Application of anhydroicaritin in preparation of anti-fatigue medicine

An icariin and anti-fatigue technology, applied in the field of medicine, can solve problems such as icariin anti-fatigue that is not mentioned, achieve improved medication safety and medication compliance, significant therapeutic effect, prolonged rotarod effect of time

Active Publication Date: 2015-06-10
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent application CN101637466A discloses the application of icariin in the preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases, and Chinese patent application CN101637467A discloses the application of icariin in the preparation of drugs for treating osteoporosis, but the existing literature does not No mention of icarigenin's anti-fatigue properties

Method used

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  • Application of anhydroicaritin in preparation of anti-fatigue medicine
  • Application of anhydroicaritin in preparation of anti-fatigue medicine
  • Application of anhydroicaritin in preparation of anti-fatigue medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 icarigenin injection

[0021]

[0022] Preparation process: Mix the prescribed amount of propylene glycol and ethanol evenly, add icariin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, that is have to.

Embodiment 2

[0023] Example 2 Icarigenin Injection

[0024]

[0025] Preparation process: Add icariin to the prescribed amount of PEG-400, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

Embodiment 3

[0026] Example 3 Icarigenin Injection

[0027]

[0028] Preparation process: Mix the prescribed amount of ethanol and Tween-80 evenly, add icariin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

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PUM

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Abstract

The invention relates to an application of anhydroicaritin in preparation of an anti-fatigue medicine, which belongs to the medicine field. According to the invention, anhydroicaritin in the invention is a traditional Chinese medicine monomer extracted from traditional Chinese medicine epimeddium, the anti-fatigue effect of anhydroicaritin is better than that of epimedium flavone and icariin, and anhydroicaritin is suitable for treating fatigue due to various reasons, especially fatigue due to disease, cancer-related fatigue and chronic fatigue syndrome. The anhydroicaritin has the advantages of definite therapeutic effect for fatigue resistance and low side effect, and has wide medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a medical application of icariin, in particular to the medical application of icariin in the preparation of anti-fatigue drugs. Background technique [0002] Fatigue refers to the inability of the body's physiological processes to continue its function at a specific level or to maintain a predetermined exercise intensity. Regarding the mechanism of fatigue, Edward once proposed the "catastrophe theory", which believed that overall fatigue is not caused by one or several reasons, but is the product of the sum of various fatigue-causing factors. The excitability of muscles before exercise fatigue , energy supply level, and output power are in a process of gradual decline. When the total effect of various fatigue-causing factors reaches a certain critical value, there will be a sudden drop, manifested as a sudden collapse of excitability, a sudden blockage of energy supply, a sudden drop in mu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P39/00
Inventor 赵志全关永霞赵云王平平
Owner LUNAN PHARMA GROUP CORPORATION
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