76 results about "Melancholia" patented technology

The invention relates to an oxadiazole derivative, a preparation method therefor and use of the oxadiazole derivative in medicines. Particularly, the invention relates to an oxadiazole derivative represented by a general formula (I) shown in the description, a preparation method therefor, a pharmaceutical composition containing the derivative and use of the pharmaceutical composition in preparation of drugs for preventing and / or treating diseases with IDO mediated pathological features of a tryptophan metabolism pathway, wherein the diseases comprise cancer, Alzheimer's disease, autoimmune disease, melancholia, anxiety neurosis, cataract, psychological barrier and acquired immunodeficiency syndrome. Each substituent of the general formula (I) is the same as defined in the specification.

The invention discloses an oral administration pharmaceutical composition for treating depression, which is prepared from Bupleurum root, lily bulb, cyperus tuber, root of herbaceous peony, wild jujuba seeds, immature bitter orange, root bark of tree peony, root of red rooted saliva, Ligusticum wallichii, cape jasmine, licorice root, grassleaved sweetflag rhizome, medicated leaven, white atractylodes rhizome, mimosa-tree bark, epimeddium, curcuma aromatica, amber and senega root. The medicament should be decocted in water for the oral dose.

The invention discloses a Chinese medicinal composition with the effects of antidepressant and anti-anxiety, and belongs to the field of Chinese traditional medicines. The Chinese medicinal composition comprises (by weight parts) radix bupleuri 6-15, cape jasmine fruit 5-15 or paeonia suffruticosa bark 5-20, and angelica sinensis 3-15 or ligusticum chuanxiong 3-15; and can be prepared into any conventional oral preparations. Different ministerial drugs and adjuvant drugs are added according to different subjects to better exert therapeutic effect. The inventive composition has the effects of antidepressant and anti-anxiety; and can be used for relieving depression and anxiety with the advantages of definite therapeutic effect and rapid drug effect. The inventive composition can also be used for relieving headache, palpitation, insomnia and melancholia.

Provided are a histamine-H3 receptor antagonist; and a preventive and / or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty liver, circulatory system diseases, for example, stenocardia, acute / congestive cardiac insufficiency, cardiac infarction, coronary arteriosclerosis, hypertension, nephropathy, sleep disorder and various diseases accompanied by sleep disorder such as idiopathic hypersomnia, repetitive hypersomnia, true hypersomnia, narcolepsy, sleep periodic acromotion disorder, sleep apnea syndrome, circadian rhythm disorder, chronic fatigue syndrome, REM sleep disorder, senile insomnia, night worker sleep insanitation, idiopathic insomnia, repetitive insomnia, true insomnia, electrolyte metabolism disorder, and central and peripheral nervous system diseases such as bulimia, emotional disorder, melancholia, anxiety, epilepsy, delirium, dementia, shinzophrenia, attention deficit / hyperactivity disorder, memory disorder, Alzheimer's disease, Parkinson's disease, sleep disorder, recognition disorder, motion disorder, paresthesia, dysosmia, epilepsy, morphine resistance, narcotic dependency, alcoholic dependency. The histamine-H3 receptor antagonist comprises a piperidine derivative compound of formula (I) [wherein X1 and X2 independently represent a nitrogen atom or CH; Y represents a specific group; X3 represents Os—(CH2)m; R1 and R2 independently represent a hydrogen atom, a halogen atom, a linear or branched lower alkyl group, a lower alkoxy group, or an acetyl group substituted with 2 or 3 fluorine atoms; s is 0 or 1; and m is an integer to make (m+s) 0 or from 1 to 4], or its pharmaceutically-acceptable salt.

Provided are a histamine-H3 receptor antagonist; and a preventive and / or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty liver, circulatory system diseases, for example, stenocardia, acute / congestive cardiac insufficiency, cardiac infarction, coronary arteriosclerosis, hypertension, nephropathy, sleep disorder and various diseases accompanied by sleep disorder such as idiopathic hypersomnnia, repetitive hypersomnnia, true hypersomnnia, narcolepsy, sleep periodic acromotion disorder, sleep apnea syndrome, circadian rhythm disorder, chronic fatigue syndrome, REM sleep disorder, senile insomnia, night worker sleep insanitation, idiopathic insomnia, repetitive insomnia, true insomnia, electrolyte metabolism disorder, and central and peripheral nervous system diseases such as bulimia, emotional disorder, melancholia, anxiety, epilepsy, delirium, dementia, shinzophrenia, attention deficit / hyperactivity disorder, memory disorder, Alzheimer's disease, Parkinson's disease, sleep disorder, recognition disorder, motion disorder, paresthesia, dysosmia, epilepsy, morphine resistance, narcotic dependency, alcoholic dependency. The histamine-H3 receptor antagonist comprises a piperidine derivative compound of formula (I) [wherein X1 and X2 independently represent a nitrogen atom or CH; Y represents a specific group; X3 represents Os—(CH2)m; R1 and R2 independently represent a hydrogen atom, a halogen atom, a linear or branched lower alkyl group, a lower alkoxy group, or an acetyl group substituted with 2 or 3 fluorine atoms; s is 0 or 1; and m is an integer to make (m+s) 0 or from 1 to 4], or its pharmaceutically-acceptable salt.

The present invention relates to a Chinese medicine composition which is made up by utilizing the Chinese medicinal materials of ginseng, licorice root, acanthopanax root, bighead atractylodes rhizome, poria and sehisandra fruit as raw material and adopting the following processes: respectively using ethyl alcohol solution and water to make decoction and extraction of the above-mentioned raw materials, concentrating and drying, etc. Said invented Chinese medicine composition has the main functions of resisting fatigue, resisting radiation and reasisting melanchelia, etc and can be used for improving and curing the diseases of network syndrome, chronic apocamnosis and office syndrome, etc. Said medicine composition has not toxic side effect, and can be made into nutrient agent and health-care food also.

The invention provides a medicine composition used to cure melancholia, which is a preparation with the following raw materials in weight proportions: 2 - 4 portions of radix bupleuri, 2 - 4 portion of radix curcumae, 2 - 4 portions of acorus gramineus, and 1- 2 portions of Paeonia lactiflora pallas. The invention also provides the preparation method and purposes of the medicine composition. The medicine composition in the invention has the advantages of apparent therapeutic effects, safety, and controllability.

The invention relates to an oral traditional Chinese medicine preparation for treating melancholia and anxiety neurosis, which is prepared by adopting the following raw materials of traditional Chinese medicines in parts by weight: 15+ / -3 of roasted astragalus root, 10+ / -2 of American ginseng, 10+ / -2 of white atractylodes rhizome, 10+ / -2 of tall gastrodia tuber, 10+ / -2 of medlar, 10+ / -2 of prepared rehmannia root, 10+ / -2 of white peony root, 10+ / -2 of radix salviae miltiorrhizae, 10+ / -2 of angelica, 10+ / -2 of rhizoma ligustici wallichii, 10+ / -2 of herba epimedii, 15+ / -3 of spine date seed, 10+ / -2 of tuckahoe, 10+ / -2 of rhizoma anemarrhenae, 10+ / -2 of rhizoma cyperi, 10+ / -2 of radix bupleuri, 10+ / -2 of TurmericRoot-tuber and 6+ / -1.2 of roasted licorice. The observation of clinical curative effect proves that the total effective rate of the invention for treating the anxiety neurosis is 92.2%; the total effective rate of the invention for treating the melancholia is 91.0%. The curative effect of the oral traditional Chinese medicine preparation is similar to the curative effect of the western medicines of buspirone for treating the anxiety neurosis and fluoxetine for treating the melancholia. Moreover, the traditional Chinese medicine preparation has no obvious toxic or side effect and can be taken for a long time. The preparation has small dose, easy release of the effective components of the medicine, quick absorption, full exertion of the medicine effect, convenient carrying and easy taking and is beneficial to large-scale production.

The invention relates to a traditional Chinese medicine for curing hepatic depression syndrome type melancholia. The traditional Chinese medicine for curing hepatic depression syndrome type melancholia can effectively solve the problems of long drug treatment cycle, low curing rate, poor effect and side effects in conventional drug treatment. The traditional Chinese medicine for curing hepatic depression syndrome type melancholia comprises the following crude drugs by weight: 6-10g albizia flower, 6-10g rose, 6-10g Armeniaca mume, 10-12g radix bupleuri, 15-20g radix paeoniae alba, 15-25g radix curcumae, 10-12g rhizoma cyperi, 10-15g Poria cocos Schw. and 12-16g ligusticum chuanxiong, the crude drugs are mixed and then added with water and immersed, soaked for 30-40 min and boiled for twice, during the first time of boiling, strong fire is adopted firstly, then slow fire is adopted for boiling for 30-40 minutes, then filtering is performed, and a first-time decoction is obtained; water is added into dregs of the decoction to immerse the dregs, strong fire is used for boiling, then slowing fire is used for boiling for 20-30 min, filtering is performed, a second-time decoction is obtained, and then the first-time decoction and the second time-decoction are combined together, so that the traditional Chinese medicine can be obtained. The traditional Chinese medicine provided by the invention is scientific in compatibility, the method is simple, the curing cycle is short, the cure rate is high, the effects are good, no side effect can be caused, and traditional Chinese medicine for curing hepatic depression syndrome type melancholia represents a great creation in the traditional Chinese medicines.

The invention provides a medicine composition for treating postpartum melancholia, which is a medicament prepared from the following raw materials of medicines proportioned by weight: 1 part of ginseng, 1-3 parts of wild jujuba seed and 0.5-2 parts of angelica. The invention also provides a preparation method and an application of the medicine composition. The medicine is used for treating the postpartum melancholia and has definite medicine effect and strong controllability. Pharmacodynamical experiments prove that the medicine has the effects of treating parturient depression, invigorating qi, nourishing the blood, promoting blood circulation and relieving the stasis of blood, has safe clinical use and provides a novel choice of the medicine for treating the postpartum melancholia in clinic.

The invention discloses a pharmaceutical composition with the effects of hypnosis, anti-depression and anti-anxiety, and belongs to the traditional Chinese medicine field. The pharmaceutical raw materials of the pharmaceutical composition are: 6 to 40 parts by weight of Szechuan lovage rhizome and 10 to 40 parts by weight of pinellia tuber which are taken as monarch drugs; and 3 to 20 parts by weight of cape jasmine fruit or 1 to 15 parts by weight of golden thread which are taken as ministcrial drugs. The pharmaceutical composition can be prepared into any common preparation form for internal usage. The different adjuvant drugs or guide drugs can be added on the basis of the monarch drugs and the ministcrial drugs according to the different individual differences, so as to play the better efficacy. The pharmaceutical composition of the invention has the effects of hypnosis, anti-depression and anti-anxiety, the efficacy for the treatment of insomnia, depression and anxiety disorder is exact, the onset of action is fast, and the pharmaceutical composition can also be used for the treatment of insomnia, melancholia, headache, palpitation and other diseases of the traditional Chinese medicine.

The invention relates to the field of traditional Chinese medicines, especially relates to a traditional Chinese medicine composition, and application and preparation method thereof, cold tea and a preparation method thereof, a medicinal preparation and a cosmetic. The traditional Chinese medicine composition is prepared from, in parts by weight, 9-18 parts of flos lonicerae, 2-8 parts of flos chrysanthemi, 1-5 parts of radix glycyrrhizae, 1-5 parts of herba lophatheri, 1-5 parts of herba menthae, 1-5 parts of spica prunellae, 1-5 parts of fructus lycii, 1-5 parts of fructus momordicae, and other raw materials. The traditional Chinese medicine composition possesses the efficacy of enhancing immunity and treating wind-heat cold, also possesses effects of resisting oxidation and maintaining beauty, has certain auxiliary treatment effect on diabetes, melancholia, hypertension, bronchitis and the like, also is capable of effectively treating excessive internal heat, heatstroke and constipation, contains heat, protein, carbohydrates, sodium and multiple elements, and other nutrients beneficial to human body, has the color, taste and other physical and chemical and hygienic indexes according to national standard requirements, and is extremely light in original unpleasant taste, sweet in taste and good in mouthfeel.

The invention discloses an osmanthus fragrans extract, a preparation method thereof, and a use thereof in preparation of medicines or health food for preventing or treating melancholia. The osmanthus fragrans extract is prepared by following steps: a extraction step of soaking osmanthus fragrans in a solvent to obtain an extract mixture liquid so as to extract antioxidants in the osmanthus fragrans to an extract mixture liquid by the solvent; a filtering step of removing solid residuals in the extract mixture liquid to obtain a extract liquid; and a drying step of drying the extract liquid to obtain a dried osmanthus fragrans extract.

The invention belongs to the Chinese traditional medicine field, in particular to a Chinese traditional medicine composition used for treating and fighting against depression, which is prepared by the raw materials with the following weight portions: 6-12 portions of Danshen root, 10-20 portions of lancelesf lily bulb, 10-20 portions of Chinese date, 4-8 portions of baked liquoric root, 20-40 portions of wheat and 8-16 potions of rehmanniae praeparatum. The Chinese traditional medicine composition of the invention has the function of treating depression as well as the function of treating both the symptoms and root causes, which can effectively cure depression. The invention also discloses the preparation method of the Chinese traditional medicine composition.

The invention relates to a medicine component used for curing or lightening melancholia or a neurodegeneration disease. The medicine component used for curing or lightening the melancholia or the neurodegeneration disease comprises at least one type of Chinese herbal medicine which is chosen from a group which is composed of ortex phellodendri, radix scutellariae, rhizoma chuanxiong,astragalus, eucommia, Saposhnikovia divaricata and rhizoma corydalis, and the Chinese herbal medicine in the group is capable of promoting rebirth of a neural stem cell and adjusting hypothalamus-infracerebral gland-adrenal gland axis or antiapoptosis. The invention further provides a purpose used for manufacturing the medicine component used for curing or lightening the melancholia or the neurodegeneration disease. The purpose used for manufacturing the medicine component used for curing or lightening melancholia or the neurodegeneration disease comprises at least one type of the Chinese herbal medicine which is capable of promoting rebirth of the neural stem cell and adjusting the hypothalamus-infracerebral gland-adrenal gland axis or the antiapoptosis.

The invention relates to a preparation method of Chinese herbal medicine preparation for treating depression and anxiety disorder, having the materials of roasted milkvetch root, Largehead Atractylodes Rhizome, Rhizoma Gastrodiae, medlar, Prepared Rehmannia Root, root of herbaceous peony, danshen root, angelica sinensis, Szechwan Lovage Rhizome, Epimedium Herb, semen zizyphi spinosae, polygalae, pachyma cocos, medicinal glue, American ginseng and Hairy Antler. The water volume of water decoction, extraction time and extraction times of the roasted milkvetch root, Largehead Atractylodes Rhizome, Rhizoma Gastrodiae, medlar, Prepared Rehmannia Root, root of herbaceous peony, danshen root, angelica sinensis, Szechwan Lovage Rhizome, Epimedium Herb, semen zizyphi spinosae, polygalae, pachyma cocos are preferred by adopting orthogonal test in the invention, which remain every component of medicinal materials having effect on the indications to the utmost extent; simultaneously the extraction of ineffective ingredient is reduced; the concentration is processed, and the active ingredient is not lost; the cost is lowered; the medicinal glue, American ginseng and Hairy Antler are ground, and the raw powder is used as medicines. The capsules prepared by the preparation method of Chinese herbal medicine preparation has the advantages of convenient administration, small administration dosage, easy discharge of the drug active ingredient, rapid absorption, increased bioavailability and fully exerted drug efficacy.

The invention discloses a new purpose of panax notoginseng saponins and the monomer saponin, that is, the application of the panax notoginseng saponins and the panax notoginseng saponins in preparation of drugs to prevent and / or treat depression.

The present invention discloses a medicine compound for curing melancholia and associated functional dyspepsia made from the raw materials including ginseng, morinda root and largehead atractylode. The present invention also discloses a preparation method of the medicine compound. The experiment proves that the medicine compound provided by the present invention can obviously reduce the immobility time in tail suspension of tested small mice and the accumulative immobility time in forced swimming of tested large mice, and promote the gastrointestinal power of tested large mice, thus inferring that the medicine compound provided by the present invention has the efficacy of resisting experimental melancholia and curing dyspepsia.

Disclosed is a Chinese medicament for treating depression in the dose forms of tablets, capsules and granules, which is prepared from Bupleurum root, herbaceous peony, mimosa-tree bark and bitter orange.

The invention relates to a duloxetine hydrochloride enteric micropill preparation which is composed of a drug-carrying pill core, an isolating coating layer and an enteric coating layer. When the enteric materials in the prescription adopt common methacrylic acid copolymers, sugar alcohol can be added into the isolating layer to achieve the goal that the active component in-vitro dissolution curve is consistent with a positive control drug (Cymbalta of Eli Lilly and Company). The product has the advantages of high acid resistance, high dissolution speed, high rate and the like; the methacrylic acid copolymers used as the enteric material are easy to purchase and low in cost; and the adopted conventional preparation method is simple in technique and suitable for industrial production, thereby providing a drug with reasonable price and reliable curative effect for patients with melancholia.

The invention relates to a Chinese medicine composite for curing climacteric melancholia and an application thereof. The Chinese medicine composite is prepared from the following raw materials in parts by weight: 10-20 parts of radix rehmanniae praeparata, 10-20 parts of herba epimedii, 15-25 parts of radix paeoniae alba, 10-20 parts of uncaria, 25-35 parts of fossilia dentis mastodi and 25-35 parts of concha ostreae. The Chinese medicine composite disclosed by the invention accords with the assistant and guide principle of a traditional Chinese medicine on compatibility, and can be used for effectively harmonizing the balanced feedback function among hypothalamus, pituitary and ovarium in the curing process of the climacteric melancholia by being verified through animal and clinical experiments, thereby harmonizing the neuroendocrine network, relieving the anxious emotion, cognitive function, day and night change, mind retardance symptoms, sleep disorder, despairing concept and the like of a patient and effectively regulating and controlling the reproductive endocrine system and the immune system; the Chinese medicine composite disclosed by the invention has the advantages of small toxic side effect, less medicine variety and better curative effect, is suitable for being taken for a long time and is a medicine for safely and effectively curing the climacteric melancholia.

The invention discloses a drug composition containing ginseng and white paeony root as raw materials used for treating depression. The invention also discloses the preparation method thereof. The experiment confirms that the drug composition can significantly reduce the tail suspending motionless time and forcing swimming motionless time of the subject mice, thus concluding that the composition of the invention has the efficacy of anti-experimental depression.

The invention discloses an oral medicament or health care food for treating melancholia with acting mechanism after being made into multiple-target drone receptor with raw materials of ginsenoside (Rg1+Rb1), glycyrrhizic acid and Chinese date cAMP. According to the experiment to prove, the medicament composition of the invention can obviously reduce the small mouse suspension tail dead time and body temperature descend induced by reserpine; obviously improve the rat horizontal and vertical movement increase and rat learning and memory function abatement caused by buibus olfactorius damage; meanwhile can improve saccharose drinking water amount decrease and body weight descend caused by unpredictable long term stress stimulus, can improve the rat horizontal and vertical movement decrease and obvious increase of the NE and 5-HT content in the rat cerebral cortex caused by unpredictable long term stress stimulus. The experiment result proves that the medicament has remarkable anti-melancholia efficacy, comparing to the current medicament Paroxetine for treating the melancholia in prior art.

The invention relates to a chinese medicine capsule used for tristimania, which is made by that: radix curcumae, polygalae, gyrophora, dwarf lilyturf Tuber, cortex albiziae, acorus granzineus, acanthopanax, gardenia, plum flower bud, and the like, are extracted and concentrated to liquid extract, then cooled, dried, powdered, sterilized and put into capsules, thus obtaining the product.

The invention provides a melitracen hydrochloride compound. Melitracen hydrochloride can inhibit reuptake of a presynaptic membrane on noradrenaline, so that the content of monoamine neurotransmitters of cynapse is improved. The product is researched by Denmark Lundbeck pharmaceuticals company and is listed in 1968. Melitracen and flupentixol are combined in use to have the function of coordinately adjusting the central nervous system and exert anti-depression, anti-anxiety and anti-excitation characteristics, so that the compound is suitable for acute and chronic schizophrenia, melancholia and depressive psychoneurosis.

The invention belongs to the field of traditional Chinese medicine preparations, and relates to a Uighur medicinal composition for treating hypomnesis and a preparation method thereof. The Uighur medicinal composition is prepared from the following raw materials by weight: 60-150g of anise seed, 60-160g of fennel, 60-360g of raisin, 60-160g of rose, 60-160g of fig, 60-160g of licorice root and 60-160g of capillaire. The Uighur medicinal composition provided by the invention has a certain treatment effect on Alzheimer's disease, melancholia and other patients and senile hypomnesis symptoms, andhas an effect of obviously improving hypomnesis.

A Chinese medicine for treating melancholia is prepared from 3 Chinese-medicinal materials including forsythia fruit, ginseng, etc through extracting, proportional mixing, pulverizing, sieving and granulating. Its advantages are high curative effect and quickly taking its effect.

The invention relates to a kit used for accurately detecting whether valine at the 66th position of BDNF in a specimen is variated into methionine by a fluorescence PCR detection technique. The invention provides effective guide for clinically and individually treating mental sickness, such as anxiety neurosis, melancholia, post-traumatic stress syndrome, and the like correlative to BDNF gene variation.