3-substituted salicylamide compound, preparation method, medicinal composition and application thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
- Publication Date
- 2010-02-17
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to 3-substituted salicylamide derivatives represented by general formula I, their pharmaceutically acceptable salts, their hydrates and solvates, their polycrystals and cocrystals, their precursors or derivatives with the same biological function, and Its preparation method, the composition containing one or more of these compounds, and the use of these compounds in treating diseases related to glucokinase such as diabetes and obesity. Background technique
[0002] Sugar is an important energy and carbon source for organisms. The decomposition of sugar produces energy, which can supply the needs of the organism's life activities, and the intermediate products of sugar metabolism can be converted into other carbon-containing compounds, such as amino acids, fatty acids, and nucleosides. Sugar metabolism can be divided into sugar decomposition and sugar synthesis. Sugar catabolism includes glycolysis, the common breakdown p...