1359 results about "Residual solvent" patented technology

The present invention relates to pharmaceutical compositions for delivery of drugs intended to reside in the nose, compositions for nasal administration of drugs, e.g., antiviral agents, and particularly antiviral agents comprising the human major rhinovirus receptor, also known as intercellular adhesion molecule-1 (ICAM-1); to methods of making said nasal drug compositions, and to an improved process for the removal of residual solvent from pharmaceutical matrices.

A vascular graft comprising a traditional graft material and an electrospun fibrous layer. The solvent used to reduce the material for the electrospun layer is also capable of reducing the graft material to a liquid solution. The electrospun layer is chemically bonded to the graft material, without adhesives, by either spraying the graft with the solvent prior to electrospinning or by assuring that a sufficient amount of residual solvent reaches the graft while electrospinning.

The invention provides a preparation method of a core-shell structure superfine fiber carrier material for medical dressing. The preparation method is basically characterized by specifically comprising the following steps: mixing and dissolving macromolecular polymers into a solvent to obtain a shell layer solution; selecting at least one of a functional high polymer and a medicine and dissolving the functional high polymer or the medicine into a solvent under the aseptic condition to obtain a core layer solution; and performing coaxial electrostatic spinning, placing into a vacuum drying box, and vacuum-drying to remove the residual solvent to obtain the core-shell structure superfine fiber carrier material for the medical dressing. The core-shell structure superfine fiber carrier material for the medical dressing has excellent water-absorbing property, moisturizing property and air permeability, can provide a wet microenvironment for wound healing, is uniform in pore size distribution, and achieves a bacterium blocking effect. The core layer high polymer or medicine can achieve zero-order release through corrosion or diffusion mechanism, so the influence of the environment on the medicine effect is reduced and unnecessary damage to a human body by the medicine is reduced.

The present invention provides a method for producing an aqueous dispersion of thermoplastic resin microparticles containing considerably less residual solvent remaining in resin particles, and a toner for electrophotography containing considerably less residual solvent. A self-water-dispersible thermoplastic resin is swollen using an organic solvent having a boiling point lower than 100° C., which does not dissolve but can swell the self-water-dispersible thermoplastic resin, to produce a swollen material and the resulting swollen material is dispersed into an aqueous medium in the form of microparticles to produce an initial aqueous dispersion, and then the organic solvent is removed from the initial aqueous dispersion to prepare a dispersion. A toner for electrophotography contains microparticles obtained by separating microparticles of the self-water-dispersible thermoplastic resin from the aqueous dispersion of thermoplastic resin microparticles and drying the microparticles.

A solvent cast film comprises a polyimide comprising structural units derived from polymerization of a dianhydride component comprising a dianhydride selected from the group consisting of 3,4′-oxydiphthalic dianhydride, 3,3′-oxydiphthalic dianhydride, 4,4′-oxydiphthalic dianhydride, and combinations thereof, with a diamine component wherein the polyimide has a glass transition temperature of at least 190° C.; wherein the film has a coefficient of thermal expansion of less than 60 ppm/° C., a thickness from 0.1 to 250 micrometers, and less than 5% residual solvent by weight; wherein the polyimide has less than 15 molar % of structural units derived from a member selected from the group consisting of biphenyltetracarboxylic acid, a dianhydride of biphenyltetracarboxylic acid, an ester of biphenyltetracarboxylic acid, and a combination thereof.

The invention provides a method for preparing a chitosan-based silver-loaded composite antimicrobial superfine fiber membrane. The method is characterized by particularly comprising the following steps: 1, adding silver nitrate powder into an acetic acid aqueous solution with the mass fraction of 50-90%, stirring to dissolve to obtain a solution, weighing and adding chitosan and polyoxyethylene or polyvinyl alcohol powder into the solution, and stirring to obtain a spinning solution; and 2, adding the spinning solution into an electrostatic spinning device, carrying out electrostatic spinning under the conditions that the voltage is 10-20kv, the spinning solution injecting speed is 0.1-1.0mL/h, the receive distance is 8-30cm, the spinning temperature is 20-50 DEG C and the relative humidity is 10-55%, carrying out vacuum drying on the obtained white nanofiber membrane for 12-36 hours, and removing the residual solvent to obtain the chitosan-based silver-loaded composite antimicrobial superfine fiber membrane. The electrospun fiber membrane has the advantages of a certain mechanical property, good antimicrobial property and water absorbing ability and can be used for the fields of wound surface nursing and medical dressings with different anti-infection requirements through designing the compositing ratio of the chitosan and the nanometer silver.

The invention relates to a method for extracting and refining paeonia rockii seed oil. The method comprises the following steps: collecting seeds, unshelling, baking and frying, carrying out screw press, filtering, deacidifying, degumming, drying, decoloring, deodorizing in vacuum, adding an antioxidant and filling. After solid impurities and residues obtained by the screw press are broken up, ethylacetate is added, then refluxing extraction is carried out, and a solvent is recovered so as to obtain the paeonia rockii seed oil for cosmetics. A two-step method is used for extracting the paeonia rockii seed oil, wherein in the first step: primary pressed oil used for eating is obtained by physical pressing, and the produced paeonia rockii seed oil has higher oil recovery rate and no residual solvents and can be securely eaten; in the second step, the ethyl acetate is adopted for extraction, and ingredients for antioxidation, inflammation resistance, sun block, and the like in the paeonia rockii seed oil can be extracted and used for producing the cosmetics. The invention not only improves the oil recovery rate of paeonia rockii seeds, but also ensures that the effective ingredients in the paeonia rockii seeds are sufficiently utilized.

A method for preparing a polyimide includes introducing a mixture of an oligomer and a solvent to an extruder, removing solvent via at least one extruder vent, and melt kneading the oligomer to form a polyimide. The polyimide has a low residual solvent content. The method is faster than solution polymerization of polyimides, and it avoids the stoichiometric inaccuracies associated with reactive extrusion processes that use monomers as starting materials.

An article comprises a solvent cast film comprising a polyetherimide comprising structural units derived from a dianhydride component selected from the group consisting of 3,4′-oxydiphthalic anhydride, 3,3′-oxydiphthalic anhydride, 4,4′-oxydiphthalic anhydride, and combinations thereof, and a diamine component. The polyetherimide has a glass transition temperature that is at least 190° C. The film has a coefficient of thermal expansion of less than 60 ppm/° C., a thickness from 0.1 to 250 micrometers, and less than 5% residual solvent by weight. The film has less than 15 molar % of a member selected from the group consisting of biphenyltetracarboxylic acid, dianhydrides of biphenyltetracarboxylic acid, esters of biphenyltetracarboxylic acid, and combinations thereof.

The invention provides a sulfide solid electrolyte material and a preparation method thereof. The preparation method comprises the following steps: mixing Li2S, P2S5 and M2Sn with an organic solvent to obtain a suspension liquid; sequentially stirring, dissolving, crystallizing, centrifuging, filtering and drying the suspension liquid; and then carrying out thermal treatment, so as to obtain the sulfide solid electrolyte material. Compared with the prior art, a compound containing Li, P, M and S is formed in an organic solution; the compound and a little of organic solvent form a crystalline state; the residual organic solvent in the suspension liquid is separated and volatilized in the centrifuging, separating and drying processes; meanwhile, most of crystalline-state solvent is also separated and volatilized; and nanopores are left by the residual solvent and the crystalline-state solvent in solid electrolyte in the volatilizing process. Due to the presence of the nanopores, the specific surface area of the sulfide solid electrolyte material is increased; and meanwhile, the material particles are relatively small, and easy to compact, therefore, the ionic conductivity of the sulfide solid electrolyte material is increased.

The invention relates to the field of manufacture of epoxy acrylate composite resin materials, in particular to a waterborne epoxy acrylate-grafted composite emulsion and a preparation method thereof. The process mainly comprises the following steps of: firstly, by taking a polymerizing monomer as a dispersing medium, enabling epoxide resin and acrylic acid to react under the action of tetrabutylammonium bromide to generate an epoxy acrylate monomer; and secondly, pre-emulsifying the epoxy acrylate monomer and other monomers and then enabling the epoxy acrylate monomer and other monomers to generate a copolymerization reaction to prepare the waterborne epoxy acrylate-grafted composite emulsion by adopting a semi-continuous seeded emulsion polymerization method. According to the process, the copolymerization monomer is used as a solvent dispersing medium for the esterification reaction of the epoxide resin and the acrylic acid in the first step and is also a monomer of the copolymerization reaction in the second step; an organic solvent in the reaction of the first step is prevented from being removed by adopting reduced pressure distillation, so that the influence of residual solvent on the performance of the product is avoided; the waterborne epoxy acrylate-grafted composite emulsion has high grafting rate and can be used for improving the compatibility of the epoxide resin and acrylic acid resin and enhancing the performances of the water resistance, the adhesive force, the salt resistance and the like of a coating and can be widely applied to the fields of metal coatings, building coating materials and the like.

The invention relates to a method for detecting multiple residual solvents in a medicament. According to the method, by utilizing a gas chromatographic method, nine organic solvents including methanol, ethanol, acetonitrile, acetone, isopropanol, methylene dichloride, ethyl acetate, tetrahydrofuran and triethylamine in the medicament are simultaneously detected, the sensitivity and the precision are high, and the repeatability is good; by utilizing a standard addition method, other standard substances do not need to serve as internal standard substances, only pure substances of to-be-measured components are needed, the accuracy requirement on the sampling volume is low, and the operation is simple; by utilizing a headspace sampling method, a direct solution sample is prevented from interfering the detection and polluting a chromatographic column; by utilizing a temperature programming method, low-boiling-point organic solvents and high-boiling-point organic solvents can be effectively separated.

The invention discloses a making method of high-full trans-beta-carotene agent, which comprises the following steps: setting the weight rate of beta-carontene, combined antioxidant and solvent with emulsifier at 1:0.01-0.1:50-500; dissolving the mass into water to form solution under 30-60 deg.c; adding into high-speed stirring alcohol or isopropanol at spraying pattern; making beta-carontene to evolve at amorphous starch powder with size less than 2um; filtering; adding filtering pie into auxiliary water protected by gel in advance; emulsifying; removing residual solvent; spraying; drying; obtaining the product with antioxidant A and B.

The invention discloses a production method of a PVDF (polyvinylidene fluoride) ferroelectric field effect transistor based on a molybdenum disulfide film. The production method is characterized by including producing the MoS2 (molybdenum disulfide) film on a Si (silicon) substrate of thermal oxide growth SiO2 (silicon dioxide), etching source and drain electrodes of a field effect transistor structure by photoetching and lift off methods, transfers a PVDF organic ferroelectric polymer film onto the MoS2 film with the source and drain electrodes, removing residual solvent on an interface and guaranteeing good crystallization characteristic of the film after annealing treatment, and finally, producing a metal gate electrode by photoetching and etching methods to produce a MoS2 ferroelectric field effect transistor device. The production method has the advantages that the production method for producing the organic ferroelectric field effect transistor structure is simple in technology and guarantees research on ferroelectric polarization control of electronic transport features, related photoelectric devices and related memory devices of MoS2.

The invention discloses a microwave-assisted subcritical essential oil extracting method. The microwave-assisted subcritical essential oil extracting method includes the steps that fresh plant tissues are frozen and then are smashed; 1,1,1,2-tetrafluoroethane is used as an extraction solvent and is led into the smashed plant tissues to perform microwave extraction; during microwave extraction, the extraction temperature is controlled to be 8-12 DEG C, the extraction pressure is controlled to be 0.8-6 Mpa, the microwave frequency is controlled to be 300-2400 MHZ, and the power is controlled to be 200-1200w; after a liquid phase in the system is separated out and microwave extraction is completed, the 1,1,1,2-tetrafluoroethane is recovered from the liquid phase, and the rest of the liquid phase is an essential oil stock solution; the essential oil stock solution is subjected to molecular distillation to obtain essential oil. By the adoption of the microwave-assisted subcritical essential oil extracting method, the essential oil free of any residual solvent can be obtained at lower temperature, the effective ingredients of the essential oil are not destroyed, and the natural quality of the essential oil can be kept to the most degree.

The invention discloses an oxygen electrode composite catalyst used for lithium-air batteries and a preparation method of the oxygen electrode composite catalyst. The composite catalyst is in a structure of nano-fiber meshes on the whole. The composite catalyst comprises a porous carbon nanometer fiber main body skeleton, and metal particles and/or metal oxide particles, wherein the metal particles and/or the metal oxide particles are uniformly grew on the carbon nanometer fiber main body skeleton in convex and embedded manners. The preparation method comprises a step of dissolving a polymer and a metal salt into a solvent, stirring until the mixture is completely dissolved, and forming an electrostatic spinning solution having a certain viscosity; a step of subjecting the electrostatic spinning solution to electrostatic spinning to prepare nanoscale polymer fibers having a diameter range of 300-800 nm; and a step of subjecting the nanoscale polymer fibers to drying under vacuum to remove residual solvent, performing low-temperature preheating treatment and high-temperature carbonization treatment to prepare the nano-fiber composite catalyst. The composite catalyst provided by the invention improves rate capacity and cyclic performance of lithium-air batteries.

The invention relates to a method for simultaneously detecting multiple residual solvents in ceftriaxone sodium, which adopts a gas chromatographic analysis process to simultaneously detect six organic solvents in medicines, including methanol, ethanol, acetonitrile, acetone, ethyl acetate and triethylamine. The gas chromatographic process is adopted to simultaneously detect the contents of the six organic solvents, and has the advantages of high sensitivity, favorable repetitiveness and high precision; by using a standard addition process, the method does not need any additional standard substance as an internal standard, only needs a pure substance for predicting components, can counteract the matrix effect, and is simple to operate; by using a headspace sampling process, the method prevents the direct solution sample from interfering with detection and from polluting the chromatographic column; and a programmed heating process is adopted to effectively separate low-boiling-point organic solvents from high-boiling-point organic solvents.

The invention provides a preparation method of a sulfide solid electrolyte material. The preparation method comprises the following steps: sulfide lithium ion conductor electrolyte powder, an adhesive and a solvent are mixed, and electrolyte slurry is obtained; the electrolyte slurry is uniformly stirred and dispersed, and uniform electrolyte slurry is obtained; the uniform electrolyte slurry is uniformly coated on a PET film, the electrolyte slurry which is coated on the PET film is dried at a set drying temperature, in order to evaporate the solvent part, and an electrolyte film is obtained; the electrolyte film is taken from the PET film, and the electrolyte film is cut according to a certain specification; the adhesive and the residual solvent in the cut electrolyte film are discharged, and a compact sulfide lithium ion conductor electrolyte sheet is obtained. The preparation method of the sulfide solid electrolyte material can effectively solve the problem that when an electrolyte sheet is prepared according to the prior preparation method of the all solid state electrolyte sheet, the electrolyte sheet which is thicker influences electrical performance of an all solid state battery.

The invention discloses a method for preparing an ultra-thin porous lamination gradient composite support of tissue engineering, belonging to the field of biomedicine material. The preparation method comprises the following steps: (1) determining materials and structures of a support to be prepared according to the condition of repair and defection; (2) preparing each layer of the support, waiting for the volatilization of a solvent, and gradually drying slurry for forming; (3) placing a formed object to a ventilation place, and demoulding the formed object after the residual solvent is completely volatilized; and (4) taking out the formed object and dry to obtain the ultra-thin porous lamination gradient composite support of the tissue engineering. The ultra-thin porous lamination composite support, the thickness of which is suitable for articular cartilage repair, can be prepared by using the method. The prepared support has favorable mechanical property, favorable biocompatibility and controllable degradation rate, is suitable for co-culture of osteoblast and chondrocyte and compound of specific growth factors, and can repair the synthetic defection of the joint cartilage tissue and the cartilage/bone tissue.

A solvent cast film comprises a polyimide comprising structural units derived from polymerization of a dianhydride component comprising a dianhydride selected from the group consisting of 3,4′-oxydiphthalic dianhydride, 3,3′-oxydiphthalic dianhydride, 4,4′-oxydiphthalic dianhydride, and combinations thereof, with a diamine component comprising 4,4′-diaminodiphenylsulfone; wherein the polyimide has a glass transition temperature from 190° C. to 400° C.; and wherein the film has a coefficient of thermal expansion of less than 60 ppm/° C., a thickness from 0.1 to 250 micrometers, endless than 5% residual solvent by weight.