A method for evaluating the quality of Wuwei Wentong Chubi Capsules

A quality evaluation and temperature communication technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., to achieve reliable quality evaluation, good linear relationship, and low relative standard deviation

Active Publication Date: 2021-11-16
FIRST AFFILIATED HOSPITAL OF ANHUI UNIV OF CHINESE MEDICINE
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Problems solved by technology

However, due to the diversity and complexity of TCM ingredients, the screening and analysis of its active ingredients face many challenges

Method used

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  • A method for evaluating the quality of Wuwei Wentong Chubi Capsules
  • A method for evaluating the quality of Wuwei Wentong Chubi Capsules
  • A method for evaluating the quality of Wuwei Wentong Chubi Capsules

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Embodiment Construction

[0047] see figure 1 As shown in the flow chart of the steps, the present invention first combined serum medicinal chemistry and UHPLC-QTOF-MS technology to track the blood components of Wuwei Wentong Chubi Capsules, and then targeted 15 quality markers from the blood components, and analyzed Wuwei Wentong Chubi Capsules. Make a scientific evaluation of the quality of Wentong Chubi Capsules.

[0048] 1. Combining serum medicinal chemistry and UHPLC-QTOF-MS technology to track Wuwei Wentong Chubi Capsules (WWCC, composed of Poria cocos, Guizhi, Epimedium, Turmeric and Scutellaria baicalensis) into the blood and target its quality markers method

[0049] (1) The compound WWCC was prepared according to the proportion of the prescription by using five traditional Chinese medicines of Poria cocos, Guizhi, Epimedium, Scutellaria turmeric and Scutellaria baicalensis, and the WWCC extract was made into freeze-dried powder, which was used for gavage of rats and later sample analysis. ...

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Abstract

A quality evaluation method for Wuwei Wentong Chubi Capsules, selecting coumarin, baicalin, epimedin C, icariin, cinnamic acid, wogonoside, cinnamaldehyde, baicalein, cinnamyl alcohol, 2‑methoxy cinnamaldehyde, wogonin, baohuoside I, dehydrated icariin, gemacharone, and pachynic acid, a total of 15 components were used as the quality markers of the compound; full-wavelength scanning detection was carried out, and two kinds of components at 203nm and 270nm were selected. The UHPLC quality evaluation of WWCC (Wuwei Wentong Chubi Capsules) was carried out under the wavelength; after the establishment and verification of the analysis method, 15 quality markers in the WWCC samples were quantitatively analyzed, and WWCC fingerprints were constructed at 270nm. Overall quality evaluation of WWCC samples. This method provides a unique idea for the comprehensive quality evaluation of WWCC, and provides a reference and demonstration role for the overall quality evaluation of traditional Chinese medicine compounds.

Description

technical field [0001] The invention belongs to the technical field of quality evaluation of traditional Chinese medicine compound, in particular to a quality evaluation method for Wuwei Wentong Chubi capsules. Background technique [0002] For thousands of years, traditional Chinese medicine has been widely used in many countries in Asia, especially China, for the prevention and treatment of various diseases. Their therapeutic effects are attributed to a large number of bioactive components extracted from single herbs or compound herbs. However, these bioactive components have not been fully elucidated. At present, the quantitative analysis of the quality control of traditional Chinese medicine compound mostly uses chemical components, rather than potential bioactive components. Therefore, in quality evaluation, there is an urgent need to develop a method suitable for finding biologically active components rather than chemical characteristics to ensure clinical efficacy a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8679G01N30/8686
Inventor 姜辉刘健王斌万磊张玉婷凡畅
Owner FIRST AFFILIATED HOSPITAL OF ANHUI UNIV OF CHINESE MEDICINE
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