103 results about "Salicylamide" patented technology

The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

Salicylamide derivatives represented by formulae (1a) and (1b); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active ingredient. The salicylamide derivatives represented by formulae (1a) and (1b) are useful as anti-inflammatory agents and immunosuppressive agents which exert an effect of inhibiting the activation of NF-kappaB with little side effects.

An organic additive to an electrolyte for a battery cell in an implant able medical device is presented. At least one organic additive is selected from a group comprising one of lithium salivate, hydroxyphthalic anhydride, a hydroxybenzoic acid, salivate ester, salicylamide, and salicylanilide.

The invention discloses a method for preparing sodium, 8-(2-hydroxybenzamido)octanoate which is a drug intermediate. The method comprises the following steps of reacting salicylamide, which serves as a raw material, with ethyl chloroformate to produce an intermediate 2H-benzo[e][1,3]oxazine-2,4(3H)-dione, reacting the intermediate with 8-bromooctanoic acid ethyl ester, carrying out hydrolysis so as to obtain 8-(2-hydroxybenzamido)octanoic acid, and then, reacting 8-(2-hydroxybenzamido)octanoic acid with sodium hydroxide so as to obtain the final product, namely sodium, 8-(2-hydroxybenzamido)octanoate. According to the method, the raw material reacts with ethyl chloroformate to produce the intermediate 2H-benzo[e][1,3]oxazin-2,4(3H)-dione, so that the yield of the reaction is greatly increased, the selectivity of reaction is greatly improved, the production cost is reduced, the production of byproducts is lowered, industrial production is facilitated; and the method is environment-friendly.

The invention discloses a preparation method of a pharmaceutical intermediate, i.e., sodium 8-[(2-hydroxybenzoyl) amino] octanoate. The preparation method comprises the steps of enabling salicylamide,used as a raw material, to react with N' N-carbonyl diimidazole so as to generate an intermediate, i.e., 2H-benzo[e][1,3]oxazine-2, 4 (3H)-dione; enabling the intermediate to react with 8-ethyl bromooctanoate to obtain 8-(2, 4-dicarbonyl-2H-benzo[e][1, 3]oxazine-3(4H)-yl) ethyl caprylate; hydrolyzing by using sodium hydroxide, and then acidizing to obtain 8-[(2-hydroxybenzoyl) amino] caprylic acid; then, enabling the 8-[(2-hydroxybenzoyl) amino] caprylic acid to react with sodium hydroxide to obtain the final product, i.e., the sodium 8-[(2-hydroxybenzoyl) amino] octanoate. The preparation method avoids the use of a genotoxic raw material-ethyl chloroformate, is low in reaction energy consumption, less in by-products and high in yield, greatly lowers the production cost, and is simple inprocess and suitable for industrial production.

The invention provides novel application of 4-hydroxy salicylamide in the field of pharmacy. The compound is an inhibitor of ribonucleotide reductase (RR), and can achieve the aims of inhibiting replication of HBV and treating hepatitis, in particular the hepatitis B by inhibiting activity of RR enzyme to block synthesis of dNTPs (deoxynucleotide triphosphates) required by hepatitis B virus (HBV)replication, achieve the aim of preventing and treating liver cancer by inhibiting the activity of RR of liver cancer cells, including the RR activity activated by HBV to inhibit proliferation of liver cancer cells, and achieve the aim of treating various tumors by inhibiting the RR. The 4-hydroxy salicylamide can be used for preventing and treating hepatitis B, liver cancer, oropharyngeal epithelioma, colorectal cancer, ovarian cancer, non-small cell lung cancer, chronic myeloid leukemia and other tumors, and has important application prospect.

The present invention relates to a method for preparing actylamide, in particular to a novel acylation method for preparing actylamide by using triethyl ammonium-alchlor (C2H5)3NHCl-nAL3 (n is equal to 2.0 minus 2.5) ion liquid as a catalyst and a solvent to catalyze salicylamide. The method is characterized in that in the presence of nitrogen, acetyl chloride is added to undergo synthesis reaction when the temperature of the salicylamide reactant in the ion liquid rises to between 32 and 46 DEG C. The method has the advantages that the obtained actylamide is high in conversion rate, good in selectivity, and high in purity, the reaction time of the process is short, the method is economic in resources, low in risk and toxicity, low in contamination, easy to control reaction conditions, and easy and simple in the process, and the like.

The invention discloses an environment friendly method for preparing a DMF (Dimethyl Formamide) solution of 2-hydroxy-benzonitril, which is characterized in that triphosgene and salicylamide are respectively added into DMF to be fully reacted. With the preparation method disclosed by the invention, more than 98% of 2-hydroxy-benzonitril (excluding solvent) can be obtained, the chemical conversion and the selectivity are both greater than 98%, and no problems exist if the 2-hydroxy-benzonitril is directly applied for the next step of reaction. In the process of production, no polluting waste gas and waste water are discharged, scraps are inorganic salts which can directly used or organic amine hydrochlorides which can be recycled, the comprehensive production cost of the 2-hydroxy-benzonitril is greatly reduced, and the production process is environment friendly.

The invention discloses a 3-substituted salicylamide compound, a preparation method, a medicinal composition and application thereof, and particularly relates to 3-substituted salicylamide derivativesexpressed by a general formula I, medicinal salts thereof, hydrate and solvent compounds thereof, polycrystal and eutectic crystal thereof, precursor or derivatives thereof with the same biological function, a preparation method thereof, a composition containing one or more compounds, and application of the compounds in the aspects of treating diseases such as diabetes, obesity and the like related to glucose kinase.

The invention provides a benzoyl fluorobenzene salicylamide compound and a preparation method and an application thereof. The benzoyl fluorobenzene salicylamide compound with a structure shown in a formula (I) is formed by the substitution reaction of benzoyl fluorobenzene salicyloylchloride as shown in a formula (III) and R1R2NH in an organic solvent at a temperature of between 0 and 160 DEG C. Derivatives of the benzoyl fluorobenzene salicylamide compound and the preparation method and the application thereof of the invention have the advantages of: (1) providing a novel anti-inflammatory and analgesic drug with remarkable anti-inflammatory and analgesic activities, and providing a research basis for selecting novel drugs; (2) simple preparation process and applicability industrialized production.

The invention relates to a composite synergistic bactericidal and preservative agent for organic foaming agents, which is prepared from 2-methylisothiazolinone and / or 1,2 benzisothiazolinone (BIT) and / or dichloroethylene based salicylamide, sodium pyrithione and / or sodium hydroxymethylglycinate, sodium dimethyldithiocarbamate and / or o-phenylphenol, phenethyl alcohol and / or phenylcarbinol, a regulator, a solvent and water. According to the invention, different bactericidal and preservative agents with various complementary bactericidal spectrums are composited, so that the products have the advantages of reasonable formula, comprehensive protection, strong synergism, good bactericidal and preservative effects and the like, and have a good application effect when being used in aqueous organic foaming agents containing large amounts of proteins and organic polysaccharides.

The invention belongs to the field of medical intermediate, and particularly discloses a method for preparing a 5-(N,N-dibenzylglycyl) salicylamide. The method comprises the following steps of mixing dibenzylamine and 5-(bromoacetyl) salicylamide with the molar ratio more than or equal to 2 and taking carbinol and water as solvent so as to react under the circumfluence condition at the temperature less than or equal to 40 DEG C; obtaining a coarse product by centrifuging the reaction products, and refining the coarse product by ethyl acetate, thus obtaining the 5-(N,N-dibenzylglycyl) salicylamide. The method has the advantages of simple preparation method, easy industrial production, high product yield, high purity, etc.

The invention relates to a method for reducing excess sludge of an aerobic unit of a sewage treatment system by an activated sludge process, which comprises a step of adding a chemical uncoupling agent into water inlet of the aerobic unit of the sewage treatment system, wherein the chemical uncoupling agent comprises the following components: 3,3,4,5-tetrachloro salicylamide, soluble copper salt and an adsorbent; the soluble copper salt is one of copper sulfate, copper chloride or copper acetate; the adsorbent is one of refined diatomite or zeolite powder or a mixture of the refined diatomiteand the zeolite powder; the weight ratio of the 3,3,4,5-tetrachloro salicylamide to the soluble copper salt is 1:0.05-0.25; the weight ratio of the total of the 3,3,4,5-tetrachloro salicylamide and the soluble copper to the adsorbent is 1:0.05-1.00; and in the water inlet, the addition amount of the chemical uncoupling agent accounted by the 3,3,4,5-tetrachloro salicylamide is controlled in the range of 0.6 to 3.8mg / l. The method has stronger sludge reduction performance. If the same weight reduction rate of the sludge is achieved, the added TCS (tetrachloro salicylamide) can be reduced by 25to 75 percent, and the removing rate of the COD (chemical oxygen demand) is basically not influenced.

The invention relates to a preparation method of salicylamide, which comprises the following steps: adding methyl salicylate and methylbenzene in a weight ratio of 1:(2.8-3.2) into a reaction kettle, heating to 40-45 DEG C, and continuously introducing to carry out ammonification reaction, wherein the reaction temperature is controlled at 40-45 DEG C, and the reaction pressure is controlled at 0.25-0.35MPa; and after the reaction is carried out for 5-6 hours, stopping introducing the ammonia gas, heating to recycle the methylbenzene and the reaction byproduct methanol, cooling the residual material to 20-25 DEG C, crystallizing, and centrifugalizing to obtain the salicylamide. The salicylamide prepared by the preparation method provided by the invention has the advantages of high yield, high product purity, and no assorted colors on the appearance; no waste water is generated in the whole production process; both the methylbenzene and the reaction byproduct methanol can be recycled and reused; and thus, the invention provides an environment-friendly production method.

The present application discloses an anti-aging packaging adhesive for a solar photovoltaic panel. The anti-aging packaging adhesive comprises in parts by weight: 50 parts of propylene-ethylene-vinylacetate copolymer, 10-12 parts of ethylene-methyl acrylate copolymer, 10-12 parts of ethylene-hydroxyethyl acrylate copolymer, 2-3 parts of N,N-dimethyl salicylamide, 0.2-0.3 parts of ammonium sulfate and 0.2-0.3 parts of lithium fluoride. According to the present application, by modifying the conventional EVA resin and introducing propylene molecules, the anti-aging property of the packaging adhesive is greatly improved; meanwhile, with the ethylene-methyl acrylate copolymer and the ethylene-hydroxyethyl acrylate copolymer as auxiliary modified resin, not only weather resistance of the packaging adhesive is coordinately improved, but also adhesive strength of the packaging adhesive is effectively improved when the packaging adhesive is exposed to outdoor for a long time; and the introduced N,N-dimethyl salicylamide can effectively prevent the packaging adhesive from ageing and yellowing so as to reduce an impact on light transmittance and ensure power generating efficiency of the photovoltaic panel.

The invention discloses a salicylamide ester type derivative and a preparation method thereof. The salicylamide ester type derivative has a general formula 1. The salicylamide ester type derivative can be disassociated into a salicylamide type compound with anti-tumor activity and a short-chain fatty acid type compound such as valproic acid, butyric acid and the like with effect of suppressing histone deacetylase activity; thus, the salicylamide ester type derivative disclosed by the invention can be used as an antineoplastic medicament with a double action mechanism.

The invention relates to an antibacterial pe pipe. 5% of antibacterial master batch is added in and mixed with pe resin. The temperature of the mixture is raised to 170-180 DEG C. Then the mixture undergoes single-screw extrusion, cooling and vacuum forming, secondary cooling, tertiary cooling, spray code printing, traction, cutting and other procedures. The antibacterial master batch is mixed with dichloroethenyl salicylamide and thiazole mixture, paint, dispersant, carrier resin and liquid lubricant. The mixture is heated and melted down and then extruded by a twin screw for purpose of pelleting. A plastic water supply pipe made of the antibacterial pe pipe can inhibit and prevent the attachment and the growth of microorganisms, kill bacteria, fungus, mould and other bacterium species in the water supply pipe, strongly inhibit colibacillus and staphylococcus aureus and has an antibiosis rate of 99 percent. The antibacterial pe pipe has simple production process and low cost.

The invention relates to a preparation method for 5-(N, N-dibenzylamino)acetylsalicylamide. The method includes: adding salicylamide and chloroacetyl chloride into a container to carry out reaction according to a mole ratio of 1: 2.5-5.5, using an ionic liquid as the solvent, with the mole ratio of the ionic liquid to salicylamide being 5-10:1, carrying out reaction at 35-55DEG C under atmospheric pressure, then at the end of the reaction, taking an organic solvent to perform extraction to obtain 5-chloracetylsalicylamide, adding the prepared 5-chloracetylsalicylamide and dibenzylamine into a mixed solution of water and methanol, with the volume ratio of methanol to water being 2-4:1, carrying out heating reaction at 50-70DEG C for 2-4h, with 5-chloracetylsalicylamide and dibenzylamine being in a mole ratio of 1:1.0-1.2, at the end of the reaction, conducting vacuum distillation to remove the solvent, and performing recrystallization to obtain 5-(N, N-dibenzylamino)acetylsalicylamide. The preparation method provided by the invention has the characteristics of low production cost, short synthesis step, high yield, and small environmental pollution.

The invention provides a synthetic method for high-yield o-hydoxybenzonitrile. The synthetic method mainly comprises the following steps: 1) adding salicylamide and a solvent xylene in a reaction vessel, starting the reaction vessel for full stirring; 2) turning on a jacket for steam heating, simultaneously introducing phosgene for a reaction; 3) after the reaction is complete, introducing nitrogen for expelling gas, setting an absorber at a gas outlet of the reaction vessel; 4) transferring a mixture in the step 3) to a rectifying tower, respectively collecting the fraction with the temperature of 137-140 DEG C and 145-155 DEG C; 5) cooling the fraction with the temperature of 137-140 DEG C and distilling the fraction to obtain the solvent xylene; and 6) condensing the fraction with the temperature of 145-155 DEG C in the step 4) and slicing the fraction to obtain the product o-hydoxybenzonitrile. The method is mature and reliable, the product quality is high, the raw material consumption is low, the cost is low, compared with the same kind of the product, the content of the o-hydoxybenzonitrile is increased by 1.5%, and the impurity is decreased by 1.0%.

A preparation method of a meropenem intermediate is disclosed. The method includes adding salicylamide and cyclohexanone into an organic solvent that is toluene; reacting the mixture under the function of a catalyst that is p-toluenesulfonic acid; then performing material centrifugation, rinsing and centrifugation until a product is dry to obtain white crystals; raising the temperature until the obtained material is dissolved; then adding an organic solvent that is toluene and a catalyst that is n-propylamine; then adding 2-chloropropionyl chloride dropwise and reacting the mixture until the reaction is finished; performing vacuum distillation to remove the toluene; performing centrifugation after crystallization; and after a centrifugation product is dry, discharging and drying. The moleratio of the salicylamide, the cyclohexanone, the p-toluenesulfonic acid, the n-propylamine and the 2-chloropropionyl chloride is 1:1.3-1.7:0.01-0.04:0.2-0.5:0.2-0.5. The salicylamide, the cyclohexanone and the 2-chloropropionyl chloride are adopted as raw materials, the p-toluenesulfonic acid and the n-propylamine are adopted as catalysts, the one-time product yield is 92.4% by reaction temperature control and material ratio control, and the mother liquor recovery rate is 5%.

The invention discloses a low-toxicity wood mould inhibitor. The low-toxicity wood mould inhibitor comprises the following raw materials including, by weight, 3-6 parts of atractylodes lancea, 2-4 parts of mugwort leaves, 3-6 parts of pyrethrums, 4-6 parts of sophora flavescens, 3-7 parts of radix stemonae, 5-7 parts of cloves, 0.01-0.05 part of dichloroethenyl salicylamide and 3-5 parts of sodium chloride. By means of the wood mould inhibitor, the traditional Chinese medicines including the atractylodes lancea, the mugwort leaves, the pyrethrums, the sophora flavescens, the radix stemonae and the cloves are added, a good mould preventing effect is achieved, the cost of raw materials is low and is one third of that of a chemical treating agent, little pollution is generated in the preparing and using processes, and the wood mould inhibitor is safe and environment-friendly compared with a traditional wood mould inhibitor; in addition, the sodium chloride is added, and the functions of color fixing and sterilizing are achieved; and due to the fact that the dichloroethenyl salicylamide is added, the mould preventing effect is further improved, and the service life of a wood product is greatly prolonged. Meanwhile, the invention provides a preparing method of the low-toxicity wood mould inhibitor, the technology is simple, operation is convenient, and the use effect is good.

The invention relates to pleuromutilin derivatives, particularly salicylamide ether compounds of pleuromutilin and a preparation method thereof. The structural formula of the salicylamide ether compounds of pleuromutilin is disclosed as a general formula I, wherein R is NHCmH2mCH3, and m is a whole number which is greater than or equal to 0. In the invention, the pleuromutilin, which is used as the raw material, is esterified, subjected to amine-ester exchange and etherified to obtain the pleuromutilin derivatives. The related pharmaceutic adjuvant groups are changed to enhance the pharmaceutic activity, thereby achieving the corresponding pharmacodynamic goal. In normal cases, most receptors are proteins or derivatives thereof; the amido group contained in the pharmaceutic molecule can promote the pharmaceutic molecule to be combined with the corresponding receptor in an easier way, thereby enhancing the pharmaceutic effect. All the pharmaceutic materials in the synthetic process are common, cheap and accessible, thereby lowering the production cost.

A method for refining chemical-grade isoprene into polymer-grade isoprene, comprising: 1) extracting and rectifying chemical-grade isoprene in the presence of a solvent, dimethylformamide, to remove heavy component impurities; 2) The isoprene extracted and rectified is then rectified to remove light component impurities to obtain polymer grade isoprene. A polymerization inhibitor is added to the extractive distillation system, and the components of the polymerization inhibitor include A, B and C, wherein: A is piperidine oxygen free radical and / or nitrophenol, B is diethylene glycol monomethyl ether and / or Diethylene glycol monobutyl ether, C is N,N-disalicylidene-1,2-propanediamine or N-salicylamide phthalimide, in parts by weight, when A=10, B=5 ~20, C=0.2~0.8. Compared with the prior art, the present invention has the advantage that the comprehensive performance of the polymerization inhibitor is greatly improved by adding an auxiliary component to the polymerization inhibitor used in the refining process to improve the solubility and dispersibility of the polymerization inhibitor component and to inhibit metal corrosion.

The invention belongs to the technical field of medicines and particularly discloses a medical bactericide. The medical bactericide comprises hydrogen peroxide, N-(beta, beta-dichloroethenyl) salicylamide, ethylene, polyoxyethylene, alkyl benzene sulfonic acid, acetic acid and isophorone. The components of the medical bactericide are low in toxicity to human bodies and low in irritation to tissue, so that the pain caused to a patient when the medical bactericide is smeared on a wound is greatly relieved, and the medical bactericide is applicable to skin and mucosa infection caused by fungi, long-acting and safe and convenient to use.

The invention discloses an anti-shedding finishing agent for rabbit fur fabrics, which is composed of the following raw materials in parts by weight: 5-10 parts of dichlorovinyl salicylamide, 4-9 parts of o-hydroxybenzoic acid ester, 3 parts of epichlorohydrin ‑6 parts, 13‑18 parts of hydroxypropyl xanthan gum, 12‑30 parts of sorbitol, 10‑14 parts of sophorolipids, 3‑6 parts of crosslinking agent, 1‑3 parts of ascorbyl palmitate, myristyl 7‑13 parts of trimethylammonium bromide, 2‑6 parts of sodium xylene sulfonate, 15‑20 parts of base oil, 6‑8 parts of dispersant, 12‑14 parts of poloxamer, fatty alcohol polyoxyethylene ether 1‑5 servings. The anti-shedding finishing agent for rabbit hair fabrics of the present invention has no damage to rabbit hair fibers, and the treated rabbit hair fabrics feel softer and finer, are not easy to depilate, and have increased mechanical strength on the contrary.

Disclosed is a catalyst of synthetic salicylamide, which has mass percent compositions of 10.0-30.0% calcium oxide and 70.0-90.0% zinc oxide. The catalyst is prepared by a precipitation method. The synthetic salicylamide is formed by adding carbamide and phenol having mol ratio of 1:1-1:50, and adding 0.5-30% catalyst, based on total weight of the reactant, into a reaction vessel; rising temperature of the reaction vessel to 100-250 DEG C., in a condition of agitating, to react for 2-24 hours; and removing the catalyst by diluting and centrifugal settling. The invention has advantages of cheap reaction material easy to get, simple preparing method of the catalyst, high selectivity of salicylamide and mild reaction condition.

The invention relates to a water-free skin care cosmetic with effects of resisting wrinkles, whitening and moisturizing. The cosmetic is prepared from, by mass, 35% of glycerinum, 10% of butanediol, 15% of squalane, 3% of cetyl polyethylene glycol, 2.5% of beewax, 15% of a red ginseng extract, 8% of vitamin C, 5% of a terminalia ferdinandiana fruit extract, 4% of bifida ferment lysate, 2.0% of salicylamide phytosphingosine and 0.5% of vitamin E, wherein an A phase comprises the glycerinum and the butanediol, a B phase comprises the squalane, the cetyl polyethylene glycol and the beewax, and aC phase comprises the red ginseng extract, the vitamin C, the terminalia ferdinandiana fruit extract, the bifida ferment lysate, the salicylamide phytosphingosine and the vitamin E. The invention further discloses a preparation method of the water-free skin care cosmetic. The water-free skin care cosmetic with the effects of resisting the wrinkles, whitening and moisturizing has the advantages that polyhydric alcohols replace water, so that antioxidant ingredients in the formula are not easily hydrolyzed and oxidized, thereby effectively achieving the antioxidative effect, also stabilizing thedosage form, and prolonging the shelf life of the product; multiple effects of resisting the wrinkles, brightening the skin and moisturizing can be combined while the skin is moistened; through the cooperation of the red ginseng extract, the vitamin C and other ingredients, the problem of the oxidation of active ingredients of antioxidants is solved, the absorption of the active ingredients is increased, and the cosmetic does not contain a preservative, and replenishes the inherent oily squalane of the skin.