capsule for warming and activating collaterals and eliminating arthralgia

A quality evaluation and temperature communication technology, applied in the direction of measuring devices, instruments, scientific instruments, etc.

Active Publication Date: 2020-10-23
FIRST AFFILIATED HOSPITAL OF ANHUI UNIV OF CHINESE MEDICINE
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Problems solved by technology

However, due to the diversity and complexity of TCM ingredients, the screening and analysis of its active ingredients face many challenges

Method used

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  • Quality evaluation method of five-ingredient capsule for warming and activating collaterals and eliminating arthralgia
  • Quality evaluation method of five-ingredient capsule for warming and activating collaterals and eliminating arthralgia
  • Quality evaluation method of five-ingredient capsule for warming and activating collaterals and eliminating arthralgia

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Embodiment Construction

[0047] see figure 1 As shown in the flow chart of the steps, the present invention first combined serum medicinal chemistry and UHPLC-QTOF-MS technology to track the blood components of Wuwei Wentong Chubi Capsules, and then targeted 15 quality markers from the blood components, and analyzed Wuwei Wentong Chubi Capsules. Make a scientific evaluation of the quality of Wentong Chubi Capsules.

[0048] 1. Combining serum medicinal chemistry and UHPLC-QTOF-MS technology to track Wuwei Wentong Chubi Capsules (WWCC, composed of Poria cocos, Guizhi, Epimedium, Turmeric and Scutellaria baicalensis) into the blood and target its quality markers method

[0049] (1) The compound WWCC was prepared according to the proportion of the prescription by using five traditional Chinese medicines of Poria cocos, Guizhi, Epimedium, Scutellaria turmeric and Scutellaria baicalensis, and the WWCC extract was made into freeze-dried powder, which was used for gavage of rats and later sample analysis. ...

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Abstract

The invention relates to a quality evaluation method of a five-ingredient capsule for warming and activating collaterals and eliminating arthralgia. 15 ingredients including coumarin, baicalin, epimedin C, icariin, cinnamic acid, wogonoside, cinnamyl aldehyde, baicalein, cinnamyl alcohol, 2-methoxycinnamyl aldehyde, wogonin, baohuoside I, dehydrated icariin, germacrone and pachymic acid are selected as quality markers of the compound; full-wavelength scanning detection is performed, and UHPLC quality evaluation is performed on WWCC (Wuwei Wuntong arthralgia-eliminating capsule) under two wavelengths of 203nm and 270nm; after the analysis method is established and verified, the 15 quality markers in the WWCC sample are quantitatively analyzed, a WWCC fingerprint spectrum under 270nm is constructed, and the overall quality evaluation of the WWCC sample is completed. The method provides a unique idea for WWCC comprehensive quality evaluation, and provides reference and demonstration effects for traditional Chinese medicine compound overall quality evaluation.

Description

technical field [0001] The invention belongs to the technical field of quality evaluation of traditional Chinese medicine compound, in particular to a quality evaluation method for Wuwei Wentong Chubi capsules. Background technique [0002] For thousands of years, traditional Chinese medicine has been widely used in many countries in Asia, especially China, for the prevention and treatment of various diseases. Their therapeutic effects are attributed to a large number of bioactive components extracted from single herbs or compound herbs. However, these bioactive components have not been fully elucidated. Currently, quantitative analysis for quality control of TCM compound recipes mostly uses chemical constituents rather than potential bioactive constituents. Therefore, in quality evaluation, there is an urgent need to develop a method suitable for finding biologically active components rather than chemical characteristics, so as to ensure clinical efficacy and safety. How...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8679G01N30/8686
Inventor 姜辉刘健王斌万磊张玉婷凡畅
Owner FIRST AFFILIATED HOSPITAL OF ANHUI UNIV OF CHINESE MEDICINE
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