Method for preparing chitosan-based superfine fiber carrier material for medical dressing

A technology of microfiber and carrier material, applied in medical science, textiles and papermaking, bandages, etc., can solve the problems of poor liquid absorption, moisture retention, poor air permeability, medical waste generation, poor material degradability, etc. Effects of care intensity, environmental protection, good biocompatibility

Active Publication Date: 2013-11-20
上海必趣医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are many types of dressings available, but the dressings currently on the market still have various deficiencies, such as poor liquid absorption, moisture retention, and air permeability, frequent dressing changes, adhesion to the wound surface, and poor degradation of materials, resulting in a large number of wounds. Medical waste generation, etc.

Method used

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  • Method for preparing chitosan-based superfine fiber carrier material for medical dressing
  • Method for preparing chitosan-based superfine fiber carrier material for medical dressing
  • Method for preparing chitosan-based superfine fiber carrier material for medical dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0026] (1) Preparation of spinning solution: at room temperature, the chitosan powder with a relative molecular mass of 800,000 and a deacetylation degree of 95% and the PEO powder with a relative molecular mass of 900,000 are dissolved in a mass fraction of 50% In the acetic acid aqueous solution, be made into the solution of polymer mass fraction 3%, wherein the mass ratio of chitosan and PEO is 50:50, place on magnetic stirrer and stir for 12 hours, obtain translucent light yellow spinning solution.

[0027] (2) Preparation of dressing nanofiber carrier film: the spinning solution is added to the electrospinning machine, and the spinning voltage is 11kv, the injection speed is 0.5ml / h, the needle G20, the distance from the needle point to the receiver (i.e. the receiving distance ) is 20cm, the spinning temperature is 50°C and the relative humidity is 10% under the conditions of electrospinning, the fiber is received on the cylindrical drum receiver to obtain the fiber film,...

Embodiment 2

[0030] (1) Preparation of spinning solution: at room temperature, the chitosan powder with a relative molecular mass of 700,000 and a deacetylation degree of 95% and the PEO powder with a relative molecular mass of 900,000 are dissolved in a mass fraction of 50% In the acetic acid aqueous solution, be made into the solution of polymer mass fraction 3%, wherein the mass ratio of chitosan and PEO is 75: 25, place on magnetic stirrer and stir for 12 hours, obtain translucent light yellow spinning solution.

[0031](2) Preparation of dressing nanofiber carrier film: the spinning solution is added to the electrospinning machine, and the spinning voltage is 11kv, the injection speed is 0.24ml / h, the needle G20, the distance from the needle point to the receiver (i.e. the receiving distance ) is 20cm, the spinning temperature is 50°C and the relative humidity is 10% under the conditions of electrospinning, the fiber is received on the cylindrical drum receiver to obtain the fiber film...

Embodiment 3

[0034] (1) Preparation of spinning solution: at room temperature, the chitosan powder with a relative molecular mass of 800,000 and a deacetylation degree of 95% and the PEO powder with a relative molecular mass of 900,000 are dissolved in 50% of the mass fraction In aqueous acetic acid solution, a solution with a mass fraction of 3% polymer was prepared, wherein the mass ratio of chitosan to PEO was 90:10, placed on a magnetic stirrer and stirred for 12 hours to obtain a translucent light yellow spinning solution.

[0035] (2) Preparation of dressing nanofiber carrier film: the spinning solution is added to the electrospinning machine, and the spinning voltage is 15kv, the injection speed is 0.24ml / h, the needle G20, the distance from the needle point to the receiver (i.e. the receiving distance ) is 20cm, the spinning temperature is 50 ℃ and the relative humidity is 10% under the conditions of electrospinning, and the fiber is received on the cylindrical roller receiver to ob...

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Abstract

The invention provides a method for preparing a chitosan-based superfine fiber carrier material for medical dressing, which is characterized in that the method comprises the following steps of: mixing chitosan powder and polyoxyethylene powder, dissolving the mixture into an acetate solution to preparing a spinning solution; adding the spinning solution into a static spinning device for static spinning, and receiving fiber on a cylindrical roller receiver to obtain a fiber film; and carrying out crosslinking treatment on the fiber film, and then placing the fiber film in a vacuum drying box to removing a residual solvent, to obtain the chitosan-based superfine fiber carrier material for medical dressing. The chitosan-based superfine fiber carrier material for medical dressing has advantages of ultrafine fiber structure, high porosity, and excellent hygroscopic property, moisture retention property and permeability, has certain bacterinertness, is conducive to healing of wound, and can reduce nursing intensity.

Description

technical field [0001] The invention relates to a preparation method of chitosan-based superfine fiber carrier material for medical dressing. Background technique [0002] Chitosan (Chitosan) is a natural polymer material and a polycationic electrolyte naturally occurring in nature. It has antibacterial and hemostatic effects, low toxicity, biodegradable, non-irritating to skin and mucous membranes, and has mucous membrane adhesion. attachment. Because chitosan has good biological characteristics, it has a positive effect on promoting wound repair, and it is widely recognized as a good wound repair material. There are many active groups on the chitosan macromolecule, which can realize the loading and controlled release of drugs. It is a good drug carrier material. Although there are many studies on chitosan as a drug carrier, its main forms are many It is cast film, sponge and microsphere, or non-woven fabric or fabric composed of single fiber with a diameter of about 10 μ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/44D04H1/728D04H1/541
Inventor 高晶王晓丽王璐程凤刘丽佳
Owner 上海必趣医疗科技有限公司
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