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Method for preparing anticancer, cancer-preventing ocean active medicine

An active drug, marine technology, used in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as large toxic side effects, single components, etc., to reduce toxic side effects, antioxidant free radicals, anti-tumor cell proliferation, and huge new drugs The effect of developing value

Inactive Publication Date: 2005-10-05
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purpose of the present invention is to overcome the disadvantages that the existing chemically synthesized anti-cancer and anti-cancer drugs have large toxic and side effects, and the traditional Chinese medicine preparation cannot be listed as a national class I new drug because of the mixed components, and aims to invent a single-component anti-cancer drug. and anti-cancer effect, a natural anti-tumor drug with significant curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: The preparation method of this anti-cancer and anti-cancer marine active drug tablet is as follows:

[0019] The first step is the purification of artificially synthesized ISA. Under the condition of avoiding light, take 100g of artificially synthesized ISA and dissolve it in a solvent with a volume ratio of 1:1-8 of ultrapure water and absolute ethanol, and slowly heat it on a magnetic stirrer at 50°C-80°C to Dissolve, then gradually cool down to obtain needle-shaped orange-red crystals, filter the supernatant and keep it for other use, repeat the above method, evaporate the ethanol, and dry it for later use; the filtered supernatant can be collected, distilled and evaporated Ethanol, concentrate the filtrate to remove water, and dry the residue, which can be used as ISA to recrystallize again according to the above method to extract the pure product; repeat the above method; grind the purified ISA crystals into powder and pass through an 80-mesh sieve fo...

Embodiment 2

[0029] Embodiment 2: The preparation method of the anti-cancer and anti-cancer marine active drug tablet is as follows:

[0030] The first step is the purification of artificially synthesized ISA. Same as the first step in Example 1.

[0031] The second step: preparation of tablets. Purified ISA 50g

[0032] Lactose 200g

[0033] Microcrystalline Cellulose 175g

[0034] Carboxymethyl Cellulose Calcium 25g

[0035] Anhydrous silicic acid 25g

[0036] Carboxypropionyl Cellulose 20g

[0037] Magnesium Stearate 5g

[0038] Total 500g

[0039]Weigh out the above-mentioned ingredients respectively, mix the five ingredients including ISA, lactose, microcrystalline cellulose, carmellose calcium, and anhydrous silicic acid, and then dissolve carboxypropionyl cellulose with isopropanol, and put The above-mentioned 5 kinds of ingredients are added therein, prepared by wet granulation method, the obtained granules are mixed with magnesium st...

Embodiment 3

[0040] Embodiment 3: The preparation method of the anti-cancer and anti-cancer marine active drug tablet is as follows:

[0041] The first step is the purification of artificially synthesized ISA. Same as the first step in Example 1.

[0042] The second step: preparation of tablets. Purified ISA 100g

[0043] Lactose 150g

[0044] Microcrystalline Cellulose 150g

[0045] Carboxymethyl Cellulose Calcium 25g

[0046] Anhydrous silicic acid 25g

[0047] Carboxypropionyl Cellulose 35g

[0048] Magnesium Stearate 15g

[0049] Total 500g

[0050] Weigh out the above-mentioned ingredients respectively, mix the five ingredients including ISA, lactose, microcrystalline cellulose, carmellose calcium, and anhydrous silicic acid, and then dissolve carboxypropionyl cellulose with isopropanol, and put The above-mentioned 5 kinds of ingredients are added therein, prepared by wet granulation method, the obtained granules are mixed with magnes...

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Abstract

The present invention relates to a preparation method of anticancer cancer-preventing marine active medicine using 2,3-indol quinone as main component. Said preparation method includes the following steps: purifying artificial synthetic 2,3-indol quinone; weighing (by mass%) 10-20% of 2,3-indol quinone, 30-40% of lactose, 25-35% of microcrystal cellulose, 1-5% of calcium carboxymethyl cellulose, 1-5% of anhydrous silicic acid, 3-8% of carboxypropionyl cellulose and 1-3% of magnesium stearate; uniformly mixing 2,3-indol quinone, lactose, microcrystal cellulose, calcium carboxymethyl cellulose and anhydrous silicic acid, adding them into carboxypropionyl cellulose dissolved by isopanol, mixing the obtained granules with magnesium stearate, using wet granule method and tabletting to obtain tablet preparation. Besides, it can use medicinal starch and 2,3-indel quinone according to mass ratio of 1:1-10 and proper quantity of magnesium stearate, uniformly mix them and make them into capsule.

Description

Technical field: [0001] The present invention relates to a preparation method of an anti-cancer and anti-cancer marine active drug, in particular to an anti-cancer drug mainly composed of 2,3-indolequinone, a natural active substance present in cruciferous Folium Folium and marine organism lobster. The invention relates to a method for preparing anticancer drugs, which belongs to the technical field of traditional Chinese medicine preparation. technical background: [0002] Malignant tumor is a common disease that seriously threatens human health, accounting for the first place in my country's death due to disease. At present, most of the commonly used anticancer drugs are chemically synthesized cytotoxic drugs, which have poor selectivity to normal cells and cancer cells, and have large toxic and side effects. However, most traditional Chinese medicine preparations with low toxic and side effects cannot be included in the national class I due to their mixed ingredients. ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61K31/404A61K35/612A61P35/00
Inventor 岳旺王蕾刘占涛张芳周明
Owner QINGDAO UNIV
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