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697 results about "Triterpenoid Compound" patented technology

Triterpenoid saponins are triterpenes which belong to the group of saponin compounds. Triterpenes are a type of terpene containing 30 carbon atoms. Triterpenes are assembled from a five-carbon isoprene unit through the cytosolic mevalonate pathway to make a thirty-carbon compound.

Novel forms of cddo methyl ester

A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.
Owner:REATA PHARM HLDG LLC

Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth

The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.
Owner:OSTEOSCREEN +2

Triterpene Compounds which are Effective on Improvement of Brain Function

The present invention relates to the triterpene compounds improving in brain functions. In particular, the present invention relates to a novel use of the triterpene compounds represented by the Formula 1 for improving decreased memory and a pharmaceutical composition for improving brain functions comprising the triterpene compounds represented by the Formula 1.
Owner:SK CHEM CO LTD

Novel forms of cddo methyl ester

A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.
Owner:REATA PHARM HLDG LLC

Liquid cement grinding aid

The invention relates to a liquid cement grinding aid which can obviously reduce the dosage of trolamine and does not contain urea. The grinding aid comprises the following compositions in weight percentage: 1 to 10 percent of trolamine, 5 to 10 percent of diglycol, 1 to 10 percent of trimeric sodium phosphate, 10 to 30 percent of molasses, 0 to 20 percent of sodium thiosulfate, 0 to 10 percent of air entraining component and the balance being water, wherein the air entraining compositions are triterpenoid saponin air entraining agent, sodium lignin sulfonate or a mixture of the triterpenoid saponin air entraining agent and the sodium lignin sulfonate at any proportion. The invention obviously reduces the dosage of the trolamine, does not contain the urea, lowers product cost and simultaneously facilitates the environmental protection. The sodium thiosulfate has the function of exciting mixed materials of cement and can improve the initial strength and the later strength of the cement, thereby effectively improving the service performance of the cement grinding aid. The triterpenoid saponin air entraining agent and the sodium lignin sulfonate have the action of the auxiliary aided grinding and simultaneously properly entrain air to reduce the water consumption of the cement standard consistence.
Owner:NANJING YONGNENG MATERIALS

Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine

The invention discloses the use of ursane type triterpenoid saponin in preparing medicine for increasing leucocyte and / or platelet which has a general formula (I), the invention also provides a pharmaceutical composition having the action of increasing human leucocyte and / or platelet, which contains ursane type triterpenoid saponin composition having a general formula (I), and pharmaceutically acceptable salts.
Owner:CHENGDU DIAO PHARMA GROUP

Triterpene saponin in camellia seeds, preparation method and medical use thereof

The invention pertains to the field of medical technology and provides triterpenoid saponin in camellia seeds, and a preparation method and medical application thereof. The triterpenoid saponin is shown in a general formula (1), wherein, R1 is hydrogen or oxhydryl or acyloxy; R2 is the hydrogen or the acyloxy; R3 is the hydrogen or the acyloxy; R4 is the hydrogen or the acyloxy; R5 is methyl or methylol or aldehyde group or carboxyl or metheyl carboxyl; R6 is the hydrogen or orglycosyl; the preparation method comprises the following steps: macroporous resins are degreased, extracted by ethanol, decocted in water, desugared and decolored to obtain crude total saponins and then go though an opened ODS chromatographic column and repeated HPLC method to obtain the total saponins of camellia seeds and monomer theasaponin. The triterpenoid saponin compounds in the camellia seeds have the functions of protecting gastric mucosa, being antineoplastic, reducing blood sugar and blood fat and thelike and are used for preparing medicaments or health-care foods having the functions of protecting gastric mucosa, being antineoplastic and reducing blood sugar and blood fat.
Owner:SHENYANG PHARMA UNIVERSITY

C-17 and c-3 modified triterpenoids with HIV maturation inhibitory activity

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:These compounds are useful for the treatment of HIV and AIDS.
Owner:VIIV HEALTHCARE UK (NO 5) LTD

Preparation method of periploca forrestii schltr extract as well as product and application of periploca forrestii schltr extract

The invention discloses a preparation method of a periploca forrestii schltr extract as well as the product and application of the periploca forrestii schltr extract. The preparation method comprises the following steps: adding 60%-80% ethanol the weight of which is 8-12 times that of the medicinal material periploca forrestii schltr into the taken periploca forrestii schltr; carrying out reflux extraction for 1-3 times, wherein each reflux extraction lasts for 1-3 hours; filtering, mixing filtrates and concentrating until the relative density of the mixed filtrate is 1.2-1.5; adding water the volume is the same as that of the mixed filtrate; and refrigerating and standing for 12-48 hours, taking supernate, recovering ethanol and drying so as to obtain the extract. In the method, the ethanol extraction and water precipitation process is adopted to extract the medicinal material periploca forrestii schltr, and the parameters of the ethanol extraction process and the water precipitation process are optimized respectively. The obtained extract mainly contains flavonoid and triterpene compounds. Tests prove that the extract has obvious therapeutical effects on primary and secondary inflammatory reaction of AA rats and has good effects in the aspects of inflammation resistance, detumescence and relief of arthritis injuries of AA rats. Thus, the extract can be applied to the preparation of medicines for rheumatoid arthritis.
Owner:GUIZHOU NORMAL UNIVERSITY

C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV:wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.
Owner:VIIV HEALTHCARE UK (NO 5) LTD

Cement concrete antifreezer

InactiveCN102140021ALate strength has no effectIncrease slumpAlcoholCalcium formate
The invention discloses a cement concrete antifreezer, which comprises the following components in part by weight: 15 to 30 parts of high-performance polycarboxylate water reducer, 20 to 30 parts of low molecular weight alcohol, 0.1 to 0.15 part of triterpenoid saponins, 10 to 30 parts of calcium formate, 2 to 5 parts of organic alkylol amine and 50 to 70 parts of water, wherein the triterpenoid saponins is used for entraining air to form a large number of superfine air bubbles and improve the frost heaving stress of concrete. By the cement concrete antifreezer, the concrete can be subjected to construction at the temperature of between -20 and -30 DEG C.
Owner:河北智胜工程技术有限公司

Anti-flaming antisepsis leather coating and preparation method thereof

The invention discloses an anti-flaming antisepsis leather coating which is composed of, by weight, 2-3 parts of hydrous zinc borate, 1-1.5 parts of linoleic acid calcium soap, 0.1-0.2 part of triterpenoid saponin, 0.7-1 part of calcium naphthenate, 1.7-2 parts of polyvinylpyrrolidone, 0.8-1 part of polyacrylamide, 1.6-2 parts of stannous chloride, 0.1-0.13 part of triethanolamine, 190-200 parts of methyl methacrylate, 3-4 parts of lauryl sodium sulfate, 0.1-0.2 part of urotropine, 0.2-0.3 part of ammonium persulfate, 6-7 parts of a 20%-25% formaldehyde solution, 16-20 parts of zinc acetate, 4-7 parts of silver nitrate, 1-2 part of decabromodiphenyl ether and 0.4-1 part of sodium lauryl sulfate. The anti-flaming antisepsis leather coating has a good antibacterial property and excellent moisture permeability and water resistance. Leather coated with the obtained emulsion is good in antibacterial property and excellent in hygiene property.
Owner:CHUZHOU VOCATIONAL & TECHN COLLEGE

High-durability prestressed high-strength concrete pipe pile

The invention discloses a high-durability pre-stressed high-strength concrete pipe pile. The invention is constituted by additive constituted by cementing material, water reduction agent of naphthalene sulfonated formaldehyde condensate and triterpenoid saponin non-ion surface active air-entraining agent, sand and stone, and water by centrifugal casting, steam curing and steam pressing. Addition amount of additive is 1.0-1.2 wt% of cementing material. The high-durability pre-stressed high-strength pipe pile is provided with good permeability resistance, sulfate-corrosion resistance and frost resistance in phase.
Owner:GUANGDONG SANHE PILE CO LTD

Polycarboxylic acid type special additive for lightweight aggregate concrete

The invention relates to a polycarboxylic acid type special additive for lightweight aggregate concrete, which is formed by uniformly mixing 40-50 parts by weight of polycarboxylic acid type water reducing agent, 0.5-6 parts by weight of sodium gluconate, 0.1-0.4 part by weight of triterpenoids saponin, 0.05-0.2 part by weight of defoamer BYK-024 and 0.005-0.02 part by weight of cellulose ether with 50-60 parts by weight of water. The adoption of the special additive can lead lightweight aggregate to be difficult to float, avoid causing great impacts on the working performance of concrete, further avoid increasing the loss of slump constant, well control the performances of workability and homogeneity of the concrete, simplify the production process of the lightweight aggregate concrete, improve the production efficiency, simultaneously improve the construction working efficiency and obtain obvious economic benefits and social benefits.
Owner:GUANGDONG PROVINCIAL CHANGDA HIGHWAY ENG

Liquid cement grinding aid and preparation method thereof

InactiveCN101318791AReduce water consumption for standard consistencyIncrease late strengthTriterpenoid saponinSodium nitrite
The invention discloses a liquid cement grinding aid. The grinding aid consists of the following compositions in weight percentage: 5 to 20 percent of trolamine, 5 to 20 percent of diglycol, 10 to 30 percent of lactose, 1 to 5 percent of triterpenoid saponin air entraining agent, 1 to 5 percent of sodium lignosulphonate and the balance being water. The technical proposal has a function of properly entraining air to reduce the water consumption of the cement standard consistence. The further optimum proposal of the invention is to add sodium nitrite with a mass ration of between 5 and 20 percent based on the technical proposal. The technical proposal can improve the later strength of cement and enhance the corrosion-inhibiting capability of reinforced concrete; meanwhile, the invention also discloses a preparation method of the liquid cement grinding aid.
Owner:NANJING YONGNENG MATERIALS

Golden fungus gingko yellow wine, preparation method and efficacy thereof

The invention discloses a golden fungus gingko yellow wine. Alcoholic strength is 8-45%, general flavone content is more than or equal to 1-5 mg / L, ginkgolide is more than or equal to 1-6 mg / kg, total triterpenoid compound content is 30-800 mg / L, protein is more than or equal to 60 mg / kg, soluble sugar is less than or equal to 2.0%, gingko phenolic acid is less than or equal to 5 ppm, and hydrocyanic acid is less than or equal to 0.1 mu g / L. A double-enzyme method is adopted to hydrolyze gingko to obtain gingko hydrolysate which contains active compounds, such as ginkgo flavone, triterpenoid compound, amino acid, peptide, starch and the like, wherein the content of amino acid and peptide is more than or equal to 1%, and starch content is more than or equal to 2%. After being added with gingko leaf extract, the hydrolysate is converted by golden fungus strains, and rice koji is added to obtain fermentation liquor; the fermentation liquor is filtered and blended to obtain golden fungus gingko yellow wine. The wine contains gingko and golden fungus active ingredients and has the efficacy of preventing diabetes and hyperlipidemia, preventing oxidation and improving immunity of body.
Owner:江苏同源堂生物工程有限公司 +1

Total triterpene of garden burnet root with anti-inflammatory and analgesic effects and preparation method thereof

The invention belongs to the technical field of medicaments, and provides a method for preparing total triterpene of Chinese medicament garden burnet root. The total triterpene is mainly obtained by performing reflux extraction by 70 percent ethanol, absorbing by a macroporous absorbent resin, using water to wash off impurities, using ethanol solution for elution, then decolorizing an eluent by daiamid powder, using the ethanol solution for elution, and recovering the ethanol through pressure reduction. The total triterpene mainly contains triterpenic acid active components such as arjunic acid, 1beta-euscaphic acid, euscaphic acid, tormentic acid and the like, and triterpenoid saponin active components such as sanguisorbin I, sanguisorbin II, sanguisorbin III, niga-ichigoside, kaji-ichigoside F1 and the like. Experimental results show that the total triterpene has remarkable anti-inflammatory and analgesic effects. The total triterpene has definite action substance basis and action mechanism as well as simple preparation technology, is suitable for industrialized production, can be taken as medicinal raw materials for treating inflammatory diseases such as burn and scald, rectitis, ulcerative colitis, pyelonephritis and the like, and is prepared into clinically acceptable dosage forms such as tablets, capsules, granules or compound preparations according to the prior process.
Owner:SHENYANG PHARMA UNIVERSITY

Anticracking waterproof agent

The present invention discloses one kind of anticracking waterproof agent, which is prepared with anhydrite, aluminum ore powder, lime, naphthalene water reducing agent, magnesium stearate, calcium glyconate, sodium tripolyphosphate, migrating antirust agent, methyl cellulose and triterpenoid saponin powder. The anticracking waterproof agent can raise the compactibility, antiseep function, antirust function and durability of concrete greatly.
Owner:SHANDONG DAYUAN IND

Detection method for dammarane type four-ring triterpenoid saponin

The invention relates to a method for detecting dammarane tetracyclic triterpenoid saponin and secondary aglycone. The inventive method uses high-efficiency liquid color spectrum-mass spectrum coupled device, wherein the conditions of high-efficiency liquid color spectrum comprises: color spectrum column is ODSC18 column; the column temperature is 20-38Deg. C; the conditions of mass spectrum comprise: the ion source is Turbo Ionspray source; the ejecting voltage is 3000-5000V; the Tem is 250-300Deg. C; the detector uses triplicate four-electrode serial mass spectrum detection and positive ion detection; the scanning method uses multi-reaction detection (MRM); CE is 17-36V; DP is 8-110V; the ion detection comprises: processing impact induce dissociation on the quasi-molecule ion peak of said saponin of first-stage scanning mass spectrum, to obtain the second-stage fragment ion; and uses multi-reaction detection (MRM) scanning method to analyze the ion reaction quantitatively, to represent the blood drug density of monomer saponin and secondary aglycone.
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI

Compound microorganism silage additive and application to preparation of grain amaranth silage

The invention discloses a compound microorganism silage additive and an application to preparation of grain amaranth silage. The compound microorganism silage additive comprises an enzyme and bacteria compound and an amaranth root extract, enzyme in the enzyme and bacteria compound comprises cellulase, hemicellulose, amylase, pectinase, protease and the like, bacteria in the enzyme and bacteria compound comprise a lactobacilli flora, a bacillus thuringiensis group, photosynthetic bacteria, a yeast flora, an actinomycete group, filamentous bacteria and the like, and main components of the amaranth root extract include plant sterol, polysaccharide, oleanolic acid, flavonoid, triterpenoid saponins, organic acid and the like. Compared with a conventional silage additive, the compound microorganism silage additive is good in fermentation effect and palatability. The grain amaranth silage is prepared from the compound microorganism silage additive, the potential advantage of raw materials serving as green feed can be effectively improved, daily gain can be remarkably increased, feed-meat ratio is increased, animal growth is promoted, and the grain amaranth silage can be widely used for livestock and poultry breeding and aquaculture.
Owner:陈日远

Loquat scented tea drink preparing method and its product

The present invention relates to a loquat flower tea beverage product and its preparation method. Said invention uses loquat flower and Chinese medicinal herbs with refreshing effect or tea as raw material and adopts the following processes: soaking the above-mentioned raw materials in boiling water to make extraction, mixing extracted filtrate with sweetening agent and water according to a certain ratio, fine filtering, UHT sterilization and sterile hot-filling so as to obtain the invented product. Said product comprises medicinal components of triterpenoid saponin, etc. and at the same time contains amino acids necessary for human body, nucleic acid, vatmins and various mineral components of Ca, Zn and Fe, etc. Besides, said beverage also has various health-care functions.
Owner:FUJIAN AGRI & FORESTRY UNIV

Method for analyzing effective components of astragali radix and poria preparation with effects of warming spleen and eliminating cysts

The invention relates to a method for analyzing effective components of a drug, in particular to a method for analyzing effective components of an astragali radix and poria preparation with effects of warming the spleen and eliminating cysts. The method comprises the steps as follows: (1) preparation of a control solution; (2) preparation of a test article solution; (3) analysis method of the effective components including flavonoids, phenolic acids, triterpenoid saponins, sesquiterpene glycosides and alkaloids.
Owner:TIANJIN TASLY PHARMA CO LTD

Panax notoginseng saponins ST-4, and medicinal composition, preparation and use thereof

The invention discloses a notoginsenoside ST-4 which is a new dammarane type triterpenoid saponin compound shown in the structural formula (I), and a preparation method thereof. The invention also provides applications of the notoginsenoside ST-4 in the preparation of drugs against HSV-1. An HSV-1 strain and HELF (MRC-5) are used as cell experimental subjects to carry out the experiment of antiviral activity of the new compound which is the notoginsenoside ST-4. The results show that the notoginsenoside ST-4 has therapeutical effect for cells infected by HSV-1 and can reduce the infectivity of HSV-1 for MRC-5 cells and be applied to the preparation of drugs against HSV-1.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI

Triterpene compound and application thereof in preparation of anti-complementary medicament

The invention belongs to the field of Chinese medicine pharmacy, and relates to a triterpene compound shown as a formula I and a novel application thereof to preparation of an anti-complementary medicament, in particular to an application of a novel compound 3beta,13beta-dihydroxyolic-11-ene-28-oic acid in preparation of an anti-complementary medicament and a preparation method of the novel compound. Four triterpene compounds are separated from an acetic ether extracting position of a labiate selfheal spike dried ear ethanol extract, and are proved to have suppressing effects on a classical path and a bypath of a complementary system. The suppressing effect CH50 of the compound on the classical path of the complementary system is 198-449 mug / ml, and the suppressing effect AP50 of the compound on the bypath is 357-602 mug / ml. The triterpene compound disclosed by the invention can be used for preparing an anti-complementary medicament and further preparing a medicament for treating complement-related diseases. The formula I is shown in the specification.
Owner:FUDAN UNIV

C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV:wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.
Owner:VIIV HEALTHCARE UK (NO 5) LTD

Salvia miltrorrhiza squalene synthase (SmSQS) gene and encoding protein and application thereof

The invention discloses a squalene synthase gene and an encoding protease and application thereof. The gene is cloned from salvia miltrorrhiza by the homology cloning technology for the first time, and fills a gap of cloning and separating the squalene synthase gene from the traditional precious Chinese herbal medicine salvia miltrorrhiza in China. The provided squalene synthase gene has a nucleotide sequence shown in SEQ ID NO.1, a homologous sequence in which one or more nucleotides are added, substituted, inserted or deleted or a nucleotide sequence of allele thereof and derivatives. The protein encoded by the gene has an amino acid sequence shown in SEQ ID NO.2, or a homologous sequence in which one or more amino acids are added, substituted, inserted or deleted. The provided squalene synthase gene can improve the content of triterpenoid saponin components in plants through biotechnology, and can improve the content of diterpene (tanshinone) substances in the salvia miltrorrhiza by the RNAi technology simultaneously. The squalene synthase gene has good application prospect on research and industrialization of medicinal plant secondary metabolic engineering.
Owner:INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI

Sea cucumber saponin, preparation method thereof and application thereof in food or medicine

The invention discloses a sea cucumber saponin, a preparation method thereof and the application thereof in food or medicines. A sea cucumber saponin mixture comprises multiple sea cucumber alkyl-type triterpenoid saponins. Preferentially, the sea cucumber saponin mixture comprises holothurin A and / or echinoside A. The sea cucumber saponin mixture can also comprise one or more in holothurin A, holothurin B, echinoside A, echinoside B, 24-dehydroechinoside A and stichoposide E. The sea cucumber saponin can be applied to preparing weight-losing food or medicines, and animal experimental resultsshow that the sea cucumber saponin can be used for remarkably inhibiting weight increment and reducing internal fat accumulation so as to realize a good weight-losing effect. The preparation method of the sea cucumber saponin is low in cost, simpler in steps and less in the pollution of organic solvents on the environment; and through animal experiments, the prepared sea cucumber saponin is proved to have a good weight-losing effect so as to be used for developing safe and effective weight-losing food or medicines.
Owner:OCEAN UNIV OF CHINA

Method for performing qualitation and quantification on triterpenoid saponin in traditional Chinese medicine by utilizing electrospray protonation pyrolysis-mass spectrum multi-reaction detection mode

The invention discloses a method for performing qualitation and quantification on triterpenoid saponin in traditional Chinese medicine by utilizing an electrospray protonation pyrolysis-mass spectrummulti-reaction detection mode. The triterpenoid saponin can form a stable [M+H]<+> and / or [M+NH4)<+> molecular ion peak in a flow phase containing formic acid or ammonium formate. According to the method disclosed by the invention, a liquid chromatogram-tandem quadrupole mass spectrometry combined instrument is utilized, an electrospray positive ion tandem mass spectrum detection mode is utilized,and mass spectrum parameters of declustering potential, impact energy, impact chamber injection voltage and the like can be quickly optimized in an online mode by a single factor and response surfacemethod; thus, high-strength triterpenoid saponin protonation pyrolysis MRM target ion pairs can be formed; a Q1 calculation formula is [M+H]<+> or [M+NH4]<+>, and a Q3 calculation formula is [aglycone +H-nH2O]<+>. By means of the series of characteristic MRM target ion pairs, the purpose of quick qualitative and quantitative detection on the triterpenoid saponin in the traditional Chinese medicine is realized. The method disclosed by the invention provides an effective technology method for the qualitative and quantitative detection on the triterpenoid saponin in the traditional Chinese medicine and has been successfully applied to content measurement on the triterpenoid saponin of caulophyllum robustum and aralia elata.
Owner:匡海学 +2
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