The invention provides DNAs encoding a weed controller metabolism protein selected from the following groups, which are useful in, for example, constructing a weed controller-tolerant plant. Proteins having an amino acid sequence represented by SEQ ID NO: 1, 2, 3, 108, 159, 160, 136, 137, 138, 215, 216, 217, 218, 219, 220, 221, 222, 223 or 224. Proteins having an amino acid sequence showing a sequence identity of 80% or more with one of the amino acid sequences represented by SEQ ID NOS: 1, 2, 3, 108, 159, 136, 137, 138, 215, 216, 217, 218, 219, 220, 221, 222, 223 or 224, or an amino acid sequence showing a sequence identity of 90% or more with one of the amino acid sequences represented by SEQ ID NO: 160, 215, 216, 218, 222 and 224, and being capable of converting the compound represented by the following formula II into the compound represented by the following formula III in the presence of an electron transfer system from an electron donor.