54 results about "Electrical brain stimulation" patented technology

Apparatus and methods for non-invasive electrical stimulation of the brain through skin surface stimulation of the peripheral nervous system as a treatment for movement disorders. Skin surface electrodes are positioned at predetermined peripheral surface stimulation sites on the skin surface using a variety of neural imaging techniques. A pulsatile electrical current is generated at the stimulation sites through a variety of standard electrical stimulation devices. Stimulation of the peripheral surface stimulation sites translates to electrical stimulation of a specific area of the brain.

The invention relates to a multielectrode probe having a silicon substrate which supports multiple conductive electrodes for deep-brain electrical stimulation or recording of neural responses. The substrate has an upper end with multiple conductive portions for bonding to lead wires, and an elongated shank extends from the upper end. The shank supports multiple spaced-apart electrodes, typically ten in number, and conductive traces electrically connect the electrodes and conductive traces. Multiple probes are combined, and supported as an array by a cylindrical alignment cylinder.

New methods for deep brain stimulation (DBS) surgery using two or more electrical leads are provided. The methods are useful for treating a wide variety of brain-associated disorders including movement-related disorders, psychiatric disorders, metabolic / eating disorders, memory disorders, and pain. Methods featuring stimulation of distinct target areas of a subject's brain, such as the thalamic ventralis intermedius (VIM) and the ventralis oralis (VOA / VOP) using multiple electrical leads for treatment of tremor provide superior clinical outcomes to stimulation with single leads implanted in these target areas.

A method and apparatus for electrical stimulation of the lower esophageal sphincter (LES) is provided. Electrode sets are placed in the esophagus in an arrangement that induce contractions of the LES by electrical stimulation of the surrounding tissue and nerves. The electrical stimulus is applied by a pulse generator for periods of varying duration and varying frequency so as to produce the desired contractions. The treatment may be short-term or may continue throughout the life of the patient in order to achieve the desired therapeutic effect. The stimulating electrode sets can be used either alone or in conjunction with electrodes that sense esophageal peristalsis. The electrode sets can be placed endoscopically, surgically or radiologically.

Systems and methods for introducing one or more stimulating drugs and / or applying electrical stimulation to the brain to at least treat or prevent obesity and / or other eating disorders, as well as drug, nicotine and alcohol addiction, uses at least one system control unit (SCU) producing electrical pulses delivered via electrodes implanted in the brain and / or producing drug infusion pulses, wherein the stimulating drug(s) are delivered to targeted areas in the brain.

The invention provides a system and method for controlling a brain computer interface (BCI) based on multimode fusion. The system comprises a brain electrostimulation and feedback module, an electroencephalogram (EEG) signal acquisition module, an EEG signal processing module and an execution module, wherein the brain electrostimulation and feedback module is used for evoking an SSVEP (Steady State Visual Evoked Potential) and inducing an MI (Motor Imagery); the EEG signal acquisition module is used for acquiring EEG signals; the EEG signal processing module is used for extracting, identifying and classifying SSVEP characteristics and MI EEG characteristics in the EEG signals and feeding classified results which respectively correspond to the SSVEP characteristics and the MI EEG characteristics back to the brain electrostimulation and feedback module; and the execution module is used for executing the classified results. According to the system and the method, a multimode fusion BCI is constructed, so that the information transmission rate, reliability and flexibility of a control system are improved, the low information transmission rate of a BCI in a single MI mode is reduced, meanwhile, the visual burden under a single SSVEP task is reduced, and the adaptation crowds of the BIC-based control system are increased.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

Systems and methods for introducing one or more stimulating drugs and / or applying electrical stimulation to the brain to at least treat or prevent obesity and / or other eating disorders uses at least one system control unit (SCU) producing electrical pulses delivered via electrodes implanted in the brain and / or producing drug infusion pulses, wherein the stimulating drug(s) are delivered to targeted areas in the brain.

An electrode—preferably an anode (current sink)—is implanted within a ventricle of the brain so that the cerebrospinal fluid therein, which is highly conductive, effectively makes the ventricle a conductive extension of the anode. An opposing electrode (i.e., a cathode) can then be situated within or outside the brain (e.g., extradurally) so that a portion of the brain to be electrically stimulated is situated between the electrodes. The electrodes can then be energized at appropriate frequencies and current / voltage levels to apply the desired stimulation, in a manner similar to preexisting Deep Brain Stimulation (DBS), Extradural Motor Cortex Stimulation (EMCS), and other electrical brain stimulation procedures.

A system and method for introducing one or more stimulating drugs and / or applying electrical stimulation to the brain to treat mood and / or anxiety disorders uses an implantable system control unit (SCU), specifically an implantable signal / pulse generator (IPG) or microstimulator with one or more electrodes in the case of electrical stimulation, and an implantable pump with one or more catheters in the case of drug infusion. In cases requiring both electrical and drug stimulation, one or more SCUs are used. Alternatively and preferably, when needed, an SCU provides both electrical stimulation and one or more stimulating drugs. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.

A system and method for controlling epilepsy and other neurological disorders by providing electrical stimulation to a patient's brain in response to detected neurological conditions. An implantable device includes a stimulation subsystem coupled to a stimulation electrode to provide responsive electrical brain stimulation in response to an event detected via an on-board processor's analysis of data received from a detection subsystem coupled to a detection electrode located in a different portion of the patient's brain.

The invention discloses a multi-target electric stimulation circuit, an electric stimulator and a signal output method thereof. The electric stimulation circuit comprises a control module, a pluralityof electroencephalogram acquisition modules and a plurality of stimulation adjustment modules, wherein each electrode is correspondingly provided with one electroencephalogram acquisition module andone stimulation adjustment module, and different electrodes are used for stimulating different targets; the electroencephalogram acquisition modules are used for acquiring electroencephalogram signalson the corresponding electrodes and transmitting the electroencephalogram signals to the control module; the control module is used for acquiring a brain rhythm phase signal according to the receivedelectroencephalogram signals, and outputting a stimulation signal at a set waveform phase point after phase locking is carried out on the brain rhythm phase signal; and the stimulation adjustment modules are used for adjusting an electroencephalogram stimulation signal output to the corresponding electrodes according to the received stimulation signal. Through the technical scheme of the invention, electric stimulation for multiple targets is facilitated, and time-locking matching for electric stimulation for multiple targets is realized.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

A lead for deep brain stimulation includes a first electrode group and a second electrode group. The first electrode group includes at least one first electrode which is adapted for being positioned in a nucleus accumben of a brain. The second electrode group includes at least one second electrode which is adapted for being positioned in an anterior limb of an internal capsule of the brain. With one single lead implanted in the brain, the first electrode group and the second electrode group simultaneously stimulating the nucleus accumben and the anterior limb of the internal capsule, and the present disclosure improves the effect and safety of DBS in the therapy of drug-addiction, OCD and / or depression.

The present invention discloses a BCI animal experiment system. Said BCI animal experiment system includes the following several portions: PC machine, cranial nerve electrostimulation / collector, electrical brain stimulation electrode and exercise training yard. Said invention also provides the connection mode of all the above-mentioned portions, and also provides the working principle of said system and its application and operation method.

The invention provides automatic control of a deep brain stimulation system (2) using tremor detection based on accelerometer signals. Because no manual interventions are necessary, the ease of use for the patient (1) is greatly enhanced. Furthermore the autonomy of the patients in normal daily life is increased. The present invention also results in a reduced energy consumption and consequently longer battery life. On the other side with the present invention an optimal treatment is possible, adjusted to the patient's symptoms without the help of a physician.

The present invention belongs to the technical field of bio-crossing, particularly relates to a mobile terminal based steady-state visual evoked potential (SSVEP) brain computer interface system, and aims to solve the problem in use of SSVEP on a mobile terminal. The system is characterized by comprising three modules: a stimulator module, an electroencephalogram collection module and a target identification module, wherein the stimulator module is used to generate electroencephalogram stimulation signals visually; the electroencephalogram collection and pre-processing module is used to collect brain waves and perform noise reduction; and the target identification module is used to identify processed brain wave signals. According to the mobile terminal based SSVEP brain computer interface system provided by the present invention, the flicker frequency is accurate, the carrying is convenient, and relatively good results can be achieved without the need for training. The system is suitable for occasions with relatively small target number and frequently changing application places, such as wheelchair controlling, mouse controlling, commercial entertainment development and the like. The system further expands the application range of brain computer interfaces and has a certain practical value.

A system for treatment of gait disorders reflects, with electrical stimulation patterns fed to electrodes (1, 8) arranged at the patient, on the event of heel-strike and heel-off, the events being generated by a wireless heel switch (5). The pulse generator (4) also transfers the electrical energy needed to operate the heel switch (5) wirelessly. The event signal from the heel switch (5) is modulated in order to achieve a longer operating range.

A system and method for introducing one or more stimulating drugs and / or applying electrical stimulation to the brain to treat mood and / or anxiety disorders uses an implantable system control unit (SCU), specifically an implantable signal / pulse generator (IPG) or microstimulator with one or more electrodes in the case of electrical stimulation, and an implantable pump with one or more catheters in the case of drug infusion. In cases requiring both electrical and drug stimulation, one or more SCUs are used. Alternatively and preferably, when needed, an SCU provides both electrical stimulation and one or more stimulating drugs. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.

The invention discloses an electroencephalogram stimulation memory enhancement system based on portable EEG equipment. The system comprises four parts of a specially-made EEG electroencephalogram stimulator, a specially-made EEG signal analysis system, a sleep analysis algorithm and a specially-made electric wave stimulation manner. A working principle of the system lies in that: the specially-made EEG electroencephalogram stimulator collects brain waves of a user during sleeping and transmits the brain waves to the specially-made EEG signal analysis system in real time; the analysis system decodes and preprocesses EEG signals, and judges the sleep stage of the user through a machine learning algorithm; when the user enters a rapid eye movement sleep stage, a stimulation instruction is sent to the stimulator for electric wave stimulation, and the brain memory function is enhanced; and when the user enters a non-rapid eye movement sleep stage, sending the stimulation instruction is stopped, and electric wave stimulation is stopped. According to the method, data characteristics of sleep EEG signals are analyzed, and a principle that slow wave frequency electroencephalogram stimulation during sleep can promote synchronization of specific neurons (ABNs), and enhance the memory, is adopted, and the function of enhancing brain memory during sleep is achieved.

The invention provides a rat cerebral electrical stimulation device and electrode fixing bases thereof. The electrical stimulation device comprises an electric simulator, two electrode fixing bases, and an electrode wire capable of electrically connecting the electric simulator and the electrode fixing bases, wherein each electrode fixing base comprises an insulated fixing section, an electrode inserting section, a conductive contact section and a bolt; two or more bolt limiting holes are formed in the insulated fixing section in a center symmetry manner; the electrode inserting section is fixedly arranged at the center position of the upper end surface of the fixing section; a conductive electrode inserting hole is formed in the center of the inserting section; the conductive contact section is arranged at the center position on the lower end surface of the fixing section; the upper end of the contact section penetrates through the fixing section and is connected with the electrode inserting hole; the lower end of the contact section is arranged to contact a cerebral dura mater of a rat after passing through the rat brain; and the bolt is matched with the bolt limiting hole and is used for fastening the fixing section on a rat skull. According to the rat cerebral electrical stimulation device, a simulation electrode can be stably arranged on the rat skull in a plug and play manner, and the technical problems that an electrode in the prior art easily falls off and the electrode inserting depth is difficult to control are solved.

The invention provides a method for electric brain stimulator. In the beginning, obtaining a brain functional amplitude modulation spectrum, wherein the brain functional amplitude modulation spectrum is a relationship between carrier frequency and amplitude-frequency on different brain sites. Then selecting a first alternating current frequency, wherein the first alternating current frequency is determined by the amplitude-frequency in which the brain functional amplitude modulation spectrum display a maximum power relation value, or a maximum correlation value with any behavior index of behavior and cognitive functions. And selecting a second alternating current frequency, wherein the second alternating current frequency is determined by the carrier frequency in which the brain functional amplitude modulation spectrum display a maximum power relation value, or a maximum correlation value with any behavior index of behavior and cognitive functions. In the end, outputting an alternating current signal, the alternating current signal is generated based on a first cosine function of the first alternating current frequency, a second cosine function of the second alternating current frequency, or a combination of the first cosine function and the second cosine function.

The invention discloses a microelectrode propelling device and a microelectrode propelling method. The device comprises a gasket, a box body, a nut, screws, a slide block and a bottom plate. The propelling method comprises the following steps that: the periphery of the bottom plate is arranged into a step shape, the bottom plate is positioned on a skull by positioning screws through two semicircular holes serving as positioning reference on the bottom plate and positioning holes at corresponding positions on the skull, and the bottom plate and the skull are bonded and fixed through dental cement; the bottom plate is connected with the box body through concavely and convexly matched grooves; the slide block is arranged inside a slideway of the box body, an array plate is arranged on a stepped groove of the slide block so as to fix a microelectrode, the position of a hole on the array plate is the position of intersecting axles of a sagittal plane and a coronal plane at a brain region-specified space encoding position, a horizontal position of the array plate is a propelling surface of a propeller, and the propeller performs electrical brain stimulation and encephalographic record on the whole brain region. The propelling device has the characteristics that: the operation is simple and the structure is light, and the device is suitable for labs for researching animal brain regions.

A lead for deep brain stimulation includes a first electrode group and a second electrode group. The first electrode group includes at least one first electrode which is adapted for being positioned in a nucleus accumben of a brain. The second electrode group includes at least one second electrode which is adapted for being positioned in an anterior limb of an internal capsule of the brain. With one single lead implanted in the brain, the first electrode group and the second electrode group simultaneously stimulating the nucleus accumben and the anterior limb of the internal capsule, and the present disclosure improves the effect and safety of DBS in the therapy of drug-addiction, OCD and / or depression.

The invention discloses a smoking-desire-reducing neural signal feedback method based on electrical activity of the brain, and relates to the field of neural signal feedback. The smoking-desire-reducing neural signal feedback method includes the following steps that S01, the smoking stimulation mode of an ex-smoker is collected in real time through an electroencephalograph; S02, the smoking stimulation reaction mode of the ex-smoker is processed and analyzed based on brain electricity; S03, feedback training is conducted on brain electricity nerves; S04, the ex-smoker is treated. According tothe smoking-desire-reducing neural signal feedback method, no foreign matter enters the body of the smoker, and the side effect caused by drugs is avoided; meanwhile, training is conducted through brain-electricity real-time feedback signals, the ex-smoker can obtain feedback information of neural signals of the brain-electricity stimulation reaction mode in real time, learn the own state in time,and improve the desire control ability through continuous trying, a desire reducing effect can be achieved, and the smoking cessation efficiency of the ex-smoker can be improved.

The invention discloses an electric brain stimulator based on a serial port and an implementation method thereof and belongs to the field of medical equipment. The electric brain stimulator based on the serial port comprises an electric brain stimulation control section and a communication device, wherein the electric brain stimulation control section comprises a designer and a player; the designer is a tool for designing processes of the electric brain stimulation control section and provides processes for a user to voluntarily design the electric brain stimulation control section; the player serves as a computer display tool of the electric brain stimulator and is used for playing pictures, sound stimulation and the like; and the communication device serves as a tool for communication interaction of a computer and an electroencephalograph (electroencephalogram acquisition system) and is used for the computer to send digital trigger signals synchronous with stimulation to the electroencephalograph.

A lead for deep brain electrical stimulation, to be inserted into liquid cavities, such as ventricles, or cysternae or subarachnoidal spaces, the lead comprising: a tubular body of biocompatible material having a side wall defining a lumen, said tubular body being suitable for being inserted over at least a fraction of its length into the inside of a patient's body in order to reach a region for stimulation; electrodes disposed close to a distal end of the tubular body; and a rigid stylet for inserting removably into the lumen of said tubular body; the lead being wherein said tubular body has an equilibrium shape that is not rectilinear, being different from the shape of the stylet and presenting one and only one bend, and that is sufficiently flexible and elastic to follow the shape of said stylet by deforming reversibly when the stylet is inserted into the lumen. A deep electrical neurostimulation system comprising an electrical pulse generator and at least one such lead having its electrodes electrically connected to said generator.